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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 369 of 675

Negative / Null Result ReportMedicine

Utility of Postoperative Thyroid Hormone Levels in Predicting the Diagnosis of Adult Growth Hormone Deficiency in Patients Undergoing Surgery for Nonfunctioning Pituitary Neuroendocrine Tumor: A Pilot Study.

Tsujimoto, Yamashiro, Suzuki et al. · 2026 · International journal of endocrinology

Adult growth hormone deficiency (AGHD) is often diagnosed after surgery for nonfunctioning pituitary neuroendocrine tumor (NF-PitNET). While a growth hormone stimulation test (GHST) is required to establish its diagnosis, it is associated…

View details →DOI: 10.1155/ije/8842344
Negative / Null Result ReportMedicine

Task Shifting in Cardiac Ablations Compared With Percutaneous Coronary Interventions: The Japanese Circulation Society Chugoku-Shikoku Regional Survey Subanalysis.

Fukue, Suetomi, Matsuura et al. · 2026 · Circulation reports

As part of work-style reform for physicians, task shifting to non-physician healthcare professionals has been promoted in Japan. We previously reported task shifting results for percutaneous coronary interventions (PCI), but the status in…

View details →DOI: 10.1253/circrep.cr-25-0329
Negative / Null Result ReportMedicine

Robotic Mitral Valve Repair in Patients With Thoracic Deformity.

Tomita, Kakuta, Kainuma et al. · 2026 · Circulation reports

Robotic mitral valve repair (MVr) offers superior visualization and dexterity, potentially overcoming challenges in severe thoracic deformity such as pectus excavatum. This study compared surgical outcomes after MVr in patients with and…

View details →DOI: 10.1253/circrep.cr-26-0003
Negative / Null Result ReportMedicine

The Impact of Kidney Donor Profile Index and Human Leukocyte Antigen Mismatch on Graft Survival in Pediatric Kidney Transplant Recipients.

Ranabothu, Smith, Perkins et al. · 2026 · Pediatric transplantation

Pediatric kidney transplant recipients typically receive low-KDPI deceased donor kidneys but often experience higher HLA mismatches. The relationship between KDPI and HLA mismatch and their combined effect on graft and patient outcomes in…

View details →DOI: 10.1111/petr.70351
Negative / Null Result ReportMedicine

Gemcitabine-Based versus Fluoropyrimidine-Based Chemotherapy and Role of Platinum Combination for First-Line Palliative Systemic Treatment in Advanced Ampullary Adenocarcinoma.

Wonglhow, Wetwittayakhlang, Sunpaweravong et al. · 2026 · Cancer management and research

Ampullary adenocarcinoma is a rare malignancy with limited evidence on the efficacy of systemic chemotherapy for advanced disease. This study aimed to evaluate the treatment outcomes of gemcitabine- and fluoropyrimidine-based regimens and…

View details →DOI: 10.2147/cmar.s608153
Negative / Null Result ReportMedicine

Effect of body mass on physiological and time-trial performance responses to mixed-method cooling applied between exercise bouts in the heat.

Yanaoka, Tyler, Hasegawa · 2026 · Frontiers in physiology

This study investigated the effect of body mass (BM) on the efficacy of mixed-method cooling (ice slurry ingestion + cooling vest) applied between exercise bouts. Sixteen males completed two experimental trials in the heat (35°C, 50%…

View details →DOI: 10.3389/fphys.2026.1817856
Negative / Null Result ReportMedicine

Immediate placement of intrauterine device after second-trimester medical abortion-Secondary outcomes with one-year follow-up.

Hogmark, Westermark, Envall et al. · 2026 · Acta obstetricia et gynecologica Scandinavica

Intrauterine devices (IUDs) effectively prevent unwanted pregnancies. Little is known about long-term outcomes of women choosing an IUD after second-trimester medical abortion. We performed a 12-month follow-up of a multicenter randomized…

View details →DOI: 10.1111/aogs.70259
Negative / Null Result ReportMedicine

Adjuvant chemotherapy for resected stage-ia lung adenocarcinoma with micropapillary histologic pattern.

Zhou, Bian, Yang et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery

The micropapillary pattern is a high-risk factor for postoperative recurrence in lung adenocarcinoma (LUAD), but the role of adjuvant chemotherapy (ACT) in stage IA LUAD with micropapillary pattern (LUADmp) after resection remains unclear.…

View details →DOI: 10.1093/icvts/ivag165
Negative / Null Result ReportMedicine

The impact of leaflet resection versus leaflet preservation on left ventricular reverse remodelling after mitral valve repair: insights from the UK mini mitral trial.

Rao, Bayliss, Wagnild et al. · 2026 · Journal of cardiothoracic surgery

Mitral valve repair (MVr) promotes left ventricular (LV) reverse remodelling, and subsequent reduction in LV diameters and volumes. The effectiveness of different MVr techniques, Resect (leaflet resection) and Respect (leaflet…

View details →DOI: 10.1186/s13019-026-04060-6
Negative / Null Result ReportMedicine

Umbilicus repositioning alleviates constipation in diabetic patients: A double-blind randomized clinical trial.

Kargar, Zareian, Rafiei et al. · 2026 · Journal of bodywork and movement therapies

Constipation is one of the most prevalent gastrointestinal issues faced by diabetic patients. An emerging therapeutic approach for addressing gastrointestinal disorders is visceral manipulation (VM). In this clinical trial, we evaluated…

View details →DOI: 10.1016/j.jbmt.2026.05.007
Negative / Null Result ReportMedicine

The Effects of Different Attentional Focus During Walking on Prefrontal Cortical Activation in Young Healthy Adults.

Grain, Ozsancak, Bonnal et al. · 2026 · The European journal of neuroscience

The aim of this study was to examine the effects of four attentional walking conditions on dorsolateral prefrontal cortex (DLPFC) activation, an approach that has not previously been investigated. We hypothesized that DLPFC activation and…

View details →DOI: 10.1111/ejn.70577
Negative / Null Result ReportMedicine

Field diagnostic performance of the Sysmex XN31 automated hematology analyser for malaria screening among febrile children in a sentinel site for malaria surveillance site in Libreville, Gabon.

Chesly, Patrick, Bedrich et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

To evaluate the diagnostic performance of the Sysmex XN-31 haematology analyser for malaria detection in a sentinel site. A prospective diagnostic assessment study was conducted among febrile children under 15 years of age, attending a…

View details →DOI: 10.1016/j.ijid.2026.108835
Negative / Null Result ReportMedicine

Revision rate and postoperative volume development of chronic subdural hematomas after burr hole craniotomy in combination with tranexamic acid vs. surgery alone - a single-center propensity score-matched analysis.

Scheer, Witte, Guenzerodt et al. · 2026 · BMC neurology

Chronic subdural hematoma (cSDH) is a common intracranial hemorrhage in elderly patients and is associated with substantial postoperative recurrence rates. Tranexamic acid (TXA) has been proposed as an adjuvant therapy to reduce recurrence…

View details →DOI: 10.1186/s12883-026-05003-3
Negative / Null Result ReportMedicine

Paraesophageal hernia repair is associated with similar safety and efficacy results in octogenarians as compared to younger patients.

Barekatain, Simon, Lyons et al. · 2026 · Surgical endoscopy

National database studies suggest elective paraesophageal hernia (PEH) repair in octogenarians is safe but provide limited detail on operative strategy and long-term symptom outcomes. We evaluated perioperative outcomes, operative…

View details →DOI: 10.1007/s00464-026-12944-w
Negative / Null Result ReportMedicine

Cryoprecipitate utilization in the neonatal intensive care unit: a single-center review.

Stoeckel, Soule-Albridge, Feldman et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Significant variability exists in the indications for and dosing of cryoprecipitate transfusions. We examined cryoprecipitate transfusions in neonates with a focus on indications, dosing, and the incidence of multi-donor exposure. In this…

View details →DOI: 10.1038/s41372-026-02740-8
Negative / Null Result ReportMedicine

Clinical correlates of ocular dominance in post-facial paralysis synkinesis.

Kapur, Henry, Lee et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

We aimed to explore the relationship between ocular dominance and synkinesis severity. Through phone interviews and a web-based survey, patients were asked to test their ocular dominance via the Miles test. Additionally, patients were…

View details →DOI: 10.1016/j.bjps.2026.05.041
Negative / Null Result ReportMedicine

Single anastomosis duodeno-ileal bypass with sleeve gastrectomy in the United States: has increased volume impacted safety?

Ballato, Shenoy, Le Gardeur De Tilly et al. · 2026 · Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

Originally described in 2007, the single anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) was only endorsed by the American Society for Metabolic and Bariatric Surgery in 2020. Since then, the procedure has grown…

View details →DOI: 10.1016/j.soard.2026.05.011
Negative / Null Result ReportMedicine

Novel Simulation-based Awake Fiberoptic Intubation Curriculum: Pilot Study.

Haas, Fredette, Murphy et al. · 2026 · The western journal of emergency medicine

Awake fiberoptic intubation is a critical skill of emergency physicians in scenarios where rapid sequence intubation may be impossible or catastrophic. While the equipment to perform awake fiberoptic intubation has become more readily…

View details →DOI: 10.5811/westjem.50778
Negative / Null Result ReportMedicine

Difference in outcomes between right and left posterior descending artery percutaneous coronary intervention: an Australian statewide registry analysis.

Rahman Zahin, Batchelor, Brennan et al. · 2026 · The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

Percutaneous coronary intervention (PCI) is an important treatment for coronary artery disease, and coronary dominance may influence procedural risk. PCI to a left-sided posterior descending artery (L-PDA) occurs in the setting of…

View details →DOI: 10.1186/s43044-026-00755-2
Negative / Null Result ReportMedicine

Glucose Metrics During School Hours in Primary School-Aged Children With Type 1 Diabetes: A Population-Based Cohort Study.

Paull, Connor, Smith et al. · 2026 · Journal of paediatrics and child health

School time represents a significant component of overall glycaemia for children with type 1 diabetes (T1D), and glucose levels during instructional time may be important for optimising academic progress. There is, however, limited…

View details →DOI: 10.1111/jpc.70463