A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19854 results in Negative / Null Result Report · page 364 of 662
Borhany M, Iqbal HT, Abid M et al. · 2026 · Clinical medicine insights. Pediatrics
Background Sickle cell disease (SCD) is characterized by a chronic hypercoagulable state. Hydroxyurea (HU) is known to reduce the frequency of vaso-occlusive events and transfusion requirements in affected individuals. Objective To assess…
Bonnet E, Ikpo D, Kodo M et al. · 2026 · Traffic injury prevention
Objective Road traffic injuries are a leading cause of death among children in Africa, especially in urban areas with inadequate infrastructure. Despite this, few scientifically taught educational initiatives to address this issue at the…
Gundrosen KF, Taraldsen K, Sverdrup K et al. · 2026 · European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity
Background This longitudinal study explored the one-year change in device-measured daily physical activity in patients attending a memory clinic. Methods Physical activity was recorded in 27 memory clinic patients over four days using…
Silverii H, Ahn J, Gopalan M et al. · 2026 · Journal of pediatric urology
Background While surgical coaching has been proven beneficial, the impact of a faculty focused coaching model on a surgeon's teaching ability and trainee education is unknown. In this study we aim to evaluate whether a surgeon's teaching…
Gan F, Zhang Q, Luo H et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR
Introduction The SuperPATH approach for total hip arthroplasty (THA) is promoted as tissue-preserving, but objective evidence of its impact on periarticular muscles is lacking. This study aimed to evaluate periarticular muscle damage one…
Boone C, Robicsek A · 2026 · JAMA internal medicine
Importance Quality metrics with financial incentives are widely used, but their impact on clinical care and patient health remains challenging to isolate. Objective To evaluate the association of a physician-facing quality metric and…
Kocuk M, Kopuz D, Alp S et al. · 2026 · American journal of dentistry
Purpose To evaluate the laboratory cleaning efficacy of six commonly used non-invasive methods for removing stains from occlusal fissures before caries diagnosis. Methods 60 extracted, caries-free permanent molars with visible occlusal…
Bhakta T, Jain K, Sudanabonia P et al. · 2026 · Investigative ophthalmology & visual science
The purpose of this study was to test the hypotheses that (1) monocular blur-driven accommodation is attenuated in keratoconus due to weaker defocus-blur signals arising from degraded image quality (IQ) compared with non-keratoconic…
Englisch CN, Wakili P, Langenbucher A et al. · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)
Purpose To assess the short-term impact of stand-alone MINIject (iSTAR Medical SA) implantation on astigmatism in a single-center retrospective study. Methods Refractive and corneal astigmatism was investigated based on preoperative and…
shi x, Jiang B, Huang C et al. · 2026 · Preprint
Abstract Objective： To evaluate changes in ciliary muscle morphology before and after accommodative training in premyopic school-age children and assess associations with myopia-related indicators. Design: Prospective controlled study.…
Nie J, Chen Y, Du Y et al. · 2026 · Preprint
Abstract Background Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by the larval stage of Echinococcus granulosus. The liver is the organ most commonly affected, whereas pancreatic involvement is extremely rare. When a…
Yu J, Grude O, Berg EAR et al. · 2026 · Intensive care medicine experimental
Background Measuring mitral annular plane systolic excursion (MAPSE) serially in a single wall may be an effective method for monitoring global left ventricular (LV) function, especially when automated with a novel deep learning method…
Butler A, Croxford R, Owusu-Bempah A et al. · 2026 · The International journal on drug policy
Background In October 2018, Canada legalized non-medical cannabis possession and use. While a stated objective of legalization was to prevent people from entering the criminal justice system for cannabis possession, we lack evidence about…
Shiraiwa K, Sueshige Y, Tanaka R et al. · 2026 · Preprint
Aims: Lenvatinib (LEN) inhibits organic anion transporting polypeptide 1B1 (OATP1B1) in vitro , raising concerns about potential risk for transporter-mediated drug–drug interactions (DDIs). This study evaluated the in vivo impact of LEN on…
Qian H, Jin H, Li S · 2026 · Clinical biochemistry
Objective To investigate the cause of markedly elevated cardiac troponin I (cTnI) levels that were inconsistent with the clinical presentation in an 18-year-old male patient with bradycardia. Methods Serial dilution analysis, heterophile…
Bellali YA, Jetté S, Delisle M et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association
Paraffin wax is applied to scar tissue for its proposed benefits of increasing skin pliability and relieving pain. However, limited studies have objectively assessed hypertrophic scar (HSc) response. This study examined immediate HSc…
Xu Y, Wang H, Wang N et al. · 2026 · Journal of cardiothoracic surgery
Background OBJECTIVE: To explore changes of tumor-infiltrating lymphocytes and the relationship with therapeutic effect before and after neoadjuvant chemoimmunotherapy in patients with esophageal squamous cell carcinoma(ESCC). Method This…
Çopur İ, Erbay RH, İlhan S et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : This prospective, randomized study aimed to evaluate the effects of different local anesthetic (LA) volume-dose combinations administered during supraclavicular brachial plexus block (SCBPB), a widely used…
Ekinci EI, Maldonado SG, Unseld A et al. · 2026 · Diabetes, obesity & metabolism
Aims This post hoc analysis evaluated the effect of survodutide on beta-cell function, insulin sensitivity, and glucose biomarkers in two phase 2 trial populations. Materials and methods Trial 1404-0002 randomised 413 participants with…
Pyasik M, Marini E, Ippolito G et al. · 2026 · Acta psychologica
In a predictive processing framework, religiosity and spirituality (R&S) have been linked to increased reliance on prior knowledge and decreased prediction error monitoring. In addition, R&S might be differentially related to processing…
Piri K, Gholamzadeh Jofreh M, Haghighizadeh MH et al. · 2026 · BMC psychology
Introduction Fear of childbirth (FOC) is a significant factor contributing to requests for elective cesarean sections. This study aimed to compare the effectiveness of internet-based cognitive behavioral therapy (ICBT) versus in-person…
Dijksterhuis J, Hurmuz MZM, van Dartel D et al. · 2026 · European geriatric medicine
Purpose Older hip fracture patients are often frail, complicating their recovery trajectories. Insight into patients' resilience may help in getting more understanding of their predicted recovery and adjusting their treatment plan…
Shanmugasundaram D, Wang RA · 2026 · Journal of toxicology
Objective Zylaria comprises a blend of botanical components, including Xylaria Nigripes (mycelium), Cuscuta Chinensis (seed) and Panax Notoginseng (root). This study aimed to evaluate the potential toxicity of Zylaria when administered…
Motomura T, Higashi M, Hattori A et al. · 2026 · Internal medicine (Tokyo, Japan)
Objective Hyperuricemia is associated with cardiovascular disease and chronic kidney disease (CKD). Dotinurad is a new uricosuric drug that has not been evaluated in clinical trials in patients with advanced CKD (CKD G3b-G5). This study…
Pedersen TA, Mori Y, Botteri E et al. · 2026 · Endoscopy
Background The effect of computer-aided detection (CADe) on performance of endoscopists with different experience levels is not well understood. This study assessed whether CADe use promotes learning or deskilling. Methods We performed a…
Hoskens S, Bamps K, Herteleer M · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie
Objectives The percutaneous placement of iliosacral (IS) and transsacral (TS) screws has become a standard practice for the treatment of pelvic fractures. Due to the complex sacral anatomy, accurate screw placement is essential to avoid…
Sacconi R, Saladino S, Forte P et al. · 2026 · Preprint
Abstract There is a lack of knowledge about the effect of smoking activity on the anatomy and functionality of retinal vessels. The aim of this low-risk, single-center, case-control, interventional clinical trial (ClinicalTrials.gov ID…
Cagini C, Messina M, Fiore T et al. · 2026 · Preprint
Abstract Purpose This study investigates the efficacy of a liposomal ophthalmic solution containing cross-linked hyaluronic acid, trehalose, and stearylamine in reducing the occurrence of dry eye-like signs and symptoms in patients…
Lu J, Shorey A, Uduba R et al. · 2026 · Clinical transplantation and research
Background Up to 23% of renal transplant recipients may develop transplant renal artery stenosis (TRAS). However, diagnosis requires angiography, and the contrast used may be nephrotoxic. We aimed to identify predictors of TRAS and clarify…
Feng J, Li S, Li X et al. · 2026 · Journal of agricultural and food chemistry
The effects of dietary supplementation with conjugated linoleic acid (CLA) on broiler duck growth performance and the quality of dry-cured products were investigated. Ten days preslaughter with the supplementation of 2 mL/d CLA was more…