A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 364 of 675
Rothell F, Nguyen MA, Xu E et al. · 2026 · Preprint
Neurolymphomatosis (NL), a rare manifestation of non-Hodgkin’s lymphoma affecting the peripheral nervous system, remains a diagnostic challenge. This study aimed to define an optimal diagnostic approach for timely and effective…
Yasuda H, Yokota K, Katabami T et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension
Primary aldosteronism (PA) causes biochemical abnormalities such as hypokalemia and metabolic alkalosis. This study aimed to compare the effects of aldosterone on serum potassium and corrected bicarbonate (cHCO 3 - , defined as Na - Cl -…
Alotaibi W, Alrasheed S · 2026 · JPMA. The Journal of the Pakistan Medical Association
Objective To evaluate axial length, anterior chamber angle, anterior chamber depth, refractive errors and white-to-white corneal diameter, and to assess their inter-correlations with intraocular pressure among young individuals. Methods…
Hsieh YT, Liao YC, Dulnuan HGP et al. · 2026 · Brain structure & function
Men typically display larger olfactory bulb (OB) volumes, while women demonstrate superior olfactory performance. Olfactory training (OT) has been shown to induce structural changes in OB, but whether sex influences OT-related plasticity…
Baharnoori M, Glanz B, Polgar-Turcsanyi M et al. · 2026 · Journal of the neurological sciences
Background Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are promising biomarkers for Multiple Sclerosis (MS) disease activity. There is less known about their association with the symptomatic…
Alhosseini R, Aghaie M, Ghorbani S et al. · 2026 · BMC research notes
BACKGROUND: Osteoporosis is a common bone disorder characterized by decreased bone density. Interleukin-6 (IL-6), plays a crucial role in bone homeostasis. This study aimed to evaluate the relationship between serum levels of IL-6 and…
Etemadifar M, Bagheri S, Dehghani A et al. · 2026 · Multiple sclerosis and related disorders
Background Multiple sclerosis (MS) prevalence varies worldwide and appears to be rising in Iran. Environmental factors like air pollution have been hypothesized to contribute to MS risk. This study aimed to map MS prevalence across Isfahan…
Mrkonjić R, Šribar A, Rudež I et al. · 2026 · Preprint
Background: Cardiac troponin I (TnI) is the reference biomarker for detecting myocardial injury. Saliva has recently emerged as a potential non-invasive diagnostic fluid; however, evidence regarding the clinical utility of salivary TnI…
Lan P, Lan T · 2026 · Metabolic syndrome and related disorders
Background Hyperlipidemia constitutes a systemic metabolic disorder. The correlation of cardiovascular disease [CVD] with the triglyceride-glucose index [TyG] in individuals with hyperlipidemia remains unclear. The current study examined…
Gahukamble A, Arikrishnan AM, Thuppale VE et al. · 2026 · Journal of pediatric orthopedics
Background Distal femoral extension osteotomy (DFEO) is an established surgical option for correcting knee flexion deformity (KFD) in children with cerebral palsy. However, the extension deformity created at the distal femur may remodel…
Almukhlifi Y, Alharbi A, Alghamdi L et al. · 2026 · Scientific reports
Emergency Medical Services (EMS) trainees are exposed to multiple occupational hazards during their training; however, the extent to which their awareness translates into safe professional behaviours remains unclear. This study aimed to…
Elrefaey R, Abdelsalam AI, Yara M et al. · 2025 · Preprint
Abstract Background Galectin-3 demonstrates multifunctionality with diverse biological roles. Its potential as a biomarker for inflammation and renal fibrosis has gathered attention. The renal doppler is commonly used as a guide for…
Sharma A, Nateghi R, Ayad M et al. · 2026 · Placenta
Introduction The placenta forms a critical barrier to infection through pregnancy, labor and, delivery. Acute placental inflammation in the membranes, diagnosed as Maternal Inflammatory Response (MIR), has short-term, and long-term…
Bandola AM, Wang MH, Guo BF et al. · 2026 · Marine pollution bulletin
Phthalate esters (PAEs) and microplastics (MPs) are emerging contaminants in aquatic environments. However, their co-occurrence in wetland sediments remains poorly understood. This study aimed to quantify PAE concentrations and MP…
Ibrahim EA, Alper E · 2026 · Preprint
Abstract Purpose: PSMA PET/CT has transformed prostate cancer management, yet its diagnostic utility is not absolute. It fails to detect PSMA-suppressed disease variants, including treatment-induced neuroendocrine prostate cancer (t-NEPC)…
Yokoyama S, Shimada M, Nakagawa J et al. · 2026 · European journal of drug metabolism and pharmacokinetics
Background and objective Vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is transported into hepatocytes via OATP1B1, which is encoded by the SLCO1B1 gene. Although interindividual variability in vadadustat…
Chen Y, Ren Z, Yan J et al. · 2026 · Urology
Objective To elucidate the association of endogenous circulating testosterone and its related substances with the onset and severity of stress urinary incontinence (SUI) in postmenopausal women. Patients and methods A comparative analysis…
Sayur V, Uc C, Baki B et al. · 2026 · Hernia : the journal of hernias and abdominal wall surgery
Background and aim With the increasing use of digital platforms in surgical education, YouTube has become a widely accessible resource for trainees. However, the absence of peer review raises concerns regarding the reliability and…
Koca SB, Kırkgöz T, Kara L et al. · 2026 · BMC endocrine disorders
BACKGROUND: Spexin has an inhibitory effect on the hypothalamus (GnRH expression), pituitary (LH and FSH expression) and ovary (estradiol expression). However, Phoenixin potentiate GnRH-stimulated GnRH receptor expression. Our aim is to…
Çiğri E, Çatan İnan F, Gülten S et al. · 2026 · Preprint
Objective: In the present study, cardiovascular risk indices (Atherogenic Index of Plasma [AIP], Atherogenic Coefficient [AC], Castelli Risk Index-1 [CRI-1], and Castelli Risk Index-2 [CRI-2]) and bone mineral density (BMD SDS) were…
Altun MNŞ, Yıldız İ · 2026 · Journal of pediatric nursing
Purpose This study aimed to determine the levels of e-health literacy and quality of life in adolescents with Congenital Heart Disease (CHD), to examine associated factors, and to explore the relationship between e-health literacy and…
Sun X, Zhou Q, Qian W et al. · 2026 · BMC medical education
Background Teaching postoperative follow-up for renal cell carcinoma (RCC) is challenging during brief urology rotations. We evaluated a structured module based on a simplified risk model (IMDB: venous invasion, tumor size ≥ 7 cm, systemic…
Mitsea A, Christoloukas N, Rontogianni A et al. · 2026 · Journal of imaging
AI methods (machine learning and deep learning methods) presented promising results concerning the accuracy of dental age estimation and sex determination. Therefore, this pilot study aims to evaluate the efficacy of an artificial…
Ye Z, Men R, Shen Y et al. · 2026 · Preprint
Abstract Purpose: The VIATORR Controlled Expansion (VCX) stent-graft was developed to allow more precise control of shunt diameter during transjugular intrahepatic portosystemic shunt (TIPS) creation. However, real-world data on its actual…
Ulas O, Yuceer RO, Hasbek Z et al. · 2025 · Medicina (Kaunas, Lithuania)
Background and Objectives : Neuroendocrine neoplasms are heterogeneous tumours arising from endocrine gland cells and the neuroendocrine system. Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) constitute two-thirds of this tumour…
Silva VBC, Lucina SB, Wolf M et al. · 2026 · American journal of veterinary research
Objective To assess right ventricular (RV) systolic function using conventional echocardiography and advanced techniques, including strain and tissue motion annular displacement (TMAD), in dogs with and without pulmonary hypertension (PH).…
Çerçer Z, Biçer Şahin F, Kanarya T · 2026 · Journal of human lactation : official journal of International Lactation Consultant Association
Background and aim It is important to include fathers in the evaluation of the breastfeeding process. This study aimed to assess fathers' breastfeeding attitudes and participation. Methods The cross-sectional study data were collected…
Igarashi A, Rekate A, Fujiwara K et al. · 2026 · Acta ophthalmologica
Purpose To evaluate whether early postoperative corneal thickness is associated with 12-month endothelial cell and visual outcomes after Descemet membrane endothelial keratoplasty (DMEK). Methods This retrospective multicentre study…
Pillet P, Tremblay-Mercier J, Picard C et al. · 2026 · Neurobiology of aging
Preclinical studies consistently associate body temperature with tau phosphorylation in the brain. This study examined the relationship between body temperature taken at lumbar puncture (LP) and CSF pTau181 levels in 142 cognitively…
CAI J, ZHAO P, LIN R et al. · 2025 · Preprint
Abstract The purpose of this study is to analyze the relationship between RPE-based method and internal training load (%HRavg, Banister's TRIMP, and Edward's TL) among high-level female volleyball players. 31 Chinese youth high-level…