A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 363 of 675
Zwaan W, Popeijus HE, Baars JJP et al. · 2026 · Nutrients
Background/Objectives : This study evaluated the immunomodulatory effects of multiple A. bisporus strains, applying both in vitro and in vivo murine models and aiming to identify specific strains with immune modulatory properties. Methods…
Kim S, Chun BC · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives To characterize pathogen-specific patterns of foodborne diseases across the full COVID-19 pandemic period, including post-non-pharmaceutical intervention (NPI) relaxation through 2024. Methods We conducted interrupted time…
Ferrández-Gómez JE, Baño-Alcaraz A, Gacto-Sanchez M · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses
Purpose Myogenic temporomandibular disorder frequently co-occurs with fibromyalgia and is associated with pain, disability, and maladaptive pain cognitions. This study evaluated the short- and long-term effects of an online Pain…
Malatiali S, Khamisi S, Kilarkaje N · 2026 · Acta diabetologica
Aim This study investigated the effects of angiotensin (1-7) on diabetes-induced renal injury and renal miRNA levels in obese type 2 diabetic db/db mice. Methods Treatment with angiotensin (1-7) (500 μg/kg; i.p.) was started when the mice…
Mahmoud WS, Alhowimel A, Almotery A et al. · 2026 · Scientific reports
Non-specific low back pain (NSLBP) represents about 80-95% of all LBP cases, yet the optimal lumbar traction position for effective treatment remains debated. To investigate the effect of different positions during lumbar traction on pain,…
Liu S, Yu J, Cheng X et al. · 2026 · Eye (London, England)
Background Multifocal intraocular lenses (MF-IOLs) have been developed to enhance far, intermediate, and near vision postoperatively of cataract surgery patients. This study investigates the improvement of visual function in cataract…
Cabizosu A, Zoffoli A, Mevi R et al. · 2026 · Physiological measurement
Objective. Infrared thermography is projected as an innovative and very promising tool for the observation of muscle response to fatigue. The aim of this study was to observe the skin temperature (Tsk) by thermography about acute muscle…
Wysokinski A, Wiśniewska-Kadżajan B, Łozak I · 2026 · BMC plant biology
Background Sulphur is an important macronutrient for legume plants because it influences the formation and functioning of root nodules, the activity of enzymes reducing molecular nitrogen to available forms for plants, the formation of…
Naka K, Ojha SK, Dimov LD · 2026 · Forest Ecology and Management.
This study examines the structural and compositional changes in Table Mountain pine (Pinus pungens Lamb.) associated forest ecosystems over a two-decade period (1997–2017) and assesses the species’ status across disturbed and undisturbed…
Bajwa MA, Lim J, Num YJ et al. · 2025 · Preprint
Abstract Objective : This study aims to analyze common radiographic parameters in adolescent idiopathic scoliosis (AIS) patients undergoing posterior spinal fusion (PSF) and determine their role in postoperative shoulder imbalance. Methods…
Tepe D, Deligozoglu D, Baskan C et al. · 2026 · Journal of pediatric endocrinology & metabolism : JPEM
Objectives Although Graves' orbitopathy (GO) in childhood is generally considered milder than in adults, data regarding its clinical course and relationship with thyroid autoimmunity remain limited. This study aimed to evaluate the…
White DE, Ghani U, Pedersen M et al. · 2025 · Journal of neuroengineering and rehabilitation
Background Unilateral nostril breathing (UNB) has a history linked to ancient yogic traditions where it is believed to affect both physical and mental states however the mechanism(s) by which this technique potentially influences brain…
Köçer MS, Yıldız MK, Akgün BM et al. · 2026 · Preprint
Abstract Learning through play provides children with meaningful and lasting knowledge while fostering empathy, social responsibility, and cooperation. In disaster education, where vital life skills are addressed, game-based approaches…
Scalvini S, Donati V, Zanelli E et al. · 2026 · European journal of internal medicine
Background Heart failure (HF) and type 2 diabetes (T2DM) are significant public health concerns. This study evaluated a 6-month home-based telemedicine program for older patients with combined HF and T2DM. The primary outcome was exercise…
Khaleel HM, Alsaffar SF · 2026 · Preprint
Background Polycystic ovarian syndrome (PCOS) is a hormonal, metabolic disorder in women of reproductive age. It can be induced by genetic, immunological, and environmental determinants. The main pathophysiology of PCOS, is…
Guillen B, Zambrano-Huailla R, Chirinos JA · 2026 · Revista de gastroenterologia de Mexico (English)
Introduction The use of artificial intelligence (AI) in endoscopic studies has grown in recent years. The present study evaluates the performance of AI in detecting polyps and adenomas in daily clinical practice. Materials and methods A…
Elabed MH, Jarbou H, Alsalim N et al. · 2026 · Preprint
Background Dentistry is considered a high-risk profession for developing work-related musculoskeletal disorders (MSDs), particularly in the cervical region, due to prolonged static postures, repetitive movements, and sustained neck flexion…
Haghighi H, Lindsey BW, Jeffries KM · 2026 · Preprint
Temperatures in aquatic ecosystems have been affected by anthropogenic activities such as agricultural and industrial water use, and climate change caused by greenhouse gas emissions. Changes in water temperature directly affect the…
Hollenbach J, Schroth FN, Hildebrand C et al. · 2026 · Placenta
Introduction Osteopontin (OPN) is an extracellular matrix protein secreted by endometrial glands during early pregnancy and is required for adhesion and signal transduction at the uterine-placental surface. In sheep, endometrial OPN…
Sas A, Jónyer D, Valikovics A et al. · 2026 · Journal of clinical medicine
Background/Objectives: Rheumatoid arthritis (RA) has been associated with accelerated atherosclerosis and cerebrovascular alterations. Our 2017 study compared 60 RA patients to healthy controls, assessing vascular, neurological, and…
Sangiorgi G, Cavinato L, Cristoferi M et al. · 2026 · Respiratory medicine
Background Elexacaftor/tezacaftor/ivacaftor (ETI) therapy rapidly improves monocyte antimicrobial activity in people with cystic fibrosis (pwCF). Here, we investigated the effect of long-term ETI therapy on Pseudomonas aeruginosa…
Gökcek Taraç M, Çolak M · 2026 · American journal of dentistry
Purpose To evaluate the effects of two commonly used pediatric medical syrups on the surface roughness and the adhesion of Streptococcus mutans (S. mutans) to three fluoride-releasing restorative materials: high-viscosity glass-ionomer,…
Houska N, McCaw N, Meneses EC et al. · 2026 · Journal of cardiothoracic and vascular anesthesia
Objectives To describe thrombotic outcomes associated with Factor Eight Inhibitor Bypassing Activity (FEIBA) exposure in neonates and infants undergoing cardiac surgery with cardiopulmonary bypass (CPB), including the Norwood procedure.…
Almuashi H, AbuMostafa A · 2026 · Quintessence international (Berlin, Germany : 1985)
Objective The management of pain in dental procedures is crucial, as local anesthetic injections may induce patient anxiety and discomfort. Various techniques including Vibraject and Dentapen have been devised to alleviate injection…
Veli-Quispe D, Urquizo-Prado S, Cesare-Ariza E et al. · 2026 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Background Cerebrovascular disease remains a leading cause of mortality worldwide. In Peru, evidence on recent mortality trends and regional disparities is limited. Objective To evaluate temporal trends and regional disparities in…
Qin LG, Camarda ND, Kasetty VM et al. · 2026 · Journal of vitreoretinal diseases
Purpose: To investigate the effect of intravitreal (IVT) aflibercept injection monotherapy on retinal ischemia in eyes with severe proliferative diabetic retinopathy (PDR) that underwent pars plana vitrectomy (PPV) without panretinal…
Li DY, Kim S, Javed S et al. · 2026 · Regional anesthesia and pain medicine
Background Methadone is commonly used as an alternative to other opioids for managing cancer-related pain. High-dose methadone, primarily in opioid dependence treatment, has been associated with QTc prolongation and dangerous arrhythmias.…
Švajger U, Kolar M, Pompe B et al. · 2026 · Cartilage
ObjectiveUmbilical cord-derived mesenchymal stromal cells (UC-MSCs) are a promising treatment for knee osteoarthritis (KOA). This study aimed to (1) characterize early synovial fluid biomarker changes after intra-articular UC-MSCs therapy…
Ramachandran I, Rajesh AT, Elumalai P · 2026 · Fish physiology and biochemistry
The current study aimed to ascertain the growth, antioxidant capacity, intestinal architecture, digestive enzyme activity, and disease resistance of S. agalactiae of Nile tilapia (Oreochromis niloticus) fed a diet enriched with…
Rocco C, Larrouy-Maumus G, Wissuwa M et al. · 2026 · Preprint
1 Summary Zinc (Zn) deficiency limits rice productivity and poses a risk to human health, particularly in populations reliant on rice-based diets. Although rice germplasm exhibits wide variation in Zn-deficiency tolerance, the underlying…