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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19854 results in Negative / Null Result Report · page 362 of 662

Negative / Null Result ReportMedicine

Is There Postoperative Fluid Accumulation After the Unilateral Biportal Endoscopic Technique as Minimally Invasive Spine Surgery: In Vivo Study.

Omer Bozduman, Kadri Yıldız, Bilal Aykaç et al. · 2025 · Turkish Neurosurgery

AIM To establish the presence and amount of fluid accumulation in UBE procedure, and the relationship of fluid management with other variables. MATERIAL AND METHODS All patients underwent UBE spinal surgery with one level between September…

View details →DOI: 10.5137/1019-5149.jtn.47037-24.1
Negative / Null Result ReportOpen accessMedicine

The effectiveness of generic emails versus a remote knowledge broker to integrate mood management into a smoking cessation programme in team-based primary care: a cluster randomised trial

N. Minian, Sheleza Ahad, Anna Ivanova et al. · 2021 · Implementation Science

Background Knowledge brokering is a knowledge translation approach that has been gaining popularity in Canada although the effectiveness is unknown. This study evaluated the effectiveness of generalised, exclusively email-based prompts…

View details →DOI: 10.1186/s13012-021-01091-6
Negative / Null Result ReportOpen accessMedicine

Effect of isolated and combined ingestion of caffeine and citrulline malate on resistance exercise and jumping performance: a randomized double-blind placebo-controlled crossover study

M. Haugen, F. T. Vårvik, J. Grgic et al. · 2023 · European Journal of Nutrition

The aim of this study was to explore the isolated and combined effects of caffeine and citrulline malate (CitMal) on jumping performance, muscular strength, muscular endurance, and pain perception in resistance-trained participants. Using…

View details →DOI: 10.1007/s00394-023-03212-x
Negative / Null Result ReportMedicine

Comprehensive Study of τ-Phase Mn–Al–C Magnets: Corrosion Resistance, Structural Integrity, and Magnetic Properties

Ulysse Rocabert, Maxim A. Parnicki-Krollik, F. Maccari et al. · 2024 · ACS Omega

This study investigates the chemical, physical, and magnetic properties of Mn–Al–C type magnets, focusing on their corrosion resistance. The hot compaction process is used for densification, producing isotropic magnets. Microstructural…

View details →DOI: 10.1021/acsomega.4c07540
Negative / Null Result ReportOpen access

Post-exercise ketone supplementation improves endurance performance, but not cardiac function during an 8-week training intervention

Y. Bekhuis, R. Robberechts, T. Rosseel et al. · 2024 · European Journal of Preventive Cardiology

Post-exercise ketone supplementation (PEKS) is commonly used in endurance athletes to alleviate overtraining symptoms and to stimulate recovery. The introduction of PEKS can blunt the development of symptoms associated with overtraining,…

View details →DOI: 10.1093/eurjpc/zwae175.286
Negative / Null Result ReportOpen accessMedicine

The effect of self-reported knee instability on plantar pressure and postural sways in women with knee osteoarthritis

Liana Chaharmahali, F. Gandomi, A. Yalfani et al. · 2021 · Journal of Orthopaedic Surgery and Research

Background Giving way and knee instability are common problems in patients with knee osteoarthritis, disrupting the daily activities and balance of the affected individual. The present study aimed to evaluate the postural control status of…

View details →DOI: 10.1186/s13018-021-02823-6
Negative / Null Result ReportOpen accessMedicine

Differing natural killer cell, T cell and antibody profiles in antiretroviral-naive HIV-1 viraemic controllers with and without protective HLA alleles

A. Moyano, Bongiwe Ndlovu, Msizi Mbele et al. · 2023 · PLoS ONE

Previous work suggests that HIV controllers with protective human leukocyte antigen class I alleles (VC+) possess a high breadth of Gag-specific CD8+ T cell responses, while controllers without protective alleles (VC-) have a different…

View details →DOI: 10.1371/journal.pone.0286507
Negative / Null Result ReportOpen accessMedicine

The Impact of Beeswax and Glycerol Monolaurate on Camellia Oil Oleogel’s Formulation and Application in Food Products

Xingchen Wei, Ronghui Xia, Chenxi Wei et al. · 2024 · Molecules

This study assessed the nutritional profile of camellia oil through its fatty acid composition, highlighting its high oleic acid content (81.4%), followed by linoleic (7.99%) and palmitic acids (7.74%), demonstrating its excellence as an…

View details →DOI: 10.3390/molecules29133192
Negative / Null Result ReportOpen accessMedicine

Minimally Invasive Approaches Versus Conventional Sternotomy for Aortic Valve Replacement: A Propensity Score Matching Study

J. Bang, Jong Wook Kim, J. Lee et al. · 2012 · The Korean journal of thoracic and cardiovascular surgery

Background The aim of this study is to evaluate our institutional results of the aortic valve replacement through minimally invasive approaches compared with conventional sternotomy. Materials and Methods From August 1997 to July 2010, 838…

View details →DOI: 10.5090/kjtcs.2012.45.2.80
Negative / Null Result ReportMedicine

Regenerated Cellulose Filaments from the Recycling of Textile Cotton Waste Using Ionic Liquids

Beatriz Barbosa de Brito, Beatriz Krüger, Lucas Souza da Silva et al. · 2025 · ACS Omega

In this study, cellulose filaments were obtained from the dissolution of an industrial cotton residue in the ionic liquids (ILs) 1-ethyl-3-methylimidazolium chloride ([Emim]Cl) and 1-ethyl-3-methylimidazolium acetate ([Emim]OAc) using…

View details →DOI: 10.1021/acsomega.5c01867
Negative / Null Result ReportMedicine

Subtrochanteric Fractures of The Femur: May a Short Nail Be a Reliable Option?

María Berta Alonso Polo, C. Peix, P. Velasco et al. · 2024 · The Archives of Bone & Joint Surgery

Objectives: Treatment of subtrochanteric fractures of the proximal femur may be challenging due to their anatomical and biomechanical features. Intramedullary nails are the most frequently used devices, although there is no consensus…

View details →DOI: 10.22038/abjs.2024.67182.3194
Negative / Null Result ReportMedicine

The Effect of Pomegranate Extract on Survival and Peritoneal Bacterial Load in Cecal Ligation and Perforation Model of Sepsis in Rats

S. Tavasoli, A. Zarnani, Mohamadreza Vafa et al. · 2014 · International Journal of Preventive Medicine

Background: Sepsis is one of the major causes of death in intensive care units. Oxidative stress and hyper-inflammation has been shown to be major cause of mortality and morbidity in septic cases. Pomegranate is a fruit considered for its…

Negative / Null Result ReportOpen accessMedicine

Influence of Gold Nanoparticle Incorporation Into Glass Ionomer Cement on Fibroblast Metabolic Activity, Surface Roughness and Hardness.

Zia A, Baldwin A, Nlemorisa C et al. · 2026 · International journal of dentistry

Objective To assess the influence of gold nanoparticle (AuNP) liquid-phase modification of glass ionomer cement (GIC) on fibroblast metabolic activity, alongside its effects on surface hardness and roughness, in an exploratory pilot in…

View details →DOI: 10.1155/ijod/3796785
Negative / Null Result ReportOpen accessMedicine

Structure-Driven Bioactivity of Chitosan-Agarose-Gelatin Hydrogels Functionalized with Tannic Acid-Cu<sup>2+</sup>/Sr<sup>2+</sup> Complexes.

Wekwejt M, Chevallier P, Desgagne F et al. · 2026 · ACS applied materials & interfaces

Hydrogels represent a versatile platform for regenerative applications; nevertheless, their translation is often limited by insufficient biofunctionality and poorly defined structure-property relationships in multicomponent networks. In…

View details →DOI: 10.1021/acsami.6c01091
Negative / Null Result ReportMedicine

A 2 year retrospective study of vegan patients and their pregnancy outcomes in a tertiary level Irish hospital.

Abdelrahman M, Maher S, Lindow SW et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective Recent previous studies have revealed outcomes of higher risk of low birth weight, small for gestational age, and pre-eclampsia for vegan pregnant women compared to other diets. This review examined if patients with vegan diet in…

View details →DOI: 10.1002/ijgo.71055
Negative / Null Result ReportMedicine

Maximizing Endodontic Cleanliness: The Role of Final Irrigation Techniques.

Maalouf F, El Hachem R, Zogheib C · 2026 · European endodontic journal

Objective The key to the success of any endodontic treatment is proper irrigation of the canal system in order to eliminate bacterial infections, pulpal tissues, and debris created during the shaping of the canal. Due to the complex…

View details →DOI: 10.65717/eej.2026.25029
Negative / Null Result Report

A Comparative Study on the Effects of Spherical and Aspheric Orthokeratology Lenses on Myopia Control and Ocular Surface Health in Adolescents: A Retrospective Cohort Study Based on Propensity Score Matching

Cai¹ J, Lan² G, Lin² Y et al. · 2026 · Preprint

Abstract Purpose To compare the 1-year efficacy of spherical versus aspheric base curve orthokeratology (OK) lenses in controlling axial length (AL) elongation in myopic adolescents, and to explore differences in their impact on tear film…

View details →DOI: 10.21203/rs.3.rs-9449494/v1
Negative / Null Result ReportOpen accessMedicine

Does Combined Intravenous and Topical Tranexamic Acid Offer Additional Benefit Compared With Intravenous or Topical Alone in Open Elbow Arthrolysis-A Pilot Randomized Controlled Trial.

Chen C, Zhang J, Hua K et al. · 2026 · Orthopaedic surgery

Purposes Open elbow arthrolysis (OEA) is a common method for treating post-traumatic elbow stiffness, which may lead to severe bleeding when resecting heterotopic ossification (HO) and fibrous scar tissue. The purpose of this study is to…

View details →DOI: 10.1111/os.70311
Negative / Null Result ReportOpen accessMedicine

Effects of muscle-tendon mechanical properties and electromyographic activity patterns on individual differences in force-power relationship.

Kosaka T, Kubo K · 2026 · PloS one

This study aimed to examine the effects of muscle-tendon mechanical properties and electromyographic activity patterns on individual differences in the force-power relationship during jumping with and without countermovement. Twenty men…

View details →DOI: 10.1371/journal.pone.0350202
Negative / Null Result ReportMedicine

The influence of lesion type and lesion location on the prediction of language laterality in patients with cerebral vascular malformations using functional MRI.

Rossmann J, Hense K, Knott M et al. · 2026 · Journal of neurosurgery

Objective Predicting language lateralization using functional MRI (fMRI) in patients with cerebral vascular malformations close to language areas is essential for treatment decision-making and patient outcomes. Functional MRI-based…

View details →DOI: 10.3171/2026.1.jns252444
Negative / Null Result ReportOpen accessMedicine

Comparable improvements in selective, but not sustained, attention in response to a multi-ingredient nootropic formulation when compared with caffeine.

Hearris MA, Langan-Evans C, Foo WL et al. · 2026 · European journal of nutrition

PURPOSE: The ergogenic effects of caffeine on cognitive performance are largely restricted to improved alertness and enhanced attention and do not typically extend to other cognitive domains. In contrast, plant extracts and phytochemicals…

View details →DOI: 10.1007/s00394-026-03926-8