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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 362 of 675

Negative / Null Result ReportMedicine

Does Misinformation Have Spillover Effects on Unrelated Health Behaviors? Promising Null Results from a Longitudinal Study of U.S. Adults.

Kikut-Stein A, Jesch E, Dhawan D et al. · 2026 · Journal of health communication

In the wake of the COVID-19 pandemic, a critical question for health communication is whether misinformation exposure and misperceptions about one health topic have far-reaching, or "spillover," effects on health behavior in general. The…

View details →DOI: 10.1080/10810730.2026.2623409
Negative / Null Result ReportMedicine

Interpersonal problems as predictors of anxiety symptom trajectories in PTSD: A retrospective multilevel modeling study.

Fasting A, Simensen MV, Sele P et al. · 2026 · Journal of affective disorders

Background This retrospective quality-control study examined whether patients with posttraumatic stress disorder (PTSD) at a specialized Norwegian inpatient hospital exhibited high levels of interpersonal problems before treatment and…

View details →DOI: 10.1016/j.jad.2026.121457
Negative / Null Result ReportMedicine

Effect of high-dose methotrexate infusion duration on 48-hour drug levels and toxicity in children with acute lymphoblastic leukaemia: a quality-of-care study.

Raha SJ, Bhatia P, Bansal D et al. · 2026 · Cancer chemotherapy and pharmacology

Background High‑dose methotrexate (HD‑MTX) is a cornerstone of pediatric acute lymphoblastic leukaemia (ALL) therapy. However, deviations from protocol-mandated infusion durations need regular monitoring as part of standard quality care.…

View details →DOI: 10.1007/s00280-026-04869-x
Negative / Null Result ReportMedicine

Are neural and behavioural measures of cognitive control associated with adaptive and maladaptive risk-taking in adolescence and young adulthood?

Hunter M, Skippen P, Templio SL et al. · 2026 · Cognitive, affective & behavioral neuroscience

Risk-taking in young people is often attributed to a mismatch between slowly maturing cognitive control networks and overactive reward networks, leading to impulsive actions. However, evidence is inconsistent, and these models do not…

View details →DOI: 10.3758/s13415-026-01420-6
Negative / Null Result ReportMedicine

Influence of Neurovascular Conflict on the Outcome of Primary Gamma Knife Radiosurgery for Trigeminal Neuralgia: A Single-Center Retrospective Study.

Pizzi A, Cotrufo PP, Farinaro G et al. · 2026 · Stereotactic and functional neurosurgery

Introduction Gamma knife radiosurgery (GKRS) is an established effective treatment for medically intractable trigeminal neuralgia (TN), but outcome predictors remain controversial. Notably, the influence of neurovascular conflict (NVC)…

View details →DOI: 10.1159/000551200
Negative / Null Result ReportMedicine

Are dating and sexual Protective Behavioral Strategies (PBS) associated with alcohol-related consequences at all levels of alcohol use?

Peterson R, Paitan SC, Belitsos OA et al. · 2026 · Experimental and clinical psychopharmacology

Alcohol use is common among college students and often linked to negative consequences. Protective behavioral strategies (PBS) can reduce alcohol use and related harms. This study examined whether dating/sexual PBS provide unique…

View details →DOI: 10.1037/pha0000838
Negative / Null Result ReportMedicine

Correlation between lymphocyte counts and PD-L1 immune-related adverse events.

Sawyer Z, Sorial M, Liauw JC · 2026 · Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

IntroductionImmune checkpoint inhibitors have improved outcomes for solid tumors but are associated with immune-related adverse events (irAEs). Literature suggests that patients with an absolute lymphocyte count (ALC) ≥ 2000 cells/mm3…

View details →DOI: 10.1177/10781552251415528
Negative / Null Result ReportOpen accessMedicine

Effect of Structured Training on ICU Nurses' Knowledge-Based Competence in Ventilator-Associated Pneumonia Prevention in a Resource-Limited Setting: An Explanatory Sequential Mixed-Methods Study.

Yakubu YH, Saani MM · 2026 · Nursing open

Aim To evaluate the effect of a structured training intervention on ICU nurses' knowledge-based competence in VAP prevention in a resource-limited setting and identify personal, environmental and organisational barriers to implementation.…

View details →DOI: 10.1002/nop2.70662
Negative / Null Result ReportOpen accessMedicine

Saddle Nose in Granulomatosis With Polyangiitis (GPA) vs. Non-GPA Patients With Septal Perforations.

Kumar N, Gomes PL, Jett S et al. · 2025 · Laryngoscope investigative otolaryngology

Objectives Saddle nose deformity (SND) can be associated with nasal septal perforation (NSP). Both SND and NSP are observed in granulomatosis with polyangiitis (GPA) patients. This study aimed to compare the prevalence and severity of SND…

View details →DOI: 10.1002/lio2.70217
Negative / Null Result ReportOpen accessMedicine

Group-Based Medical Mistrust and Logistical Factors Influencing Rheumatology Clinical Trial Enrollment: A Single-Center Cross-Sectional Survey.

Martinez Paulino A, Arias Diaz DJ, King M et al. · 2026 · ACR open rheumatology

Objective To examine whether group-based medical mistrust predicts willingness to enroll in a rheumatology clinical trial and, among those unwilling, to identify logistical factors that most influence their decision. Methods We conducted a…

View details →DOI: 10.1002/acr2.90030
Negative / Null Result Report

Similar exercise adherence and physical fitness outcomes are observed across distinct motivation profiles in older adults participating in a home-based structured exercise programme

Munns A, Feron J, Duda J et al. · 2026 · Preprint

Purpose:Motivation and self-efficacy are established predictors of engagement and persistence within structured exercise programmes; however, it remains unclear whether these psychological factors predict objective adherence metrics and…

View details →DOI: 10.31234/osf.io/gk74p_v1
Negative / Null Result ReportMedicine

Co-Occurring Substance Use and Psychiatric Disorders in Psychiatric Emergency Services: Suicidality, Substance Use, and Treatment Utilization.

Beaugard CA, Khan S, Oblath R et al. · 2026 · Journal of dual diagnosis

Objective Psychiatric and substance use disorders commonly co-occur, yet treatment is often siloed. To improve treatment utilization for individuals with co-occurring disorders in the psychiatric setting it important to understand current…

View details →DOI: 10.1080/15504263.2025.2606022
Negative / Null Result ReportMedicine

Novel measures of frontal plane knee wobbling predict anterior cruciate ligament injury in Japanese female basketball players: A prospective pilot study.

Aoki A, Koresawa K, No Y et al. · 2026 · Clinical biomechanics (Bristol, Avon)

Background To prospectively examine how lower extremity movement patterns during single-leg landings predict anterior cruciate ligament (ACL) injuries in adolescent Japanese basketball players during a 3-year follow-up period. Methods 44…

View details →DOI: 10.1016/j.clinbiomech.2026.106768
Negative / Null Result ReportOpen accessMedicine

Does Bone Quality Predict Pseudarthrosis, Subsidence, or Loss of Lordosis After Anterior Cervical Discectomy and Fusion? Minimum 5-Year Cohort Study.

Kim S, Park S, Ahn DK et al. · 2026 · Global spine journal

Study DesignRetrospective cohort study.ObjectivesTo determine whether preoperative cervical bone quality assessed by computed tomography Hounsfield units (CT HU) predicts pseudarthrosis, cage subsidence, or loss of cervical lordosis after…

View details →DOI: 10.1177/21925682261424749
Negative / Null Result ReportMedicine

Chicken or the egg: The relationship between cognitive deficits and negative symptoms in first episode psychosis.

Au-Yeung C, Christophe NK, Lavigne KM et al. · 2026 · Schizophrenia research

Background Cognitive impairments and negative symptoms (NS) represent an unmet therapeutic need in psychotic disorders. Both NS and cognitive impairments, are key predictors of functioning. Both also appear during the illness prodrome,…

View details →DOI: 10.1016/j.schres.2026.02.008
Negative / Null Result Report

Social Attunement and Alcohol Use: The Role of Age and Gender

Romein C, Colyer-Patel K, Kroon E et al. · 2025 · Preprint

Background: Alcohol use typically peaks during adolescence and early adulthood, when its social reinforcement value is high, and then decreases as individuals take on more adult-like responsibilities. The present study investigates whether…

View details →DOI: 10.31234/osf.io/srk3e_v2
Negative / Null Result Report

The time course of neural activity predictive of self-initiated movement

Jeay-Bizot L, Basbug M, Maoz U et al. · 2025 · Preprint

Decades of research have shown that early ramping activity is a very reliable antecedent of self-initiated movement. However, the dominant paradigm has been to only analyze data epochs culminating in movement, which discounts how often…

View details →DOI: 10.31234/osf.io/vdbg8_v3
Negative / Null Result Report

Cannabis Use, Affect, and Emotion Regulation in Daily Life: A 3-Week Experience Sampling Method Study in People Who Smoke Cannabis Almost Daily

Donate APG, Cousijn J, Kroon E et al. · 2026 · Preprint

Background and Aims: Although many people who use cannabis report mood-enhancing effects, affective responses are thought to vary within and between individuals. This study examined the bidirectional associations between momentary affect…

View details →DOI: 10.31234/osf.io/w5fd3_v1
Negative / Null Result ReportMedicine

On how people describe paintings with mirrors.

Bertamini M, Lucia M, Diaz S et al. · 2025 · British journal of psychology (London, England : 1953)

Since antiquity humans have been fascinated by mirrors; yet, when asked to predict what is made visible in the reflection, or to interpret a scene with a mirror, observers make systematic errors. Many observers claim that a character in a…

View details →DOI: 10.1111/bjop.70042
Negative / Null Result Report

Dynamics of Torque Teno Virus DNA Load in Bronchoalveolar Lavage in COVID-19 associated Acute Respiratory Distress Syndrome

Bumberger AM, Kastner M, Rüsing L et al. · 2026 · Preprint

Background: Torque teno virus (TTV) DNA load has been proposed as a surrogate marker of the net state of immunosuppression. While plasma TTV levels have been associated with infection risk and adverse outcomes, the clinical relevance of…

View details →DOI: 10.22541/au.176770094.44860022/v1
Negative / Null Result Report

Predicting AI Anxiety: An Existential Perspective

Gobet F, Evans N, Chatfield-Jouin F et al. · 2025 · Preprint

Artificial Intelligence (AI) is transforming many aspects of daily life and improving efficiency and outcomes in various sectors, ranging from healthcare to education. However, this rapid integration also introduces significant anxiety…

View details →DOI: 10.31234/osf.io/h7zje_v1
Negative / Null Result ReportMedicine

Temperature and precipitation mismatches increase infection risk in amphibians.

Thumsová B, Martínez-Silvestre A, Pérez-Vallejo M et al. · 2025 · Current biology : CB

The thermal mismatch hypothesis (TMH), the notion that cool- and warm-adapted hosts have higher infection risk during unusually warm and cool spells, respectively, was recently proposed to explain how temperature shifts driven by climate…

View details →DOI: 10.1016/j.cub.2025.07.053
Negative / Null Result ReportMedicine

ICANS mitigation in high-risk elderly patients treated with CD28 co-stimulatory anti-CD19 CAR-T cells using a standardization protocol: a pilot study.

Fridberg G, Amit O, Sherf Y et al. · 2026 · Haematologica

CAR-T has transformed relapsed/refractory LBCL treatment, with CD28-based products yielding rapid responses but higher ICANS rates. With Axicabtagene-ciloleucel and Brexucabtagene-autoleucel, overall and severe ICANS reach 78% and 35%,…

View details →DOI: 10.3324/haematol.2025.288954