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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19854 results in Negative / Null Result Report · page 361 of 662

Negative / Null Result ReportOpen accessMedicine

Misinformation interventions and online sharing behaviour: lessons learned from two pre-registered field studies.

Roozenbeek J, Lasser J, Marks M et al. · 2025 · Royal Society open science

The spread of misinformation on social media continues to pose challenges. While prior research has shown some success in reducing susceptibility to misinformation at scale, how individual-level interventions impact the quality of content…

View details →DOI: 10.1098/rsos.251377
Negative / Null Result ReportOpen accessMedicine

Mendelian randomization analysis reveals no causal association between non-alcoholic fatty liver disease and hepatocellular carcinoma: implications for lipid metabolomics and shared pathophysiological mechanisms.

Wei Y, Li J · 2025 · Discover oncology

Background Non-alcoholic fatty liver disease (NAFLD) has been increasingly associated with hepatocellular carcinoma (HCC) risk in observational studies, yet the causal nature of this relationship and its impact on systemic lipid metabolism…

View details →DOI: 10.1007/s12672-025-03582-0
Negative / Null Result ReportOpen accessMedicine

Atezolizumab plus bevacizumab and chemotherapy in metastatic nonsquamous NSCLC: the randomized double-blind phase 3 IMpower151 trial.

Zhou C, Dong X, Chen G et al. · 2025 · Nature medicine

After the global approval of atezolizumab plus bevacizumab and chemotherapy as first-line metastatic nonsquamous non-small-cell lung cancer (nsqNSCLC) treatment, the IMpower151 ( NCT04194203 ) trial was conducted in China to address…

View details →DOI: 10.1038/s41591-025-03658-y
Negative / Null Result ReportMedicine

Olaparib in recurrent isocitrate dehydrogenase mutant high-grade glioma: A phase 2 multicenter study of the POLA Network.

Esparragosa Vazquez I, Sanson M, Chinot OL et al. · 2024 · Neuro-oncology advances

Background Based on preclinical studies showing that IDH-mutant (IDHm) gliomas could be vulnerable to PARP inhibition we launched a multicenter phase 2 study to test the efficacy of olaparib monotherapy in this population. Methods Adults…

View details →DOI: 10.1093/noajnl/vdae078
Negative / Null Result Report

A prospective multicenter phase II study of FOLFIRINOX as a first-line treatment for patients with advanced and recurrent biliary tract cancer

Takahara N, Nakai Y, Isayama H et al. · 2022 · Preprint

Purpose: Given the promising activity and tolerability of FOLFIRINOX as a second-line treatment for advanced biliary tract cancer (BTC), it can be an attractive first-line treatment option as well. Materials: and Methods: This is a…

View details →DOI: 10.21203/rs.3.rs-2075157/v1
Negative / Null Result ReportOpen accessMedicine

The 2024 Public Health Emergency of International Concern: A Global Failure to Control Mpox.

Zumla A, Rosenthal PJ, Sam-Agudu NA et al. · 2025 · The American journal of tropical medicine and hygiene

On August 14, 2024, following a regional declaration by the Africa Centres for Disease Control and Prevention, the World Health Organization declared mpox a Public Health Emergency of International Concern, marking the second such…

View details →DOI: 10.4269/ajtmh.24-0606
Negative / Null Result ReportMedicine

Gastrointestinal tract exposure to particles and DNA damage in animals: A review of studies before, during and after the peak of nanotoxicology.

Møller P, Roursgaard M · 2024 · Mutation research. Reviews in mutation research

Humans ingest particles and fibers on daily basis. Non-digestible carbohydrates are beneficial to health and food additives are considered safe. However, titanium dioxide (E171) has been banned in the European Union because the European…

View details →DOI: 10.1016/j.mrrev.2024.108491
Negative / Null Result ReportOpen accessMedicine

Pro-inflammatory dietary patterns and their association with cardiovascular disease and pancreatic cancer in a hospital population: a cross-sectional study.

Jin Q, Liu Y, Tong Q et al. · 2025 · Frontiers in nutrition

Objective To examine whether a concise, clinic-feasible Patient Inflammatory Diet Score (PIDS) relates to prevalent pancreatic cancer and cardiovascular disease (CVD) in a hospital population, and to explore associations with systemic…

View details →DOI: 10.3389/fnut.2025.1666682
Negative / Null Result ReportMedicine

Learning to draw parametric faces.

Davidenko N, Day J · 2025 · Memory & cognition

Humans' ability to draw faces accurately from memory is extremely rare. One source of difficulty is the drawing process itself, which requires converting a complex, three-dimensional mental representation to a two-dimensional drawing. To…

View details →DOI: 10.3758/s13421-023-01498-0
Negative / Null Result ReportMedicine

Extreme ambient heat and outcomes of assisted reproduction in the continental United States, 1996 to 2018.

Gaskins AJ, Newman AJ, Kawwass JF et al. · 2026 · Environmental research

Background While extreme ambient heat has been associated with several adverse pregnancy and birth outcomes little is known regarding the link between extreme ambient temperatures and human fertility. Objective To evaluate the associations…

View details →DOI: 10.1016/j.envres.2026.123783
Negative / Null Result ReportOpen accessMedicine

No evidence that visual impulses enhance the readout of retrieved long-term memory contents from EEG activity.

van Bree S, Mackenzie AS, Wimber M · 2024 · Imaging neuroscience (Cambridge, Mass.)

The application of multivariate pattern analysis (MVPA) to electroencephalography (EEG) data allows neuroscientists to track neural representations at temporally fine-grained scales. This approach has been leveraged to study the locus and…

View details →DOI: 10.1162/imag_a_00330
Negative / Null Result ReportOpen accessMedicine

Sodium Reduction Program Incorporating Genetic Profile and an AI-Based App: A Randomized Clinical Trial.

Sato K, Inoue K, Yamaguchi T et al. · 2025 · JAMA network open

Importance Excess salt intake is a major modifiable risk factor for hypertension and cardiovascular disease. Personalized interventions using genetic information and digital tools, such as smartphone applications, may enhance sodium…

View details →DOI: 10.1001/jamanetworkopen.2025.37540
Negative / Null Result ReportOpen accessMedicine

No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis.

Liu P, Zeng Q · 2025 · Journal of multidisciplinary healthcare

Background The causal relationship between HIV infection and insulin resistance, as well as diabetes mellitus, remains uncertain. This study explores these associations using genome-wide association study data and Mendelian randomization…

View details →DOI: 10.2147/jmdh.s546669
Negative / Null Result ReportOpen accessMedicine

New Vistas for the Relationship between Empathy and Political Ideology.

Zebarjadi N, Kluge A, Adler E et al. · 2024 · eNeuro

The study of ideological asymmetries in empathy has consistently yielded inconclusive findings. Yet, until recently these inconsistencies relied exclusively on self-reports, which are known to be prone to biases and inaccuracies when…

View details →DOI: 10.1523/eneuro.0086-24.2024
Negative / Null Result ReportOpen accessMedicine

In the eastern Mediterranean, the rat lungworm Angiostrongylus cantonensis is absent or extremely rare according to recent surveys.

Anettová L, Šipková A, Cibulka P et al. · 2025 · Parasitology research

This study summarizes the findings of a comprehensive field investigation into the presence of Angiostrongylus cantonensis, a zoonotic nematode responsible for meningitis, in selected regions of the eastern Mediterranean. Samples were…

View details →DOI: 10.1007/s00436-025-08580-3
Negative / Null Result ReportOpen accessMedicine

Musical groove listening does not enhance primary motor cortex activation.

O'Connell SR, Wilson GE, Berkowitz DH et al. · 2026 · Imaging neuroscience (Cambridge, Mass.)

Groove is the pleasurable urge to move to the beat of music, a universally experienced human phenomenon. Because listeners are often inspired to move to music with groove, we asked whether high-groove music would promote greater motor…

View details →DOI: 10.1162/imag.a.1185
Negative / Null Result ReportMedicine

Impact of increasing workforce racial diversity on black-white disparities in cardiovascular disease mortality.

Colbeth HL, Riddell CA, Thomas M et al. · 2024 · Journal of epidemiology and community health

Background Structural racism's influence on workforce policies and practices presents possible upstream targets for assessing and reducing racial health disparities. This study is the first to examine workforce racial diversity in…

View details →DOI: 10.1136/jech-2024-222094
Negative / Null Result ReportOpen accessMedicine

Psychobehavioral profiles of eating risk: schema-emotion regulation patterns differ in central adiposity with genotype (FTO rs9939609) as external validator-a pilot study.

Obara-Gołębiowska M · 2026 · Eating and weight disorders : EWD

Purpose To identify person-centered psychological profiles of eating-related risk based on early maladaptive schemas (EMS), emotion regulation difficulties, and eating behaviors, and to examine their external validation using…

View details →DOI: 10.1007/s40519-026-01853-5
Negative / Null Result ReportOpen accessMedicine

Effect of a Pragmatic eHealth Behavioral Gestational Weight Gain Intervention on Household Chaos in Pregnant People of Lower Socioeconomic Status: Randomized Controlled Trial.

Kracht CL, Falkenhain K, Flanagan EW et al. · 2026 · JMIR mental health

Background Household chaos is an emerging risk factor for childhood obesity development, especially in families with lower socioeconomic status (SES). It is unclear if changes in household chaos, especially in pregnancy, may mediate the…

View details →DOI: 10.2196/74146
Negative / Null Result ReportOpen accessMedicine

Homocysteine and Peripheral White Blood Cell Count-derived Ratios: Insights from Healthy Population.

Neelam P, Sowndarya K, Anupama H et al. · 2025 · Advanced biomedical research

Background Homocysteine (Hcy) and dyslipidemia are established risk parameters of atherosclerosis. Considerable research has been conducted using ratios of lymphocytes to other cellular components of the peripheral white blood cell count…

View details →DOI: 10.4103/abr.abr_550_24
Negative / Null Result ReportOpen accessMedicine

Polygenic risk for schizophrenia and subjective well-being in a general population sample.

Serimaa O, Keltikangas-Järvinen L, Lyytikäinen LP et al. · 2025 · Psychological medicine

Background Previous evidence has reported associations of a polygenic risk score for schizophrenia (PRS SCZ ) with negative developmental outcomes, such as psychiatric symptoms, adverse health behaviors, and reduced everyday functioning.…

View details →DOI: 10.1017/s0033291725000911
Negative / Null Result ReportOpen accessMedicine

Fragile Mentalizing: Lack of Behavioral and Neural Markers of Social Cognition in an Established Social Perspective Taking Task when Combined with Stress Induction.

Cheema S, Augustin C, Göttlich M et al. · 2024 · eNeuro

The growing field of social neuroscience is reliant on the development of robust, ecologically valid paradigms for simulating social interaction and measuring social cognition in highly controlled laboratory settings. Perspective taking is…

View details →DOI: 10.1523/eneuro.0084-24.2024
Negative / Null Result ReportOpen accessMedicine

The relationship between dental occlusion and visual dysfunctions: A literature review.

Alshehri FS, Alshehri AS, Alhejali AE et al. · 2025 · Journal of orthodontic science

Theoretical and anatomical pathways suggest a connection between the stomatognathic and visual systems. However, the evidence for associations between dental occlusion, temporomandibular disorders (TMD), and visual function is fragmented…

View details →DOI: 10.4103/jos.jos_141_25