A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19854 results in Negative / Null Result Report · page 360 of 662
Pak K, Yoon C, Sadda SR · 2026 · Eye (London, England)
Purpose To evaluate longitudinal change in hard exudate (HEs) volume over 5-years following anti-VEGF treatment for diabetic macular oedema (DMO). Methods This study was a post-hoc analysis of structural optical coherence tomography (OCT)…
Holgado D, Martínez-Pérez V, Martín-Arévalo E et al. · 2026 · Preprint
Inconsistent evidence regarding the cognitive effects of transcranial direct current stimulation (tDCS) highlights the need for more comprehensive approaches to assess its impact. This study aimed to investigate the effects of…
Kim HSW, Cha S, Choi JY et al. · 2026 · The Journal of craniofacial surgery
This study compared the upper airway dimensions following maxillomandibular advancement (MMA) surgery in adults with obstructive sleep apnea (OSA) with those of normal controls. Korean adult OSA patients who underwent conventional MMA…
Haflidadottir S, Helgadottir FD, Sighvatsson MB · 2026 · Scandinavian journal of psychology
The global burden of infertility and its associated psychological distress is substantial, yet many individuals face barriers to accessing psychological support. A scalable, low-cost online intervention presents a promising solution. A…
Yu C, Huang W, Yu B et al. · 2026 · Preprint
Synthetic 6-Br-Q0C10 has been shown to have a partial electron transfer activity of native coenzyme Q in the isolated mitochondria. It reduces energy coupling efficiency by 30 %, suggesting that it may be useful in the management of…
May R, Hernández Gómez MÁ, Aguirre Martínez JL et al. · 2026 · Preprint
One of the most notable impacts of wind energy is bird mortality due to collisions with wind turbines, making it necessary to adopt measures to prevent or mitigate this impact. In recent years, studies have been carried out to test the…
Leal Barbosa V, Westenhofen D, Scherdien Silva P et al. · 2026 · Lasers in medical science
Purpose To evaluate the efficacy of 8% arginine-based desensitizing toothpaste and photobiomodulation (PBM), used alone or in combination, in the treatment of dentin hypersensitivity (DH). Materials and methods This randomized,…
Baek JS, Lokhande A, Neuenschwander D et al. · 2026 · Preprint
Purpose To investigate the relative efficacy of nine distinct visual field (VF) denoising artificial intelligence (AI) methods and a pathology-aware AI strategy to discourage over-correction of glaucomatous defects. Design Retrospective…
van Lohuizen Q, Fransen SJ, Yiasemis G et al. · 2026 · European radiology
Objectives To determine whether AI-reconstructed prostate MRI at reduced acquisition times maintains prostate cancer (PCa) detection performance comparable to conventional scans. Materials and methods This multicenter, retrospective,…
Akay T, Arslan RS · 2026 · Scientific reports
Patients with deep perianal abscess (DPA) and transsphincteric fistula typically require incision and drainage as emergency treatment. However, recurrent abscesses and fistulas are common. This study aimed to evaluate the impact of…
Verhulst E, Ten Broek R, Bislenghi G et al. · 2026 · Techniques in coloproctology
Postoperative intraabdominal adhesions remain one of the most common and clinically significant complications following abdominal and pelvic surgery. Adhesions contribute to adhesive small bowel obstruction (aSBO), chronic abdominal pain,…
Murray CS, Marx L, Aluru N et al. · 2026 · Preprint
Ocean Alkalinity Enhancement (OAE) is a marine carbon dioxide removal (mCDR) strategy that involves adding alkaline substances to surface waters to enhance CO 2 uptake and storage. The dispersal of alkaline materials such as sodium…
Ichie K, Asomugha A, Okafor I · 2026 · BMC neuroscience
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder strongly associated with dopaminergic neuronal degeneration and alpha-synuclein pathology. Paraquat (PQ) has been implicated in Parkinsonian neurodegeneration;…
Somerville E, Bollinger RM, Haxton M et al. · 2026 · OTJR : occupation, participation and health
Interventions to address polypharmacy and improve adherence are insufficient for community-dwelling older adults. To examine the feasibility, acceptability, and preliminary efficacy of a tailored medication management intervention (TIMM)…
Hsieh YC, Lu WY, Chen YL et al. · 2026 · BMC ophthalmology
Background Selective laser trabeculoplasty (SLT) is a widely accepted treatment for primary open-angle glaucoma (POAG), but its role in primary angle-closure glaucoma (PACG) remains less defined. This study aimed to evaluate the short-term…
Liu W, Guo C, Ding W et al. · 2026 · Preprint
Background Postpartum asthenia, characterized by severe fatigue, sleep disturbances, and physiological stress, lacks effective targeted interventions. Ergothioneine (EGT) is a unique, naturally occurring antioxidant that actively…
Verbo A, Verbo I · 2026 · Langenbeck's archives of surgery
Background Enhanced Recovery After Surgery (ERAS) protocols are widely implemented in colorectal surgery to improve postoperative recovery and reduce hospital stay. However, their impact on postoperative morbidity in elderly and clinically…
Maiorca C, Tramontano D, Di Costanzo A et al. · 2026 · Internal and emergency medicine
Residual cardiovascular risk persists in many patients despite optimal control of established factors such as low-density lipoprotein cholesterol (LDL-C), blood pressure and glycaemia. Mounting evidence indicates that hypertriglyceridemia…
Osorio Oliveros AV, Velasco Jaramillo JA, Alejo-Martínez H et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Purpose To implement a continuous improvement cycle aimed at identifying and reducing radiation exposure incidents in patients undergoing PET-CT scans. Methods A comparative quasi-experimental study was conducted within a nuclear medicine…
Ortiz BM, Orozco SM, Dueñas LL et al. · 2026 · Preprint
Abstract Major depressive disorder (MDD) has increased in recent years, affecting 16.1% of the adult population nationwide. Currently, there are pharmacological and psychological treatments that have a 67% remission rate for depressive…
Schalch TO, Ando-Suguimoto ES, Ferreira BS et al. · 2026 · Clinical oral investigations
Objectives The aim of this study was to compare the effectiveness of two antimicrobial photodynamic therapy (aPDT) protocols using different methylene blue formulations in the treatment of initial pericoronitis. The research question was…
Scampoli A, Governatori L, Solimeo A et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose To evaluate whether baseline glycosylated hemoglobin (HbA1C) levels play a predictive role in faricimab loading phase outcomes. In addition, the authors assessed the efficacy of faricimab loading phase for diabetic macular edema…
Pajina B, Leurcharusmee P · 2026 · Minerva anestesiologica
Background The anterior quadratus lumborum (QL) block provides effective post-cesarean delivery analgesia, but the optimal local anesthetic (LA) volume remains unknown. This is critical for balancing efficacy and safety in pregnant…
Shalash Al Maliky WK, Hasan Mohammed J, Dh Hazim M · 2026 · Preprint
Background Green synthesis of silver nanoparticles (AgNPs) using plant extracts has gained increasing attention as an environmentally friendly alternative to conventional chemical methods. Salix alba L contains bioactive phytochemicals…
Koubek CT, Aghaee MA · 2026 · Journal of economic entomology
Lygus hesperus Knight (Hemiptera: Miridae) is a major pest of California strawberries, where feeding injury from nymphs and adults leads to fruit deformation and economic losses. Management relies heavily on insecticides, with supplemental…
Terang L, Nath J, Goswami M et al. · 2026 · Preprint
Abstract Urban human–monkey conflict is a growing management concern across India, particularly in cities where forest fragments, food provisioning, and unmanaged waste draw monkeys into human settlements. Guwahati represents one such…
Li Z, Li X, Yang B et al. · 2026 · Frontiers in oncology
Background Multidisciplinary team (MDT) care is widely advocated for soft tissue sarcoma (STS), yet real-world evidence in high-grade disease remains limited and subject to confounding. We investigated whether pre-treatment MDT care was…
Guz LS, Galushkin A, Gozes I · 2026 · Preprint
Estrogen is an essential hormone that critically impacts bodily and brain functions, supporting learning, memory, and motor activities. A decrease in estrogen levels is associated with cognitive decline and motor dysfunction, such as…
Shah M, Burshtein J, Zakria D et al. · 2026 · Journal of drugs in dermatology : JDD
Background Mineral sunscreens are increasingly favorable among consumers. However, mineral sunscreens typically cause a white cast that can impact consumer selection and application. Objective This study measured the whitening effect of…
Wei W, Shi Y, Hu Q · 2026 · Cirugia y cirujanos
Objectives This study aimed to evaluate and compare the effects of prolonged daily wear of a surgical mask (SM) versus a KN95 respirator on tear film stability in healthcare workers. Methods Forty-eight healthcare workers (96 eyes) were…