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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 356 of 675

Negative / Null Result ReportMedicine

Association of maternal hemoglobin and ferritin levels with fetal cortical maturation: a prospective neurosonographic study.

Haksever M, Taşdemir D · 2026 · BMC pregnancy and childbirth

To evaluate the association between maternal hemoglobin and ferritin levels and fetal cortical maturation assessed by neurosonography between 30 and 34 weeks of gestation. This prospective observational study included 187 singleton…

View details →DOI: 10.1186/s12884-026-09529-9
Negative / Null Result ReportOpen accessMedicine

Comparison of programmed death-1 (PD-1)-positive T-cells with known prognostic indicators in breast cancer.

Kaushik A, Jaiswal A, Priya B et al. · 2025 · Journal of family medicine and primary care

Background Breast cancer is the most common cancer in women across the world. Immune cells can detect and destroy cancer cells. However, cancer cells acquire certain immune evasion mechanisms such as PD-1+ T-cells, to combat immune…

View details →DOI: 10.4103/jfmpc.jfmpc_320_25
Negative / Null Result Report

Does Chemotherapy Affect Sleep Quality in Patients with Cancer?

Isikoglu BD, Senler FC · 2026 · Preprint

Abstract Purpose. Insomnia is a heterogeneous symptom cluster of multiple etiologies, frequently encountered in oncology patients, and chemotherapy has been implicated as a contributing factor. We aimed to evaluate the effects of…

View details →DOI: 10.21203/rs.3.rs-9973460/v1
Negative / Null Result Report

Health Literacy and Its Association with Emergency Department Use and Primary Care Preferences Among Adults: A Cross-Sectional Study in Turkey

Coban S, Yavuz S, Dogan C et al. · 2026 · Preprint

Abstract Background Emergency department overcrowding is a persistent global public health issue, often driven by non-urgent visits. Health literacy is considered a key determinant of appropriate healthcare utilization. Objective This…

View details →DOI: 10.21203/rs.3.rs-9744500/v1
Negative / Null Result ReportOpen accessMedicine

Nonalcoholic fatty liver disease assessed by multiple tools are correlated to periodontal conditions.

Hiroshimaya T, Iwai K, Marutani M et al. · 2026 · Scientific reports

This study aimed to clarify the relationship between periodontitis and non-alcoholic fatty liver disease (NAFLD). A survey was conducted with 2,453 participants who visited the dental clinic at the Asahi University Hospital. Periodontitis…

View details →DOI: 10.1038/s41598-026-40128-y
Negative / Null Result ReportOpen accessMedicine

The Association Between SARS-CoV-2 Exposure, COVID-19 Vaccination and Psoriatic Arthritis-A Nested Case-Control Study.

Haddad A, Zabari Parnis E, Stein N et al. · 2026 · Vaccines

Background/Objective : The emergence of the COVID-19 pandemic has raised significant concerns regarding its impact on immune-mediated diseases, particularly with respect to disease induction and exacerbation. We aimed to investigate the…

View details →DOI: 10.3390/vaccines14040289
Negative / Null Result ReportMedicine

Is it possible for type 2 diabetic patients with low level of copper to have better glycemic control under different apolipoprotein B levels?

Wu Z, He S, Zhu F et al. · 2026 · Frontiers in endocrinology

Objective Copper overload has been implicated in impaired β -cell function and insulin resistance through oxidative stress and inflammatory pathways. As a major lipoprotein component involved in lipid oxidation, apolipoprotein B (apoB) may…

View details →DOI: 10.3389/fendo.2026.1764209
Negative / Null Result ReportOpen accessMedicine

Relationship Between Central Sensitization and Genetic Polymorphisms-A Case-Control Study in Fibromyalgia.

Macian N, Dualé C, Delay M et al. · 2026 · European journal of pain (London, England)

Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was…

View details →DOI: 10.1002/ejp.70308
Negative / Null Result ReportOpen accessMedicine

Procalcitonin for Predicting Sepsis in Infants in the Emergency Department: A Retrospective Study.

Alharthy N, Alreefi M, Alsenani M et al. · 2026 · Pediatric health, medicine and therapeutics

Background Among children younger than 5 years, infectious conditions account for the majority of pediatric emergency department visits. Due to nonspecific presentation, early identification of Sepsis and serious bacterial infection is…

View details →DOI: 10.2147/phmt.s589691
Negative / Null Result Report

Attitudinal and infrastructural determinants of food safety practices among informal food vendors in Sokoto metropolis northwestern Nigeria

Buhari HM, Akpan SN, Ballah FM et al. · 2026 · Preprint

Abstract Foodborne illnesses remain a significant public health challenge in low and middle-income countries. Local food vendors operating in informal settings represent a critical point of intervention, yet their food hygiene knowledge…

View details →DOI: 10.21203/rs.3.rs-9811667/v1
Negative / Null Result ReportMedicine

Assessment of allergenic peanut residue in commercial baby biscuits: implications for food safety and consumer protection.

Önder N, Muratoglu K · 2026 · Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

Peanuts are among the most clinically important food allergens and may cause severe reactions even at very low exposure levels. This study investigated the presence of peanut residues in packaged baby biscuits marketed on the European side…

View details →DOI: 10.1080/19440049.2026.2683667
Negative / Null Result ReportMedicine

Utility of End Tidal Carbon Dioxide Monitoring in Patients of Shock Presenting to the Emergency Department.

Kanani P, Shinde V, Bhimani K et al. · 2026 · Annals of African medicine

Background Shock is a critical, life-threatening syndrome defined by a state of global hypoperfusion that results in inadequate oxygen and nutrient delivery to tissues, leading to cellular dysfunction and ultimately, organ failure. Despite…

View details →DOI: 10.4103/aam.aam_276_26
Negative / Null Result ReportOpen accessMedicine

The Role of <i>REL</i> and <i>IL2</i> and Their Polymorphisms in the Pathogenesis of Vitiligo-Exploratory Genetic Association Study.

Kądziela M, Migdalska-Sęk M, Domańska-Senderowska D et al. · 2026 · International journal of molecular sciences

Vitiligo is a chronic autoimmune skin disorder characterized by progressive melanocyte loss and depigmented skin lesions, whose pathogenesis has been attributed to genetic and immunological factors. The aim of this exploratory study was to…

View details →DOI: 10.3390/ijms27115084
Negative / Null Result ReportMedicine

Relationship between gestational diabetes and term infant hearing outcomes: a cross-sectional data linkage study.

Anderson N, Kimlin K, O'Rourke JL et al. · 2026 · Pediatric research

Background Congenital hearing loss can significantly affect childhood development, yet more than half of affected infants present without identifiable risk factors. A possible association between maternal diabetes and congenital hearing…

View details →DOI: 10.1038/s41390-026-04846-3
Negative / Null Result ReportMedicine

Associations between atherogenic index of plasma and chronic kidney disease in individuals with hypertension, diabetes mellitus, and hyperuricemia.

Li Y, Zhu YX, Qiu Y et al. · 2026 · Clinical nephrology

Objective The association between the atherogenic index of plasma (AIP) and chronic kidney disease (CKD) among individuals with different metabolic syndromes remains inadequately characterized. The aim of this study is to assess the…

View details →DOI: 10.5414/cn111841
Negative / Null Result ReportMedicine

Surgical Site Infections in Spine Surgery: A Retrospective Study of 1,578 Procedures with Identification of Tattooed Skin as a Novel Risk Factor Associated with Surgical Site Infection.

Mostofi K, Caragliano G · 2026 · The Journal of hospital infection

Background Surgical site infections (SSIs) are a major complication of spinal surgery. The influence of tattoos overlying the operative incision has not been previously evaluated as a risk factor in this context. Methods Retrospective…

View details →DOI: 10.1016/j.jhin.2026.06.006
Negative / Null Result ReportOpen accessMedicine

Association of biofilm formation with multidrug resistance in burn wound patients isolates of <i>Pseudomonas aeruginosa</i> in Sana'a City, Yemen.

Maher AA, Maad AH, Al-Jaufy AY et al. · 2026 · Frontiers in medicine

Background Burn wound infections (BWIs) represent a major cause of morbidity and mortality among hospitalized burn patients. Pseudomonas aeruginosa is recognized for its ability to acquire multidrug resistance (MDR) and form biofilms that…

View details →DOI: 10.3389/fmed.2026.1762684
Negative / Null Result Report

Anthropometric Correlates of Systolic and Diastolic Blood Pressure Among Children and Adolescents in Ibadan, Southwest, Nigeria

Alayande AA, Williams JE, Olawuni DA et al. · 2026 · Preprint

Abstract Introduction: Abnormal anthropometric indices in children and adolescents, can potentially increase the risk of developing elevated blood pressure at a younger age. Children and adolescents with abnormal blood pressure at an early…

View details →DOI: 10.21203/rs.3.rs-8625118/v1
Negative / Null Result ReportOpen accessMedicine

Preliminary Psychometric Evaluation of the Romanian Version of the Hospital Anxiety and Depression Scale in Relapsing-Remitting Multiple Sclerosis.

Böckels L, Lisnic V, Alexa D et al. · 2026 · Journal of clinical medicine

Background/Objectives: Relapsing-remitting multiple sclerosis (RRMS) is frequently associated with anxiety and depressive symptoms, which significantly impact quality of life and clinical outcomes. The Hospital Anxiety and Depression Scale…

View details →DOI: 10.3390/jcm15114165
Negative / Null Result ReportOpen accessMedicine

Association between alpha 1-antitrypsin levels and intracranial aneurysms: a case-control study.

Rosi Júnior J, Telles JPM, Santana LS et al. · 2026 · Arquivos de neuro-psiquiatria

Background Alpha 1-antitrypsin (A1AT) helps maintain vascular-wall integrity, but its role in the formation and rupture of intracranial aneurysms is unclear. Objective To compare A1AT levels between patients with ruptured and unruptured…

View details →DOI: 10.1055/s-0046-1820525