e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19854 results in Negative / Null Result Report · page 355 of 662

Negative / Null Result ReportMedicine

Clinical Characteristics and Long-Term Outcomes of Atypical Choroid Plexus Papillomas: A Single-Center Experience of 40 Cases.

Zuo P, Jiang K, Zou W et al. · 2026 · Neurosurgery

Background and objectives Atypical choroid plexus papillomas (ACPPs) are exceedingly uncommon. The treatment strategies for managing this condition remain a topic of debate. The main aim of this study was to elucidate the clinical features…

View details →DOI: 10.1227/neu.0000000000004026
Negative / Null Result ReportMedicine

Effectiveness and safety of REVIVENT-TC system for the left ventricular reconstruction in ischaemic heart failure. A literature review.

Kakoudaki T, Poon SS, Kumar P · 2026 · Cardiovascular revascularization medicine : including molecular interventions

Background Surgical ventricular reconstruction (SVR) is not always feasible in patients with ischaemic cardiomyopathy and left ventricular (LV) aneurysm, due to high surgical risk. The Revivent-TC Transcatheter Ventricular Enhancement…

View details →DOI: 10.1016/j.carrev.2026.04.002
Negative / Null Result ReportMedicine

Is Adjuvant Chemotherapy Necessary for All Patients with pT3N0 Rectal Cancer after Upfront Surgery? A Multicenter Retrospective Study.

Kang KM, Lee HY, Ahn HM et al. · 2026 · Cancer research and treatment

Purpose The role of adjuvant chemotherapy (ACT) in pathologic T3N0 (pT3N0) rectal cancer, which has a favorable prognosis, remains controversial because high-risk groups for recurrence are not well defined. This study investigated…

View details →DOI: 10.4143/crt.2025.1308
Negative / Null Result ReportMedicine

Stenting, surgery, or medical therapy alone in asymptomatic carotid artery stenosis? Interpreting the CREST-2 findings.

Narayan P · 2026 · Indian journal of thoracic and cardiovascular surgery

There has been controversy over the ideal management strategy for asymptomatic carotid artery stenosis. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trials (CREST-2) evaluated whether adding carotid…

View details →DOI: 10.1007/s12055-025-02160-x
Negative / Null Result ReportOpen accessMedicine

Is there a role for adjuvant radiotherapy after partial laryngectomy? A propensity score matched analysis.

Belgioia L, D'Onofrio I, Filauro M et al. · 2026 · Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

Objective To evaluate the impact of postoperative radiotherapy (PORT) on survival outcomes in patients with laryngeal cancer treated with partial laryngectomy. Methods In this retrospective multicentre study, 312 patients with supraglottic…

View details →DOI: 10.14639/0392-100x-suppl.1-46-2026-a2292
Negative / Null Result ReportMedicine

Diabetes Mellitus and Early Antiplatelet Treatment for Minor Stroke Following Intravenous Thrombolysis: Prespecified Secondary Analysis of the EAST Trial.

Cui Y, Liu JL, Jiang CH et al. · 2026 · Diabetes, obesity & metabolism

Background Early dual antiplatelet therapy (DAPT) after intravenous thrombolysis is safe but ineffective in improving 90-day functional outcomes in minor stroke. Given the effect of diabetes mellitus (DM) with antiplatelet treatment, we…

View details →DOI: 10.1111/dom.70745
Negative / Null Result ReportMedicine

Baseline neutrophil-to-lymphocyte ratio predicts survival time after the initiation of nintedanib in patients with interstitial lung disease.

Goda S, Yamada T, Goto Y et al. · 2026 · BMC pulmonary medicine

Background The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation, with prognostic value in interstitial lung disease (ILD). However, the association between baseline NLR and the therapeutic efficacy of nintedanib…

View details →DOI: 10.1186/s12890-026-04347-3
Negative / Null Result ReportMedicine

Is postoperative routine thoracic imaging necessary to detect thoracic complications in patients undergoing supracostal mini percutaneous nephrolithotomy (m-PCNL) surgery?

Esmeray A, Yazili HB, Gelmis M et al. · 2026 · The Canadian journal of urology

Objectives Supracostal access during percutaneous nephrolithotomy (PCNL) increases the risk of pulmonary complications. Although routine postoperative thoracic imaging is commonly performed to detect these events, its clinical necessity…

View details →DOI: 10.32604/cju.2025.069657
Negative / Null Result ReportMedicine

Preoperative Management of Patients With Myasthenia Gravis: A Review of the Evidence.

Alhammadi S, Chalk C · 2026 · The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterized by fatigable weakness and increased perioperative vulnerability. Postoperative myasthenic crisis, defined as respiratory failure requiring prolonged ventilation…

View details →DOI: 10.1017/cjn.2025.10524
Negative / Null Result ReportMedicine

Carotid Artery Intervention May Still Be Justified in Asymptomatic Patients with End-Stage Renal Disease.

Tsukagoshi J, Penaloza N, Laico AJ et al. · 2026 · Annals of vascular surgery

Background While carotid endarterectomy (CEA) and carotid artery stenting (CAS) reduce the long-term risk of stroke, patients with a short life expectancy or multiple medical comorbidities, including end-stage renal disease (ESRD), may not…

View details →DOI: 10.1016/j.avsg.2026.03.006
Negative / Null Result ReportMedicine

Beta-blocker therapy and all-cause mortality after a coronary event: A matched nested case-control study using the Victorian Cardiac Outcomes Registry linked data.

Cataldo-Miranda P, Koh HJW, Stub D et al. · 2026 · Current problems in cardiology

Aims Beta-blocker therapy has traditionally been recommended following coronary events based on clinical trials involving patients with systolic dysfunction. Its survival benefit in patients with preserved left ventricular ejection…

View details →DOI: 10.1016/j.cpcardiol.2026.103340
Negative / Null Result ReportMedicine

A comparison of hysteroscopic tubal electrocoagulation and laparoscopic salpingectomy for hydrosalpinx: short- and long-term pregnancy outcomes.

Tan W, Chen L, Li X et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Purpose Hydrosalpinx impairs embryo implantation and development, leading to infertility or miscarriage. Therefore, the effective treatment of hydrosalpinx is crucial for improving pregnancy outcomes. Here, we investigated the comparative…

View details →DOI: 10.1016/j.ejogrb.2026.115015
Negative / Null Result ReportMedicine

Evaluating the Impact of Ursodeoxycholic Acid on Hepatic Clearance of [<sup>99m</sup>Tc]Tc-Sestamibi: A Randomized Controlled Trial to Improve Myocardial Perfusion Imaging.

Hosseinzadeh E, Arefnia M, Bayat M et al. · 2026 · Cancer biotherapy & radiopharmaceuticals

Background Intense hepatobiliary uptake of [ 99m Tc]Tc-sestamibi in myocardial perfusion scintigraphy (MPS) often degrades image quality by obscuring the inferior myocardial wall, leading to equivocal studies. While nonpharmacological…

View details →DOI: 10.1177/10849785251376736
Negative / Null Result ReportMedicine

Baseline body mass index modifies the effects of digital health interventions compared with usual care on cardiovascular disease risk in people with type 2 diabetes: a secondary analysis of the SMARTDiabetes trial.

Ren J, Sun X, Zhang Z et al. · 2026 · The American journal of clinical nutrition

Background Body weight is a critical determinant of cardiovascular disease (CVD) risk among people with type 2 diabetes mellitus (T2DM), substantially contributing to the incidence of and outcomes from CVD. However, the impact of body…

View details →DOI: 10.1016/j.ajcnut.2026.101282
Negative / Null Result ReportMedicine

Lactobacillus rhamnosus GG to Reduce Necrotising Enterocolitis, Sepsis, and Mortality in Very Low Birth Weight Infants: A Randomized Controlled Trial.

Shah S, Kaul A, Pandey P et al. · 2026 · Indian pediatrics

Objectives To evaluate the efficacy of oral Lactobacillus rhamnosus GG (LGG) in reducing neonatal enterocolitis (NEC), sepsis and mortality in very low birth weight (VLBW) infants. Methods This open-label randomized controlled trial…

View details →DOI: 10.1007/s13312-025-00252-w
Negative / Null Result ReportOpen accessMedicine

Effect of HEPA filtration air purifiers on cognitive function from a secondary outcome analysis of a pragmatic randomized crossover trial.

Pellegrino N, Eliasziw M, Fortinsky R et al. · 2026 · Scientific reports

Exposure to particulate matter is associated with adverse health outcomes such as cardiovascular and neurological diseases. However, there are few intervention studies that have examined short-term changes in air particulate exposure and…

View details →DOI: 10.1038/s41598-026-48063-8
Negative / Null Result ReportMedicine

The Effect of Coach's Drawing and Visuospatial Abilities on Visual Attention and Soccer Tactics Memorization: An Eye-Tracking Study.

Tlili S, Ben Mahfoudh H, Zoudji B · 2025 · Perceptual and motor skills

Generated drawing is a specific instructional approach that has been investigated in academic settings. However, in sports, tactical drawings are often presented based more on coaches' preferences than on empirical evidence. This study…

View details →DOI: 10.1177/00315125251391658
Negative / Null Result ReportMedicine

Real world experience of intraoperative radiation therapy (IORT) during lumpectomy for early-stage breast cancer: retrospective data from a single large institutional observational study.

Scherer C, Fung V, Anzellini D et al. · 2026 · Breast cancer (Tokyo, Japan)

Background We report outcomes of patients who received intraoperative radiation therapy (IORT) using 50 kV after lumpectomy and sentinel lymph node biopsy. Methods Women with age > 45 and post-menopausal status, localized, unifocal,…

View details →DOI: 10.1007/s12282-026-01824-9
Negative / Null Result ReportMedicine

Retrospective Analysis of Intervention Effectiveness in Preventing Glaucoma Blindness in a Tertiary Care Setting.

Kanthar T, Vatcharavongvan P, Prasert V · 2025 · Journal of evaluation in clinical practice

Rationale The global prevalence rate of glaucoma blindness is extremely high and is a leading cause of irreversible blindness. Despite many advancements in treatment, evaluating glaucoma blindness remains challenging due to the long time…

View details →DOI: 10.1111/jep.70341
Negative / Null Result ReportMedicine

Dual Antiplatelet Therapy beyond 1 Year after a Myocardial Infarction Compared with Low-Dose Aspirin Alone: A 3-Year Follow-Up Cohort Study Within the French SNDS Nationwide Claims Database.

Blin P, Danchin N, Benichou J et al. · 2026 · American journal of cardiovascular drugs : drugs, devices, and other interventions

Introduction Antiplatelet therapy with low-dose aspirin, alone or as dual antiplatelet therapy (DAPT) with a P2Y 12 inhibitor, is used in secondary prevention following myocardial infarction (MI). However, the optimal duration of DAPT is…

View details →DOI: 10.1007/s40256-025-00782-5
Negative / Null Result ReportMedicine

[Analysis of the reimbursement times of antitumor drugs in Italy in relation to the clinical benefit expressed by the European Society for Medical Oncology (ESMO-MCBS)].

Romagnoli A, Marcellusi A, Lasala R · 2025 · Recenti progressi in medicina

Introduction Rapid access to safe and effective oncological therapies is crucial. In recent years, many expensive drugs have been commercialized, making it essential to prioritize those with significant clinical benefits. For this purpose,…

View details →DOI: 10.1701/4518.45175
Negative / Null Result ReportOpen accessMedicine

Propensity score-matched evaluation of prophylactic hyperthermic intraperitoneal chemotherapy in geriatric patients with locally advanced colorectal cancer: safety and survival benefits.

Yang M, Yang S, Zhang W et al. · 2026 · BMC cancer

AIM: The role of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with locally advanced colorectal cancer (LACRC) remains controversial. This study aimed to evaluate the perioperative safety and survival…

View details →DOI: 10.1186/s12885-026-16073-4