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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 354 of 675

Negative / Null Result ReportOpen accessMedicine

Bidirectional Mendelian randomization study reveals no causal association between polycystic ovary syndrome and IgA nephropathy.

Wang X, Zhang R, Chai W et al. · 2026 · Medicine

The incidence of IgA nephropathy (IgAN) is increasing, and some observational studies reported the potential correlation of polycystic ovary syndrome (PCOS) with the risk of IgAN. We performed a bidirectional Mendelian randomization…

View details →DOI: 10.1097/md.0000000000048704
Negative / Null Result ReportMedicine

Magnetic resonance imaging-derived anterior tibial translation after anterior cruciate ligament reconstruction and its association with postoperative adverse events: A retrospective cohort study.

Gonzalez W, Isla J, Barba D et al. · 2026 · Journal of ISAKOS : joint disorders & orthopaedic sports medicine

Background Anterior tibial translation (ATT) measured on magnetic resonance imaging (MRI) is a reproducible marker of anterior cruciate ligament (ACL) deficiency. However, its longitudinal evolution after ACL reconstruction (ACLR) and its…

View details →DOI: 10.1016/j.jisako.2026.101134
Negative / Null Result ReportOpen accessMedicine

Tibial genu varum and primary cam morphology in healthy young adults: A cross-sectional study uncovering the double threat to joint health.

Bax EA, Colyn W, Bellemans J et al. · 2026 · Osteoarthritis and cartilage open

Objectives This study investigated the association between alpha angles of the hip and tibial genu varum in a healthy population with equal male-to-female distribution. It also examined sex-based differences, explored the impact of sports…

View details →DOI: 10.1016/j.ocarto.2026.100803
Negative / Null Result Report

Ultra-Processed Food Consumption, Additive Co-occurrence, and Associated Risk Factors Among University Students in Peru

GUILLEN SANCHEZ JS, Saenz Tolay M, Cabanillas Chirinos L et al. · 2026 · Preprint

Background: The rising consumption of ultra-processed foods (UPFs) is a global concern, given their poor nutritional quality and the presence of multiple additives that may pose health risks when consumed in excess. Young populations are…

View details →DOI: 10.12688/f1000research.166729.2
Negative / Null Result ReportOpen accessMedicine

Early Dynamic Changes in Haematoma Thickness in Medically Managed Type A Intramural Haematoma: A Multicentre Retrospective Study.

Motoji Y, Kitamura T, Naito N et al. · 2026 · Interdisciplinary cardiovascular and thoracic surgery

Objectives This study aimed to investigate changes in haematoma thickness (HT) and the maximum ascending aortic diameter (MAD) early after onset and their association with in-hospital disease progression in type A intramural haematoma…

View details →DOI: 10.1093/icvts/ivag146
Negative / Null Result ReportOpen accessMedicine

Association of Osteosarcopenia with Functional Outcomes in Older Adult Patients Undergoing Rehabilitation.

Mannen R, Maeda K, Inoue T et al. · 2026 · Journal of frailty, sarcopenia and falls

Objectives Osteosarcopenia is characterized by the coexistence of sarcopenia and osteoporosis. This comorbid condition is thought to negatively affect functional outcomes. In this study, we investigated the negative impact of…

View details →DOI: 10.22540/jfsf-11-118
Negative / Null Result ReportMedicine

Addressing Biases in Analysis of Time of Infusion: NCI/SWOG Trial S1404 Among Participants With High-Risk Resectable Melanoma Who Received Adjuvant Anti-PD-1 Therapy.

Othus M, Truong TG, Sharon E et al. · 2026 · JCO oncology practice

Purpose Multiple reports have suggested that receiving immunotherapy infusions earlier in the day is associated with improved outcomes, including longer overall survival (OS) and lower toxicity rates. However, the definition of early…

View details →DOI: 10.1200/op-25-01413
Negative / Null Result ReportMedicine

Association of Menopause and Hormone Replacement Therapy with Hearing Loss.

Hsu JZ, Gu K, Nguyen B et al. · 2026 · The Annals of otology, rhinology, and laryngology

Objective Estrogen has been found to impact cochlear blood flow and auditory function, but epidemiological studies on menopause and hearing are inconsistent. This study investigates the associations of menopause, its age at onset,…

View details →DOI: 10.1177/00034894261435259
Negative / Null Result ReportMedicine

The association between mode of delivery and severe intraventricular hemorrhage in very preterm infants.

Keel E, Kalimeris S, Adams M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Background Infants born before 32 weeks of gestation are at high risk of developing intraventricular hemorrhage (IVH), which is associated with significant mortality and morbidity as well as long-term neurodevelopmental impairment. There…

View details →DOI: 10.1080/14767058.2026.2650951
Negative / Null Result ReportMedicine

Perinatal use of targeted synthetic DMARDs and maternal-neonatal outcomes in autoimmune disease: A population-based cohort study.

Cheng V, Sayre EC, Amiri N et al. · 2026 · Journal of autoimmunity

Objectives While targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs) have advanced autoimmune disease management, the paucity of perinatal safety data limits evidence-based decision-making in pregnancy. We aimed to…

View details →DOI: 10.1016/j.jaut.2026.103538
Negative / Null Result ReportOpen accessMedicine

Transumbilical single-port appendectomy in children: a retrospective study.

Berto LG, da Silva CL, Durante MV et al. · 2026 · Pediatric surgery international

Objective Acute appendicitis is the leading cause of abdominal surgery. This study evaluated outcomes of transumbilical single-incision laparoscopic appendectomy (TSILA) compared with conventional laparoscopy and open surgery. Methods A…

View details →DOI: 10.1007/s00383-026-06448-w
Negative / Null Result ReportMedicine

No significant association between <i>Helicobacter pylori</i> infection and Barrett's esophagus: results from a large screening cohort in Central Europe.

Götz N, Völkerer A, Hofer H et al. · 2026 · Scandinavian journal of gastroenterology

Background Barrett's esophagus (BE) is a premalignant condition associated with gastroesophageal reflux disease (GERD) and an increased risk of esophageal adenocarcinoma (EAC). While Helicobacter pylori ( H. pylori ) has been proposed as a…

View details →DOI: 10.1080/00365521.2026.2632058
Negative / Null Result ReportMedicine

Polyethylene thickness showed no significant association with implant survival in primary posterior-stabilized total knee arthroplasty at 13-year follow-up: a regional registry-based study of 5625 crosslinked inserts.

Benvenuti L, Digennaro V, Colangelo A et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Purpose The influence of polyethylene (PE) insert thickness on long-term implant survival after total knee arthroplasty (TKA) remains controversial. Thicker PE inserts are generally reserved for cases in which adequate ligament balance…

View details →DOI: 10.1007/s00590-026-04743-9
Negative / Null Result ReportMedicine

Influence of Sociodemographic Factors and Incontinence Care Practices on the Development of Incontinence-Associated Dermatitis.

Garcia-Ruiz MP, Torres-Bautista RM, Lopez-Franco MD et al. · 2026 · Journal of clinical medicine

Objectives: The general objective of the study was to analyze the influence of sociodemographic factors and care and hygiene practices on the appearance of Incontinence-Associated Dermatitis (IAD). The specific objectives were to identify…

View details →DOI: 10.3390/jcm15051752
Negative / Null Result ReportOpen accessMedicine

Investigating the neurodevelopmental consequences of anesthesia and surgical interventions on cognitive and behavioral outcomes: A comprehensive Mendelian randomization study.

Wu W, Fan Y · 2026 · Medicine

Anesthesia is indispensable to modern surgical practice and clinical care; however, its potential impact on neurodevelopment and behavioral outcomes has raised growing concerns. Discrepancies among previous studies may partly arise from…

View details →DOI: 10.1097/md.0000000000049209
Negative / Null Result ReportOpen accessMedicine

Risk of Intraoperative Periprosthetic Femoral Fracture According to Cementless Femoral Stem Geometry: A Cohort Study Based on the Radaelli Classification.

Izquierdo JA, Kerbel J, Apodaca G et al. · 2026 · Cureus

Background Intraoperative periprosthetic femoral fracture is an uncommon but clinically significant complication of total hip arthroplasty (THA) that may compromise implant stability and increase the risk of early revision surgery. Several…

View details →DOI: 10.7759/cureus.106425
Negative / Null Result ReportMedicine

Social inequality and the mental health of Chinese youth.

Wang Y, Zhang Y, Lan Y · 2026 · Scientific reports

The mental health of young people serves as a social barometer, reflecting societal conditions. However, the relationship between social inequality and youth mental health remains a contested issue. This study uses data from the China…

View details →DOI: 10.1038/s41598-026-58041-9
Negative / Null Result ReportMedicine

Steroid with Temporary Stent Versus Steroid Alone for Preventing Stricture After Endoscopic Submucosal Dissection for Early Esophageal Cancer.

Chen Z, Zhang L, Liang Y et al. · 2026 · Digestive diseases and sciences

Background and aims Post-ESD esophageal stricture remains a major complication despite steroid prophylaxis. Temporary stent placement has been proposed as an adjunctive strategy in high-risk cases, yet its independent effect remains…

View details →DOI: 10.1007/s10620-026-09842-5
Negative / Null Result ReportOpen accessMedicine

Association Between Possible Sarcopenia and Fracture Risk Assessment Tool (FRAX)-Estimated Fracture Risk Without Bone Mineral Density in Institutionalized Older Adults: A Cross-Sectional Study.

Yubaitsa CN, Gani KS, Mitchel M et al. · 2026 · Cureus

Background Musculoskeletal problems in the elderly pose a significant challenge for healthcare providers, as they constitute a vulnerable group. Fractures are often undetected, leading to a reduced quality of life due to increased…

View details →DOI: 10.7759/cureus.103678