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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19854 results in Negative / Null Result Report · page 354 of 662

Negative / Null Result ReportOpen accessMedicine

Effects of current smoking on treatment outcomes in metastatic and locally advanced pancreatic carcinoma: a retrospective cohort study using the international PURPLE pancreas cancer registry.

Hayat F, Chiu S, Stuart A et al. · 2025 · Journal of gastrointestinal oncology

Background Tobacco smoking accounts for 22% of the pancreatic cancer burden in Australia. Smoking may increase therapy-related adverse effects and was associated with shorter survival in the previous analysis of all stages of pancreatic…

View details →DOI: 10.21037/jgo-2025-186
Negative / Null Result ReportOpen accessMedicine

Revisiting Janus Kinase Inhibitors in Hospitalized COVID-19: Evidence for Baricitinib's Superiority and the Absence of a Class Effect.

Gu L, Lin J, Yue J et al. · 2025 · Journal of inflammation research

Janus kinase (JAK) inhibitors, developed for autoimmune diseases, have been repurposed as potential therapies for severe COVID-19. Growing evidence indicates that their clinical utility is heterogeneous and cannot be generalized as a class…

View details →DOI: 10.2147/jir.s554898
Negative / Null Result ReportMedicine

Failure to correct the fractional curve in adult spinal deformity surgery is associated with rod fractures.

Jain H, Zakieh O, Chanbour H et al. · 2025 · Clinical neurology and neurosurgery

Introduction Coronal malalignment (CM) remains an understudied and challenging problem in adult spinal deformity (ASD) surgery, and the impact of the lumbosacral fractional curve (LSF) correction on postoperative outcomes remains poorly…

View details →DOI: 10.1016/j.clineuro.2025.109152
Negative / Null Result ReportMedicine

Use of a Personalised Early Warning Decision Support System for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Results of the "Predict & Prevent" Phase III Trial.

Gkini E, Mehta RL, Tearne S et al. · 2025 · COPD

Rationale The Predict&Prevent trial was designed to provide a definitive randomised clinical trial of a personalised early warning decision support system, COPDPredict™. Methods Adults with ≥1 AECOPD were randomly assigned in a 1:1 ratio…

View details →DOI: 10.1080/15412555.2025.2544719
Negative / Null Result Report

Lack of evidence for cargo release of CD63-EVs into recipient cells

Askarian-Amiri S, Weissenhorn W, Sadoul R et al. · 2025 · Preprint

Extracellular vesicles (EVs), including exosomes, are widely believed to mediate intercellular communication by delivering molecular cargo to recipient cells. However, the efficiency and mechanisms of such cargo delivery remain unclear. In…

View details →DOI: 10.1101/2025.04.01.646561
Negative / Null Result ReportMedicine

Machine Learning and Urinary Incontinence in Prostate Cancer: A Generalized Additive Model of Physical Activity and Recovery Patterns.

Manolitsis I, Feretzakis G, Tzelves L et al. · 2025 · Studies in health technology and informatics

The ASCAPE project aims to improve the health-related quality of life of prostate cancer patients using artificial intelligence-driven solutions. This study tries to unravel the complex relationships between patient data variables and…

View details →DOI: 10.3233/shti250634
Negative / Null Result ReportMedicine

Long-term Results from the LEA Randomized Trial: Extended Versus Standard Lymph Node Dissection in Patients with Bladder Cancer Undergoing Radical Cystectomy.

Heck MM, Lehmann J, Amiel T et al. · 2025 · European urology

The extent of lymph node dissection (LND) at the time of radical cystectomy (RC) for bladder cancer (BC) may affect oncologic outcomes. We present updated long-term data from a prospective, multicenter, phase 3 trial involving patients…

View details →DOI: 10.1016/j.eururo.2025.09.001
Negative / Null Result ReportOpen accessMedicine

Clinical Determinants of Urinary Podocyte Biomarkers and Their Feasibility in Paraprotein-Related Kidney Disease.

Helk O, Wagner L, Sengölge G et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: Kidney injury is a frequent complication of multiple myeloma (MM) and monoclonal gammopathies. Podocyte stress markers, such as urinary nephrin and podocin, have been studied in other renal diseases but their utility…

View details →DOI: 10.3390/diagnostics16060922
Negative / Null Result ReportMedicine

[Hortitherapy and well-being in day care centres].

Zivkovic Habibi L, Zaibat M, Frenkiel J et al. · 2025 · Soins. Gerontologie

Day care centers are medical and social facilities that provide day care for people over 60 with Alzheimer's or related diseases. The main aim of the study presented here was to assess the impact of horticultural therapy sessions on the…

View details →DOI: 10.1016/j.sger.2024.10.008
Negative / Null Result ReportMedicine

Anteriorization of the inferior oblique muscle versus anteriorization and resection for asymmetrical dissociated vertical deviation.

Osama G, Elhilali H, Salah M et al. · 2025 · Strabismus

Purpose To compare the efficacy of two methods: first, bilateral symmetric anteriorization of the inferior oblique muscle and second: combined resection and anteriorization of the inferior oblique (IO) muscle for asymmetric dissociated…

View details →DOI: 10.1080/09273972.2024.2402925
Negative / Null Result ReportMedicine

Combination of short pulse and smooth modality of Er: YAG laser versus short pulse alone in treatment of striae distensae: a split-lesion study.

Sadeghinia A, Emadi SN, Jamshidi S et al. · 2025 · Lasers in medical science

Background Despite extensive research, there is still no consensus on the optimal treatment for Striae distensae (SD). Aim To evaluate the efficacy of ablative (short pulse (SP) mode) versus combined ablative and non-ablative (short pulse…

View details →DOI: 10.1007/s10103-025-04488-7
Negative / Null Result ReportMedicine

Comparison of different scoring systems for prediction of postoperative complications after robot-assisted radical prostatectomy.

Yilmaz AB, Karimzada K, Ozercan AY et al. · 2025 · Journal of robotic surgery

To evaluate the predictive value of the Estimation of Physiologic Ability and Surgical Stress (E-PASS) score, Comorbidity Score for Robotic Surgery (CRS) and Charlson Comorbidity Index (CCI) in relation to postoperative complications in…

View details →DOI: 10.1007/s11701-025-02406-1
Negative / Null Result ReportOpen accessMedicine

Revisiting Eysenck: The Association Between Personality and Acute Stress Reactivity.

Marshall MJ, Peck K, Hunter R et al. · 2024 · Behavioral sciences (Basel, Switzerland)

Eysenck's biopsychological model of stress posits that the extraversion-introversion distinction is associated with different thresholds of arousal, which in turn moderate the stress response. Although higher thresholds of activation have…

View details →DOI: 10.3390/bs14111098
Negative / Null Result Report

An Atypical Manifestation of Giant Cell Arteritis (GCA): Constitutional Symptoms & Lingual Ulcer in a 78-Year-Old Male with Negative Temporal Artery Biopsies

Gow J, Roofeh D · 2025 · Preprint

Abstract Background: Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features…

View details →DOI: 10.21203/rs.3.rs-5860997/v1
Negative / Null Result ReportMedicine

[Hydroxyurea-resistant primary erythrocytosis in a juvenile mixed-breed bitch].

Graf J, Buder A · 2025 · Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere

Primary erythrocytosis, also known as polycythemia vera, is a myoproliferative disease resulting in an increased red blood cell mass and is associated with increased hematocrit and hemoglobin concentrations. Patients have an augmented risk…

View details →DOI: 10.1055/a-2471-6729
Negative / Null Result ReportMedicine

Neoadjuvant chemoradiation and surgical excision versus definitive radiotherapy for locally advanced cervix uteri carcinoma: in terms of early and late complications and locoregional recurrence.

Khalifa H, Ayaty M, Oreaba R et al. · 2025 · Journal of the Egyptian National Cancer Institute

Objectives Following external beam radiation therapy (EBRT) with concurrent chemotherapy, we analyzed the benefits of surgical resection for locally advanced cervical carcinoma in terms of the frequency and severity of complications and…

View details →DOI: 10.1186/s43046-025-00292-0
Negative / Null Result ReportMedicine

[Comparison of the modified Kadish, AJCC T and Dulguerov T staging systems for olfactory neuroblastoma: analysis of the SEER database].

Lyu HH, Wen X, Lin JT et al. · 2025 · Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery

Objective: To compare the Kadish T staging, AJCC T staging, and Dulguerov T staging system in terms of their impact on surgical treatment selection and survival prognosis in patients with olfactory neuroblastoma (ONB). Methods: The cases…

View details →DOI: 10.3760/cma.j.cn115330-20240723-00438
Negative / Null Result ReportMedicine

Hearing Outcome in Idiopathic Sudden Sensorineural Hearing Loss After COVID-19 Vaccine in Asian Population: A Preliminary Study.

Chen PY, Young TC, Lin CY et al. · 2025 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To determine the hearing outcomes in patients with sudden sensorineural hearing loss (SSNHL) after exposure to different brands of vaccines against COVID-19. Study design Cohort study. Setting Tertiary referral center. Patients…

View details →DOI: 10.1097/mao.0000000000004509
Negative / Null Result ReportMedicine

Effects of different positive end-expiratory pressure strategies on treating overweight patients with acute respiratory distress syndrome: A retrospective study based on large intensive care unit databases.

Zheng X, Zhang T, Zhan T et al. · 2025 · Respiratory medicine

Purpose Positive end-expiratory pressure (PEEP) refers to a vital respiratory therapeutic tool for treating ARDS. Since overweight individuals face a greater risk of pulmonary complications than others, this study aims to assess whether…

View details →DOI: 10.1016/j.rmed.2025.108093
Negative / Null Result ReportMedicine

Futility of plasmapheresis, insulin in normoglycaemic individuals, or heparin in the treatment of hypertriglyceridaemia-induced acute pancreatitis.

Syed-Abdul MM, Tian L, Hegele RA et al. · 2025 · The lancet. Diabetes & endocrinology

There is a well-established link between the severity of hypertriglyceridaemia and acute pancreatitis and long-term triglyceride-lowering therapies known to prevent episodes of acute pancreatitis. Therefore, it has been assumed, without…

View details →DOI: 10.1016/s2213-8587(25)00028-2
Negative / Null Result Report

The Autoimmune March: Bullous lichen planus and new-onset lupus erythematosus associated with COVID-19 mRNA vaccine in a Filipino female with rheumatoid arthritis

Gonzalez PA, Zamora-Abrahan G, Roa F et al. · 2024 · Preprint

Background: A 32-year-old Filipino female with rheumatoid arthritis and lichen planus of low activity was admitted following a five-week period of painful oral mucosal and cutaneous bullae and erosions over her prior lichen planus lesions…

View details →DOI: 10.22541/au.172880901.19591056/v1
Negative / Null Result ReportMedicine

Therapy resistant hypertrophic lichen planus and its response to oral tofacitinib with a priori tissue cytokine expression: a real-world hospital-based study.

Sharath S, Sardana K, Khurana A et al. · 2025 · Archives of dermatological research

Background Although there are several reports on use of tofacitinib in lichen planus (LP), its usage in hypertrophic LP is sparse with no data on tissue cytokine expression. Methods We retrospectively analyzed the records of recalcitrant…

View details →DOI: 10.1007/s00403-025-04088-z
Negative / Null Result ReportOpen accessMedicine

Refractory severe aplastic anemia in a child: treatment failure and access barriers in a low-resource setting.

Karaki Z, Chemaly C, Kotaich J et al. · 2025 · Annals of medicine and surgery (2012)

Introduction and importance Aplastic anemia (AA) is a rare but potentially fatal hematologic disorder in children, marked by bone marrow failure and pancytopenia. Early diagnosis and access to curative treatment such as hematopoietic stem…

View details →DOI: 10.1097/ms9.0000000000004007
Negative / Null Result ReportOpen accessMedicine

Development of Machine Learning Models to Predict Daily Gas Ebullition Flux in Waterways from Sediment Characteristics.

Mansouri M, Rockne KJ · 2026 · ACS environmental Au

Gas ebullition plays a critical role in facilitating contaminant transport from the sediment to the water column. Predicting gas ebullition accurately is necessary for managing sediments and assessing sediment/water flux, and many…

View details →DOI: 10.1021/acsenvironau.5c00221
Negative / Null Result ReportMedicine

The Effect of External Distractions on Simulated Laparoscopic Performance.

Ingram I, Hughes MA · 2024 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background: Surgeons are exposed to unavoidable distractions while operating. Distractions can cause stress, and stress can impair cognition and motor skills to the detriment of surgeon performance. This study assessed the impact of…

View details →DOI: 10.1089/lap.2024.0280