A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19850 results in Negative / Null Result Report · page 341 of 662
Rodríguez-Sánchez GT, Rogers DW, Rainey PB · 2026 · Preprint
Understanding the genetic basis of adaptive traits requires linking mutation to phenotypic change and fit-ness. The Wrinkly Spreader (WS) mutants of Pseudomonas fluorescens SBW25, which colonize the air–liquid interface (ALI) in static…
Zeldenrust EG, Carlton K, Jenkins EJ et al. · 2026 · Veterinary parasitology
Klossiella equi Baumann, 1946 (Apicomplexa: Coccidia) is a globally distributed adeleorinid parasite that infects the kidneys of equid hosts. Considered an uncommon parasite, when K. equi is detected, it is typically an incidental finding…
Jimenez CM, Kreizinger Z, Gyuranecz M et al. · 2026 · Poultry science
The control and prevention of Mycoplasma (M.) synoviae infections have been significantly improved by the use of the MS-H live vaccine strain. This vaccine has been used globally for decades; therefore, many technical approaches have been…
Zhang H, Wu W, Xu J · 2026 · Frontiers in oncology
Early ampullary tumors are challenging to diagnose due to their complex surrounding structures and deep anatomical location. We report a rare case in which enhanced computed tomography (CT), magnetic resonance imaging (MRI), magnetic…
Busi R, Machingal P, Hemachandra N et al. · 2025 · Preprint
The size of the protein sequence database is increasing without a consequent increase in the number of proteins with known molecular function, especially at the fine-grained level. Alignment-based approaches such as BLAST and profile…
Sato T, Nishitsuka K, Itoh T et al. · 2025 · Preprint
Deep learning has shown promise in diabetic retinopathy screening using fundus images. However, many existing models operate as “black boxes,” providing limited interpretability at the lesion level. This study aimed to develop an…
T JS, Chetty N · 2025 · Preprint
Abstract Wind speed distribution modelling serves as an essential tool to assess wind energy resources while identifying optimal wind turbine locations. Three statistical models, including Bimodal Mixture Weibull (BMW), Modified Bimodal…
An SY, Kim I, Hong SH et al. · 2026 · Protein science : a publication of the Protein Society
Anti-CRISPR (Acr) proteins are phage-encoded anti-defense factors that suppress CRISPR-Cas immunity in bacteria. AcrIIA8 was previously identified as an inhibitor of Streptococcus pyogenes Cas9 (SpyCas9) through functional assays of…
Qiu W, Yan YK, Kang JP et al. · 2025 · Clinical laboratory
Background Nucleated red blood cells (NRBCs) play a crucial role in automated blood analysis, particularly in the diagnosis and monitoring of blood disorders. This study examines the limitations of the Sysmex XN-9000 fully automated…
Dachraoui K, Ben Osman R, Ben Slama S et al. · 2025 · Vector borne and zoonotic diseases (Larchmont, N.Y.)
A total of 20 horses belonging to the Pasteur Institute of Tunis used for the production of therapeutic serum antiscorpion venom were tested for the presence of antibodies anti-West Nile virus (WNV) during the 2023 outbreak of West Nile…
Nkoy AB, Mumaka FM, Matoka TT et al. · 2026 · Pediatric nephrology (Berlin, Germany)
Background Serum creatinine (SCr), the most used biomarker to evaluate glomerular filtration rate (GFR), might be inaccurate in children with sickle cell anemia (SCA). In this context, cystatin C (SCys) could be of interest. This study…
Hagenbeek A, Masukagami Y, Palanichamy P et al. · 2026 · BMC genomics
The intracellular endosymbiont Candidatus Lariskella (Alphaproteobacteria, Candidatus Midichloriaceae) has been found across a wide diversity of terrestrial arthropods, including ticks, true bugs, beetles, fleas, wasps and moths. Despite…
Wang Y, Kong X, Wei H et al. · 2025 · Haemophilia : the official journal of the World Federation of Hemophilia
Introduction The Bethesda assay (BA) and the Nijmegen-Bethesda assay (NBA) are commonly used to measure inhibitors in patients with haemophilia A (HA). The laboratory results of inhibitor assays have been demonstrated to be highly…
Malinowska K, Wawrzynowicz M, Markowska K et al. · 2025 · Preprint
Conservation decision-making requires accurate identification of causes of population changes. Ecologists often rely on analytical protocols that aggregate high-dimensional monitoring data. We hypothesise that compressing data - either…
Jena S, Kim D, Lee AM et al. · 2025 · Preprint
Abstract Background: Disease heterogeneity across a diverse patient cohort poses challenges to cancer drug development due to inter-patient variability in treatment responses. However, current preclinical models fail to depict…
Hall AD, Whitehurst DA, Mortensen JE et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Malaria remains a significant public health concern in sub-Saharan Africa, particularly in Ethiopia where Plasmodium falciparum and Plasmodium vivax are co-endemic. Most cases in the United States are acquired abroad and imported.…
Atencia S, Mateu N, Rodríguez-Cobos A et al. · 2025 · Veterinary research communications
Bordetella bronchiseptica (Bb) is a frequent pathogen in dogs and a component of the Canine Infectious Respiratory Disease Complex (CIRDC). However, it can also be detected in the lower respiratory tract of healthy animals, complicating…
Kaiser A, Resasco J, Dee L · 2025 · Preprint
Abstract As urban populations grow, conserving biodiversity within cities is increasingly vital and of global policy interest. However, urban environments pose unique challenges for understanding drivers of biodiversity change, as…
Robinson ZP, Steele J, Helms ER et al. · 2025 · Preprint
ABSTRACT Purpose There is growing emphasis on investigating heterogeneity in resistance training (RT) outcomes, likely motivated by observations of substantial gross variability in training effects. However, gross variability does not…
Al Sawafi M, Potdar S · 2025 · Trauma case reports
Background Focused Assessment with Sonography for Trauma (FAST) is a cornerstone in the early assessment of trauma patients. However, a negative initial FAST does not always rule out intra-abdominal injury. Case presentation A middle-aged…
Cooper WR, Ohler B, Wenninger EJ et al. · 2025 · Environmental entomology
Bactericera maculipennis (Crawford) and Bactericera cockerelli (Šulc) (Hemiptera: Triozidae) share hosts within the Solanaceae and Convolvulaceae (Solanales), and both are associated with "Candidatus Liberibacter solanacearum" (Lso). Lso,…
Xia MH, Liu KC, Zhao W et al. · 2025 · Brachytherapy
Purpose To compare the effectiveness and safety of CT-guided iodine-125 seed brachytherapy in conjunction with chemotherapy against chemotherapy alone for the management of intermediate and advanced non-small cell lung cancer (NSCLC)…
Joly A, Thoumas J, Lambert A et al. · 2024 · Preprint
Dysregulation of energy metabolism, including hyperglycemia, insulin resistance and fatty liver have been reported in a substantial proportion of lean children. However, non-obese murine models recapitulating these features are lacking to…
Kavoussi PK, Weiss J, Pyo J et al. · 2026 · The Journal of urology
Purpose To assess varicocele repair effect on semen parameters and improved candidacy for in vitro fertilization/intracytoplasmic sperm injection or lesser involved treatment options depending on semen parameter response following…
Strowd RE, de la Fuente M, Bauer TM et al. · 2026 · Neuro-oncology advances
Recurrent isocitrate dehydrogenase (IDH) wild-type glioblastoma has no established standard-of-care treatment. Preclinical models have demonstrated that hypoxia-inducible factor-2 alpha (HIF-2α) contributes to stabilizing the hypoxic…
Hellingman A, Göttle NL, Walz A et al. · 2026 · ACS infectious diseases
Malaria remains a major global health threat, and the emergence of partial artemisinin resistance challenges current treatment regimens. Reliable antimalarial screening assays are therefore essential for identifying new drug candidates.…
Zhang C, Li J, Zhuang W · 2026 · Frontiers in oncology
Background Acute myeloid leukemia (AML) is an acute leukemia characterized by aberrant proliferation of myeloid blasts in the bone marrow. Auer bodies are identifiable in the blasts of certain AML subtypes, but their "faggot-like"…
Hashimoto G, Tsukagoshi Y, Saito A et al. · 2026 · JACC. Case reports
Background Inferior sinus venosus (SV) atrial septal defect (ASD) is a rare interatrial communication, found near the inferior vena cava (IVC)-right atrial (RA) junction, that may be overlooked on transesophageal echocardiography (TEE).…
Cutarelli A, De Falco F, Brunetti R et al. · 2024 · Frontiers in veterinary science
Virological evaluation was performed on equine semen to detect the presence of papillomaviruses (PVs) using droplet digital polymerase chain reaction (ddPCR) as the aim of this study was to investigate whether the sperm from asymptomatic…
Thakur M, Mewara A, Lakshmi P et al. · 2025 · Diagnostic microbiology and infectious disease
Ascariasis, caused by Ascaris lumbricoides, is a widespread parasitic infection. Traditional diagnostic methods, such as microscopy, can miss infections with low worm burdens, leading to false negatives. This study compares four diagnostic…