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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 331 of 675

Negative / Null Result Report

Utilizing raw rapeseed press cake in foods: A case study on sensory quality and profile of selected bitter compounds in snack bars

Thorsen JS, Bononad-Olmo A, Toft AM et al. · 2026 · Preprint

ABSTRACT Today’s canola quality rapeseed press cake (RPC) is a protein-rich co-product with potential as human food, but its application is limited due to antinutritional compounds and bitter taste. It remains, however, unknown how…

View details →DOI: 10.64898/2026.03.20.712648
Negative / Null Result ReportMedicine

Beef quality and expression of genes involved in lipid metabolism in the muscle of Nellore and Nellore × Angus steers fed whole shelled corn diets.

Teixeira PD, Casagrande DR, Rodrigues AC et al. · 2026 · Meat science

Sixteen Nellore and Sixteen Nellore × Angus steers with an initial body weight of 353 kg ±25.3 kg were randomly assigned into 2 feeding groups: whole shelled corn without forage (WSC) or WSC with sugarcane bagasse (WSCB), to evaluate…

View details →DOI: 10.1016/j.meatsci.2026.110078
Negative / Null Result ReportMedicine

Chinese Young Children Engage in Social Role-Based Sharing Behavior.

Wu X, Chai Q, He J · 2026 · Developmental science

Role ethics suggests that moral obligations arise from the duties associated with one's social roles. Yet, the influence of social roles on children's moral behavior remains unclear. This research addressed this gap by testing whether…

View details →DOI: 10.1111/desc.70140
Negative / Null Result ReportMedicine

Intraoperative 3D Fluoroscopy Reduces Revision Rates and Improves Reduction Quality in Acetabular Fracture Fixation.

Le Baron M, David G, Ward BA et al. · 2026 · Journal of orthopaedic trauma

Objectives To evaluate whether the use of intraoperative 3D fluoroscopy during acetabular fracture fixation reduces the rate of unplanned returns to the operating room and improves radiographic quality of reduction without increasing…

View details →DOI: 10.1097/bot.0000000000003100
Negative / Null Result ReportMedicine

Brain Activity Changes During Bladder Filling in Women With Overactive Bladder After Percutaneous Tibial Neuromodulation.

Tam J, Wengler K, Yang J et al. · 2026 · Neurourology and urodynamics

Purpose Percutaneous tibial neuromodulation (PTNM) is a standard third line therapy for patients with overactive bladder (OAB). While the therapy has demonstrated efficacy, its exact mechanism of action is unclear. Functional neuroimaging…

View details →DOI: 10.1002/nau.70238
Negative / Null Result ReportMedicine

Redefining the role of carbon nanoparticles in colorectal cancer surgery: From lymph node yield to diagnostic paradox.

Lv Y, Wang F, Shen Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Background Accurate lymph node (LN) staging is critical in colorectal cancer (CRC). Carbon nanoparticles (CNPs), used as a tumor localization agent, incidentally stain LNs, creating uncertainty about their utility for improving staging and…

View details →DOI: 10.1016/j.ejso.2026.111782
Negative / Null Result ReportMedicine

The Opioid Safety Toolkit: An interactive prescription opioid safety toolkit to increase opioid safety literacy and behaviours among people prescribed opioids for pain-a randomised controlled trial.

Nielsen S, Fox F, Lam T et al. · 2026 · Addiction (Abingdon, England)

Background and aims Prescription opioid-related harm remains a significant public health concern. This study aimed to evaluate the efficacy of the Opioid Safety Toolkit, a co-designed, interactive online resource, in increasing naloxone…

View details →DOI: 10.1111/add.70412
Negative / Null Result ReportMedicine

Epidemiologic and Clinical Trends of Pediatric Human Rhinovirus Infections: A 2-year Comparative Analysis From a Single Center.

Yildirim Arslan S, Turanli E, Dinc F · 2026 · The Pediatric infectious disease journal

Background Human rhinovirus is one of the leading causes of pediatric respiratory infections worldwide. Its circulation patterns have shown notable changes in recent years. This study aimed to compare the epidemiologic, clinical and…

View details →DOI: 10.1097/inf.0000000000005171
Negative / Null Result ReportMedicine

Glucocorticoid dose at discharge and the risk of infectious complications and rehospitalization in renal diseases.

Yahata K, Seta K, Osaki K et al. · 2026 · Clinical and experimental nephrology

Background Glucocorticoids have diverse adverse effects, particularly infections that may be severe or opportunistic. Therefore, glucocorticoids are often initiated during hospitalization; however, the optimal glucocorticoid dose at…

View details →DOI: 10.1007/s10157-026-02868-z
Negative / Null Result ReportMedicine

Disinfection by-products in ballast water treated with oxidants - effects of treatment type, filter pre-treatment, test location, and salinity.

Sverdrup LE, Pollestad BM, Sigvaldsen I et al. · 2026 · Chemosphere

Ballast water is essential for ship stability during cargo operations and voyage, but its discharge can introduce invasive aquatic species to new environments. To mitigate this risk, ballast water is commonly treated with oxidants such as…

View details →DOI: 10.1016/j.chemosphere.2026.144899
Negative / Null Result ReportMedicine

Evaluation of a Clinical Practice Algorithm for Pediatric Complicated Pneumonia: A Retrospective, Observational, Single-Center Study.

Ostertag-Hill CA, Cummings OW, Renaud EJ · 2026 · Rhode Island medical journal (2013)

Objective The diagnostic evaluation, antibiotic treatment, and type and timing of surgical intervention for pediatric patients with complicated pneumonia is not standardized and may lead to increased length of stay, more radiation…

Negative / Null Result ReportMedicine

Comparison of Different Lighting Protocols on Female Cat Reproduction.

Lantermino A, Lapuente C, Blanco PG et al. · 2026 · Reproduction in domestic animals = Zuchthygiene

The aim of this study was to describe and compare the effect of different lighting protocols on sexual cyclicity and serum melatonin in domestic female cats. Additionally, anti-Müllerian hormone (AMH) concentrations and ultrasound or…

View details →DOI: 10.1111/rda.70177
Negative / Null Result ReportMedicine

Comparison of the somatic mutations in breast carcinomas in sporadic and BRCA1 carrier patients through targeted next generation sequencing.

Barron CR, Ramineni M, Finkelman BS et al. · 2026 · Human pathology

Objectives Women who carry a germline mutation in BRCA1 have an increased lifetime risk of developing breast cancer (BC). Prior Next-Generation Sequencing (NGS) studies on BCs from patients with germline BRCA1 mutations (gBRCA1) were…

View details →DOI: 10.1016/j.humpath.2026.106144
Negative / Null Result ReportMedicine

Nocturnal Sleep Breathing Patterns in Healthy Adolescents Residing at Very High Altitudes in Bolivia.

Patterson K, Rodríguez SU, Arancibia-Levit EN et al. · 2026 · Journal of sleep research

Data on sleep and respiratory patterns among adolescents residing at very high altitude (> 3500 m) remain scarce, and altitude-related physiological differences may influence these parameters. Studying adolescents at different very high…

View details →DOI: 10.1111/jsr.70326
Negative / Null Result ReportMedicine

Incidence of Gastrointestinal Adverse Events Following Left Hepatic Lobe Radiation Segmentectomy for the Treatment of Hepatocellular Carcinoma.

De La Garza-Ramos C, Silver C, Islam F et al. · 2026 · Cardiovascular and interventional radiology

Purpose Describe the incidence and severity of gastrointestinal tract-related adverse events (GIAE) following radiation segmentectomy (RS) for hepatocellular carcinoma (HCC) in the left hepatic lobe. Materials and methods A single-center…

View details →DOI: 10.1007/s00270-026-04376-9
Negative / Null Result ReportMedicine

Evaluation of squid shiokara products marketed in Japan using sensory tests, amino acid and organic acid profiles, and analysis of bacterial communities

Mizusawa N, Nishimura K, Ouchi D et al. · 2026 · Fish Sci

Shiokara is a traditional Japanese salted and fermented seafood product. The aim of this study was to compare various commercially available squid shiokara products in Japan by examining their NaCl content, free amino acid content (all…

Negative / Null Result ReportMedicine

Preliminary evaluation of a developmentally centred approach to optimise comfort in neonates following cardiac surgery.

Jones MB, Caprarola SD, Gordish H et al. · 2026 · Cardiology in the young

Introduction Children with CHD are at risk for neurodevelopmental impairments, and though these are often mild, some children face severe developmental challenges. Both unalleviated pain and exposure to opioids in the neonatal period have…

View details →DOI: 10.1017/s1047951125110949
Negative / Null Result ReportMedicine

Dung beetles do not profit from enhanced spatial heterogeneity in temperate production forests: A forest manipulation experiment

Asch J, Scherer‐Lorenzen M, Pierick K et al. · 2026 · Journal of Applied Ecology.

Central European forest management strategies promoting structurally homogeneous closed‐canopy forests have led to landscape‐level declines in biodiversity and ecosystem multifunctionality. Conservation‐targeted management programs aim at…

Negative / Null Result ReportMedicine

Exopolysaccharide biosynthesis and regulation in Leuconostoc mesenteroides influences water holding capacity of fermented plant-based milks.

Sukarno AS, Dong A, Gumulya Y et al. · 2026 · International journal of food microbiology

Physical instability remains a major challenge in fermented plant-based yoghurts in the absence of added texturizing agents. Cultures can improve water holding capacity (WHC) through production of exopolysaccharide (EPS). This study…

View details →DOI: 10.1016/j.ijfoodmicro.2026.111797
Negative / Null Result ReportMedicine

The influence of adolescent idiopathic scoliosis on hip joint development: a two-year longitudinal evaluation of the hip center-edge angle.

Matsumoto T, Yokoe T, Takahashi T et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

PURPOSE: Several studies have reported an association between adolescent idiopathic scoliosis (AIS) and hip decentration (HD). However, these previous studies evaluated the hip center-edge (CE) angle at only a single time point. This study…

View details →DOI: 10.1007/s00586-026-09787-3
Negative / Null Result ReportMedicine

Non-modifiable cardiovascular risk factors and coronary plaque characteristics in patients with acute coronary syndromes.

Scalamera R, Covani M, Andreaggi S et al. · 2026 · European heart journal. Cardiovascular Imaging

Aims Cardiovascular risk factors predict adverse clinical outcomes, including acute coronary syndromes (ACS). A recent study showed a close correlation between the number of modifiable risk factors and plaque vulnerability. However, the…

View details →DOI: 10.1093/ehjci/jeag023
Negative / Null Result ReportMedicine

Bark beetles as ecosystem engineers: triggered tree mortality rearranges the assemblage of Tree-related Microhabitats in old-growth coniferous forest

Przepióra F, Ciach M · 2025 · Forest Ecology and Management.

Although species with ecosystem engineering capabilities like woodpeckers, ungulates or saproxylic insects may initiate the formation of Tree-related Microhabitats (TreMs), their overall impact on TreM assemblages remains unexplored. Bark…

Negative / Null Result ReportOpen accessMedicine

No significant increase in thrombotic risk following the widespread adoption of TPO-RAs in ITP: A comparative study.

Wang Y, Li H, Chen Y et al. · 2026 · Global medical genetics

In patients with primary immune thrombocytopenia (ITP), the risk of thrombosis associated with thrombopoietin receptor agonists (TPO-RAs) remains debated. This study compared the thrombosis occurrence in ITP patients before and after the…

View details →DOI: 10.1016/j.gmg.2026.100107
Negative / Null Result ReportMedicine

Outcomes of Patients With Mitral Stenosis With Prior Percutaneous Mitral Commissurotomy Undergoing Mitral Valve Surgery.

Ruangsubvilai N, Au-Yeung K, Wongbuddha C et al. · 2026 · The American journal of cardiology

Limited data exist on outcomes for patients with mitral stenosis (MS) who have previously undergone percutaneous mitral commissurotomy (PMC) and later require surgical mitral valve replacement (MVR). This study evaluates the impact of…

View details →DOI: 10.1016/j.amjcard.2025.12.023
Negative / Null Result ReportMedicine

Good enough assessment: A comparison of brief screener and detailed interview assessments of borderline personality disorder symptoms in a clinical research setting.

Furtado Fernandes L, Davis MT, Luo W et al. · 2026 · Personality disorders

Structured clinical interviews are the gold standard for identifying borderline personality disorder (BPD) in research. No self-report instrument has been validated as a replacement tool for BPD diagnosis. However, clinical interviews can…

View details →DOI: 10.1037/per0000771
Negative / Null Result ReportMedicine

Does Resident Involvement Affect Clinical Outcomes and Postoperative Complication Rates in Orthopaedic Sports Medicine Surgery?

Stokes DJ, Cram TR, Pasic N et al. · 2026 · The American journal of sports medicine

Background The "July effect" suggests increased patient morbidity and mortality during the early academic year due to new resident involvement. Evidence specific to orthopaedic sports medicine is limited. Purpose To evaluate the effect of…

View details →DOI: 10.1177/03635465261423216
Negative / Null Result ReportMedicine

Patiromer for Patients With Heart Failure at Risk of Hyperkalemia: CARE-HK in HF Registry.

Cantu-Martinez O, Greene SJ, Chinnakondepalli KM et al. · 2026 · Journal of cardiac failure

Background For patients with heart failure (HF), hyperkalemia (HK) may prevent optimal renin-angiotensin system inhibitor (RASi) use. Randomized trials show that patiromer, a contemporary potassium binder, reduces serum potassium (sK + )…

View details →DOI: 10.1016/j.cardfail.2026.03.025
Negative / Null Result ReportMedicine

Effect of clarithromycin versus placebo on risk of atrial fibrillation.

Jensen GB, Olsen MH, Jensen MT et al. · 2026 · Danish medical journal

Introduction The CLARICOR randomised trial of clarithromycin versus placebo in patients with stable ischaemic heart disease found increased all-cause and cardiovascular mortality after a brief clarithromycin regimen, suggesting a possible…

View details →DOI: 10.61409/a08250630