Negative / Null Result ReportOpen accessMedicine
Lauren S. Keenan-Devlin, Ann E. B. Borders, Alexa Freedman et al. · 2023 · Scientific Reports
Abstract Exposure to traumatic events during pregnancy may influence pregnancy and birth outcomes. Growing evidence suggests that exposure to traumatic events well before pregnancy, such as childhood maltreatment (CM), also may influence the course of pregnancy and risk of adverse birth outcomes. We aimed to estimate associations between maternal CM exposure and small-for-gestational-age birth (SGA) and preterm birth (PTB) in a diverse US sample, and to examine whether common CM-associated health and behavioral sequelae either moderate or mediate these associations. The Measurement of Maternal
View details →DOI: 10.1038/s41598-023-36831-9 Negative / Null Result ReportOpen accessMedicine
Amir Mari, Wasef Na’amnih, Loay Ghantous et al. · 2023 · Scientific Reports
Abstract Gastro-esophageal reflux disease (GERD) can cause erosive esophagitis (EE) and compromise the quality of life (QoL). We examined differences in symptom severity and QoL according to EE severity grade. A follow-up study was conducted among GERD patients at the Nazareth Hospital in Israel. Patients underwent a baseline gastroscopy in 2014–2020 during which the EE grade was determined using the Los Angeles classification. Follow-up telephone interviews were conducted during 2019–2020 with a mean time interval of 18.9 months (SD = 14.9) after the baseline gastroscopy to assess GERD sympto
View details →DOI: 10.1038/s41598-023-41332-w Negative / Null Result ReportOpen accessShipment of goods. Delivery of goods
Theuns F.J. Oosthuizen · 2014 · Journal of Transport and Supply Chain Management
A lack of optimum selection and application of decision-making techniques, in conjunction with suitable decision-making practice and perception of employees in a transport work environment demands attention to improve overall performance. Although multiple decision-making techniques exist, five prevalent techniques were considered in this article, namely the Kepner-Tregoe, Delphi, stepladder, nominal group and brainstorming techniques. A descriptive research design was followed, using an empirical survey which was conducted among 210 workers employed in a transport work environment and studyin
View details →DOI: 10.4102/jtscm.v8i1.118 Negative / Null Result ReportOpen accessMedicine
Otobo I Ujah, Omojo C Adaji, Innocent A O Ujah et al. · 2025 · PLoS ONE
Food insecurity (FI) has been identified as a determinant of child development, yet evidence quantifying this association using the newly developed Early Childhood Development Index 2030 (ECDI2030) remains limited. Herein, we provide national estimates of early childhood development (ECD) risks using the ECDI2030 and examined to what extent FI was associated with ECD among children aged 24-59 months in Nigeria. This population based cross-sectional analyses used data from the UNICEF-supported 2021 Multiple Indicator Cluster Survey in Nigeria. The analytic sample comprised children aged 24-59 m
View details →DOI: 10.1371/journal.pone.0316381 Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases
Rohith N. Thota, Shamasunder H. Acharya, Manohar L. Garg · 2019 · Lipids in Health and Disease
Abstract Background Lowering insulin resistance and dyslipidaemia may not only enhance glycaemic control but also preserve the β-cell function, reducing the overall risk of developing type 2 diabetes (T2D). The current study was aimed to evaluate the effects of curcumin and/or long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) supplementation on glycaemic control and blood lipid levels in individuals at high risk of developing T2D. Methods This was a 2 × 2 factorial, randomised, double-blinded, placebo-controlled study. Participants were allocated to either double placebo (PL) or curcu
View details →DOI: 10.1186/s12944-019-0967-x Negative / Null Result ReportOpen accessBiology (General)
Aviad Schnapp, Moria Harel, Dalit Cayam-Rand et al. · 2022 · Biomedicines
Autism spectrum disorder (ASD) is often associated with debilitating sleep disturbances. While anecdotal evidence suggests the positive effect of cannabinoids, randomized studies are lacking. Here, we report the effects of cannabinoid treatment on the sleep of 150 children and adolescents with ASD, as part of a double-blind, placebo-controlled study that assessed the impact of cannabinoid treatment on behavior (NCT02956226). Participants were randomly assigned to one of the following three treatments: (1) whole-plant cannabis extract, containing cannabidiol (CBD) and Δ9-Tetrahydrocannabinol (T
View details →DOI: 10.3390/biomedicines10071685 Negative / Null Result Report
Patrícia Fernandes Albeirice da Rocha, Luciano Marques dos Santos, Amanda J. Ullman et al. · 2025 · Revista da Sociedade Brasileira de Enfermeiros Pediatras
Objective To assess the feasibility of conducting a randomized clinical trial to evaluate the effectiveness of virtual reality on pain perception in children undergoing peripheral intravenous insertion, compared to traditional clinical…
View details →DOI: 10.31508/1676-3793202501i Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Christian Borel, Caroline Even, Christophe Le Tourneau et al. · 2023 · BMJ Oncology
Objective Salivary gland cancers (SGC) are rare cancers with currently no standard treatment for recurrent/metastatic disease. Based on checkpoint inhibitors benefit in a broad range of tumours, NIvolumab in Salivary gland CArcinoma of the Head and Neck (NISCAHN) evaluated nivolumab efficacy in SGC.Methods and analysis In this phase II single-stage Fleming design, patients with SGC with a progressive disease progression within 6 months prior to entering the study, were divided into ACC (adenoid cytic carcinoma) and non-ACC. All received nivolumab for a maximum of 12 months. The primary endpoin
View details →DOI: 10.1136/bmjonc-2023-000065 Negative / Null Result ReportOpen accessMicrobiology
José C. Segovia, Juan C. Ramírez, Paula Río et al. · 2025 · Microbiology Spectrum
ABSTRACT Two strains of the minute virus of mice (MVM) parvovirus (of the species Protoparvovirus rodent1), named i (immunosuppressive) and p (prototype), show disparate tropism and pathogenicity in mice. Unlike the virulent MVMi, the MVMp is attenuated and infection-restricted in primary mouse hematopoietic cells; however, it does infect human transformed, established, and stem cells. We thus seek here a putative MVMp natural tropism to humans compared to MVMi. Infectious purified MVMp virions suppress in vitro the clonogenic potential of human committed (erythroid and myeloid) and primitive
View details →DOI: 10.1128/spectrum.02339-25 Negative / Null Result ReportOpen accessMedicine
Lei Huang, Tong Li, Lei Xu et al. · 2016 · Chinese Medical Journal
Background: There has been no external validation of survival prediction models for severe adult respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO) therapy in China. The aim of study was to compare the performance of multiple models recently developed for patients with ARDS undergoing ECMO based on Chinese single-center data. Methods: A retrospective case study was performed, including twenty-three severe ARDS patients who received ECMO from January 2009 to July 2015. The PRESERVE (Predicting death for severe ARDS on VV-ECMO), ECMOnet, Respiratory Extracorpore
View details →DOI: 10.4103/0366-6999.185871 Negative / Null Result ReportOpen access
Dwi Gemina, Tini Kartini, Pra Gemini · 2021 · JURNAL AKUNIDA
Cooperatives are directed as a collective community effort to increase the level of economic prosperity together. The research objective was to analyze the effect of external capital, business volume and total assets on the residual…
View details →DOI: 10.30997/jakd.v7i2.4283 Negative / Null Result ReportOpen accessSports medicine
Max K Dummar, Michael S Crowell, Will Pitt et al. · 2024 · International Journal of Sports Physical Therapy
# Background Concussions are often accompanied by balance disturbances. Clinically accurate evaluation systems are often expensive, large, and inaccessible to most clinicians. The Sway Balance Mobile Application (SWAY) is an accessible method to quantify balance changes. # Purpose To determine the known groups and convergent validity of the SWAY to assess balance after a concussion. # Study Design Case-Control Study. # Methods Twenty participants with acute concussion and twenty controls were recruited. At initial, one-week, and final return to activity (RTA) evaluations, all participants comp
View details →DOI: 10.26603/001c.92234 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Yiding XIAO, Zhujun LI, Bozhi HU et al. · 2025 · Neurologia Medico-Chirurgica
For resectable malignant peripheral nerve sheath tumors, the additional benefits of radiotherapy remain controversial. This study aims to investigate whether there is an additional benefit of radiotherapy for resectable malignant peripheral nerve sheath tumors. We retrospectively collected data on malignant peripheral nerve sheath tumor cases from the Surveillance, Epidemiology, and End Results database. Overall, 926 malignant peripheral nerve sheath tumor cases occurred in soft tissues, with surgical resection performed in 783 cases. After excluding cases with distant metastasis, incomplete f
View details →DOI: 10.2176/jns-nmc.2025-0104 Negative / Null Result ReportOpen accessMedicine
H. Pinnock, J. Hanley, L. McCloughan et al. · 2013 · British medical journal
Objective To test the effectiveness of telemonitoring integrated into existing clinical services such that intervention and control groups have access to the same clinical care. Design Researcher blind, multicentre, randomised controlled…
View details →DOI: 10.1136/bmj.f6070 Negative / Null Result ReportOpen accessMedicine
Sungha Park, Sang-Hyun Ihm, In-Jeong Cho et al. · 2023 · Clinical Hypertension
Abstract Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving
View details →DOI: 10.1186/s40885-023-00249-2 Negative / Null Result ReportOpen accessDentistry
Ahmed Hassan Kamil Mustafa, Ahmed Mohammed Suleiman · 2020 · International Journal of Dentistry
Background. Bell’s palsy is an acute idiopathic facial nerve paralysis of sudden onset. It is the most common cause of lower motor neuron facial nerve paralysis with an annual incidence of 15–30 per 100,000 population. The objective of this work is to study the grade of the attack and the associated symptoms of Bell’s palsy in a group of Sudanese patients. The study type is an analytical prospective-based study. The study was carried out at Khartoum Teaching Dental Hospital, Khartoum General Teaching Hospital. In this prospective of the study, 48 patients with Bell’s palsy were evaluated using
View details →DOI: 10.1155/2020/2160256 Negative / Null Result ReportOpen accessMedicine
Vera Dias, Eunsung Junn, M. Maral Mouradian · 2013 · Journal of Parkinson’s Disease
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential in neurons interfere with several biological processes, ultimately leading to cell death. Evidence has been developed for oxidative and nitrative damage to key cellular components in the PD substantia nigra. A number of sources and mechanisms for the generation of reactive oxygen species (ROS) are recognized including the metabolism of dopamine itself, mitochondrial dysfunction, iron, neuroinflammatory cells, calcium
View details →DOI: 10.3233/jpd-130230 Negative / Null Result ReportOpen accessMedicine
Lisa Baquet, Helge Hasselmann, Stefan Patra et al. · 2018 · PeerJ
Background Only few aerobic exercise intervention trials specifically targeting cognitive functioning have been performed in multiple sclerosis. Objective and Methods This randomized controlled trial with 34 patients in the intervention group (IG) (mean: 38.2 years (±9.6)) and 34 patients in the control group (CG) (mean: 39.6 years (±9.7)) aimed to determine the effects of aerobic exercise on cognition in relapsing-remitting multiple sclerosis (RRMS). The primary outcome was verbal learning assessed by the verbal learning and memory test (VLMT). Patients were randomized to an IG or a waitlist
View details →DOI: 10.7717/peerj.6037 Negative / Null Result ReportOpen access
Nelly Masnila, R. Mayasari, Firmansyah Firmansyah et al. · 2021 · International Journal of Business, Management and Economics
This study aimed to determine the relationship and effect of the GGG variable on the quality of the financial reports in municipal governments in Indonesia by implementing the IIAG (The Ibrahim Index of African Governance) indicator. The…
View details →DOI: 10.47747/ijbme.v2i4.385 Negative / Null Result Report
Yoga Wahyu Pratama, Fransiska Prihatini, Orissa Octaria et al. · 2025 · Mars : Jurnal Teknik Mesin, Industri, Elektro Dan Ilmu Komputer
The use of technology in data management has become the key to improving the efficiency and effectiveness of company performance. PT Indofood CBP Sukses Makmur Tbk has implemented a computerized employee attendance system through the…
View details →DOI: 10.61132/mars.v3i5.1099 Negative / Null Result ReportOpen access
Okunlola D. O, Otinwa G.O · 2024 · African Journal of Social Issues
The purpose of this research was to investigate effects of two massage therapy techniques on the rate of perceived exertion and performance recovery among adolescent footballers in Lagos state. Pre-test post-test experimental research…
View details →DOI: 10.4314/ajosi.v7i1.7 Negative / Null Result Report
Angga Kurniawan, Nelson Lajuni, Tasrim Tasrim et al. · 2026 · EKUITAS (Jurnal Ekonomi dan Keuangan)
This study aims to analyze the effects of Electronic Word of Mouth Effect, Brand Image, and Email Marketing on Purchase Intention in the context of purchasing official MotoGP merchandise. It was conducted among respondents who are members…
View details →DOI: 10.24034/j25485024.y2025.v9.i4.7457 Negative / Null Result ReportMedicine
de-la-Llave-Rincón, Ambite-Quesada, Pacho-Hernández et al. · 2026 · Pain research & management
To determine the influence of sensitization-associated and neuropathic-like symptoms and clinical features in conditioned pain modulation (CPM) activity in women with episodic or chronic migraine. A cross-sectional study including 70 women…
View details →DOI: 10.1155/prm/8331529 Negative / Null Result ReportMedicine
Yersel, Ucan, Tekce · 2026 · Journal of prosthodontics : official journal of the American College of Prosthodontists
This in vitro study aimed to evaluate the effect of layer thickness, printing orientation angle, and resin type on the radiopacity of 3D-printed dental resins. Three dental 3D-printed resins (VarseoSmile TriniQ, Crowntec, and Primeprint…
View details →DOI: 10.1111/jopr.70163 Negative / Null Result ReportMedicine
Na Z, Guo X, DuMei Y · 2026 · Medicine
Osteoporosis is a systemic skeletal disease characterized by decreased bone mass and microstructural destruction of bone tissue, leading to fragile bones and susceptibility to fractures, significantly affecting the quality of life of…
View details →DOI: 10.1097/md.0000000000048754 Negative / Null Result ReportMedicine
Pennings VHM, Verwijk E, de Bie RMA et al. · 2026 · Journal of Parkinson's disease
BackgroundDespite the frequent decline in verbal fluency after STN-DBS surgery, the cause of decline remains unclear.ObjectiveThis study investigates whether mental speed and executive dysfunctions are underlying mechanisms of the phonemic…
View details →DOI: 10.1177/1877718x261455458 Negative / Null Result ReportOpen accessMedicine
Chen CD, Aguero C, Melloni A et al. · 2026 · Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Alzheimer's disease (AD) biomarkers are assessed on their ability to detect AD pathophysiology in vivo, with confirmation of AD neuropathology only at autopsy. Methods Positron emission tomography (PET), plasma, and cognitive…
View details →DOI: 10.1002/alz.71092 Negative / Null Result ReportMedicine
Karunakaran KB, Purushottam M, Balakrishnan N et al. · 2026 · Translational psychiatry
Depressive disorder (DD), Alzheimer's disease (AD), and schizophrenia (SZ) are evolutionarily relevant traits that disrupt neural networks supporting affect and cognition. While genome-wide association studies have identified risk-related…
View details →DOI: 10.1038/s41398-026-04198-w Negative / Null Result ReportOpen accessMedicine
Thapa M, Adhikari GP, Saroj GC et al. · 2026 · BMC ophthalmology
BACKGROUND: To evaluate reliability and agreement of non-contact tonometry (NCT) and trans-palpebral tonometry (TPT) compared with Goldmann-applanation tonometry (GAT). METHODS: A total of 224 eyes from 112 patients were included between…
View details →DOI: 10.1186/s12886-026-04821-w Negative / Null Result Report
Wang F, Chen L, Xu X et al. · 2026 · Preprint
Abstract Background This study aimed to apply a 3D vertical cephalometric analysis to evaluate vertical skeletal relationships in adult patients. Methods The CBCT data of ninety-seven first-visit adult patients were retrospectively…
View details →DOI: 10.21203/rs.3.rs-8984975/v1 