A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 329 of 675
Lim LS · 2025 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Geriatrics: [Formula: see text] Public Health: [Formula: see text].
Pak MA, Güzel Altıntaş F, Okyar G et al. · 2026 · Scientific reports
Anastomotic leakage is a serious complication after colorectal surgery. Smoking is known to impair anastomotic healing. The use of electronic cigarettes is increasing worldwide, and information about their effects on wound healing remains…
Amoroso F, Miere A, Kodjikian L et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose This study aimed to compare exudative recurrence features detected by optical coherence tomography angiography (OCTA) with those identified by spectral domain optical coherence tomography (SD-OCT), considered the gold standard, and…
Kalli AJ, Mäkelä P, Huhtala H et al. · 2026 · Acta anaesthesiologica Scandinavica
Background Sternotomy causes substantial postoperative pain. Recently, several less invasive nerve blocks have been described that are safer to use even on anticoagulated patients. This study aims to evaluate early pain management using…
Quan S, Xie H, Zhang D et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society
Background Postoperative chylothorax is a serious complication following esophagectomy. The efficacy of thoracic duct ligation (TDL) for chylothorax prevention is controversial. This study aimed to evaluate the impact of TDL on chylothorax…
Osmani R, Cavallotto L, William N et al. · 2026 · Cryobiology
Cryopreservation of zebrafish embryos remains challenging due to their low tolerance for cryoprotectant exposure and their susceptibility to lethal ice formation. Ice recrystallization inhibitors (IRIs) such as…
Wick B, Sahibzada O, Cherner A et al. · 2026 · Journal of vascular surgery. Venous and lymphatic disorders
Objective The optimal clinical management of isolated distal deep venous thrombosis (IDDVT) remains controversial as the benefits of routine anticoagulant therapy are not clearly defined amid the risk of bleeding events. Our study aimed to…
Hetherington A, Bauer L, Rablin S et al. · 2026 · Australasian emergency care
Background Acute wheeze is a common emergency department presentation among pre-school aged children. Innovative models of care that safely optimise treatment and streamline patient flow are needed. A nurse-led stretching of inhaled…
Agweyu A, Mwaniki P, Menon V et al. · 2026 · Nature medicine
Rigorous evidence on the performance of large language models (LLMs) in real-world, low-resource clinical settings remains limited. Here we conducted a pragmatic, cluster-randomized trial in 16 primary care facilities in Kenya. Clinical…
Khan S, Simmons KL, Khan S et al. · 2026 · Orbit (Amsterdam, Netherlands)
Purpose To determine whether prophylactic antibiotic administration following the development of an orbital floor fracture or after orbital floor fracture repair is associated with a reduced risk of orbital or periorbital cellulitis.…
Connor V, Mitsi E, Cheliotis KS et al. · 2026 · Preprint
Nasopharyngeal colonisation with Streptococcus pneumoniae is a prerequisite for transmission and disease and represents an important immunising event. While colonisation induces serotype-specific immunity, the mechanisms underlying…
Spotts EK, Chatterjee A, Coleman L et al. · 2026 · Psychology & health
Objective Informing individuals about the nocebo effect, termed nocebo education, can minimise the experience of side effects. One untested possibility is that nocebo education promotes behaviour change, such that it decreases the…
Cheung LC, Mao F, Rydzak G et al. · 2026 · Annals of internal medicine
Background Cervical intraepithelial neoplasia (CIN) grade 2 (CIN 2) is an equivocal diagnosis of cervical precancer, and appropriate management continues to be debated. Objective To estimate the effect of immediate (by 6 months) versus…
Yu Q, Zeng L, Chen Z et al. · 2026 · Preprint
Abstract Fibroblast growth factor 23 (FGF23) is closely associated with atrial fibrillation (AF), yet whether it modulates sodium and calcium currents in atrial myocytes remains unclear. ETV1, a key transcription factor regulating atrial…
Kam MK, Kim JW, Choi JY et al. · 2026 · Biochemical and biophysical research communications
Tau aggregation in neurons is a pathological hallmark of Alzheimer's disease (AD). The development of therapeutic drugs that inhibit tau aggregation in tauopathies, including AD, remains challenging. Herein, we developed a tau…
Lopez DE, Carmalt JL · 2026 · Frontiers in veterinary science
Background The equine temporomandibular joint (TMJ) is divided into two non-communicating joint (discotemporal DTJ and discomandibular DMJ) compartments. Ultrasound has been extensively used as a diagnostic tool in the horse, but previous…
Lex JR, Ekhtiari S, Entezari B et al. · 2026 · The Journal of bone and joint surgery. American volume
Background Obesity is an independent risk factor for complications following total hip arthroplasty (THA). Preoperative bariatric surgery to facilitate weight loss has been used to reduce complication risk, but its effectiveness remains…
Giaccari LG, Brunetti S, Coppolino F et al. · 2026 · Medical sciences (Basel, Switzerland)
Background : Obesity increases the risk of postoperative pulmonary complications (PPCs), and active smoking may further amplify this risk. Whether smoking status identifies a subgroup of obese surgical patients with differential PPC risk…
Zhao H, Shin D, Tucker E et al. · 2026 · Preprint
Aldoximes are amino acid-derived metabolites that serve as precursors of auxins and modulate phenylpropanoid production in Arabidopsis. However, the enzymes responsible for aldoxime production in Solanaceae remain unknown. Here, we report…
Jdidi H, de Bisschop C, Dugué B et al. · 2026 · European journal of applied physiology
Purpose Whole-body cryostimulation (WBC) has recently been shown to improve autonomic nervous control of the cardiovascular system. This study aimed to investigate the acute and repeated effects of WBC on baroreflex sensitivity (BRS),…
Pittmann R, Herring E, Pennington S et al. · 2026 · Frontiers in health services
Introduction Telehealth etiquette refers to professional behaviors that support effective virtual communication between patients and providers. While telehealth has become a lasting part of healthcare delivery, most health professions…
Glenthøj LB, Vernal DL, Mariegaard LS et al. · 2026 · Schizophrenia (Heidelberg, Germany)
Virtual reality (VR)-assisted avatar therapy has shown promising effects for reducing voice-related distress and overall severity of persistent auditory verbal hallucinations (AVH) in psychosis, yet the mechanisms underlying these…
Brar MS, Park JJ, de Buck van Overstraeten A · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Background and aims Fertility and mode of delivery are major concerns for women with ulcerative colitis (UC) undergoing ileal pouch-anal anastomosis (IPAA). Although infertility after IPAA has been attributed to pelvic adhesions, the…
Caunca M, Gutierrez S, Wheeler K et al. · 2026 · Neurology
Background and objectives The mechanisms underlying racial/ethnic differences in dementia incidence and pathology are multifactorial, and hypertension represents an actionable target for reducing these differences. We aimed to estimate the…
Parlak Insel B, Guven Y, Sepet E et al. · 2026 · BMC oral health
Within the concept of minimal invasive dentistry, the progression of initial caries lesions can be inhibited with preventive measures. This study evaluated the microleakage and remineralization potential of a bioactive fissure sealant (FS)…
Duje ML, Scharlovsky HR, Crivelli A et al. · 2026 · Nutricion hospitalaria
Background home enteral nutrition (HEN) maintains nutritional status in patients unable to feed orally. While established globally, data on its costs in Argentina are scarce. This study aimed to describe HEN costs and analyze differences…
Takeda Y, Sakakibara T, Horiuchi K et al. · 2026 · Brain & development
Background We previously reported that adrenocorticotropic hormone (ACTH) therapy for infantile epileptic spasm syndrome (IESS) decreases plasma fibrinogen (Fbg) levels. However, the underlying mechanism(s) has not been elucidated. An…
Li C, Shu L, Teng YL et al. · 2026 · Inorganic chemistry
To exploit the electron-sponge properties of polyoxometalates (POMs) and elucidate the mechanistic impact of doping with saturated versus metal-substituted Dawson-type POMs on electrocatalytic CO 2 reduction, P 2 W 18 @PCN-222 and P 2 W 17…
Shaposhnikov MM, Trmcic A, Martin NH · 2026 · Journal of dairy science
The microbial quality of fluid milk is improved via processing steps, such as pasteurization which reduces the overall microbial population of milk and in particular is effective against Gram-negative, heat sensitive bacteria. Therefore,…
Cook DP · 2025 · Annals of internal medicine
Clinical impact ratings GIM/FP/GP: [Formula: see text] Critical Care: [Formula: see text] Pulmonology: [Formula: see text].