Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Lu He, Suzhen Lin, Hong Pan et al. · 2019 · Frontiers in Aging Neuroscience
Low DJ-1 protein level caused by DJ-1 gene mutation leads to autosomal recessive Parkinson’s disease (PD) due to impaired antioxidative activity. In sporadic PD patients, although mutations were rarely found, lower DJ-1 protein level was also reported. Dysregulation of DJ-1 gene expression might contribute to low DJ-1 protein level. Since the promoter is the most important element to initiate gene expression, whether polymorphisms in the DJ-1 promoter result in the dysregulation of gene expression, thus leading to low protein level and causing PD, is worth exploring. The DJ-1 promoter region w
View details →DOI: 10.3389/fnagi.2019.00024 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Natalia Pereira Machado, Eliana Nogueira, Karen Oseki et al. · Revista Brasileira de Reumatologia
ABSTRACT Objectives: Innate immunity is involved in the physiopathology of ankylosing spondylitis (AS), with the participation of Gram-negative bacteria, modulation of human leukocyte antigen (HLA) B27 and the involvement of pattern recognition receptors, such as Toll-like receptors (TLRs). The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS. Methods: A cross-sectional study was carried out involving 200 patients with a diagnosis of AS and a healthy control group of 200 in
View details →DOI: 10.1016/j.rbre.2016.07.004 Negative / Null Result ReportOpen accessNursing
Juliana Ribeiro da Silva Vernasque, Miriam Fernanda Sanches Alarcon, Daiana Bonfim et al. · 2025 · Revista Latino-Americana de Enfermagem
Objective: to evaluate the impact of a gamified educational intervention on violence against the elderly on the knowledge, perceptions and attitudes of university students. Method: a non-randomized clinical trial involving 44 university students from the health sciences, humanities and exact sciences, with 22 in the intervention group and 22 in the control group. The intervention group participated in hybrid activities on gamification applied to the topic of violence against the elderly. The evaluation was conducted using thematic cases validated by experts, with statistical analysis using Chi
View details →DOI: 10.1590/1518-8345.7874.4662 Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases
Renyue Ji, Haisheng Wu, Hongli Lin et al. · 2025 · Diabetology & Metabolic Syndrome
Abstract Background Epidemiological research on the association between heavy metals and congestive heart failure (CHF) in individuals with abnormal glucose metabolism is scarce. The study addresses this research gap by examining the link between exposure to heavy metals and the odds of CHF in a population with dysregulated glucose metabolism. Method This cross-sectional study includes 7326 patients with diabetes and prediabetes from the National Health and Nutrition Examination Survey from 2011 to 2018. The exposure variables are five environmental heavy metals—cadmium (Cd), lead (Pb), mercur
View details →DOI: 10.1186/s13098-024-01556-w Negative / Null Result ReportOpen accessMedicine
Paschalina C Ezechukwu, Emmanuel O Ugwu, Samuel N Obi et al. · 2023 · International Journal of Medicine and Health Development
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality in Nigeria and worldwide. It is not yet concluded as to whether or not elevated levels of serum creatinine and/or uric acid could be regarded as a predictive indicator for the severity of the disease. Objectives: To compare the mean serum levels of uric acid and creatinine in preeclamptic and normotensive pregnant women and assess for any associations between these renal biomarkers and the severity of preeclampsia in Nigeria. Materials and Methods: It was a cross-sectional analytical study o
View details →DOI: 10.4103/ijmh.ijmh_11_22 Negative / Null Result ReportOpen accessMedicine
Kibum Kim, Linda Kaitlyn Craft · 2022 · BMJ Open
Objective Non-invasive prenatal testing (NIPT) is a front-line screening for fatal chromosomal aneuploidy. In pregnant women with a risk of having fetal congenital disorders, NIPT is anticipated to reduce the needs of invasive prenatal diagnostic test (IPD). The objective of this study was to understand the acceptance of NIPT and the utility of NIPT to mitigate concerns about IPD in the US high-risk pregnancy management.Design and setting This was a retrospective observational research using healthcare records obtained from an academic healthcare system in the US. The study consisted of site-l
View details →DOI: 10.1136/bmjopen-2021-057658 Negative / Null Result Report
Audu K, Nurudeen YZ, Ogbadu EE et al. · 2026 · Preprint
Abstract This study aimed at investigating the effect of employee motivation on job satisfaction of selected Federal Universities in North Central, Nigeria. The specific objectives are to: (i) investigate the effect of employee career…
View details →DOI: 10.21203/rs.3.rs-8839962/v1 Negative / Null Result ReportOpen accessPediatrics
Claire Howarth, Christian Mifsud, Christian Mifsud et al. · 2024 · Frontiers in Pediatrics
IntroductionThere is significant uncertainty regarding the role that anaemia or red blood cell transfusion (RBCT) plays in the development of gut injury in preterm infants. This study evaluated Near Infrared Spectroscopy (NIRS) together with a range of known biomarkers of gut inflammation to identify their relationship with anaemia and RBCT.MethodA prospective observational study of preterm infants born at <30 weeks gestation was conducted from birth until either 36 weeks post conceptional age or discharge home. Gut perfusion and biomarkers of gut injury were assessed weekly by: 60 min NIRS me
View details →DOI: 10.3389/fped.2024.1440537 Negative / Null Result ReportOpen accessTheory and practice of education
Chatelaine M. Wansi · 2026 · International Journal of Multidisciplinary Educational Research and Innovation
Physics and engineering are like two peas in a pod; one cannot be complete without the other. Physics is an integral part of the engineering curricula as the latter is founded on principles of our physical world. Thus, understanding the level of physics conceptual comprehension and mathematical proficiency of civil engineering students as well as identifying factors that affect it helps educators, academic institutions, and policy-makers better serve and prepare students as reliable future civil engineers. This research utilized a quantitative research design, specifically a predictive correla
View details →DOI: 10.64637/709619 Negative / Null Result ReportOpen accessMedicine
Haure Osman Muhammad Hamadamin, Samir Mahmood Othman · 2026 · Zanco Journal of Medical Sciences
Background and objective: Obesity is a chronic, multifactorial condition characterized by an excessive accumulation of body fat that presents significant health risks. Community pharmacists, for instance, are highly accessible and often serve as the first point of contact for patients seeking advice on weight management. This study aims to fill a research gap by evaluating community pharmacists’ knowledge, attitudes, and practices related to obesity and weight management. Methods: A cross-sectional study was carried out among 331 community pharmacists among different pharmacy settings in Erbil
View details →DOI: 10.15218/zjms.2026.003 Negative / Null Result ReportOpen accessPublic aspects of medicine
Hatice Özyılmaz, Serdar Bağlar · 2026 · BMC Public Health
Abstract Background Adolescence is a critical milestone in the transition to adulthood. Factors affecting oral health, an essential component of general health during this period, also influence public health. This study investigates the potential impact of parental education level (PEL) and daily total daily screen time (DTST) on adolescent oral health using a large sample size. Methods A total of 1300 adolescents aged 17 and 18 from Ordu Province were included in this study. A structured questionnaire was used to assess PEL, DTST, and other habits that may influence dental caries. Oral healt
View details →DOI: 10.1186/s12889-025-25923-y Negative / Null Result ReportOpen accessMedicine
Michinobu Umakoshi, Akiko Nakamura, Hiroyuki Tsuchie et al. · 2023 · Scientific Reports
Abstract Even when treated comprehensively by surgery, chemotherapy, and radiotherapy, soft-tissue sarcoma has an unfavorable outcome. Because soft-tissue sarcoma is rare, it is the subject of fewer clinicopathological studies, which are important for clarifying pathophysiology. Here, we examined tumor-associated macrophages in the intratumoral and marginal areas of sarcomas to increase our knowledge about the pathophysiology. Seventy-five sarcoma specimens (not limited to a single histological type), resected at our institution, were collected, and the number of CD68-, CD163-, and CD204-posit
View details →DOI: 10.1038/s41598-023-28024-1 Negative / Null Result ReportOpen accessMedicine
N Bushra Thasneem, Resmi S. Kaimal, Abdul Hakeem Thengu Murichathil · 2025 · Journal of Family Medicine and Primary Care
Introduction: Anaemia is one of the significant public health problems faced by developing countries. It occurs more frequently in women of childbearing age. Anaemia causes poor work capacity, and severe forms may even cause cardiac failure. In pregnant women, anaemia may lead to preterm labour, low-birth-weight babies, and increased risk of maternal mortality due to post-partum haemorrhage. Even though there are national programmes to supply iron free of cost and other measures to tackle anaemia, it is still prevalent in our country. Anaemia prevalence has increased between NFHS-4 and NFHS-5,
View details →DOI: 10.4103/jfmpc.jfmpc_1456_24 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Mylène Duivon, Joy Perrier, Carine Segura-Djezzar et al. · 2022 · Frontiers in Neuroscience
BackgroundPrevious studies have revealed both sleep alterations and prospective memory (PM) impairments in breast cancer (BC) patients. PM refers to memory of intended actions and is crucial for daily living tasks and treatment compliance. As sleep is known to favor memory consolidation, one may expect that changes in sleep quality related to BC would have an impact on PM performance. This study aimed at assessing sleep-dependent consolidation of intentions using an ecological, virtual reality-based PM task in BC patients not treated with chemotherapy.Materials and methodsThirty-seven early st
View details →DOI: 10.3389/fnins.2022.908268 Negative / Null Result ReportOpen accessMedicine
Esmee M. Breddels, Johanna Simin, Romina Fornes et al. · 2022 · BMC Medicine
Abstract Background Approximately half of all women suffer from heartburn at some stage during pregnancy. The most effective treatment is proton pump inhibitors, but the safety of use during pregnancy cannot be guaranteed. This study aimed to elucidate the effect of proton pump inhibitors on the risk of pre-eclampsia, gestational diabetes mellitus, preterm birth, an Apgar score at 5 min below 7, and a child being small or large for its gestational age. Methods This Swedish population-based study included 1,089,514 live singleton deliveries between July 2006 and December 2016 in Sweden. Multipl
View details →DOI: 10.1186/s12916-022-02673-x Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Manisha Ghate, Pallavi Shidhaye, Shraddha Gurav et al. · 2022 · Journal of the International Association of Providers of AIDS Care
Background : We aimed to determine the anti-SARS-CoV-2 IgG antibodies among people living with HIV (PLHIV) in Pune, India. Methods : This cross-sectional study was conducted between March 2021 and June 2021. Demographic and clinical information related to coronavirus disease 2019 (COVID-19) were recorded on structured questionnaires. Blood samples were collected and tested for anti-SARS-CoV-2 IgG antibodies using commercial ELISA. Results : Of the 405 HIV infected individuals enrolled in the study, 223(55.1%) were females. Mean age and CD4 count of participants were 42 years (SD: 10) and 626 c
View details →DOI: 10.1177/23259582221077943 Negative / Null Result ReportOpen accessSpecialties of internal medicine
Li Y, Yu T, Liu Z et al. · 2020 · Diabetes, Metabolic Syndrome and Obesity
Yan Li,1,* Tingwei Yu,2,* Zengyou Liu,2 Hengying Chen,3 Yao Liu,4 Yuanhuan Wei,4 Ruifang Sun,4 Hongmei Zhang,2 Wei Wang,2 Yihua Lu,2 Yingyu Zhou,1 Guifang Deng,4 Zheqing Zhang1 1Department of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, People’s Republic of China; 2Department of Obstetrics, Union Shenzhen Hospital of Huazhong University of Science and Technology, Shenzhen, People’s Republic of China; 3Injury Prevention Research Center, Shantou University Medical College
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Justin G. Mygatt, Jennifer Cullen, Samantha A. Streicher et al. · 2020 · Cancer Medicine
Abstract Background The relationship between race, prostate tumor location, and BCR‐free survival is inconclusive. This study examined the independent and joint roles of patient race and tumor location on biochemical recurrence‐free (BCR) survival. Methods A retrospective cohort study was conducted among men with newly diagnosed, biopsy‐confirmed, NCCN‐defined low risk CaP who underwent radical prostatectomy (RP) at the Walter Reed National Military Medical Center from 1996 to 2008. BCR‐free survival was modeled using Kaplan‐Meier estimation curves and multivariable Cox proportional hazards (P
View details →DOI: 10.1002/cam4.2864 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yiyi Chen, Yiyi Chen, Yiyi Chen et al. · 2021 · Frontiers in Neurology
Background: High plasma levels of trimethylamine N-oxide (TMAO) and its precursor choline have been linked to stroke; however, their association with cerebral small vessel disease remains unclear. Here we evaluated the association of plasma levels of TMAO and choline with imaging markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and cerebral microbleeds.Methods: We performed a baseline cross-sectional analysis of a multicenter hospital-based cohort study from 2015 to 2018. The data were collected from 30 hospitals in China and included 1,098 patients w
View details →DOI: 10.3389/fneur.2021.648702 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Tina Taule, Ole-Bjørn Tysnes, Jörg Aßmus et al. · 2025 · Journal of Rehabilitation Medicine
Objective: To determine whether early cognitive function in amyotrophic lateral sclerosis patients predicts future cognitive function and the decision to cease driving. Design: Observational study. Subjects: Patients with amyotrophic lateral sclerosis. Methods: Subjects underwent baseline assessments of cognitive function and driving ability within 4 months of diagnosis, with follow-up evaluation conducted 4 months thereafter. Two hypotheses were tested: (H1) cognitive status remains stable between baseline and follow-up, (H2) patients with baseline cognitive impairment cease driving earlier t
View details →DOI: 10.2340/jrm.v57.43483 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Guglielmo Arzilli, Lorenzo Stacchini, Virginia Casigliani et al. · 2023 · Human Vaccines & Immunotherapeutics
The decline in children’s vaccination coverage and the resurgence of preventable infectious diseases draw attention to parents’ vaccine hesitancy. Our study introduces two validated tools to independently assess vaccine hesitancy and health literacy among parents with school-age children. We developed a Vaccine Confidence Index (VCI) from 10 Likert items, exploring their relationships through exploratory and confirmatory factor analyses. We modified the IMETER (Italian medical term recognition test) to measure health literacy. We assessed the internal consistency of the modified IMETER and the
View details →DOI: 10.1080/21645515.2023.2271765 Negative / Null Result ReportOpen accessDermatology
Das Nilay, Ghosh Pramit, Das Suchibrata et al. · 2008 · Indian Journal of Dermatology
Background: Onychomycosis manifests itself in various forms, notably onychodystrophy, onycholysis, subungual hyperkeratosis, or nail-plate discoloration. Not necessarily nail changes mentioned here should always be of fungal origin. Objective: The present study is planned to get an idea about etiological agent and clinical correlation in fingernail onychomycosis. Materials and Methods: Nail-clipping and subungual debris of patients with above mentioned nail changes were subjected to KOH preparation. Culture was done on SDA and SDCCA media. Species identification was done by colony character, p
Negative / Null Result ReportOpen accessCytology
Weijie Cao, Xingang Li, Xiaoyu Zhang et al. · 2019 · Cells
Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches. Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate instrumental variables (IVs), summarized from a genome-wide m
View details →DOI: 10.3390/cells8020159 Negative / Null Result ReportOpen accessPublic aspects of medicine
Batoul Ghosn, Leila Azadbakht, Mohammad Reza Monazzam Esmaeilpour et al. · 2024 · BMC Public Health
Abstract Background Despite numerous studies that have explored the association between individual antioxidants or specific combinations and the risk of hearing loss, there is lack of information regarding the relationship between dietary total antioxidant capacity (dTAC) and hearing loss. The conflicting results on this association further highlight the need for more research in this area. This study aims to investigate the association between overall dietary antioxidant intake and the risk of hearing loss among Iranian adults. Methods This cross-sectional study recruited 3443 adult participa
View details →DOI: 10.1186/s12889-024-18108-6 Negative / Null Result ReportOpen accessMedicine
Muhammad Hussain Iqbal, Tanveer Hussain, Fariha Khalid et al. · 2020 · Pakistan Armed Forces Medical Journal
Objective: To determine the frequency of diastasis recti abdominis and its associated risk factors in postpartum women. Study Design: Cross-sectional study. Place and Duration of Study: Omar Medical Center Lahore, Yaseen Medical Center Lahore and Social Security Hospital Lahore, from Sep 2019 to Dec 2019. Methodology: This study included 128 participants fulfilling the eligibility criteria. The assessment of diastasis recti abdominis was done manually by a female physiotherapist using single finger, double finger and three finger methods on abdomen at three levels: at the umbilicus, 4.5 cm bel
Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Mohammad Mehrazmay, Ensi Khalili Pouya, Elham Keshavarz · 2021 · Journal of Kerman University of Medical Sciences
Background: Breast cancer is a major health problem in Iran with increasing incidence in the recent years. Breast density is one of the most important risk factors for developing breast cancer. Metabolic syndrome that is defined by the presence of multiple clinical and lab data findings has also been shown to be related with breast cancer.Methods: A sample of 246 cases who referred to Mahdiyeh hospital in Tehran were selected according to the inclusion criteria and a form was prepared including breast density in the screening mammogram done in our center and recent lab tests including FBS, HDL
View details →DOI: 10.22062/jkmu.2021.91831 Negative / Null Result ReportOpen accessSurgery
Farzaneh Dasturian, Nadereh Naderi, Gholamreza Farshidfar et al. · 2020 · Brazilian Journal of Cardiovascular Surgery
Abstract Objective: To investigate the association between interleukin-35 (IL-35) levels and single nucleotide polymorphisms (rs3761548, rs3761547) of the FoxP3 gene in coronary artery bypass grafting (CABG) patients. Methods: We conducted a prospective study including 140 patients, who were scheduled for elective isolated on-pump CABG with cardiopulmonary bypass (CPB) from January 2017 to September 2018 in the Jorjani heart center. Blood samples were collected before and 12 hours after the operation. Serum levels of IL-35 were measured by enzyme-linked immunosorbent assay and the pattern of g
View details →DOI: 10.21470/1678-9741-2019-0377 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Hye‐Sun Park, Sang Ho Park, Yeseul Seong et al. · 2024 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background The association between the adiponectin‐to‐leptin ratio (A/L ratio) and the risk of incident chronic kidney disease (CKD) is poorly understood. This study aimed to investigate the association between A/L ratio and the risk of incident CKD and to examine whether such a relationship varied according to sex and body composition. Methods In this prospective community‐based cohort, participants with normal kidney function were analysed (N = 5192). The association between the A/L ratio at baseline and the risk of incident CKD, defined as two or more occasions with an estimated gl
View details →DOI: 10.1002/jcsm.13475 Negative / Null Result ReportMedicine
Li L, You C, Yan X et al. · 2026 · Echocardiography (Mount Kisco, N.Y.)
Background Little is known about the differences in left atrial (LA) volume and strain assessed with two-dimensional (2DE) and three-dimensional echocardiography(3DE). Therefore, this study aimed to compare 2DE and 3DE parameters in…
View details →DOI: 10.1111/echo.70538 Negative / Null Result ReportMedicine
Kralj R, Barčot Z, Kurtanjek M et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association
The primary aim of this study was to determine whether a significant correlation exists between the relative decline in serum concentrations of interleukin-6 (IL-6) and interleukin-8 (IL-8) between the third and eighth days after injury…
View details →DOI: 10.1093/jbcr/iraf136 