Negative / Null Result ReportOpen accessMicrobiology
Zhuo Li, Yuan Zong, Dayu Chen et al. · 2025 · Frontiers in Cellular and Infection Microbiology
ObjectiveTo compare and analyze the efficacy and safety of different antifungal drug treatment regimens for patients with invasive pulmonary aspergillosis (IPA) in the intensive care unit (ICU).MethodsWe retrospectively collected the clinical data of patients with IPA in the ICU in two grade-A tertiary hospitals from January 2019 to January 2024 using the HIS system and compared the clinical efficacy, incidence of adverse drug reactions (ADRs), and all-cause mortality at discharge among different antifungal treatments, such as voriconazole alone, caspofungin alone, and a combination of voricon
View details →DOI: 10.3389/fcimb.2025.1584950 Negative / Null Result ReportOpen accessDentistry
Selin Yalnız, Hayal Boyacıoglu, Lezize Sebnem Turkun · 2026 · BMC Oral Health
Abstract Background To investigated the combined effect of adhesive type and film thickness on dentin bond strength by comparing one and two-step universal adhesives applied in single and double layers. Methods Forty caries-free human third molars were collected and standardized Class I cavities were prepared. Specimens were restored using one-step (Clearfil Tri-S Bond Universal, Japan) and two-step (G2-Bond Universal, Japan) universal adhesive systems. Each group was subdivided into single and double-layer applications, light-cured, and restored with a universal composite resin. Sticks with a
View details →DOI: 10.1186/s12903-026-07837-2 Negative / Null Result ReportOpen accessSurgery
Homero Zapata-Chavira, Marco Hernández-Guedea, Julio César Jiménez-Pérez et al. · 2019 · Journal of Investigative Surgery
Aim: Remote ischemic preconditioning (RIPC) has been used as a strategy to reduce acute renal injury and ischemia-reperfusion injury (IRI) in renal transplantation (RT) with controversial results. Objective: To determine if RIPC modifies IRI in cadaveric RT recipients through inflammatory mediators and graft function. Methods: Twenty-nine RT recipients were studied, 12 in the control group (CG) and 17 in the RIPC group. RIPC which was performed on donors using a pneumatic tourniquet placed on both thighs for 10 min followed by the determination of IL-1, IL-6, TNF-α, VEGF, and ICAM-1, and hemat
View details →DOI: 10.1080/08941939.2017.1375052 Negative / Null Result ReportOpen accessMedicine
Wenyun Zeng, Danbin Wu, Yingxin Sun et al. · 2021 · Scientific Reports
Abstract NLRP3 inflammasome is a vital player in macrophages pyroptosis, which is a type of proinflammatory cell-death and takes part in the pathogenesis of atherosclerosis. In this study, we used apoE−/− mice and ox-LDL induced THP-1 derived macrophages to explore the mechanisms of MCC950, a selective NLRP3 inhibitor in treating atherosclerosis. For the in vivo study, MCC950 was intraperitoneal injected to 8-week-old apoE−/− mice fed with high-fat diet for 12 weeks. For the in vitro study, THP-1 derived macrophages were treated with ox-LDL and MCC950 for 48 h. MCC950 administration reduced pl
View details →DOI: 10.1038/s41598-021-98437-3 Negative / Null Result ReportMedicine
Wongtangman, Reddy Janga, Azimaraghi et al. · 2026 · Critical care (London, England)
Patients recovering from cardiac surgery in the intensive care unit (ICU) do not sleep well. Commonly used sedative-hypnotic medications can disrupt sleep architecture and increase the risk of delirium in critically ill patients after…
View details →DOI: 10.1186/s13054-026-06151-1 Negative / Null Result ReportOpen accessMicrobiology
Akihiro Ito, Tadashi Ishida, Hiromasa Tachibana et al. · 2020 · Journal of Global Antimicrobial Resistance
Objectives: Nursing and healthcare-associated pneumonia (NHCAP) was proposed by the Japanese Respiratory Society to refer to healthcare-associated pneumonia. This study aimed to investigate whether antipseudomonal antibiotic therapy improved the prognosis of NHCAP patients at high risk for antimicrobial-resistant pathogens. Methods: Consecutive hospitalised NHCAP patients in Kurashiki Central Hospital between October 2010 and December 2016 were prospectively enrolled. NHCAP patients who were at high risk for antimicrobial resistance were defined as those who received antimicrobials in the prec
View details →DOI: 10.1016/j.jgar.2020.04.021 Negative / Null Result ReportOpen accessOphthalmology
Park HM, Ryu YU, Park IJ et al. · 2020 · Clinical Optometry
Hyung Min Park, 1 Young Uk Ryu, 2 In Jee Park, 1 Byoung Sun Chu 1 1School of Optometry and Vision Science, Daegu Catholic University, Gyeongsan-si, Republic of Korea; 2Department of Physical Therapy, Daegu Catholic University, Gyeongsan-si, Republic of KoreaCorrespondence: Byoung Sun ChuSchool of Optometry and Vision Science, Daegu Catholic University, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do 38430, Republic of KoreaTel +82-53-850-2553Fax +82-53-359-6793Email bschu@cu.ac.krBackground: The purpose of this study is to investigate the effect of wearing neutral density (ND) filt
Negative / Null Result ReportOpen accessAnimal culture
K. Krag, L.L. Janss, M.M. Shariati et al. · 2013 · Animal
Heritability is a central element in quantitative genetics. New molecular markers to assess genetic variance and heritability are continually under development. The availability of molecular single nucleotide polymorphism (SNP) markers can be applied for estimation of variance components and heritability on population, where relationship information is unknown. In this study, we evaluated the capabilities of two Bayesian genomic models to estimate heritability in simulated populations. The populations comprised different family structures of either no or a limited number of relatives, a single
View details →DOI: 10.1017/s1751731112002017 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Ryoko Sato, Benjamin Fintan · 2020 · Human Vaccines & Immunotherapeutics
Background: Despite the proven effectiveness of vaccinations, vaccination uptake is limited in Nigeria. According to the Multiple Indicator Cluster Survey (MICS), one of the main barriers is the lack of accurate knowledge of the vaccination schedule. This study evaluates caregivers’ knowledge of the vaccination schedule and their ability to read the immunization card. Methods: The study evaluated the knowledge of caregivers in 11 settlements in the Jada local government area of Adamawa State in September 2019. The change in knowledge among caregivers before and after referring to the immunizat
View details →DOI: 10.1080/21645515.2020.1726682 Negative / Null Result ReportOpen accessBiotechnology
Alicja Hinz, Joanna Lewandowska-Łańcucka, Ewa Werner et al. · 2024 · Journal of Nanobiotechnology
Abstract Background The elastomechanical properties of nanocarriers have recently been discussed as important for the efficient delivery of various therapeutics. Some data indicate that optimal nanocarriers’ elasticity can modulate in vivo nanocarrier stability, interaction with phagocytes, and uptake by target cells. Here, we presented a study to extensively analyze the in vivo behavior of LIP-SS liposomes that were modified by forming the silicone network within the lipid bilayers to improve their elastomechanical properties. We verified liposome pharmacokinetic profiles and biodistribution,
View details →DOI: 10.1186/s12951-024-02698-9 Negative / Null Result ReportOpen accessSpecial aspects of education
Rima Khasawneh, Kari Simonsen, Jessica Snowden et al. · 2016 · Medical Education Online
Background: Electronic learning allows individualized education and may improve student performance. This study assessed the impact of e-modules about infection control and congenital infections on medical knowledge. Methods: A descriptive study was conducted involving third-year medical students on pediatric clerkship. e-Module content in three different formats was developed: a text monograph, a PowerPoint presentation, and a narrated PowerPoint lecture. Students’ use of the e-modules was tracked, as was participation in the infectious disease rotation and the order of pediatric rotation. Pr
View details →DOI: 10.3402/meo.v21.29516 Negative / Null Result ReportOpen accessPsychology
Ζωή Μπαμπλέκου, Ελισάβετ Χρυσοχόου, Σμαράγδα Καζή · 2023 · Ψυχολογία: το Περιοδικό της Ελληνικής Ψυχολογικής Εταιρείας
Despite the established interplay between executive functioning and metacognition, evidence remains limited regarding children’s metacognitive monitoring in the form of offline performance estimates of their executive efficiency. Moreover, we know little about the relations among listening comprehension, executive functions, and metalinguistic awareness in childhood. The present study constitutes a first exploration of developmental profiles related to executive functioning, listening comprehension, and corresponding metacognitive-metacomprehension monitoring in periods marking their emergence
View details →DOI: 10.12681/psy_hps.36222 Negative / Null Result ReportOpen accessDiseases of the respiratory system
Rizna Abdul Cader, Kanagerajan Thoriappa, Rozita Mohd et al. · 2019 · Respiratory Medicine Case Reports
A 54 year old lady with underlying chronic lung disease on long term oxygen therapy and end stage renal disease of unknown aetiology on regular haemodialysis for two years started developing progressive shortness of breath during her routine haemodialysis. She was unable to tolerate her haemodialysis sessions which had to be terminated prematurely in view of her symptoms despite adjustment of her dry weight and treatment of anaemia. She was not in chronic fluid overload and her symptoms always worsened after initiation of haemodialysis and improved after termination of haemodialysis. She was a
View details →DOI: 10.1016/j.rmcr.2018.10.022 Negative / Null Result ReportOpen accessEngineering (General). Civil engineering (General)
Mohammed Hefni, Maaz A. Ali · 2021 · Advances in Civil Engineering
The effectiveness of mine backfilling depends on the properties of its constituents. The high cost of cement, which is commonly used as a binder in mine backfill, has led researchers to seek alternatives to partially replace it with other binders. This study investigated the potential to use nano-calcium carbonate (NCC) and natural pozzolans (zeolite and pumice) along with Portland cement (PC) in mine backfill. Two types of experimental samples were prepared: (1) gold tailings and silica sand to investigate the effect of NCC and (2) nickel tailings to investigate the effect of natural pozzolan
View details →DOI: 10.1155/2021/5574761 Negative / Null Result ReportOpen accessMedicine (General)
Ravieh Golchoobian, Fatemeh Nabavizadeh, Mehrdad Roghani et al. · 2018 · Acta Medica Iranica
Hepatotoxicity is one of the clinically adverse effects of ecstasy (3, 4-methylenedioxymethamphetamine; MDMA) consumption. The detoxification tissue, liver, plays a central role in maintaining circulating levels of glucose and lipid. Hypoglycemia and hypotriglyceridemia have been reported due to ecstasy abuse. Ghrelin is a 28-amino-acid peptide secreted predominantly from the stomach. It has been demonstrated that ghrelin has hepatoprotective effects and is able to increase blood glucose concentration. In the current study, we explored the effect of hepatotoxic dose of MDMA and therapeutic use
Negative / Null Result ReportOpen accessPublic aspects of medicine
Armando García-Guerra, Lynnette M Neufeld, Sonia Hernández-Cordero et al. · 2009 · Salud Pública de México
OBJECTIVE: The objective of this analysis was to test the impact of daily supplementation with multiple micronutrients (MM) during pregnancy on Zn, vitamin A and folate status compared to iron only (Fe). MATERIAL AND METHODS: The study was carried out during 1997-2000 in a semi-urban community in Morelos state, Mexico. Women were randomly assigned to MM (n= 249) or Fe (n= 258) and received supplements daily (6 d/wk) under supervision by the field team from recruitment (approximately 9 weeks pregnancy) until delivery. Blood samples were collected on a sub-sample of women at baseline, 32 weeks p
Negative / Null Result ReportOpen accessMedicine
Tatsuya Yasuda, Tomohiko Hasegawa, Yu Yamato et al. · 2015 · Asian Spine Journal
Study DesignCase series.PurposeThe objective of this study was to investigate the change in pulmonary function in adult patients with a spinal deformity who underwent spinal corrective surgery.Overview of LiteratureDegenerative lumbar and/or thoraco-lumbar deformities are is often prominent in adult spinal deformity cases, whereas a thoracic deformity involving the chest wall is inconspicuous. A lumbar spine deformity could affect the pulmonary function; however, few reports have investigated pulmonary function in adult patients with a spinal deformity.MethodsThis study included 14 adult patie
View details →DOI: 10.4184/asj.2015.9.6.923 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Wioletta Sacharczuk, Rafał Dankowski, Stefan Ożegowski et al. · 2023 · Frontiers in Cardiovascular Medicine
We aimed to compare therapies of sacubitril/valsartan + spironolactone (S/V + S) with angiotensin-converting enzyme inhibitors + spironolactone (ACEI + S) on the left-sided cardiac reverse remodeling (L-CRR). The second objective was to analyze the usefulness of GLS and LVEF in response to therapy.Methods78 patients (mean age 63.4 years, 20 females) with symptomatic heart failure with reduced ejection fraction were randomized to groups of equal numbers, i.e., 39 patients, and started on therapy of S/V + S or ACEI + S. Second evaluations were made after 6–8 weeks of therapy.ResultsGLS changed f
View details →DOI: 10.3389/fcvm.2023.1103688 Negative / Null Result ReportOpen accessMedicine (General)
Weishen WANG, Wenhui LOU, Zhiwei XU et al. · 2023 · Journal of Advanced Research
Introduction: The value of extended lymphadenectomy in pancreatoduodenectomy (PD) has been discussed by five randomized controlled studies. However, the limitations in the studies made their conclusions not sufficiently reliable. Objectives: This multi-center randomized controlled study was designed to clarify the efficacy of extended lymphadenectomy in PD for pancreatic ductal adenocarcinoma (PDAC). Methods: From December 2016 to October 2018, 170 consecutive patients undergoing PD were enrolled and randomized to standard or extended lymphadenectomy for the treatment of PDAC from three high-v
View details →DOI: 10.1016/j.jare.2022.09.011 Negative / Null Result ReportOpen accessSpecial aspects of education
Maryam Amiri, Zahra Khademian, Reza Nikandish · 2018 · BMC Medical Education
Abstract Background The complexity of patients’ condition and treatment processes in intensive care units (ICUs) predisposes patients to more hazardous events. Effective patient safety culture is related to lowering the rate of patients’ complications and fewer adverse events. The present study aimed to determine the effect of empowering nurses and supervisors through an educational program on patient safety culture in adult ICUs. Methods A randomized controlled trial was conducted during April–September 2015 in 6 adult ICUs at Namazi Hospital, Shiraz, Iran. A total of 60 nurses and 20 supervi
View details →DOI: 10.1186/s12909-018-1255-6 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maiko Miyamoto, Aika Miya, Akinobu Nakamura et al. · 2026 · Journal of Diabetes Investigation
ABSTRACT Aims/Introduction We aimed to explore the short‐term effects of tofogliflozin on the insulin secretory capacity of people with type 2 diabetes. Materials and Methods We performed a multicenter, prospective, randomized, active‐controlled, open‐label, parallel‐group comparison study of people with type 2 diabetes aged 20–89 years, with hemoglobin A1c (HbA1c) 6.5%–9.0%, not previously treated with antihyperglycemic agents. The participants were randomly assigned to a group that received 20 mg tofogliflozin per day or a group that received 500 mg metformin per day for 4 weeks. Fasting blo
View details →DOI: 10.1111/jdi.70245 Negative / Null Result ReportMedicine
Reda, Ollaek, Mostafa et al. · 2026 · Anaesthesia reports
Open total abdominal hysterectomy is associated with substantial postoperative pain. We compared ultrasound-guided transversus abdominis plane block with ilioinguinal-iliohypogastric nerve block for postoperative analgesia. We conducted a…
View details →DOI: 10.1002/anr3.70074 Negative / Null Result ReportOpen accessOrthopedic surgery
Scott Yang, MD, Apeksha Gupta, MS, MPH, Michael E. Trask, BS et al. · 2025 · JBJS Open Access
Background:. Longitudinal pulmonary outcomes after surgical treatment of early-onset scoliosis (EOS) are not well reported. This study aims to evaluate change in serial pulmonary function in children with EOS after surgery. Methods:. A retrospective review was performed at a single academic hospital. All patients who had surgical treatment of EOS and repeated pulmonary function test (PFT) data were included. Pulmonary function test (PFT) measures included forced vital capacity (FVC), FVC % of predicted norms (FVC%), forced expiratory volume in 1 second (FEV1), and FEV1% of predicted norms (FEV
View details →DOI: 10.2106/jbjs.oa.25.00120 Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs
Matthias M. Engelen, Quentin Van Thillo, Albrecht Betrains et al. · 2022 · Research and Practice in Thrombosis and Haemostasis
Abstract Background Thromboinflammation plays a central role in severe COVID‐19. The kallikrein pathway activates both inflammatory pathways and contact‐mediated coagulation. We investigated if modulation of the thromboinflammatory response improves outcomes in hospitalized COVID‐19 patients. Methods In this multicenter open‐label randomized clinical trial (EudraCT 2020‐001739‐28), patients hospitalized with COVID‐19 were 1:2 randomized to receive standard of care (SOC) or SOC plus study intervention. The intervention consisted of aprotinin (2,000,000 IE IV four times daily) combined with low
View details →DOI: 10.1002/rth2.12826 Negative / Null Result ReportOpen accessPediatrics
Davene R. Wright, Karen Glanz, Trina Colburn et al. · 2018 · BMC Pediatrics
Abstract Background Previous studies have examined correlations between BMI calculated using parent-reported and directly-measured child height and weight. The objective of this study was to validate correction factors for parent-reported child measurements. Methods Concordance between parent-reported and investigator measured child height, weight, and BMI (kg/m2) among participants in the Neighborhood Impact on Kids Study (n = 616) was examined using the Lin coefficient, where a value of ±1.0 indicates perfect concordance and a value of zero denotes non-concordance. A correction model for par
View details →DOI: 10.1186/s12887-018-1042-x Negative / Null Result ReportMedicine
Chen, Si, Chen et al. · 2026 · Frontiers in medicine
This study aimed to evaluate the long-term effects of an automated eye position fixation training device (AEPFTD) on intraoperative cooperation, surgical efficiency, complications, and recurrence rates in patients undergoing pterygium…
View details →DOI: 10.3389/fmed.2026.1764636 Negative / Null Result ReportOpen accessPlant culture
David Matthew Deery, Greg J Rebetzke, Jose Antonio Jimenez-Berni et al. · 2016 · Frontiers in Plant Science
Lower canopy temperature (CT), resulting from increased stomatal conductance, has been associated with increased yield in wheat. Historically, CT has been measured with hand-held infrared thermometers. Using the hand-held CT method on large field trials is problematic, mostly because measurements are confounded by temporal weather changes during the time requiredto measure all plots. The hand-held CT method is laborious and yet the resulting heritability low, thereby reducing confidence in selection in large scale breeding endeavours.We have developed a reliable and scalable crop phenotyping m
View details →DOI: 10.3389/fpls.2016.01808 Negative / Null Result ReportOpen accessMedical technology
Mike J Crawford, Christian Gold, Helen Odell-Miller et al. · 2017 · Health Technology Assessment
Background: Preliminary studies have indicated that music therapy may benefit children with autism spectrum disorders (ASD). Objectives: To examine the effects of improvisational music therapy (IMT) on social affect and responsiveness of children with ASD. Design: International, multicentre, three-arm, single-masked randomised controlled trial, including a National Institute for Health Research (NIHR)-funded centre that recruited in London and the east of England. Randomisation was via a remote service using permuted blocks, stratified by study site. Setting: Schools and private, voluntary and
View details →DOI: 10.3310/hta21590 Negative / Null Result ReportOpen accessPediatrics
Jin Wha Choi, Jisook Kim, So Yoon Ahn et al. · 2018 · Neonatal Medicine
Purpose The aim of this study is to examine the tolerability and effect of early high-dose amino acid administration in extremely low birth weight infants (ELBWIs). Methods This retrospective cohort study included ELBWI (birth weight <1,000 g, n=142). Biochemical, nutritional, and neurodevelopmental data were compared between infants who received conventional low amino acid (LAA; 1.5 g/kg/day) and those who received high amino acid (HAA; 3 g/kg/day) within the first 48 hours after birth. Neurodevelopmental data included weight, height, and head circumference at discharge, 12 to 14 and 18 to 24
View details →DOI: 10.5385/nm.2018.25.4.153 Negative / Null Result ReportOpen accessAgriculture
Sindesi Olwetu A., Lewu Muinat N., Ncube Bongani et al. · 2021 · Agriculture
Vegetables are essential components in human diets because they are rich in vitamins, minerals, and dietary fibre. There is a growing interest in human nutrition enhancement through vegetable consumption to reduce micro mineral deficiencies, especially in households with low buying power. A greenhouse pot experiment was conducted to evaluate the effect of zeolite amendment on the mineral composition of cabbage (Brassica oleracea var. capitata L.), in relation to the soil chemical status. The experiment was carried out over two growing seasons (winter/spring) of 2018 and 2019. The treatments we
View details →DOI: 10.2478/agri-2021-0010 