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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19850 results in Negative / Null Result Report · page 324 of 662

Negative / Null Result ReportOpen accessMedicine

Psychological Impact of AI-Simplified Brain MRI Reports: A Randomized Trial of Patient Understanding, Anxiety, and Health Literacy.

Alarifi M, Luo J, Jabour A et al. · 2026 · Journal of clinical medicine

Background/Objectives : Immediate patient access to radiology reports has increased the need for communication that patients can understand, yet it remains unclear whether simplifying report language improves comprehension without…

View details →DOI: 10.3390/jcm15114158
Negative / Null Result ReportMedicine

Argipressin for prevention of blood loss in hepatic resection: a randomised, placebo-controlled, double-blind trial.

Wisén E, Pivodic A, Skagervik A et al. · 2026 · British journal of anaesthesia

Background Blood loss and blood transfusion are associated with negative short-term and long-term outcomes in hepatic resection. Vasopressin decreases portal blood flow and could reduce bleeding during liver surgery. We compared the…

View details →DOI: 10.1016/j.bja.2025.09.021
Negative / Null Result ReportMedicine

In adults with TBI and anemia, liberal vs. restrictive RBC transfusion did not reduce unfavorable neurologic outcomes by 10% at 6 mo.

Malik A, Martin GS · 2024 · Annals of internal medicine

Source citation Turgeon AF, Fergusson DA, Clayton L, et al; HEMOTION Trial Investigators on behalf of the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group, and the Canadian Traumatic Brain…

View details →DOI: 10.7326/annals-24-02456-jc
Negative / Null Result ReportMedicine

Association of Stepping Up to High-Dose Inhaled Corticosteroids and Risk of Future Asthma Exacerbations: Data From the United States.

Tran TN, Kerkhof M, Le TT et al. · 2026 · The journal of allergy and clinical immunology. In practice

Background Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) after exacerbation are limited. Objective To investigate whether stepping up to high-dose ICS after severe exacerbation reduces future asthma exacerbation…

View details →DOI: 10.1016/j.jaip.2025.10.005
Negative / Null Result ReportOpen accessMedicine

Reducing Noise Induced by Cardiac Pulsatility in Brain Maps of R<sub>2</sub>* and Magnetic Susceptibility Using Tailored k-space Sampling.

Raynaud Q, Dardano T, Oliveira R et al. · 2026 · NMR in biomedicine

Maps of the transverse relaxation rate R 2 * and magnetic susceptibility (χ) are computed from gradient-echo data and are sensitive to signal instabilities induced by cardiac pulsation. Here, we introduce two k-space sampling strategies…

View details →DOI: 10.1002/nbm.70305
Negative / Null Result ReportMedicine

Common channel length and implications to the weight loss.

Santoro S, Mota FC, de Aquino CGG et al. · 2025 · Updates in surgery

To present and analyze the results of sleeve gastrectomy with transit bipartition (SG + TB) with three different lengths of common channel (CC) and its implications for the weight loss and signals of residual malabsorption. A total of 790…

View details →DOI: 10.1007/s13304-025-02343-6
Negative / Null Result ReportMedicine

Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial.

Shu W, Wan J, Xu H et al. · 2025 · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Background Although previous studies have shown the potential advantages of albumin administration in critically ill patients, it has not been tested in patients with severe acute pancreatitis. Methods In this single-center trial, we…

View details →DOI: 10.1016/j.pan.2025.08.012
Negative / Null Result ReportMedicine

The Effect of Intraoperative Methadone During Spine Fusion Surgery on Postoperative Opioid Requirements: A Randomized Clinical Trial.

Uhrbrand CG, Carlé N, Valancius K et al. · 2025 · Spine

Study design A randomized blinded trial with three groups. Objective To evaluate whether a single intraoperative methadone dose reduces postoperative opioid requirements and pain intensity in patients undergoing lumbar fusion surgery.…

View details →DOI: 10.1097/brs.0000000000005477
Negative / Null Result ReportMedicine

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial.

Cariou B, Thys A, Oliveira AR et al. · 2025 · Diabetes, obesity & metabolism

Aims Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to…

View details →DOI: 10.1111/dom.16305
Negative / Null Result ReportMedicine

Impact of an electronic clinical decision support algorithm (eCDSA) on antibiotic prescribing in primary care in Cambodia: A cluster randomised controlled trial.

Wynberg E, Mishra A, Liverani M et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Poorly targeted antibiotic use in primary care is a driver of antimicrobial resistance. Electronic clinical decision support algorithms (eCDSAs) integrating point-of-care tests may improve prescribing. We evaluated the impact of…

View details →DOI: 10.1016/j.ijid.2026.108382
Negative / Null Result ReportMedicine

Proactive versus standard support of labor in the latent phase - A randomized, controlled clinical trial.

Larsen M, Underdal M, Salvesen Ø et al. · 2025 · Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives

Objective Long latent phase of labor with subsequent prolonged total labor duration increases the risk of obstetric interventions and complications. We explored whether Proactive Support of Labor (PSL) compared to Standard Support of Labor…

View details →DOI: 10.1016/j.srhc.2025.101144
Negative / Null Result ReportMedicine

Minimal Impact of Prophylactic Antibiotics in Pediatric Inguinal Hernia Surgery: Evidence From Real-World Data.

Fujii T, Kitadani Y, Tanaka A et al. · 2025 · Journal of pediatric surgery

Background The effectiveness of prophylactic antibiotics in pediatric inguinal hernia repair remains unclear. As the procedure is considered clean, the necessity of prophylactic antibiotics is debated. Methods We conducted a retrospective…

View details →DOI: 10.1016/j.jpedsurg.2025.162607
Negative / Null Result ReportOpen accessMedicine

Impact of electrocardiogram monitoring on the frequency of tracheal intubation at birth.

de Souza Freire T, Kawakami MD, de Almeida MF et al. · 2026 · Jornal de pediatria

Objective To determine whether the use of an electrocardiogram monitor in newborns receiving positive pressure ventilation (PPV) at birth affects the frequency of tracheal intubation in the delivery room. Methods Retrospective cohort of…

View details →DOI: 10.1016/j.jped.2026.101504
Negative / Null Result ReportOpen accessMedicine

Impact of Pre-Elite Anterior Cruciate Ligament (ACL) Reconstruction on Draft Outcomes and Reinjury Risk in Elite Australian Football Players: A Retrospective Cohort Study.

Veale JP, Shawdon A, D'Alessandro P et al. · 2025 · Sports (Basel, Switzerland)

A history of anterior cruciate ligament reconstruction (ACLR) during the Australian Football (AF) talent pathway may impact draft prospects and increase the risk of a second injury during a professional career. This study investigated…

View details →DOI: 10.3390/sports13090308
Negative / Null Result ReportOpen accessMedicine

Magnesium supplementation did not reduce serum calciprotein crystallization and arterial stiffness in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.

Meer R, Xu JY, Newsom SP et al. · 2026 · The American journal of clinical nutrition

Background Medial arterial calcification (MAC) and increased arterial stiffness contribute to cardiovascular disease risk in type 2 diabetes mellitus (T2DM). Experimental studies suggest that magnesium supplementation may halt arterial…

View details →DOI: 10.1016/j.ajcnut.2026.101299
Negative / Null Result ReportOpen accessMedicine

Effectiveness of a virtual hospital model of care for patients with low back pain presenting to emergency departments (Back@Home).

Sigera C, Oliveira CB, Melman A et al. · 2026 · NPJ digital medicine

This study evaluated the effectiveness of a virtual hospital model of care (Back@Home) for low back pain (LBP). We conducted an observational study across four hospitals in the Sydney Local Health District, Australia. We included patients…

View details →DOI: 10.1038/s41746-026-02425-8
Negative / Null Result ReportMedicine

Does Reiki Therapy ReducePreoperative Anxiety and Postoperative Pain in Third Molar Surgery? A Randomized Controlled Trial.

Ozden Yuce M, Simsek B, Dadas OF et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Preoperative anxiety in patients undergoing third molar extraction can influence pain perception. Limited evidence suggests Reiki therapy may help manage anxiety and pain, but its effectiveness in dentistry is unclear. Purpose…

View details →DOI: 10.1016/j.joms.2025.09.003
Negative / Null Result ReportOpen accessMedicine

Biological vs Synthetic Mesh in Laparoendoscopic Inguinal Hernia Repair: The BIOLAP Randomized Clinical Trial.

Seefeldt CS, Knievel J, Deeb M et al. · 2025 · JAMA surgery

Importance Chronic postoperative pain and recurrence are relevant complications after inguinal hernia repair. Biological meshes have been proposed as a resorbable alternative to synthetic implants that may reduce postoperative pain.…

View details →DOI: 10.1001/jamasurg.2025.4071
Negative / Null Result ReportOpen accessAnimal culture

Influence of supplemental canola or soybean oil on milk yield, fatty acid profile and postpartum weight changes in grazing dairy goats

Israel Lerma-Reyes, German D. Mendoza-Martínez, Rolado Rojo-Rubio et al. · 2018 · Asian-Australasian Journal of Animal Sciences

Objective This experiment was designed to evaluate the effect of supplementation with soybean or canola oil on milk production and the composition of long chain fatty acids as well as weight changes in the goats and their kids. Methods Thirty nine mulitparous crossed Alpine×Nubian goats (initial body weight [BW] 43.5±1.7 kg) from the day of parturition were assigned to the treatments: grazing control (n = 15); grazing plus 20 mL/goat/d of supplemental soybean oil (n = 12); and grazing plus 20 mL/goat/d of supplemental canola oil (n = 12) from November 26, 2014 to March 7, 2015. The planned con

View details →DOI: 10.5713/ajas.17.0058
Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology

Continuous venovenous hemodiafiltration versus standard medical therapy for the prevention of rhabdomyolysis-induced acute kidney injury: a retrospective cohort study

Yan Meng, Ming-xue Zhou, Chun-bo Wu et al. · 2023 · BMC Nephrology

Abstract Aim To determine whether continuous venovenous hemodiafiltration (CVVHDF) plus standard medical therapy (SMT) vs. SMT alone prevents rhabdomyolysis (RM)-induced acute kidney injury (AKI) and analyze the related health economics. Methods This retrospective cohort study involved 9 RM patients without AKI, coronary heart disease, or chronic kidney disease treated with CVVHDF plus SMT (CVVHDF + SMT group). Nine matched RM patients without AKI treated with SMT only served as controls (SMT group). Baseline characteristics, biochemical indexes, renal survival data, and health economic data w

View details →DOI: 10.1186/s12882-023-03242-x
Negative / Null Result ReportOpen accessAnimal culture

Frações da parede celular e digestibilidade in vitro da matéria seca de três genótipos de girassol ensilados com aditivos In vitro dry matter and cell wall fractions of three genotypes of sunflower ensiled with additives

P.P. Porto, E.O.S. Saliba, L.C. Gonçalves et al. · 2006 · Arquivo Brasileiro de Medicina Veterinária e Zootecnia

Ensilaram-se três genótipos de girassol (M734, Rumbosol 91 e variedade V2000), enriquecidos no material original com: 0,5% de uréia (U); 0,5% de carbonato de cálcio (CC); 0,5% de uréia mais 0,5% de carbonato de cálcio (U+CC); inoculante bacteriano comercial (IB) comercial e sem aditivo que serviu como silagem testemunha (T). Foram utilizados silos de laboratório de PVC, abertos com 1, 3, 5, 7, 14, 28 e 56 dias de ensilados, sendo determinados fibra em detergente neutro (FDN), fibra em detergente ácido (FDA), lignina e digestibilidade in vitro da matéria seca (DIVMS). As silagens de Rumbosol 91

View details →DOI: 10.1590/s0102-09352006000100015
Negative / Null Result ReportOpen accessPublic aspects of medicine

How peer conversations about HIV/AIDS media messages affect comprehension and beliefs of young South African women

E. Lubinga, A.A. Maes, C.J.M. Jansen · 2016 · SAHARA-J

Most existent research on the effects of interpersonal discussions about health campaign messages is based on surveys. In this study, we analysed actual conversations about an HIV/AIDS poster to find out possible effects. Young South African women in 59 dyads (n = 118) participated in conversations about a deliberately puzzling HIV and AIDS poster that cautioned the target group to be faithful to one sexual partner. We measured their comprehension of the poster and beliefs about the message, before and after the conversations. Overall, actual comprehension (AC) was low, and we observed a large

View details →DOI: 10.1080/17290376.2016.1197146
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Biventricular versus Conduction System Pacing after Atrioventricular Node Ablation in Heart Failure Patients with Atrial Fibrillation

Maja Ivanovski, Miha Mrak, Anja Zupan Mežnar et al. · 2022 · Journal of Cardiovascular Development and Disease

Conduction system pacing (CSP) modalities, including His-bundle pacing (HBP) and left bundle branch pacing (LBBP), are increasingly used as alternatives to biventricular (BiV) pacing in heart failure (HF) patients scheduled for pace and ablate strategy. The aim of the study was to compare clinical outcomes of HF patients with refractory AF who received either BiV pacing or CSP in conjunction with atrio-ventricular node ablation (AVNA). Fifty consecutive patients (male 48%, age 70 years (IQR 9), left ventricular ejection fraction (LVEF) 39% (IQR 12)) were retrospectively analysed. Thirteen pati

View details →DOI: 10.3390/jcdd9070209
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Long term outcomes following embolisation of bronchial and non-bronchial systemic arteries for the management of haemoptysis – a 20-year experience

Shyamal Patel, Lucy Rose Howroyd, Helen Bucknall et al. · 2025 · CVIR Endovascular

Abstract Background Bronchial artery embolisation (BAE) is considered the most effective non-surgical technique for management of moderate-massive haemoptysis. Associated risks include neurological compromise such as stroke and spinal cord ischaemia. We aim to evaluate post-procedural outcomes and complication rates. Materials and methods A single-centre retrospective observational study was conducted for BAE cases performed between January 2002-June 2022 in a London teaching hospital. Data was collected from electronic medical records and Picture Archiving Communications System (PACS). Primar

View details →DOI: 10.1186/s42155-025-00551-0
Negative / Null Result ReportOpen accessEnvironmental technology. Sanitary engineering

Systematic errors in northern Eurasian short-term weather forecasts induced by atmospheric boundary layer thickness

Igor Esau, Mikhail Tolstykh, Rostislav Fadeev et al. · 2018 · Environmental Research Letters

Systematic errors in forecast near-surface air temperature (SAT) still constitute a considerable problem for numerical weather prediction (NWP) at high latitudes. Numerous studies in the past have attempted to reduce this problem through recalibration of physical parameterization schemes and better approximation of the surface energy budget. The errors, however, remain despite notable improvements in the overall weather forecast performance. This study looks at the problem from a different perspective. It analyzes asymmetries in the SAT forecast errors. The study reveals a statistical pattern

View details →DOI: 10.1088/1748-9326/aaecfb
Negative / Null Result ReportMedicine

Comparative clinical and radiographic evaluation of autogenous dentin graft versus xenograft in periodontal intrabony defects - A nonrandomized controlled trial.

Anusuya, Balaji, Manikandan · 2026 · Journal of Indian Society of Periodontology

Periodontal regeneration aims to restore the natural structure of the periodontium, therefore improving the long-term stability and function of the affected teeth. Traditional bone graft materials such as allografts, autografts,…

View details →DOI: 10.4103/jisp.jisp_210_24
Negative / Null Result ReportMedicine

Does Local Excision Without Salvage Surgery Affect the Prognostic Outcome of Patients With Malignant Colorectal Polyp? A Long-Term Survival Analysis.

Ng, Chu, Chan et al. · 2026 · Journal of gastroenterology and hepatology

Management of malignant colorectal polyp has been a treatment dilemma for clinicians. This study aims to evaluate the long-term survival outcome of patients with and without salvage surgery after local excision. From January 2000 to…

View details →DOI: 10.1111/jgh.70506