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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20233 results in Negative / Null Result Report · page 313 of 675

Negative / Null Result ReportOpen accessMedicine

The Association of p27 With Prostate Cancer Outcomes: A Secondary Analysis of NRG/RTOG 8610 and 9202.

Patel KR, Pugh SL, Simko JP et al. · 2026 · Advances in radiation oncology

Purpose The cyclin-dependent kinase inhibitor p27 is a well-profiled modulator of cell cycle progression. Low nuclear p27 levels have been demonstrated to have a negative prognostic impact on outcomes in patients undergoing prostatectomy.…

View details →DOI: 10.1016/j.adro.2026.102022
Negative / Null Result ReportOpen accessMedicine

Skeletal muscle index, grip strength, and physical performance as predictors of severe chemotherapy toxicity among older adults with malignancy.

Papadopoulos E, Rozenberg D, Wong AKO et al. · 2025 · PloS one

Background Skeletal muscle index (SMI), grip strength, and physical performance have been shown to predict clinically relevant outcomes in geriatric oncology. However, their predictive ability for chemotherapy toxicity is poorly…

View details →DOI: 10.1371/journal.pone.0336968
Negative / Null Result ReportOpen accessMedicine

No Evidence of Interaction Between FADS2 Genotype and Breastfeeding on Cognitive or Other Traits in the UK Biobank.

Centorame G, Warrington NM, Hemani G et al. · 2025 · Behavior genetics

Breastfeeding is hypothesised to benefit child health and cognitive functioning by providing long-chain polyunsaturated fatty acids, which are essential for brain development. In 2007, Caspi et al. found evidence in two cohorts for an…

View details →DOI: 10.1007/s10519-024-10210-0
Negative / Null Result ReportOpen accessMedicine

Effects of Emergency Department Training on Buprenorphine Prescribing and Opioid Use Disorder-Associated ED Revisits: Retrospective Cohort Study.

Torchiano A, Roberts B, Haroz R et al. · 2025 · The western journal of emergency medicine

Introduction Prescribing patients buprenorphine from the emergency department (ED) is recommended by multiple organizations. However, it is unclear how best to encourage physicians to prescribe buprenorphine from the ED. Our objectives in…

View details →DOI: 10.5811/westjem.35589
Negative / Null Result ReportOpen accessMedicine

Quantification of the neuropathology of alcohol use disorder using tissue microarrays.

Liu J, Catanzariti MJ, Nguyen-Hao HT et al. · 2026 · Journal of neuropathology and experimental neurology

Alcohol use disorder (AUD) is characterized by an inability to stop consuming alcohol. Neuroimaging studies of patients with AUD show mild grey and white matter atrophy, while pathological studies suggest that atrophy is restricted to the…

View details →DOI: 10.1093/jnen/nlaf147
Negative / Null Result ReportOpen accessMedicine

Hand posture, but not vision of the hand, affects tactile spatial resolution in the grating orientation discrimination task.

French B, Chiaro NVD, Holmes NP · 2022 · Experimental brain research

The grating orientation discrimination task (GOT) is a sensitive and reliable measure of tactile spatial resolution, or acuity. We used the GOT in three experiments to investigate the effects of hand posture and hand visibility on spatial…

View details →DOI: 10.1007/s00221-022-06450-3
Negative / Null Result ReportMedicine

Comparison of CATCH, PECARN and CHALICE rules in children with minor head trauma.

Ferhatlar ME, Cumhur BA, Koca Y et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Purpose The aim of this study is to prospectively compare the diagnostic performance of the PECARN, CATCH, and CHALICE clinical decision rules in pediatric patients presenting with minor head trauma, within a rural secondary-level…

View details →DOI: 10.1007/s00068-026-03186-5
Negative / Null Result ReportOpen accessMedicine

Computer vision for pain detection during procedural sedation.

Zarghami Y, Rad MG, Mafeld S et al. · 2026 · Scientific reports

Continual automated pain detection from facial expressions using computer vision during procedural sedation could optimize sedation dose titration and minimize pain. A prospective observational study was conducted. Participants' faces were…

View details →DOI: 10.1038/s41598-026-45130-y
Negative / Null Result ReportMedicine

Unresponsive Systemic Mastocytosis in a Young AML With RUNX1::RUNX1T1 Fusion With Rare KIT c.1255_1257delGAC Mutation: A Clinical Deadlock.

Balraam Kv V, Nayak AR, Dass J et al. · 2026 · Journal of pediatric hematology/oncology

Background Systemic mastocytosis (SM) with associated acute myeloid leukemia (AML) is a rare malignancy usually linked to KIT p.D816V mutations. Observations We report a 17-year-old female with RUNX1::RUNX1T1-positive AML and florid mast…

View details →DOI: 10.1097/mph.0000000000003232
Negative / Null Result Report

Multiple evidence supporting a novel species amid complex phylogenomic discordance: a case of Indian Ledebouria based on Angiosperms353 target capture sequencing

Nayak S, Deshmukh P, Yadav SR et al. · 2026 · Preprint

Ledebouria , a geophytic herb native genus to Africa and represented by a few species in the Arabian Peninsula, Madagascar, India and Sri Lanka. For a long time Indian species were named as L. revoluta until recent molecular work clarified…

View details →DOI: 10.64898/2026.06.18.733124
Negative / Null Result ReportMedicine

Sensorimotor Adaptation of Vocal Pitch Is Impaired in Cerebellar Ataxia.

Slis A, Parrell B · 2026 · Journal of cognitive neuroscience

Sensory errors, mismatches between predicted sensory outcomes of movement and reafferent sensory feedback, drive changes in the feedforward control of future motor behavior that correct for those errors. Across a wide variety of motor…

View details →DOI: 10.1162/jocn.a.2630
Negative / Null Result Report

Virtual screening and zebrafish phenotype-based evaluation argues against repurposing 4-phenylbutyrate for STXBP1-related disorders

Frick A, Whyte-Fagundes P, Baraban SC · 2026 · Preprint

Syntaxin-binding protein 1 ( STXBP1 ) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18-1 ( STXBP1 ) C.…

View details →DOI: 10.64898/2026.05.07.723632
Negative / Null Result ReportMedicine

Point-of-Care Ultrasound and Clinical Findings in 14 Cats With High-Rise Syndrome.

Swanstein HKJ, Gommeren K, Langhorn R et al. · 2026 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)

Objective To describe point-of-care ultrasound (POCUS) and clinical findings in cats with high-rise syndrome. Design Retrospective descriptive study. Setting University hospital. Animals Fourteen cats that fell from a height. Measurements…

View details →DOI: 10.1111/vec.70119
Negative / Null Result ReportMedicine

Assessment of Geographic Atrophy Using a Novel Hyperspectral Gradient Imaging Approach.

Romano F, Overbey K, Durocher-Jean A et al. · 2026 · Ophthalmic surgery, lasers & imaging retina

Background and objective This study describes a novel hyperspectral imaging (HSI) approach for visualizing and measuring geographic atrophy (GA) lesions in age-related macular degeneration. Patients and methods This cross-sectional…

View details →DOI: 10.3928/23258160-20260323-01
Negative / Null Result ReportMedicine

GPT-4.1 and Llama 3.3 70 fail to detect clinically relevant errors in radiology reports in zero-shot evaluation.

Akinci D'Antonoli T, Adams LC, Lübberstedt J et al. · 2026 · European radiology

Objectives To evaluate whether GPT-4.1 and Llama 3.3 70B, large language models (LLMs) assessed in zero-shot, baseline configurations, detect and categorize clinically consequential errors across types that range from pattern-based to…

View details →DOI: 10.1007/s00330-026-12697-z
Negative / Null Result ReportMedicine

Hemoglobin Hekinan II (HBA1:c.84G>T): an electrophoretically silent α-globin variant missed by routine screening in northern Thailand.

Theingi M, Ruengdit C, Punyamung M et al. · 2026 · Laboratory medicine

Introduction This study aimed to characterize the molecular and hematologic features of hemoglobin (Hb) Hekinan II in northern Thailand and to evaluate its phenotypic expression when co-inherited with other hemoglobinopathies. Methods In…

View details →DOI: 10.1093/labmed/lmag028
Negative / Null Result ReportMedicine

Klossiella equi, an underreported parasite of equids in the Americas.

Zeldenrust EG, Carlton K, Jenkins EJ et al. · 2026 · Veterinary parasitology

Klossiella equi Baumann, 1946 (Apicomplexa: Coccidia) is a globally distributed adeleorinid parasite that infects the kidneys of equid hosts. Considered an uncommon parasite, when K. equi is detected, it is typically an incidental finding…

View details →DOI: 10.1016/j.vetpar.2026.110781