A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19847 results in Negative / Null Result Report · page 309 of 662
Li N, Wu C, Cao P et al. · 2024 · Access microbiology
Background Rhodococcus equi is one of the most important causes of zoonotic infections from grazing animals. It poses a particular risk to immunocompromised individuals, including those who are undergoing long-term immunosuppressive…
Zhang Q, Yan Y, Li J et al. · 2023 · Preprint
Objectives: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) can improve pregnancy and neonatal outcomes for patients with limited good-quality embryos. Design: Retrospective cohort study. Setting: University…
Liu H, Hu Z, Song Q et al. · 2025 · JAMA network open
Importance Evidence from everyday dining situations regarding the effects of traffic light labels (TLLs) on dietary improvement remains inconsistent. Objective To evaluate the effects of TLLs on dietary consumption and choices in cafeteria…
Cearns K, Lazarus ER, Wahid R · 2026 · The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres
BackgroundMental health nurses represent only 1.03% of the global nursing workforce, contributing to persistent workforce shortages. Undergraduate nursing students demonstrate limited interest in mental health nursing (MHN), often…
Zhao Y, Zhang H, Gao J et al. · 2026 · Preprint
Abstract Background Venetoclax (VEN)-based regimens are increasingly used in frontline treatment for acute myeloid leukaemia (AML), resulting in a growing number of patients who develop relapsed or refractory disease after prior VEN…
S YK, Dwibedi B, Das RR · 2026 · European journal of pediatrics
Because of the excessive endogenous inflammatory mediators, acute encephalitis syndrome (AES) results in death, or sequelae in survivors. Pentoxifylline, a modulator of inflammation, can have beneficial role in AES. The primary objective…
Ansaloni LS, Domingues CEC, Gregori M et al. · 2026 · Insects
Given the current global agricultural system, honey bees are exposed to a complex network of stressors that can act simultaneously, making it challenging to maintain healthy colonies. Therefore, studies on natural products to improve…
Li J, Lu X, Yue S et al. · 2026 · Preprint
Abstract Non-small cell lung cancer (NSCLC) patients carrying HER2 20ins exon 20 insertion (HER2 20ins) are poorly respond to conventional therapies and pan HER inhibitors. Trastuzumab Deruxtecan (T-DXd) has been approved in second line…
Schmid SR, Blume C, Ell J et al. · 2026 · Journal of sleep research
Cognitive behavioural therapy for insomnia (CBT-I) is recommended as first-line treatment for insomnia disorder. However, around 25% of the patients do not respond to the treatment, and only 40% achieve full remission. The current study…
Goričan I, Šorgo A, Strnad M · 2026 · Preprint
Background: and Objectives: Slovenia, as many other European nations, have introduced voluntary first responders to enhance survival rates in out-of-hospital cardiac arrests. In currently published research exists no conclusive data on the…
Li N, Wu C, Cao P et al. · 2023 · Preprint
Abstract Background: Rhodococcus equi is one of the most important causes of zoonotic infections from grazing animals. It poses a particular risk to immunocompromised individuals, including those who are undergoing long-term…
Akbarzadeh G, Abedi P, Jahanfar S et al. · 2024 · Frontiers in medicine
Background Sexual dysfunction is prevalent among breastfeeding women. Objective This study was designed to evaluate the effect of Rose damascene extract on sexual function and anxiety of breastfeeding women. Materials and methods This was…
Nishiofuku H, Mori M, Yokomichi N et al. · 2024 · Journal of palliative medicine
Delirium is a distressing condition in terminally ill cancer patients, often treated with antipsychotics. Administering them orally, subcutaneously, or intravenously can be challenging in severely agitated patients. Transdermal…
Oliver-Pons C, Sala-Vila A, Cofán M et al. · 2024 · Journal of the American Geriatrics Society
Background Nutritional strategies to maintain bone health in aging individuals are of great interest. Given the beneficial nutrient composition of walnuts, rich in alpha-linolenic (the vegetable n-3 fatty acid) and polyphenols, their…
Polauke E, Stage Sø J, Carl H et al. · 2024 · Journal of environmental management
Ambitious to fulfill the European Water Framework Directive obligations, the European governments support projects to rehabilitate lakes with poor water quality. However, most lake restorations having relied on biomanipulation by fish…
Li J, Zhou J, Ha Q et al. · 2026 · Frontiers in cardiovascular medicine
Objective Obesity is an independent risk factor for cardiovascular diseases and elevated mortality, yet the underlying mechanisms remain incompletely understood. Impaired endothelium-dependent relaxation is an early manifestation of…
Carnes N, McAnany J, Khodr Z et al. · 2026 · Journal of attention disorders
Objective Attention-deficit/hyperactivity disorder (ADHD) can potentially disqualify individuals for military service. However, some past research suggests the performance of individuals with ADHD in military service may be comparable to…
Heilmann F, Langsdorf LE, Schubert T · 2026 · Psychological research
This study investigated how stimulus material and effector specificity influence interference control (a form of inhibitory control) in adolescent players. Ninety-one males aged 15-18 years (28 handball players, 34 soccer players, 29…
DeBoest A, Holley C, Hickey M et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Purpose To determine the impact of pharmacist intervention with real-time continuous glucose monitors (rtCGMs) on glycated hemoglobin (HbA1c) levels and the number of pharmacist touchpoints compared to standard of care (SOC). Methods…
Michelutti N, Baud A, Meyer-Jacob C et al. · 2026 · Preprint
Abstract The “top–bottom” approach in paleolimnology provides a rapid means of assessing environmental change by comparing modern surface sediments with deeper intervals assumed to pre-date major anthropogenic disturbances (ca. pre-1880).…
Phan TH, Phan MQ · 2026 · La Clinica terapeutica
Background Residual cardiovascular risk after acute myocardial infarction (AMI) is driven not only by dyslipidemia but also by systemic inflammation. High-sensitivity C-reactive protein (hs-CRP) and low-density lipoprotein cholesterol…
Xiao H, Zeng X, Pang Q et al. · 2026 · Transplant immunology
Background Sodium-glucose cotransporter-2 inhibitors (SGLT2i) yield additional cardiorenal benefits beyond glycemic control. Emerging evidence suggests that SGLT2i have potential benefits in organ transplantation, though causal…
Park M, Park H, Baek IH et al. · 2026 · Journal of patient safety
Objectives Erythropoiesis-stimulating agents (ESAs), classified as long-acting or short-acting, is a primary treatment for anemia in chronic kidney disease and chemotherapy. Given ongoing safety concerns regarding cardiovascular events and…
Tulsian V, Kant R, Patnaik I et al. · 2026 · Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Background and objectives Helicobacter pylori infection is highly prevalent globally. Standard bismuth quadruple therapy is commonly used in India, but there are growing concerns regarding the emergence of anti-microbial resistance and…
Hong WJ, Huang JM, Liu YH et al. · 2025 · Aesthetic plastic surgery
Background The postauricular injection technique is a needle-based technique that places soft tissue fillers behind the ears into the supra-periosteal plane of the mastoid process of the temporal bone. The resulting clinical effect pushes…
Morris JS, Rajshekhar S, Gremmo G et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Deep endometriosis (DE) is established to cause chronic pelvic pain (CPP), lower urinary tract symptoms (LUTS) and altered bowel function. Although the aim of surgical excision is often to relieve CPP, evidence suggests it could also…
Sit B, Sanderlin AG, Zhu CY et al. · 2025 · Preprint
Obligate intracellular bacterial pathogens cannot grow extracellularly, a trait that renders them highly understudied, but also endows them with unexpected host dependencies. Here, using the emerging obligate intracellular tickborne…
Reiter T, Dörrler AL, Hasenauer N et al. · 2026 · European journal of nuclear medicine and molecular imaging
Introduction Acute myocardial infarction (AMI) triggers local inflammation in the injured myocardium, followed by a systemic inflammatory response of lymphatic organs. This prospective trial (NCT05519735) focused on molecular imaging of…
Shabbir A, Abbas G, Alharby HF et al. · 2026 · International journal of phytoremediation
Heat stress and soil arsenic (As) contamination are resulting in severe decline in crop production around the world. The present experiment aimed to assess physiological and biochemical changes induced by the combination of As and heat…
Jeneson J, van den Berg-Faay A, Hooijmans M · 2025 · Preprint
We employed interleaved dynamic 1H magnetic resonance imaging (MRI) and 31P MR spectroscopy in combination with arm-cycling to investigate correlations of exercise hyperemia and muscle energetics in the triceps brachii (TB) muscle of the…