A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19847 results in Negative / Null Result Report · page 308 of 662
Yamano Y, Shimizu Y, Inata Y et al. · 2026 · Clinical nutrition ESPEN
Background & aims Lipid emulsions are key components of parenteral nutrition (PN); however, concerns persist that soybean oil-based lipid emulsions may increase the risk of infection and catheter occlusion. In pediatric intensive care…
Matsumura M, Yasuda A, Murakami M et al. · 2025 · Biochemical genetics
Hepcidin centrally regulates systemic iron status. We previously revealed that activities of trans-factor to induce hepcidin expression are distinct between cattle and humans/mice in which regulation of hepcidin expression is…
Ruiz-Palacios GM, Cahn PE, Halperin SA et al. · 2026 · Vaccine
Background There is a concern about the potential increased risk of acquiring HIV infection after vaccination with adenovirus type 5 (Ad5) vector-based vaccines. We aimed to investigate whether Ad5-nCoV increases the risk of HIV infection.…
Al-Mansor AN, Alhamd AD, Al-Musawi FM · 2025 · Preprint
Abstract Date palms (Phoenix dactylifera L.) struggle in arid places due to water scarcity and rising demand. Therefore, we must find more efficient ways to water them to maintain economically viable water use. Researchers in the southern…
Li RQ, Su S, Zhan LP et al. · 2026 · Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Objective: To investigate the differences in the changes of periodontal ligament area (PDLA) and related clinical indicators before and after maxillary central incisor movement under different orthodontic treatment regimens. Methods: This…
Zhang XR, Yang GJ, Jiang LC et al. · 2026 · The New phytologist
Nitrogen (N) inputs generally benefit grassland biomass production. Supporting evidence, however, comes mainly from experiments with high N input rates and from grasslands without utilization. Using a 10-yr field experiment in temperate…
Liang XS, Ning Y, Wang HY et al. · 2026 · The New phytologist
Nitrogen (N) enrichment is expected to exacerbate plant phosphorus (P) limitation, yet this assumption has seldom been empirically tested. We investigated the effects of 7-9 yr of N and P addition on grassland aboveground net primary…
Schaefer N, Kelaher BP, Bishop MJ · 2026 · Marine environmental research
Climate warming is exposing intertidal species to increasing temperatures, threatening the survival of those already experiencing conditions close to their upper thermal limit. On intertidal rocky shores, habitat-forming seaweeds can…
Dupla X, Bertagni MB, Grand S · 2025 · Environmental science & technology
Enhanced rock weathering (ERW) is a CO 2 removal technology that involves spreading finely ground silicate rock on fields. The chemical weathering of this rock powder removes atmospheric CO 2 in the form of bicarbonate ions and secondary…
Hernigou P, Caton J · 2025 · International orthopaedics
Purpose Calcium pyrophosphate dihydrate (CPPD) deposition, often visible radiographically as chondrocalcinosis, frequently accompanies knee osteoarthritis and is usually encountered at the time of arthroplasty. Whether its presence…
Grummon AH, Zeitlin AB, Lee CJY et al. · 2026 · American journal of preventive medicine
Introduction As of 2025, 9 states have adopted Universal Free School Meal programs. The success of these programs depends in part on high participation. This study tested whether a social media campaign promoting school meal participation…
Sazuka T, Habu Y, Matsusaka K et al. · 2026 · International journal of clinical oncology
Background Pelvic lymph-node dissection is performed across multiple surgical specialties. However, inconsistent terminology and unclear anatomical boundaries hinder standardization. This study established a multidisciplinary team with a…
Hamrick MW, Fulzele S, Isales CM et al. · 2025 · Biochimie
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is thought to play important roles in aging, oxidative stress, and cellular senescence. We have previously shown that the AhR agonist kynurenine (Kyn), a…
Busse A, Müller J, Benbow ME et al. · 2025 · Journal of Applied Entomology
Understanding the dispersal ability of insects is critical for conservation efforts, as well as for preventing economic and health risks, such as the spread of bluetongue disease or African swine fever (ASF). However, knowledge of the…
de Faria OAC, Kussano NR, de Faria LC et al. · 2026 · Reproduction in domestic animals = Zuchthygiene
This study aimed to evaluate whether the quality of injection and number of oocytes injected during Intrafollicular Transfer of Immature Oocytes (IFIOT) affect ovulation timing, follicle dynamics, oocyte recovery, nuclear maturation and in…
Ng PH, St-Hilaire S · 2025 · Diseases of aquatic organisms
Microcystis spp. blooms in fish ponds can lead to fluctuations in water parameters, and the microcystin-LR (MC-LR) toxin they produce may pose health risks for fish, as well as consumers. Hydrogen peroxide (H2O2) treatment has been…
Klaassen AD, Willigenburg NW, Musters JWQ et al. · 2026 · The Journal of bone and joint surgery. American volume
Background Hip dislocation is the most common reason for early revision after total hip arthroplasty (THA). To prevent dislocation, patients are often prescribed movement restrictions following THA; however, these restrictions can be…
Xie Z, Yang C, Yin Y et al. · 2025 · Heart (British Cardiac Society)
Background Intensive blood pressure (BP) control Methods This is a post hoc analysis of the China Rural Hypertension Control Project. Mixed-effect Cox proportional regression and generalised estimating equation models were used to…
Boito L, Rijnders J, Steinwidder L et al. · 2025 · Preprint
Abstract Enhanced weathering (EW) of silicate minerals has emerged as a promising carbon dioxide removal (CDR) strategy, with potential benefits for soil fertility and crop performance. However, the soil processes that determine these…
Chandan Reddy S, Mao T, Gendreau J et al. · 2026 · Clinical neurology and neurosurgery
Objective Oligodendrogliomas are typically benign tumors that arise within the white matter tracts of the cerebral hemispheres. Surgical resection, radiotherapy (RT), and chemotherapy (CT) are utilized to prolong survival in patients…
Davila-Piñón P, Díez-Martín AI, Nogueira-Rodríguez A et al. · 2026 · Endoscopy
Background and study aim The impact of computer-aided detection (CADe) systems remains uncertain. We evaluated whether PolyDeep, a CADe system, improves adenoma detection rate (ADR) in a colorectal cancer (CRC) screening program. Patients…
de Lint L, de Vries R, van Rookhuijzen M et al. · 2026 · Appetite
Food choices are not made within a vacuum but depend upon earlier decisions, resulting in spillover effects where subsequent choices are either similar (consistency) or contrasting (balancing). Little is known about spillovers in…
Pervane YD, Bağlan E · 2025 · Expert opinion on biological therapy
Objective Biologic agents have been used in colchicine-resistant familial Mediterranean fever (FMF) patients and in patients with comorbidities including juvenile idiopathic arthritis (JIA). The main aim of our study was to evaluate the…
Savin Z, Ben-David R, Shem-Tov Dlugy A et al. · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada
Introduction Active surveillance (AS) requires regular monitoring to detect disease progression. Multiparametric magnetic resonance imaging (mpMRI) and targeted biopsies are commonly used to identify clinically significant prostate cancer…
Collins SF, Soliz L, Tucker G et al. · 2025 · Science of the Total Environment
Here, we assessed patterns of microplastics (MP; particles <5 mm) and microfibers (MF; fibers <5 mm) within benthic macroinvertebrates and fishes collected from a polluted urban stream (10-km segment; n = 5 reaches; 200-m reach lengths).…
Akiyama H, Sasaki Y, Tago K et al. · 2025 · Agriculture, Ecosystems and Environment.
Previous studies have reported that nitrification inhibitors are effective in reducing nitrous oxide emissions. However, no studies have reported the effectiveness of 3,4-dimethylpyrazole phosphate, and 3,4-dimethylpyrazole succinic acid…
Vavricka SR, Zeitz J, Madanchi M et al. · 2025 · The American journal of gastroenterology
Introduction Retrospective data suggest association of high-altitude exposure and inflammatory bowel disease flares. Knowledge about underlying pathogenesis remains limited. Methods This prospective interventional trial evaluated the…
Hammett JF, Kirwan M, Chen W · 2026 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
Objective Intimate partner violence (IPV) is a major public health concern. Heavy episodic drinking (HED; i.e., drinking 5+ drinks for men or 4+ drinks for women in a 2-hr period) is a contributing cause of IPV, yet HED does not elicit IPV…
Savran F, Bayram F, Küçük F · 2026 · The Journal of craniofacial surgery
Objective This study aimed to evaluate the effects of intravenous dexamethasone and tranexamic acid (TXA), used alone and in combination, on perioperative bleeding and postoperative edema and ecchymosis in rhinoplasty. Methods In this…
Lipps KM, Samuel AM, Patel D et al. · 2025 · Journal for healthcare quality : official publication of the National Association for Healthcare Quality
Background Hypertension (HTN) is common in the inpatient setting, with many patients receiving as-needed (PRN) antihypertensive medications (anti-HTN) despite lack of benefit and risk of adverse events. We aimed to decrease PRN anti-HTN…