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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19847 results in Negative / Null Result Report · page 303 of 662

Negative / Null Result ReportMedicine

Primary Care Physicians' and Hospitalists' Experience with Advance Care Planning with South Asian Canadian Older Adults before and during COVID-19.

Vashisht A, Gutman G, Mackey D et al. · 2024 · Canadian journal on aging = La revue canadienne du vieillissement

Few older adults discuss their end-of-life care wishes with their physician, and even fewer minorities do this. We explored physicians' experience with advance care planning (ACP) including the barriers/facilitating factors encountered…

View details →DOI: 10.1017/s0714980823000739
Negative / Null Result ReportOpen accessMedicine

Human <i>in vivo</i> assessment of ketamine binding of the serotonin transporter-follow up at a higher dose.

Schlosser G, Murgaš M, Godbersen GM et al. · 2025 · Frontiers in neuroscience

Ketamine is a rapid-acting antidepressant approved in the indication of treatment-resistant depression. As its clinical use expands, identifying underlying molecular mechanisms is essential. The serotonin transporter (SERT) is well known…

View details →DOI: 10.3389/fnins.2025.1651016
Negative / Null Result ReportOpen accessMedicine

Exploring physiological factors underlying individual differences in exercise-induced blood pressure responses.

Ogoh S, Takeda R, Kunimatsu N et al. · 2026 · Experimental physiology

Even among healthy individuals, arterial blood pressure (ABP) responses to exercise vary widely. However, the mechanisms underlying this individual variability remain unclear. To investigate these mechanisms, 29 participants performed…

View details →DOI: 10.1113/ep093208
Negative / Null Result ReportOpen accessMedicine

The independent and combined effect of price increase and price labelling on sugar-sweetened beverage vending machine sales in an Australian university: a factorial randomised controlled trial.

Blake MR, Dancey J, Cameron AJ et al. · 2026 · The international journal of behavioral nutrition and physical activity

BACKGROUND: No studies have examined how price increases on unhealthy drinks in university vending machines impact customer purchasing or vendor financial implications. Vending machines often display prices only upon product selection,…

View details →DOI: 10.1186/s12966-026-01890-4
Negative / Null Result ReportOpen accessMedicine

Variations of sex-hormones in reproductive aged females do not impact the repeated bout effect following maximal unaccustomed eccentric exercise of the elbow flexors.

Rilling A, Power GA · 2025 · Biology of sport

Neuromuscular function is impaired following unaccustomed eccentric exercise, the repeated bout effect (RBE) however, protects from damage following a subsequent bout. Muscle damage may be mitigated in females due to protective effects of…

View details →DOI: 10.5114/biolsport.2025.150041
Negative / Null Result ReportMedicine

The effect of Section 1557 of the Affordable Care Act on surgical outcomes in non-English primary language speakers.

Bakillah E, Finn CB, Sharpe J et al. · 2024 · American journal of surgery

Background In 2016, Section 1557 mandated use of qualified language interpreter services. We examined the effect of Section 1557 on surgical outcomes. Methods Utilizing the Healthcare Cost and Utilization Project State Inpatient Database…

View details →DOI: 10.1016/j.amjsurg.2023.10.018
Negative / Null Result ReportMedicine

Interaction between cold ischemia time and Kidney Donor Profile Index on postrenal transplant outcomes.

Cashion WT, Zhang X, Puttarajappa C et al. · 2024 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

We analyzed whether there is an interaction between the Kidney Donor Profile Index (KDPI) and cold ischemia time (CIT) in recipients of deceased donor kidney transplant (KTs). Adults who underwent KTs in the United States between 2014 and…

View details →DOI: 10.1016/j.ajt.2024.01.026
Negative / Null Result ReportMedicine

Patients with chronic bipolar disorder show impairments in interpreting literary fiction - A preliminary explorative study with the short story task.

Herold M, Kovács GX, Herold R et al. · 2024 · Journal of psychiatric research

Introduction Theory of mind (ToM) is a crucial skill in navigating and functioning in the social world. Significant ToM impairment was consistently found in bipolar disorder; it can be both a state and trait marker of the disorder.…

View details →DOI: 10.1016/j.jpsychires.2024.01.022
Negative / Null Result ReportOpen accessMedicine

Impact of a brief series of soccer matches on vascular conditions in youth women.

Sugawara J, Ogoh N, Watanabe H et al. · 2024 · Frontiers in physiology

Background Accumulative excessive physical load elevates central arterial stiffness and smooth muscular tone of peripheral vascular beds in endurance athletes. The aim of this study was to test the hypothesis that a brief series of soccer…

View details →DOI: 10.3389/fphys.2024.1476627
Negative / Null Result ReportOpen accessMedicine

Correlation of Physical Activity Level with Muscle Strength and Size During One Week of Knee Joint Immobilization.

Harmon KK, Pourhatami Z, Malinowski D et al. · 2025 · Journal of functional morphology and kinesiology

Background : Knee joint immobilization is common after surgery or injury. Whether remaining physically active during immobilization preserves muscle strength and size has not been studied. Objectives : This observational study examined…

View details →DOI: 10.3390/jfmk10020192
Negative / Null Result ReportMedicine

The emergence of inflammatory microglia during gut inflammation is not affected by FFAR2 expression in intestinal epithelial cells or peripheral myeloid cells.

Caetano-Silva ME, Rund L, Vailati-Riboni M et al. · 2024 · Brain, behavior, and immunity

Gut inflammation can trigger neuroinflammation and is linked to mood disorders. Microbiota-derived short-chain fatty acids (SCFAs) can modulate microglia, yet the mechanism remains elusive. Since microglia do not express free-fatty acid…

View details →DOI: 10.1016/j.bbi.2024.03.016
Negative / Null Result ReportMedicine

Chronic estrogen supplementation in the aging castrated male rat is not associated with renal injury or activation of the renin angiotensin system.

Mallette JH, Crudup BF, Oudomrath Speyrer A et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

The biological effects of chronic estrogen supplementation on renal function and injury with aging in men are unknown. Using an experimental model of feminizing hormone therapy (FHT) induced by 17β-estradiol (E2) (5 mg/kg sc)…

View details →DOI: 10.1152/japplphysiol.00052.2026
Negative / Null Result ReportMedicine

Light exposure impact on cardiac autonomic control before and following exercise.

Marin TC, Oliveira GF, Azevêdo LM et al. · 2025 · Chronobiology international

We aimed to investigate whether bright light (BL) exposure affects sympathovagal activity in controlling heart rate (HR) before and after exercise. Eighteen healthy men (28 ± 4 years) underwent two experimental conditions: one under BL…

View details →DOI: 10.1080/07420528.2025.2556841
Negative / Null Result Report

Brain Glutathione and GABA+ levels in autistic children

Song Y, Hupfeld KE, Davies-Jenkins CW et al. · 2023 · Preprint

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication challenges and repetitive behaviors. Altered neurometabolite levels, including glutathione (GSH) and gamma-aminobutyric acid (GABA),…

View details →DOI: 10.1101/2023.09.28.559718
Negative / Null Result ReportMedicine

Tell Me about yourself: Analyzing self-referential language use in borderline personality disorder.

Welch JE, Luo W, Ambroise KJ et al. · 2024 · Journal of psychiatric research

Depression and some other illnesses are associated with increased self-reference and negative emotion in language. Research findings on lexical patterns in Borderline Personality Disorder (BPD) have been inconsistent. We conducted two…

View details →DOI: 10.1016/j.jpsychires.2024.11.011
Negative / Null Result ReportMedicine

The Contemporary Probability of Occult Colorectal Cancer in Patients With Colitis-Related Dysplasia Undergoing Colectomy.

Boparai ES, Lee JK, Zhu S et al. · 2023 · The American journal of gastroenterology

Occult colorectal cancer (CRC) has historically driven recommendations for colectomy in patients with inflammatory bowel disease with dysplasia . We defined the contemporary risk of occult CRC at colectomy among 93 patients with…

View details →DOI: 10.14309/ajg.0000000000002291
Negative / Null Result ReportOpen accessMedicine

Effect of Ramp Lesions on Outcomes After Anterior Cruciate Ligament Reconstruction.

Ishibashi HK, Sasaki E, Chiba D et al. · 2025 · Orthopaedic journal of sports medicine

Background Ramp lesions (RLs) associated with anterior cruciate ligament (ACL) injury increase knee instability. However, whether RLs should be treated surgically remains unclear. Purpose/hypothesis This study aimed to investigate the…

View details →DOI: 10.1177/23259671241308015
Negative / Null Result ReportOpen accessMedicine

Participants with restricted dominant shoulder internal rotation range of motion demonstrate no side-to-side difference in humeral head translation; and no difference before and after joint mobilization: a pilot study.

Hoops JF, Hooper TL, Sobczak S et al. · 2024 · Journal of physical therapy science

[Purpose] To compare humeral head translation (HHT) during shoulder elevation between dominant and non-dominant shoulders in participants with limited dominant shoulder internal rotation range of motion (ROM). To determine if joint…

View details →DOI: 10.1589/jpts.36.259
Negative / Null Result ReportOpen accessMedicine

No effects of respiratory muscle endurance exercises on postprandial glucose excursions.

Beltrami FG, Mullarkey J, Spengler CM · 2026 · Frontiers in sports and active living

Introduction Whole-body exercise can attenuate postprandial glucose (PPG) excursions, one of the three main components in glucose control. Respiratory muscle endurance exercises (RMEE) based on resisted hyperpnea could offer an alternative…

View details →DOI: 10.3389/fspor.2026.1831908
Negative / Null Result ReportOpen accessMedicine

Parental political engagement and self-efficacy: An exploratory study.

Randolph C, Needlman R, Hutchinson E · 2024 · American journal of community psychology

Political engagement (PE) is associated with a sense of empowerment. PE by parents affects children's lives. This study explored parents' attitudes about inclusion of political engagement discussion in well-child care. Because voting is an…

View details →DOI: 10.1002/ajcp.12761
Negative / Null Result ReportMedicine

Patterns of Symptom Change in Behaviors and Cognitions During 10-Session Cognitive Behavioral Therapy (CBT-T) for Non-Underweight Eating Disorders.

Kambanis PE, Graver H, Palmer LP et al. · 2025 · The International journal of eating disorders

Objective Little is known about the timing of behavioral versus cognitive change in 10-session cognitive-behavioral therapy for non-underweight eating disorders (CBT-T). We aimed to: (a) evaluate the magnitude of behavioral and cognitive…

View details →DOI: 10.1002/eat.24429
Negative / Null Result ReportOpen accessMedicine

Exosome enriched serum enhances engineered ligament mechanics and collagen content with no additional benefit of resistance exercise.

Paulussen KJM, Hayden CMT, Griffin T et al. · 2025 · Matrix biology plus

Following resistance exercise, systemic changes foster improved functionality of tendons and ligaments. Post-exercise, muscle tissue releases exosomes that are thought to facilitate inter-tissue communication. To determine the potential…

View details →DOI: 10.1016/j.mbplus.2025.100181
Negative / Null Result ReportMedicine

Rete ridges are decreased in dyschromic burn hypertrophic scar: A histological study.

Carney BC, Travis TE, Keyloun JW et al. · 2024 · Burns : journal of the International Society for Burn Injuries

Dyschromic hypertrophic scar (HTS) is a common sequelae of burn injury, however, its mechanism has not been elucidated. This work is a histological study of these scars with a focus on rete ridges. Rete ridges are important for normal skin…

View details →DOI: 10.1016/j.burns.2023.09.005
Negative / Null Result ReportOpen accessMedicine

Modulation of response inhibition with event-related atVNS showed EEG but no behavioral effects.

Becker LF, Sallandt GM, Rosolowsky E et al. · 2025 · Scientific reports

Response inhibition can be explained within the theory of event coding. Event file binding and reconfiguration have previously been studied in relation to various neurotransmitters. We aimed to activate the noradrenergic system through…

View details →DOI: 10.1038/s41598-025-24491-w
Negative / Null Result ReportOpen accessMedicine

Comparison of Medial Meniscus Root Repair with Two Surgical Techniques Using Medial and Lateral Tunnels: A Prospective Cohort Study.

Shahsavari Pour A, Hosseini A, Ghomashi I et al. · 2026 · The archives of bone and joint surgery

Objectives This study aimed to compare the clinical outcomes of trans-tibial pullout repair of the medial meniscus posterior root using the lateral tibial tunnel versus the conventional medial tibial tunnel. Methods In this prospective…

View details →DOI: 10.22038/abjs.2025.86673.3939
Negative / Null Result ReportOpen accessMedicine

Does the change between the native and the prosthetic posterior tibial slope influence the clinical outcomes after posterior stabilized TKA? A review of 793 knees at a minimum of 5 years follow-up.

Alhamdi H, Deroche E, Shatrov J et al. · 2025 · SICOT-J

Introduction The understanding of the influence of posterior tibial slope (PTS) on knee kinematics has increased. However, the PTS influence on clinical outcomes remains unclear. The study aimed to evaluate whether a significant change…

View details →DOI: 10.1051/sicotj/2025014