e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19847 results in Negative / Null Result Report · page 301 of 662

Negative / Null Result ReportMedicine

Clinical Features, Treatment, and Outcomes of Nivolumab-induced Autoimmune Hemolytic Anemia.

Liu M, Kong L, Sun W et al. · 2026 · Journal of immunotherapy (Hagerstown, Md. : 1997)

To investigate the clinical profile of nivolumab-induced autoimmune hemolytic anemia (AIHA) and to reveal the diagnostic and therapeutic patterns of this disease. Articles on nivolumab-induced AIHA published before October 31, 2025 were…

View details →DOI: 10.1097/cji.0000000000000612
Negative / Null Result ReportMedicine

When the test lies: Fatal cryptococcosis and the prozone effect in advanced HIV infection.

Costa M, Rodrigues P, Araújo B et al. · 2026 · Diagnostic microbiology and infectious disease

Cryptococcal meningitis is a life-threatening opportunistic infection in advanced HIV disease. Cryptococcal antigen (CrAg) detection by lateral flow assay (LFA) is the diagnostic cornerstone, offering high sensitivity and specificity.…

View details →DOI: 10.1016/j.diagmicrobio.2026.117512
Negative / Null Result ReportOpen accessMedicine

False-negative results of combined endobronchial and endoscopic ultrasound in mediastinal staging of lung cancer.

Gambuś K, Moszczyński K, Popovchenko S et al. · 2026 · Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

Introduction Accurate assessment of mediastinal lymph node involvement is crucial for treatment planning in lung cancer. Combined endobronchial and endoscopic ultrasound (CUS) offers high sensitivity and negative predictive value (NPV),…

View details →DOI: 10.5114/kitp.2026.160677
Negative / Null Result Report

Anterior middle cingulate cortex gamma-aminobutyric acid level is elevated in children with both familial and prenatal alcohol exposure-associated attention deficit hyperactivity disorder

Alger JR, Gupta I, Farkouh L et al. · 2026 · Preprint

Background Prior neuroimaging suggests brain differences between children with attention deficit hyperactivity disorder due to prenatal alcohol exposure (ADHD+PAE) and non-exposed children with ADHD due to other, e.g., familial, causes…

View details →DOI: 10.64898/2026.05.25.26354065
Negative / Null Result ReportMedicine

[Tuberculous mastitis: A rare manifestation of extrapulmonary tuberculosis].

Dellbrügge F, Schaumann N, Kruppa M et al. · 2026 · Pneumologie (Stuttgart, Germany)

Abstract We present the case of a 39-year-old Indian female patient diagnosed with tuberculous mastitis and lymph node tuberculosis. The patient had a history of tuberculosis infection treatment as a newborn. She initially presented with…

View details →DOI: 10.1055/a-2845-3440
Negative / Null Result ReportMedicine

A Case Report of HIV Transmission Within a Household Involving a Married Man Who Has Sex with Men in China.

Li X, Huang Y, Hao J et al. · 2026 · Current HIV research

Background Married Men who have Sex with Men (MSM) constitute a bridge population for HIV diffusion into low-risk groups, with spousal non-disclosure rates exceeding 60% in China. It will increase the risk of secondary transmission within…

View details →DOI: 10.2174/011570162x444930260409114355
Negative / Null Result ReportMedicine

Evaluation of a Point-of-Care Multiplex PCR Analyser for Detection of <i>Babesia gibsoni</i> in the Canine Population of Hong Kong.

Tsang SM, Merino Gutierrez V, Yu J et al. · 2026 · Veterinary sciences

Canine babesiosis caused by Babesia gibsoni is prevalent in Hong Kong. While molecular diagnosis via PCR is highly sensitive, it typically requires reference laboratory access, delaying clinical decisions. This study evaluated the…

View details →DOI: 10.3390/vetsci13060548
Negative / Null Result ReportMedicine

The Usefulness of Antinuclear Antibody Multiplex Immunoassay for Screening of Rheumatological Diseases: A Real-World Population-Based Study.

Hijaze E, Razi T, Arbel R et al. · 2026 · Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

Objective To evaluate the diagnostic performance of BioPlex 2200 multiplex immunoassay (BI) for detecting antinuclear antibodies (ANA), compared with the gold standard, the indirect immunofluorescence assay (IIF), as a screening…

View details →DOI: 10.1097/rhu.0000000000002372
Negative / Null Result ReportMedicine

Early computed tomography may miss main pancreatic duct injury in distal pancreatic trauma: a prospective surgically verified diagnostic accuracy study.

Tri PM, Hung NT, Liet DH et al. · 2026 · Emergency radiology

Purpose To assess the diagnostic performance of computed tomography (CT) for predicting main pancreatic duct injury in surgically explored patients with distal pancreatic trauma. Methods We conducted a prospective single-center diagnostic…

View details →DOI: 10.1007/s10140-026-02504-z
Negative / Null Result ReportMedicine

[Evaluation of the screening performance of ultrasound for fatty liver using transient elastography in the elderly population of Shanghai communities].

Wei XT, Zhu LY, Wu YL et al. · 2026 · Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

Objective: To evaluate the screening performance and related factors of ultrasound for hepatic steatosis in community-based elderly populations using controlled attenuation parameter (CAP) measured by transient elastography as the…

View details →DOI: 10.3760/cma.j.cn112338-20250626-00436
Negative / Null Result Report

Diagnostic Accuracy of Magnetic Resonance Imaging versus Computed Tomography for Lumbar Spondylolysis in Patients with Chronic Low Back Pain: A Single-Center Retrospective Study

TEZCE A, DURMUŞ E · 2026 · Preprint

Abstract Purpose The objective of this study is to compare the diagnostic efficacy of Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) in detecting lumbar spondylolysis among patients presenting with chronic low back pain, and…

View details →DOI: 10.21203/rs.3.rs-9247900/v1
Negative / Null Result ReportOpen accessMedicine

Diagnostic and therapeutic impact of PCR in uveitis: real-world data from intraocular fluid analysis of 45 uveitis patients in a tertiary referral center in Turkey.

Zorlutuna Kaymak N, Pekel İ, Demir Tekol S et al. · 2026 · BMC ophthalmology

Purpose To evaluate the diagnostic utility and real-world clinical impact of polymerase chain reaction (PCR) analysis of aqueous humor (AH) and vitreous samples in patients with uveitis including suspected infectious and mixed…

View details →DOI: 10.1186/s12886-026-05002-5
Negative / Null Result ReportMedicine

[Expert consensus on newborn genetic screening process, interpretation of results, and recall (2026 Edition)].

Genetic And Metabolic Disorders Screening Subgroup Of The Birth Defects Prevention And Control Committee Chinese Preventive Medicine Association, Rare Diseases Branch Of Shandong Medical Association, Genetic Metabolism Branch Of Shandong Provincial Rare Disease Association et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

High-throughput sequencing technology has recently been used in neonatal disease screening. To address the issues related to the screening process, interpretation of screening results, and recall of positive cases in neonatal genetic…

View details →DOI: 10.3760/cma.j.cn511374-20250922-00559
Negative / Null Result ReportMedicine

Detection of <i>Aphelenchoides besseyi</i> in Major Rice-Growing Regions of Portugal: Tracing a Possible Introduction Pathway Through Seed Trade.

Inácio ML, Rusinque L, Nóbrega F et al. · 2026 · Plant disease

Aphelenchoides besseyi , the causal agent of the white-tip disease, is a quarantine nematode known to affect rice ( Oryza sativa ) by colonizing leaf tips and panicles. In January 2021, A. besseyi was detected in Portugal in imported…

View details →DOI: 10.1094/pdis-07-25-1513-sc
Negative / Null Result ReportMedicine

Political trust and health compliance during a health crisis: A systematic literature review from the COVID-19 pandemic.

Goren T, Vashdi DR, Beeri I · 2026 · Social science & medicine (1982)

Political trust is considered crucial for enhancing civic compliance with government policies and instructions, particularly during a health crisis. However, evidence from the COVID-19 pandemic, a major global health crisis, suggest a more…

View details →DOI: 10.1016/j.socscimed.2026.119093
Negative / Null Result ReportMedicine

Editorial: Stratified, Stepped Care for Youth at Risk for Suicidal Behavior.

Brent DA · 2026 · Journal of the American Academy of Child and Adolescent Psychiatry

In this issue of JAACAP, Asarnow and colleagues report the results of their innovative, elegantly conducted clinical trial that assessed the added value of stratified, stepped care (SSC) for youth at risk for suicidal behavior in a health…

View details →DOI: 10.1016/j.jaac.2026.02.001
Negative / Null Result ReportMedicine

18F choline PET/MR to assess clinically significant disease in prostate cancer: correlation with maximum and total cancer core length obtained via template mapping biopsies.

Haroon A, Almuhaideb A, Adeleke S et al. · 2026 · Nuclear medicine communications

Objective To assess the accuracy of 18F choline PET/magnetic resonance (MR) when compared with the reference standard MRI-guided template mapping (TPM) biopsies for evaluation of biochemical relapse of prostate cancer in patients with…

View details →DOI: 10.1097/mnm.0000000000002158
Negative / Null Result ReportOpen accessMedicine

The sonographic Murphy sign: does analgesia matter?

Goldstein EL, Marcelo KR, Harjes WR et al. · 2025 · Emergency radiology

Purpose Controversy exists regarding analgesia premedication prior to right upper quadrant ultrasound (RUQUS) in the setting of abdominal pain when evaluating for acute cholecystitis (AC). The purpose of this study was to examine the…

View details →DOI: 10.1007/s10140-025-02387-6
Negative / Null Result Report

Decline of PD-L1 Immunoreactivity with Storage Duration in Formalin-Fixed Paraffin-Embedded Breast Cancer Specimens: Implications for Diagnostic Accuracy and Immunotherapy Eligibility in Triple-Negative Breast Cancer

Yanagihara K, Nagata K, Yamakawa T et al. · 2025 · Preprint

Backgrounds: . Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of…

View details →DOI: 10.20944/preprints202508.1544.v1
Negative / Null Result ReportOpen accessMedicine

A machine learning algorithm to predict the success of a second microsurgical testicular sperm extraction.

Obeidat A, Sabbah BN, Mandourah H et al. · 2025 · Annals of medicine and surgery (2012)

Introduction Testicular sperm extraction (TESE) is a common procedure for retrieving sperm in men with azoospermia. However, the success rates of a second TESE following an initial unsuccessful attempt remain low. This study aims to…

View details →DOI: 10.1097/ms9.0000000000003560
Negative / Null Result ReportMedicine

Underutilization of fentanyl testing masks substantial fentanyl exposure in routine urine drug screens in Indiana.

Olaniyan H, Beckman J, Crosby E et al. · 2026 · Clinica chimica acta; international journal of clinical chemistry

Objectives Timely and locally relevant drug testing is helpful for overdose assessment; however, immunoassay (IA)-based urine drug screens (UDS) often fail to detect emerging substances. This study assesses fentanyl screen utilization and…

View details →DOI: 10.1016/j.cca.2026.120948
Negative / Null Result ReportMedicine

Clinical significance of negative BioFire® pneumonia panel in ICU: Diagnosis, management, and outcomes.

Nardy T, Rondinaud E, Dessajan J et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives This study assessed the clinical significance of negative BioFire® FilmArray® Pneumonia Panel (FA-PP) results in ICU patients with suspected hospital-acquired (HAP) or ventilator-associated pneumonia (VAP), evaluating its impact…

View details →DOI: 10.1016/j.ijid.2026.108665
Negative / Null Result ReportMedicine

Evaluation of the stability and cross-reactivity of zopiclone and eszopiclone using immunoassay kits.

Saito T, Namera A, Yamamoto R et al. · 2026 · The Journal of toxicological sciences

Zopiclone (ZOP) and eszopiclone (EZOP) are hypnotics belonging to the cyclopyrrolone class, which are metabolized to zopiclone-N-oxide (ZOPNO) and N-desmethylzopiclone (NDZOP), respectively, and finally to 2-amino-5-chloropyridine (2A5C)…

View details →DOI: 10.2131/jts.51.173
Negative / Null Result ReportMedicine

A critical review of styrene and styrene-7,8-oxide genotoxicity literature: an update.

Pottenger LH, Banton M, Barranco WT et al. · 2026 · Journal of environmental science and health. Part C, Toxicology and carcinogenesis

Recent studies investigating mutagenic/cytogenetic effects of styrene and styrene-7,8-oxide (SO) were reviewed to update published critical evaluations of these data from 2019. Transcriptomics studies relevant to styrene/SO genotoxicity…

View details →DOI: 10.1080/26896583.2026.2623381