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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19847 results in Negative / Null Result Report · page 300 of 662

Negative / Null Result Report

Combined Ketamine and Psychotherapy Provide No Additional Benefit Beyond Ketamine Alone in Treating Depression or PTSD: Evidence from a Help-Seeking Sample

Moore TM, Walker K, Tung E et al. · 2024 · Preprint

Depression and PTSD are prevalent psychiatric conditions that often co-occur and significantly impact quality of life. Ketamine has emerged as a promising rapid-acting treatment for both conditions, while traditional treatments like…

View details →DOI: 10.31234/osf.io/cs24j
Negative / Null Result Report

Effects of Resistance Training Exercise on Cognitive Functioning in Older Adults with and without Chronic Obstructive Pulmonary Disease (COPD)

Andreassen M, Larsen EO, Mølmen KS et al. · 2024 · Preprint

Abstract Introduction: A positive relationship between physical exercise training and cognitive function in humans is well-established. However, knowledge of how resistance exercise training affects patients with chronic obstructive…

View details →DOI: 10.21203/rs.3.rs-4842070/v1
Negative / Null Result ReportMedicine

Effects of oxotremorine on convulsions in mice induced by scopolamine and food intake after fasting.

Midilli B, Nurten A, Gürtekin B et al. · 2025 · Behavioural brain research

Antimuscarinic administration and food intake cause convulsions in mice and rats after fasting for 48 h or less. Increased M 1 and M 2 muscarinic receptor expression in brain regions during fasting, and reversal of changes by refeeding may…

View details →DOI: 10.1016/j.bbr.2024.115402
Negative / Null Result ReportOpen accessMedicine

Patients undergoing thyroid surgery suffer preoperatively from poor quality of life.

Honkanen J, Molnár K, Karhumaa T et al. · 2025 · Journal of endocrinological investigation

Purpose Thyroid surgery is performed for various indications, including goiter, suspected or diagnosed malignancy, and hyperthyroidism. While previous studies have focused on postoperative quality of life (QoL) improvements, limited data…

View details →DOI: 10.1007/s40618-025-02661-x
Negative / Null Result ReportMedicine

Chronic Restraint Stress Did Not Alter Active Avoidance Coping or Neuronal Activation Levels of the Medial Prefrontal Cortex or the Nucleus Accumbens in Male Rats.

Kuan HY, Chang CH · 2024 · Journal of physiological investigation

Abstract Stress is an adaptive response crucial for survival. However, chronic stress can lead to maladaptive behaviors and health issues. Prolonged stress reduces the flexibility of defensive coping behaviors. Previous studies have shown…

View details →DOI: 10.4103/ejpi.ejpi-d-24-00066
Negative / Null Result ReportOpen accessMedicine

Human corticospinal tract lateralization at the height of the internal capsule is not related to handedness.

Domin M, Lindenberg R, Lotze M · 2025 · Scientific reports

Evaluating the integrity of the corticospinal tract at the height of the posterior limb of the internal capsule with a lateralization index has been applied to predict upper limb motor recovery after stroke in numerous diffusion tensor…

View details →DOI: 10.1038/s41598-025-19580-9
Negative / Null Result ReportMedicine

Glucocorticoid and glycemic responses to immune challenge in a viviparous snake afflicted with an emerging mycosis.

Lind CM, Agugliaro J, Ortega J et al. · 2024 · The Journal of experimental biology

Disease may be both a cause and a consequence of stress, and physiological responses to infectious disease may involve stress coping mechanisms that have important fitness consequences. For example, glucocorticoid and glycemic responses…

View details →DOI: 10.1242/jeb.247962
Negative / Null Result ReportMedicine

Age-related changes in time perception: Effects of immersive virtual reality and spatial location of stimuli.

Bogon J, Jagorska C, Steinecker I et al. · 2024 · Acta psychologica

The perception of time is subject to various environmental influences and exhibits changes across the lifespan. Studies on time perception have often been conducted using abstract stimuli and artificial scenarios, and recent claims for…

View details →DOI: 10.1016/j.actpsy.2024.104460
Negative / Null Result ReportOpen accessMedicine

Associations of mid-childhood per- and polyfluoroalkyl substances and early childhood metals with mid-childhood antibody titers.

Smith A, Lin PD, Rifas-Shiman SL et al. · 2026 · Environmental epidemiology (Philadelphia, Pa.)

Background Per- and polyfluoroalkyl substances (PFAS) and nonessential metals impair immune responses, while essential metals promote immune maintenance. We evaluated associations of childhood PFAS and metal mixtures with measles, mumps,…

View details →DOI: 10.1097/ee9.0000000000000471
Negative / Null Result Report

Chronosequence and Temporal Changes in Soil Traits, Vegetation Structure and Leaf Traits in a Tropical Dry Forest in Brazil

Ferreira KF, Silva JO, Reyes PC et al. · 2024 · Preprint

The structure and diversity of tropical vegetation are shaped by biotic and abiotic factors, which function as environmental filters affecting plant performance in different spatial and temporal scales. We compared soil traits, vegetation…

View details →DOI: 10.20944/preprints202408.1237.v1
Negative / Null Result ReportMedicine

The interplay between ADHD and school shift on educational outcomes in children and adolescents: a cross-sectional and longitudinal analysis.

Porto IM, do Amaral JV, Pacheco JPG et al. · 2025 · European child & adolescent psychiatry

Many countries implement double-shift schooling systems, offering morning or afternoon shifts. Given attention-deficit/hyperactivity disorder (ADHD) is associated with circadian preference for eveningness, this study hypothesised that…

View details →DOI: 10.1007/s00787-025-02758-x
Negative / Null Result ReportOpen accessMedicine

Behavioral and neurophysiological changes associated with a single session of bimanual task practice after stroke.

Jacob J, Hesling-Fox J, Yamada M et al. · 2026 · Clinical neurophysiology practice

Objective Stroke survivors often show slower, uncoordinated bimanual performance. This study examined the effects of a single session of bimanual task practice on performance, coordination, motor corticospinal excitability (CSE), and…

View details →DOI: 10.1016/j.cnp.2026.05.005
Negative / Null Result ReportOpen accessMedicine

Enhancing Experience-Dependent Plasticity Accelerates Vision Loss in a Murine Model of Retinitis Pigmentosa.

Attaway CA, Brown TC, McCall MA et al. · 2026 · Investigative ophthalmology & visual science

Purpose Retinitis pigmentosa (RP) causes retinal degeneration and the progressive loss of vision. Here, we evaluated whether enhancing experience-dependent plasticity prolongs vision in a mouse genetic model of autosomal dominant RP.…

View details →DOI: 10.1167/iovs.67.3.15
Negative / Null Result ReportMedicine

Do French speakers have an advantage in learning English vocabulary thanks to familiar suffixes?

Menut A, Brysbaert M, Casalis S · 2024 · Quarterly journal of experimental psychology (2006)

Previous research has shown that languages from nearby families are easier to learn as second languages (L2) than languages from more distant families, attributing this difference to the presence of shared elements between the native…

View details →DOI: 10.1177/17470218241245685
Negative / Null Result ReportMedicine

Neighborhood deprivation is not associated with abortion consideration or completion in patients with fetal myelomeningocele.

Papastefan ST, Bian Y, Singh M et al. · 2024 · Prenatal diagnosis

Objective The objective of this study was to evaluate whether patient-level neighborhood deprivation index (NDI) was associated with termination of pregnancy consideration and completion in patients presenting with fetal myelomeningocele.…

View details →DOI: 10.1002/pd.6633
Negative / Null Result ReportOpen accessMedicine

The effects of approach bias modification on smoking cue-reactivity in individuals who smoke: A randomized controlled fMRI study.

Motka F, Tan H, Vollstädt-Klein S et al. · 2026 · Scientific reports

Approach bias modification (ApBM), a computerized training designed to retrain involuntary approach action tendencies toward drug-related cues, has been shown to reduce relapse rates when added to treatment-as-usual (TAU) in alcohol use…

View details →DOI: 10.1038/s41598-026-45748-y
Negative / Null Result ReportMedicine

The urge to fill the void: Emptiness, impulsivity, and mentalizing in the daily life of individuals with borderline personality disorder.

Sheena-Peer L, Rafaeli E, Berenson KR et al. · 2025 · Personality disorders

Emptiness is central to borderline personality disorder (BPD), significantly impacts quality of life, and is associated with increased impulsivity. Nevertheless, studies of emptiness in daily life are scarce and little is known about…

View details →DOI: 10.1037/per0000721
Negative / Null Result ReportMedicine

Industry Interactions at Medical Conferences: Representatives' Credentials and the Disclosure of Data Limitations Influence Clinician Perceptions.

O'Donoghue AC, Aikin KJ, Amoozegar JB et al. · 2025 · Journal of the American Board of Family Medicine : JABFM

Purpose Exhibit hall booths at medical conferences are a key avenue for promoting prescription drugs to health care providers (HCPs). Because HCPs spend considerable time interacting with industry representatives at conferences, we…

View details →DOI: 10.3122/jabfm.2024.240368r1
Negative / Null Result ReportMedicine

Should Communication Campaigns Promoting Vaccination Address Misinformation Beliefs? Implications from a Nationally Representative Longitudinal Survey Study among U.S. Adults.

Clark D, Kikut-Stein A, Jesch E et al. · 2024 · Journal of health communication

Public health communication campaign planners must carefully consider whether misinformation beliefs are important to target and, ideally, correct. Guided by the reasoned action approach, we hypothesized that behavior-specific beliefs…

View details →DOI: 10.1080/10810730.2024.2331488
Negative / Null Result ReportOpen accessMedicine

Social working memory in adolescence.

Grunewald K, Andrews JL, Schweizer S · 2026 · Child development

Little is known about how social network associations are tracked in cognition during adolescence, when social networks change in size and complexity. In 2023, 123 ethnically diverse adolescents and emerging adults (13-24 years; 52.9%…

View details →DOI: 10.1093/chidev/aacaf039
Negative / Null Result ReportOpen accessMedicine

Environmental Supports, Expectations, and Barriers to Leisure-Time Physical Activity During Pregnancy: A Rural-Urban Comparison.

Rogers CW, Crisp A, Wilhite K et al. · 2026 · The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association

Background Physical activity (PA) during pregnancy has well-documented benefits, yet pregnant rural residents may face additional barriers to PA. Objective To examine whether leisure-time physical activity (LTPA) and correlates of LTPA,…

View details →DOI: 10.1111/jrh.70166