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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20233 results in Negative / Null Result Report · page 299 of 675

Negative / Null Result ReportOpen accessMedicine

Absence of lipopolysaccharide (LPS) expression in breast cancer cells.

de Miranda NFCC, Smit VTHBM, van der Ploeg M et al. · 2025 · Cellular oncology (Dordrecht, Netherlands)

The relationship between bacterial activity and tumorigenesis has gained attention in recent years, complementing the well-established association between viruses and cancer. A recent study employed immunodetection of lipopolysaccharide…

View details →DOI: 10.1007/s13402-025-01071-8
Negative / Null Result ReportOpen accessMedicine

Use of baloxavir as adjunctive antiviral therapy to neuraminidase inhibitors in severely immunocompromised individuals infected with influenza.

Vetter P, Cabecinhas ARG, Schibler M et al. · 2026 · Antimicrobial agents and chemotherapy

Immunocompromised patients are at risk of developing severe influenza, with protracted viral shedding and development of resistance-associated mutations under antiviral treatment. We report a case series of severely immunocompromised…

View details →DOI: 10.1128/aac.01659-25
Negative / Null Result ReportMedicine

Leukocyte-Poor Platelet-Rich Plasma as a Treatment for Patellar Tendinopathy A Multicenter, Randomized Controlled Trial.

Herrero C, Wasterlain A, Bloom DA et al. · 2024 · Bulletin of the Hospital for Joint Disease (2013)

Purpose The purpose of this study was to compare regimens of eccentric exercise and dry-needling, with and without an ultrasound-guided leukocyte-poor platelet-rich plasma (LP-PRP) injection, in patients with patellar tendinopathy. Methods…

Negative / Null Result ReportOpen accessMedicine

An analytical observational study for diagnostic accuracy of volume, conductivity & scatter (VCS) indices of neutrophils for diagnosis of sepsis in an emergency hospital setting.

Bharti A, Palta A, Bedi RK et al. · 2024 · The Indian journal of medical research

Background & objectives The newer technique using an innovative volume conductivity scatter (VCS) technology is emerging as a surrogate for sepsis diagnosis. The VCS technology offers a more objective method to measure cell volume (V),…

View details →DOI: 10.25259/ijmr_1898_23
Negative / Null Result ReportOpen accessMedicine

In Vitro Assessment of the Potential Effect of Vertical Peri-Implant Soft Tissue Thickness on Nonsurgical and Surgical Implant Surface Decontamination Methods.

Rahner A, Eickholz P, Gueth JF et al. · 2025 · Clinical oral implants research

Objectives In vitro analysis of the influence of vertical peri-implant soft tissue thickness (STT) on nonsurgical and surgical implant surface decontamination efficacy. Material and methods A total of 360 implants were dipped in indelible…

View details →DOI: 10.1111/clr.14415
Negative / Null Result ReportMedicine

Comparison of computed tomography findings between perianal tumors originating from the anal sacs and perianal glands in dogs.

Jeong J, Goh J, Nam C et al. · 2025 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

Tumors originating from the anal sacs and perianal glands are common tumors of the perianal region. However, differentiation of perianal tumors based on CT findings remains challenging because perianal tumors can show overlapping CT…

View details →DOI: 10.1111/vru.13453
Negative / Null Result ReportOpen accessMedicine

A ubiquitous organophosphate flame retardant disrupts energy and glucose homeostasis in mice.

Sewell KM, Oriakhi K, Ngo Tenlep SY et al. · 2026 · Ecotoxicology and environmental safety

Organophosphate flame retardants (OPFRs) are used in many consumer products, and their presence in our environment raises concerns about potential health dangers. In humans, exposure to OPFRs, such as tris(1,3-dichloro-2-propyl) phosphate…

View details →DOI: 10.1016/j.ecoenv.2026.119827
Negative / Null Result ReportOpen accessMedicine

An Observational Study on Clinical Insights and Outcome Prediction of Lupus Enteritis in Indian Systemic Lupus Erythematosus Patients.

Kotha S, Baisya R, Yerram KV et al. · 2025 · Mediterranean journal of rheumatology

Background Lupus enteritis (LE) is the most common serious gastrointestinal manifestation of SLE. Indian literature on LE is limited, while most of the data comes from China and Western series with recent efforts on developing prediction…

View details →DOI: 10.31138/mjr.300924.ioe
Negative / Null Result ReportOpen accessMedicine

An atypical manifestation of Giant cell arteritis (GCA): constitutional symptoms & lingual ulcer in a 78-Year-Old male with negative temporal artery biopsies.

Gow J, Roofeh D · 2025 · BMC rheumatology

Background Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features which…

View details →DOI: 10.1186/s41927-025-00505-y
Negative / Null Result ReportMedicine

Robotic carotid artery stenting: a multicenter, propensity score-matched analysis of clinical outcomes and cost-effectiveness.

Patel SA, Roy JM, Musmar B et al. · 2024 · Neurosurgical focus

Objective Preclinical studies suggest that robotic carotid artery stenting (CAS) could be superior to manual CAS. However, very limited comparative data exist for patients who have undergone robotic versus manual CAS. In addition, no data…

View details →DOI: 10.3171/2024.9.focus24479
Negative / Null Result ReportMedicine

The level of agreement between the numerical rating scale and visual analogue scale for assessing pain intensity in adults with chronic pain.

Goudman L, Pilitsis JG, Billet B et al. · 2024 · Anaesthesia

The numerical rating scale and visual analogue scale are used to quantify pain intensity. However, it has not yet been explored whether these scores are interchangeable in adults with chronic pain. Data from the prospective multicentre…

View details →DOI: 10.1111/anae.16151
Negative / Null Result ReportMedicine

Long-term impact of posterior reconstruction urethrovesical anastomosis during robot-assisted prostatectomy A secondary analysis of a randomized cohort.

Millan B, Hoogenes J, Uy M et al. · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction We aimed to assess early and late continence rates post-robot-assisted radical prostatectomy (RARP), comparing posterior reconstruction (PR) urethrovesical anastomosis (UVA) to conventional urethrovesical anastomosis (C-UVA).…

View details →DOI: 10.5489/cuaj.9121
Negative / Null Result ReportOpen accessMedicine

Children with Dyslexia Benefit from Short Combined Reading and Motor Training: Objective Measures Assessed by Eye Movements and Postural Sway Recordings.

Caldani S, Khoury E, Delorme R et al. · 2025 · Brain sciences

Background/Objectives: Children with dyslexia report poor motor control; several studies have shown poor eye movements control during reading and important body instability in these children. The present study aimed to test in children…

View details →DOI: 10.3390/brainsci15111218
Negative / Null Result ReportMedicine

Sensory Stimulation and Robot-Assisted Arm Training After Stroke: A Randomized Controlled Trial.

Egger M, Bergmann J, Krewer C et al. · 2024 · Journal of neurologic physical therapy : JNPT

Background and purpose Functional recovery after stroke is often limited, despite various treatment methods such as robot-assisted therapy. Repetitive sensory stimulation (RSS) might be a promising add-on therapy that is thought to…

View details →DOI: 10.1097/npt.0000000000000486
Negative / Null Result ReportOpen accessMedicine

Analysing the clinical outcomes between FIGO 2009 and 2023 staging for endometrial cancer-a single institution retrospective study.

Vuppu DP, Rajanbabu A, Nair IR et al. · 2025 · Ecancermedicalscience

The latest International Federation of Gynaecology and Obstetrics (FIGO) staging for endometrial cancer incorporated molecular profiles and histopathological factors into the basic staging framework. This study was done to determine its…

View details →DOI: 10.3332/ecancer.2025.1836
Negative / Null Result ReportOpen accessMedicine

Insulin resistance as a modifiable contributor to breast cancer: mechanisms, biomarkers, and therapeutic implications.

Marouf SP, Meskar Z, Rezaei N · 2026 · Discover oncology

Insulin resistance (IR) has emerged as a metabolically relevant contributor to the development and progression of breast cancer (BC), with a case fatality of nearly 15%. IR mainly shows a relationship with obesity, type 2 diabetes mellitus…

View details →DOI: 10.1007/s12672-026-04828-1
Negative / Null Result ReportMedicine

Development of an evaluation and treatment strategy for olfactory neuroblastoma: a review of evidence from large-scale studies, including population-based and multicenter studies, and meta-analyses.

Ariizumi Y, Asakage T · 2024 · Japanese journal of clinical oncology

Olfactory neuroblastoma is a rare sinonasal malignancy arising from the olfactory epithelium that is characterized by skull base involvement and a modest natural history. Because of its rarity and long course, identification of independent…

View details →DOI: 10.1093/jjco/hyae062
Negative / Null Result ReportMedicine

Alteration of methylation pattern and gene expression of FTO, PPARγ and Slc2a4 on pre-diabetes-induced BALB/c mice.

Listiyani P, Sanjaya R, Nathanael J et al. · 2025 · Molecular and cellular biochemistry

T2DM is a serious global health problem and usually caused by unhealthy diet, such diet with high carbohydrate or monosodium glutamate (MSG). In this study, we used the T2DM mice (BALB/c) model by exposing the mice with foods high in…

View details →DOI: 10.1007/s11010-024-05141-7
Negative / Null Result ReportMedicine

Immunonutrition to improve the quality of life of upper gastrointestinal cancer patients undergoing neoadjuvant treatment prior to surgery (NEOIMMUNE): double-blind randomized controlled multicenter clinical trial.

Markar S, Markar S, Mariette C et al. · 2025 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

Background Malnutrition is common with esophagogastric cancers and is associated with negative outcomes. We aimed to evaluate if immunonutrition during neoadjuvant treatment improves patient's health-related quality of life (HRQOL) and…

View details →DOI: 10.1093/dote/doae113
Negative / Null Result ReportOpen accessMedicine

Is fixation of a single end of flail segment rib fractures enough?

Perugini A, Iandoli J, Pelz N et al. · 2025 · Trauma surgery & acute care open

Background Segmental rib fractures in blunt thoracic trauma present with increased morbidity and mortality with an association of increased pulmonary insult and concomitant injuries. There is a paucity within the literature regarding the…

View details →DOI: 10.1136/tsaco-2024-001707
Negative / Null Result ReportMedicine

Fundus blood flow density changes in the smoking population by artificial intelligence-based optical coherence tomography angiography.

Zhang LY, Li QJ, Zhou Q et al. · 2025 · International journal of ophthalmology

Aim To determine whether chronic smoking affects fundus blood flow density using optical coherence tomography angiography (OCTA) based on artificial intelligence (AI). Methods All participants underwent a comprehensive ophthalmological…

View details →DOI: 10.18240/ijo.2025.09.01
Negative / Null Result ReportOpen accessMedicine

Evaluation of spot urine CA 19 - 9/creatinine ratio in diagnosis and management of hydronephrosis in children: a prospective study.

Kutukoglu MU, Altuntas T, Sekerci CA et al. · 2025 · BMC pediatrics

Background To demonstrate that the CA19-9/creatinine level could be a potential biomarker in children with obstruction by including ureteropelvic junction obstruction (UPJO) patients and comparing them not only with healthy controls but…

View details →DOI: 10.1186/s12887-025-06453-3
Negative / Null Result Report

Multiple solute binding proteins for gamma-aminobutyrate and 5-aminovalerate in Pseudomonas aeruginosa : assessment of their potential role in sensor kinase activation

Vargas JPC, Krell T · 2024 · Preprint

The canonical mode of receptor activation consists in the binding of signals or signal-loaded solute binding proteins (SBPs) to sensor domains. Many sensor histidine kinases (SHK), that are activated by SBP binding, are encoded next to…

View details →DOI: 10.22541/au.171656259.90626428/v1
Negative / Null Result ReportOpen accessMedicine

Neuromuscular and Neurocognitive Performance Associated with ACL Injury Risk in Youth Handball Players: A Prospective Cohort Study.

Sinka GC, Pavlik A, Mayer Á et al. · 2026 · Sports (Basel, Switzerland)

Background Anterior cruciate ligament (ACL) injuries in youth athletes are multifactorial, and the relative contributions of neuromuscular and neurocognitive variables remain inadequately comprehended. Methods In this prospective cohort…

View details →DOI: 10.3390/sports14050185