e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20233 results in Negative / Null Result Report · page 297 of 675

Negative / Null Result ReportMedicine

Transmucosal detomidine gel induces emesis in approximately half of cats presenting for dietary indiscretion.

Neufeld MR, Hanson KR, Mochel JP et al. · 2026 · Journal of the American Veterinary Medical Association

Objective To evaluate the efficacy and safety of transmucosal administration of detomidine gel to induce emesis in cats. Methods Cats presenting on an emergency basis due to dietary indiscretion were eligible for enrollment at 2 emergency…

View details →DOI: 10.2460/javma.25.10.0644
Negative / Null Result ReportOpen accessMedicine

Unplanned hospital presentations in oncology patients receiving chemotherapy: a secondary analysis of a randomized controlled trial to explore opportunities for improving supportive care.

Kim B, Boustany C, Fethney J et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Purpose This study aimed to report the incidence, common reasons, and associated risk factors for unplanned hospital presentations during chemotherapy treatment. Methods A secondary analysis using data from a randomized controlled trial…

View details →DOI: 10.1007/s00520-026-10510-7
Negative / Null Result ReportMedicine

Acute dysfunction of granular-based anaerobic reactor triggered by short-term exposure to colloid-containing wastewater: from irreversible sludge flotation to systemic failure.

Xie L, Lian H, Yin H et al. · 2026 · Bioresource technology

Inert colloidal substances (ICS) are ubiquitous in industrial wastewater; however, their effects on the stability of anaerobic granular sludge beds remain insufficiently understood. Using polyacrylamide as a model ICS, this study…

View details →DOI: 10.1016/j.biortech.2025.133919
Negative / Null Result ReportMedicine

Efficacy and safety of cannabidiol oil in psoriasis: a randomized, double-blind, placebo-controlled trial.

Roongpisuthipong W, Klangjareonchai T, Kurathong S et al. · 2026 · The Journal of dermatological treatment

Background The management of psoriasis presents challenges, prompting many patients to seek alternative treatments. Cannabidiol (CBD) has demonstrated potential antioxidant and anti-inflammatory properties which may offer therapeutic…

View details →DOI: 10.1080/09546634.2025.2604448
Negative / Null Result ReportMedicine

The effect of autologous platelet-rich plasma on donor site wound healing: a randomised crossover clinical trial.

Dasmeh U, Mohammadi AA, Shahrokhi R et al. · 2025 · Journal of wound care

Objective This study aimed to investigate whether application of autologous platelet-rich plasma (PRP) at split-thickness skin grafting (STSG) donor sites in patients with burns can promote wound healing. Method A randomised crossover…

View details →DOI: 10.12968/jowc.2023.0210
Negative / Null Result ReportMedicine

Dry Needling Plus Manual Therapy and Exercise for Subacromial Pain Syndrome: A Sham-Controlled Randomized Clinical Trial.

Hando BR, Rhon DI, Barker D et al. · 2026 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To determine the effect on Shoulder Pain and Disability Index (SPADI) scores of adding dry needling to a program of exercise and manual therapy in individuals with subacromial pain syndrome (SAPS). DESIGN: Three-arm randomized…

View details →DOI: 10.2519/jospt.2025.13460
Negative / Null Result ReportMedicine

Harvesting of peroneus longus tendon autograft

Liang C, He J · 2025 · Journal of Visualized Experiments

Autografts are always used in anterior cruciate ligament (ACL) reconstruction. Traditional sources, such as hamstring tendons, bone-patellar tendon-bone, and quadriceps tendon, are popular choices but may result in muscle imbalances and…

Negative / Null Result ReportMedicine

Prenatal and Early Intimate Partner Psychological Violence and Children's Hospital Health Care Use: The ELFE Cohort.

Bailhache M, El-Khoury F, Chazelas E et al. · 2026 · Academic pediatrics

Objective To determine the association between parental psychological intimate partner violence (IPV) before and around the time of the child's birth, and their use of an emergency department (ED) and hospitalization from 2 months to 10…

View details →DOI: 10.1016/j.acap.2026.103270
Negative / Null Result Report

Clavipectoral fascia block associated with intermediate cervical plexus block versus intermediate cervical plexus block alone in clavicle surgeries: a randomized clinical trial

Conceicao D, Helayel P, Garcia J et al. · 2025 · Preprint

Abstract Background: Midshaft clavicular fractures account for approximately 5% of bone fractures. Surgical correction is often necessary to ensure adequate functional recovery. There is no consensus in the literature on which Regional…

View details →DOI: 10.21203/rs.3.rs-5327123/v1
Negative / Null Result ReportMedicine

Effect of Local Cold Application on Nausea and Vomiting in Early Postoperative Period-A Randomized Controlled Trial.

Türkiş NA, Taşdemir N · 2026 · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

Purpose Postoperative nausea and vomiting (PONV) is one of the most common complications in surgical patients during the first 24 hours after general anesthesia. This research aimed to evaluate the effect of cold application on early PONV…

View details →DOI: 10.1016/j.jopan.2025.06.003
Negative / Null Result ReportMedicine

Cytogenotoxic effects of polycyclic aromatic hydrocarbons complex mixture in human peripheral blood, lung A549 and liver HepG2 cells: Translation of a real-scenario exposure to in vitro.

Kazensky L, Lovrić Štefiček MJ, Kašuba V et al. · 2026 · Environmental research

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous air pollutants, where their genotoxic potential raises significant public health concerns. This study evaluated the cytotoxic and genotoxic effects of an environmentally relevant…

View details →DOI: 10.1016/j.envres.2026.124252
Negative / Null Result ReportMedicine

Using self-tailored deposit contracts and reinforcement thinning to increase physical activity of sedentary adults.

McCullen MN, Zerger HM · 2025 · Journal of applied behavior analysis

Previous research supports behavioral interventions, such as contingency management, to increase physical activity. A common limitation of these interventions is a lack of maintenance effects or assessment of the target behavior following…

View details →DOI: 10.1002/jaba.70032
Negative / Null Result ReportMedicine

Verification of the protective effect of transfecting brain-derived neurotrophic factor and B-cell lymphoma 2 genes on retina ganglion cells in a rat model of optic nerve injury.

Zhao Z, Fang Y, Xu G et al. · 2026 · Drug discoveries & therapeutics

This pilot study investigated the protective effect of transfecting brain-derived neurotrophic factor (BDNF) and B-cell lymphoma 2 (bcl-2) genes in retinal ganglion cells (RGCs) using in vivo electroporation in an adult rat optic nerve…

View details →DOI: 10.5582/ddt.2025.01101
Negative / Null Result ReportMedicine

Rediscovering a Neotropical anuran fluke: a morphological and phylogenetic study of <i>Rauschiella proxima</i> (Trematoda: Plagiorchioidea).

Queiroz MS, López-Hernández D, Anjos LA et al. · 2025 · Journal of helminthology

Species of the genus Rauschiella are trematodes of frogs and snakes in the Americas. The taxonomy of the group is complex, and most of the 18 currently valid species are known only from the original description. Moreover, genetic data are…

View details →DOI: 10.1017/s0022149x25100874
Negative / Null Result ReportMedicine

Outcomes of Pars Plana Vitrectomy in Inherited Retinal Degenerations.

Al-Moujahed A, Lu ES, Zhou HW et al. · 2026 · Ophthalmology. Retina

Purpose To describe the management and outcomes of pars plana vitrectomy (PPV) for common surgical retinal conditions, including epiretinal membrane (ERM), full-thickness macular hole (FTMH), and retinal detachment, in patients with…

View details →DOI: 10.1016/j.oret.2025.12.013
Negative / Null Result ReportMedicine

Procedural eptifibatide administration as an alternative to preprocedural dual antiplatelet therapy for patients undergoing flow diversion procedures: case series and review of the literature.

Mosallami Aghili SM, Santori D, Denice C et al. · 2025 · Journal of neurointerventional surgery

Introduction Pretreatment with dual antiplatelet agents (DAPT) has been standard practice for patients undergoing aneurysm treatment with flow diversion (FD). Rates of periprocedural diffusion lesions observed after FD procedures remain…

View details →DOI: 10.1136/jnis-2025-024406
Negative / Null Result ReportOpen accessMedicine

The impact of violation of the proportional hazards assumption on the discrimination of the Cox proportional hazards model.

Austin PC, Giardiello D · 2026 · Diagnostic and prognostic research

Background The Cox proportional hazards regression model is frequently used to estimate an individual's probability of experiencing an outcome within a specified prediction horizon. A key assumption of this model is that of proportional…

View details →DOI: 10.1186/s41512-026-00223-0
Negative / Null Result ReportMedicine

Instructed increase in fear activation during exposure exercises does not enhance treatment effects of cognitive behavioral therapy for panic disorder and agoraphobia.

Richter J, Hamm AO, Lang T et al. · 2026 · Behaviour research and therapy

The efficacy of exposure-based cognitive behavioral therapy (eCBT) for panic disorder and agoraphobia (PD/AG) is well established, but the mechanisms of action are still under debate. Here we investigated whether increased fear activation…

View details →DOI: 10.1016/j.brat.2025.104946
Negative / Null Result ReportMedicine

Improvements in pharmacokinetics, bleeding control, and cost analysis after PK-guided transition to extended-half-life factor IX in hemophilia B: A multicentric study.

Chovi-Trull M, Megías-Vericat JE, Palanques-Pastor T et al. · 2026 · Thrombosis research

Introduction Extended half-life factor IX concentrates (FIX-EHL) have been shown to improve clinical outcomes and reduce treatment burden in patients with hemophilia B (HB). Objectives To analyze the differences in pharmacokinetic (PK) and…

View details →DOI: 10.1016/j.thromres.2025.109580
Negative / Null Result ReportMedicine

Calcium silicate-based bone cement incorporated with carbon nanotubes (CNT)<i>: In vitro</i> and <i>in vivo</i>.

Silva LAS, Fernandes MS, Campos TMB et al. · 2026 · Journal of biomaterials applications

Calcium silicate cements (CaSiO 3 ) are widely used in bone repair treatments for both medical and dental applications. To meet the demands of tissue engineering, three calcium silicate cements were developed: a control group without…

View details →DOI: 10.1177/08853282251405355
Negative / Null Result ReportOpen accessMedicine

Opicapone for the Treatment of Nocturnal Hypokinesia in Patients With Parkinson's Disease: An Open-Label Pilot Clinical Trial.

Shin C, Kim JM · 2026 · Journal of movement disorders

Nocturnal hypokinesia (NH) is common in patients with moderate-stage Parkinson's disease (PD). This open-label, single-arm pilot study aimed to assess the effect of bedtime opicapone administration on NH and to evaluate the clinical…

View details →DOI: 10.14802/jmd.25250
Negative / Null Result ReportMedicine

Exploring Dynamic Brain Oscillations in Motor Imagery and Low-frequency Sound.

Dupont W, Poulin-Charronnat B, Madden-Lombardi C et al. · 2025 · Journal of cognitive neuroscience

Although both motor imagery (MI) and low-frequency sound listening have independently been shown to modulate brain activity, the potential synergistic effects that may arise from their combined application remains unexplored. Any further…

View details →DOI: 10.1162/jocn_a_02311