A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19843 results in Negative / Null Result Report · page 297 of 662
Wang T, Jiang X · 2026 · BMC cancer
Background The optimal PD-1 inhibitor to combine with disitamab vedotin in advanced urothelial carcinoma remains unclear. This study aimed to compare the real-world efficacy and safety of toripalimab plus disitamab vedotin versus…
Zhao G, Liu M, Liu Y et al. · 2026 · Preprint
Abstract Background The reliability of contrast-enhanced CT (CHCT) as a reference image for MR-based dose calculation in lung stereotactic body radiation therapy (SBRT) with MR-Linac remains uncertain due to contrast-induced electron…
Kang Z, Li Y, Canavese F et al. · 2026 · Journal of pediatric orthopedics. Part B
To investigate the impact of gender on the prognosis of children with developmental dysplasia of the hip (DDH) treated with closed reduction and spica cast immobilization (CR-SCI). A retrospective analysis was conducted on 302 DDH children…
Golbasi A, Ozercan AY, Elmaagac B et al. · 2026 · Urologia internationalis
Background The aim of this study is to compare the clinical outcomes of cystoscopy and laser resectoscope used during transurethral cystolithotripsy (TUC) and to evaluate the efficacy and reliability of these two endoscopic instruments.…
Arslan İ, Aslan Y, Arı M et al. · 2026 · Brazilian journal of otorhinolaryngology
Objective This study aimed to evaluate whether Secretoneurin (SN) was elevated in Metabolic Syndrome (MetS) and could serve as a potential predictive biomarker in the development of MetS in patients with Obstructive Sleep Apnea Syndrome…
Gomes C, Gomes C, Cowan B et al. · 2026 · Journal of bronchology & interventional pulmonology
Background Outcomes of robotic-assisted bronchoscopy (RAB) in patients of small stature remain uncertain due to concerns about their potentially smaller lung volumes. We assess the effectiveness and safety of RAB across height variations.…
Chen Y, Deng M, Xie L et al. · 2026 · Journal of translational medicine
Background The rarity of right heart masses challenges diagnostic proficiency, while reproducibility is affected by the echocardiography operator. Artificial intelligence (AI)-based imaging tools may help address these limitations. Methods…
Ibarretxe D, Tameish S, González-Lleó A et al. · 2026 · Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis
Introduction and objectives Preeclampsia (PE) is a multisystem hypertensive disorder affecting 2-8% of pregnancies worldwide and represents a major cause of maternal and fetal morbidity and mortality. Its pathophysiology involves placental…
de la Torre JD, Blázquez Sanchez V, Bonnin Arias C et al. · 2026 · Journal francais d'ophtalmologie
Purpose To evaluate the differences and interchangeability of white-to-white (WTW) distance and anterior chamber depth (ACD) measurements among three devices: Anterion (Heidelberg Engineering, Heidelberg, Germany), IOL Master 700 (Carl…
Li Y, Keqie Y, Peng C et al. · 2026 · Frontiers in genetics
Chromosomal inversion is one of the common types of chromosomal structural rearrangements. For couples with chromosomal inversions, the appropriate recommendations for preimplantation genetic testing (PGT) remain a subject of ongoing…
Gönüllü İ, Devrimci EE, Singün B et al. · 2026 · Journal of clinical medicine
Background: The aim of this study was to evaluate the whitening efficacy and long-term stability of different in-office bleaching agents containing high concentrations of hydrogen peroxide (HP). Methods: Records of 50 patients who…
Landi FS, Gholami M, Abdollahzadeh N et al. · 2026 · Journal of materials science. Materials in medicine
Topical minoxidil is typically administered over an extended period for the therapeutic management of androgenic alopecia. Given the adverse effects of commercial preparations of minoxidil (i.e., minoxidil solution), researchers are…
Sun H, Du M, Guo S et al. · 2026 · Frontiers in endocrinology
Objective To investigate the impact of three endometrial preparation protocols-hormone replacement therapy (HRT), natural cycle (NC), and down-regulation HRT-on pregnancy outcomes in frozen embryo transfer (FET) cycles among patients with…
Varhan B, Tanrıöğen B, Akpulat HMG et al. · 2026 · Preprint
Background: /Objectives: This study aimed to investigate the effects of different taping techniques commonly used in the management of hallux valgus (HV) on plantar pressure distribution under static and dynamic conditions. Methods: Thirty…
Perng PS, Chang Y, Chuang MT et al. · 2026 · Stroke and vascular neurology
Background Dual antiplatelet therapy (DAPT) is often necessary following endovascular treatment for ruptured cerebral aneurysms; however, the optimal drug combination and treatment duration remain uncertain. Method Patients with…
Long Q, Wen Y, Li J · 2026 · BMC gastroenterology
Background Anemia is a common complication of long-term hematochezia in patients with mixed hemorrhoids. This study aimed to evaluate the effect of preoperative anemia on the prognosis of mixed hemorrhoids after Milligan-Morgan…
Liu L, Wang C, Chen X et al. · 2026 · International journal of women's health
Objective To investigate the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and subclinical hypothyroidism (SCH) in early pregnancy. Methods This retrospective case-control study included 100 pregnant…
Zhu Y, Lin J, Zhang R et al. · 2026 · BMC oral health
BACKGROUND: This pilot study evaluated the repeatability and consistency of three methods—conventional, ultrasonic, and optical—for measuring mandibular functional parameters, with the goal of providing guidance for clinical…
Wang Y, Xu X, Shen WJ et al. · 2026 · Zhonghua yi xue za zhi
Objective: To investigate the effects of oliceridine versus sufentanil for anesthesia induction and postoperative patient-controlled intravenous analgesia (PCIA) on postoperative nausea and vomiting (PONV) in patients undergoing…
Chen J, Li X, Tian Z et al. · 2026 · Preprint
Abstract Objective To investigate the structural basis of white matter fiber tracts in cognitive dysfunction following radiochemotherapy in patients with frontal lobe glioma. Methods A total of 40 patients with frontal lobe glioma who…
Garcés-Pellejero M, Torres-Ferrús M, Mas-de-Les-Valls R et al. · 2026 · European journal of neurology
Objectives To compare response (reduction in headache frequency and differences in patient-reported outcomes) between Erenumab and OnabotulinumtoxinA from two phase-IV trials after 6 months of treatment. Materials/methods A prospective…
Ramírez-Pérez L, Cuesta-Vargas AI · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Kinematic movement analysis is highly relevant in patients with glenohumeral instability, a pathology characterized by fatigue-induced slowing of repetitive movements. However, the optimal exercise approach for this symptom remains…
Özdemir BG, Agakishiyeva L, Bilgi A et al. · 2026 · Journal of lower genital tract disease
Objectives Assessment of clitoral artery flow parameters (eg, pulsation and resistance indices) is important for individual patient evaluation of sexual function quality. Selected hormonal treatments may also influence these vascular…
Sitorasmi PH, Ningtiyas YS, Wahyuni I et al. · 2026 · Preprint
Background Corneal collagen cross-linking (CXL) is a procedure for making bonds that connect polymer chains to one another. Corneal CXL aims to slow or stop the progression of keratoconus by using photooxidative therapy so as to increase…
Hernández-Rodríguez D, Contreras A, Melgar Lalanne G et al. · 2026 · PeerJ
Background The gut microbiota maturation extends beyond the first two years of life. Early perinatal and postnatal factors may influence the child's nutritional status, which, in turn, can affect the composition of their gut microbiota.…
Cañones-Zafra R, Allendes-Urquiza G, Muñiz C et al. · 2026 · Journal of ophthalmology
Purpose Our purpose is to report the results of a prospective study on ocular discomfort and objective tear film parameters (osmolarity and NIKBUT), in myopic patients, and observe the possible differences at 1 month between randomized…
Still MEH, Alberts A, Nagda P et al. · 2026 · The Journal of craniofacial surgery
Introduction Craniosynostosis is a common pediatric condition that results in variable symptoms that range from asymptomatic cosmetic deformities to severe signs of intracranial hypertension. Little is understood about the relationship…
Ko Y, Qiao R, Guo Y et al. · 2026 · Preprint
Abstract Purpose To compare pregnancy outcomes following FET in patients with moderate-to-severe IUA treated with GnRH-a versus HRT therapy before hysteroscopy. It might offer novel insights into hysteroscopy before embryo transfer.…
Azriel M, Shohat H, Blinderman D et al. · 2026 · Journal of experimental botany
Dehydration-responsive element-binding (DREB) transcription factors play an important role in plant responses to drought. DREB subfamily A4 contains a subgroup named TINY. Previous studies in Arabidopsis suggest that TINYs suppress plant…
Johnson CM, Kenne KA, Bradley CS et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Perioperative gabapentin is widely used in gynecology ERAS protocols, but evidence for its use for vaginal prolapse procedures is very limited. Objective The objective of this study was to evaluate the effect of preoperative…