A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19843 results in Negative / Null Result Report · page 295 of 662
Targhetta VP, Vieira RdS, Ranfley H et al. · 2025 · Preprint
Inflammasomes are multiprotein complexes that activate pro-caspase-1, leading to the maturation of the pro-inflammatory cytokines IL-1β and IL-18. Nlrp1 , the first receptor identified with inflammasome-forming capacity, is highly…
Farber C, Jackson C, Renteria K et al. · 2026 · Nutrition (Burbank, Los Angeles County, Calif.)
Background Exposure to a Western diet during gestation and lactation adversely impacts offspring mood, learning, and memory. We determined if high dose maternal methyl donor nutrient (MDN) supplementation ameliorated the effects of a high…
Khaliji E, Marycz K, Horna M et al. · 2025 · American journal of veterinary research
Objective To evaluate IA autologous platelet-derived mitochondrial preparation versus vehicle control in a bilateral lipopolysaccharide (LPS)-induced model of equine synovitis. Methods 2 ng of LPS was injected into bilateral intercarpal…
Rodriguez CG, Choolani M, Illanes S · 2025 · Preprint
Objective: To study variation in moral attitudes toward selective abortion in case of prenatal diagnosis of a disability in the general population. Methods: 926 participants completed a survey in which they expressed their moral views…
Rodriguez CG, Choolani M, Illanes S · 2025 · Preprint
Objective: To study variation in moral attitudes toward selective abortion in case of prenatal diagnosis of a disability in the general population. Methods: 926 participants completed a survey in which they expressed their moral views…
VanRyzin JW, Laraia GA, Gyawali U et al. · 2025 · Preprint
ABSTRACT Astrocyte dysfunction within the nucleus accumbens (NAc) has been increasingly implicated in maladaptive reward processing and the development of addiction-like behaviors. In this study, we investigated how impairing astrocyte…
Quan F, Ma J, Zhao Y et al. · 2025 · Aquaculture international
This study investigated the effects of supplementing high soybean meal diets with alpha-ketoglutaric acid (AKG) on the intestinal health and growth performance of spotted sea bass (Lateolabrax maculatus). A total of 270 fish (average…
Zoughaib WS, Fry MJ, Singhal A et al. · 2026 · Medicine and science in sports and exercise
Purpose Increasing nitric oxide bioavailability via nitrate (NO 3- ) ingestion enhances muscle contractility, which may be due to phosphorylation of the regulatory light chain of myosin. If so, there should be an interaction between NO 3-…
Svigruha R, Yañez-Guerra LA, Caña-Bozada VH et al. · 2025 · Preprint
Abstract Ecdysone-controlled pathways regulate ecdysozoan development through both a nuclear (nEcR) and a membrane receptor (mEcR). Ecdysone signaling was long thought to be exclusive to ecdysozoans; however, studies since 2010 have…
Wackernagel D, Gavelli V, Nydert P · 2025 · Clinical nutrition ESPEN
Background & aims In preterm and sick newborn infants, peripherally inserted central catheters (PICC) are used for the delivery of concentrated parenteral nutrition and other high risk drugs. Despite the precaution issued by the ESPGHAN…
Barbosa MG, Vos DY, Verzijl CRC et al. · 2026 · Cellular and molecular gastroenterology and hepatology
Background & aims Hepatocellular carcinoma is the third leading cause of cancer-related mortality worldwide. Therapeutic options for hepatocellular carcinoma remain limited, and the mechanisms underlying hepatocellular carcinoma are not…
Wooliver R, Neupane A, DeBruyn JM et al. · 2026 · Journal of environmental quality
Microplastics derived from agricultural plastic films accumulate in soils, potentially impacting ecosystem functions such as soil organic carbon (SOC) storage. Microbial degradation of biodegradable plastics, which are intentionally tilled…
Inoue H · 2025 · Preprint
Abstract The novel coronavirus SARS-CoV-2, commonly referred to as COVID-19, triggered a global pandemic. Although understanding the nature of international infection spread is critically important, extracting diffusion networks from…
Zhao X, Tian Q, Michelsen A et al. · 2025 · Applied Soil Ecology.
Roots and extraradical mycelium (EMM) influence the soil carbon (C) cycle, but it remains unclear how warming alters their effects on soil organic carbon (SOC) and its composition in alpine swamp meadows. A three-year ingrowth core…
Bertrand-Ndoye M, Girard H, Hakim F et al. · 2026 · Forensic science international
In forensic thanatology, post-mortem blood is often stored for long periods, leading to in vitro variations in drug concentrations. This study evaluated the use of dried blood microsampling supports dried (Dried Blood Spot - DBS and…
Fukunaga N, Takanishi T, Wakami T et al. · 2026 · Circulation reports
Background The impact of emergency surgery for acute type A aortic dissection (ATAAD) on renal function in patients with autosomal dominant polycystic kidney disease (ADPKD) remains unclear. Methods and results The renal function of 4…
Li T, Jiang X, Tian X et al. · 2026 · The Journal of endocrinology
Postmenopausal osteoporosis, characterized by estrogen deficiency-induced bone loss and elevated fracture risk, is commonly managed with hormone replacement therapy (HRT). This study aimed to evaluate whether passive exercise via…
Chen W, Zhang C, Guo W et al. · 2026 · Journal of experimental botany
Apple is an important economic species, but it suffers from biotic stress during its growth and development. Fungi and pests are two types of biotic stress that have significant destructive effects on apple. Members of the leucine-rich…
Fischer J, Seguel JM, Drole K et al. · 2026 · BMC sports science, medicine & rehabilitation
Background This study investigated the comparative acute effects of 3 × 30 s of vibration foam rolling (VFR) or percussive massage (PM) on the hamstring muscles, specifically range of motion (ROM), maximum voluntary isometric contraction…
Fujii N, Katagiri A, Nakagome K et al. · 2026 · Scandinavian journal of medicine & science in sports
Continuous monitoring of core temperature is crucial for optimizing exercise performance, promoting health, and ensuring safety. Here, we evaluated the validity of a machine learning-based earbud-type core temperature sensor during…
Lamekina Y, Panela R, Kortje C et al. · 2026 · Preprint
Event segmentation – the division of continuous experience into meaningful units – is essential for understanding narratives. Although event segmentation has been widely studied in visual contexts, little is known about how listeners…
Lamekina Y, Panela R, Kortje C et al. · 2026 · Preprint
Event segmentation – the division of continuous experience into meaningful units – is essential for understanding narratives. Although event segmentation has been widely studied in visual contexts, little is known about how listeners…
Selimović-Pašić A, Haglund L, Bensberg M et al. · 2026 · Preprint
The BCL-2 inhibitor venetoclax (VEN) in combination with hypomethylating agents (HMAs) has improved treatment responses in acute myeloid leukaemia (AML), but the mechanisms underlying their synergy remain unclear. We investigated the role…
Maksymowych WP, Weiss PF, Francavilla ML et al. · 2026 · Seminars in arthritis and rheumatism
Objective The OMERACT JAMRIS working group has defined a spectrum of MRI lesions in the sacroiliac joint (SIJ) in pediatric cases with spondyloarthritis (SpA) that match domains for inflammation and structural damage. We aimed to assess…
Aguiar PV, Paul BT · 2026 · Preprint
Older adults with age-related hearing loss (OAHL) are more strongly influenced by vision during audiovisual perception tasks compared to typical-hearing old adults, suggesting a greater weighting of visual input in the former group. This…
Brandon AS, Murphy BS, Nam Y et al. · 2026 · The American journal of cardiology
Peripheral arterial disease (PAD) has many established risk factors, but social determinants of health (SDoH) are increasingly recognized as a cardiovascular disease risk factor. The multi-ethnic study of atherosclerosis (MESA) cohort was…
Arnaoutis G, Vallas G, Toubekis AG et al. · 2026 · International journal of sport nutrition and exercise metabolism
Beetroot juice (BRJ) has been proposed as an ergogenic aid due to its high nitrate content, yet evidence from field-based studies in elite swimmers remains limited. This study investigated the acute effects of concentrated BRJ ingestion on…
Ayaz SN, Kucuk M, Yanık Nalbantoğlu D et al. · 2025 · Odontology
We evaluated the effect of supplementary instrumentation on the removal of gutta-percha and compared the efficacy of three file systems with different metallurgical properties via micro-computed tomography (micro-CT). Forty-two moderately…
Moghadam H, Sourinejad I, Kalbassi MR et al. · 2026 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
Widely recognized for its translational relevance, the zebrafish (Danio rerio) is a validated model for evaluating antihyperglycemic agents. Nanocapsulation technologies have been proposed to enhance the bioefficacy of natural compounds…
Micca L, Albouy G, King BR et al. · 2026 · Preprint
Motor memory retention is impaired in Parkinson’s disease (PD), affecting long-term rehabilitation outcomes. It appears that NREM sleep could be beneficial for consolidation processes in PD, and could be leveraged with non-invasive sleep…