A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20233 results in Negative / Null Result Report · page 293 of 675
Ford BE, Chachra SS, Alshawi A et al. · 2024 · Preprint
ABSTRACT Glucokinase activators (GKAs) have been developed as blood glucose lowering drugs for type 2 diabetes. Despite good short-term efficacy, several GKAs showed a decline in efficacy chronically during clinical trials. The underlying…
Mogensen DG, Aanaes K, Andersen IB et al. · 2025 · The Laryngoscope
Objectives Olfactory training is a recommended treatment in patients with olfactory dysfunction after COVID-19. However, the effectiveness of olfactory training in COVID-19-induced olfactory dysfunction has been studied; only a few studies…
Sehgal I, Eells K, Hudson I · 2024 · Pharmacy (Basel, Switzerland)
Small interfering RNA (siRNA)-based medications offer the ability to target previously undruggable targets and have now received FDA approval in five instances for orphan or uncommon diseases. The current siRNA "-sirans" are directed…
Goldschmied N, Lambrecht J, Castro A et al. · 2023 · Scandinavian journal of medicine & science in sports
Hockey is a sport known for its violent nature. Specifically, hockey fights have consistently been an integral part of the National Hockey League. Past research has demonstrated that players are likely to be involved in fighting as a…
Riise HS, Simpson MR, Espnes KA et al. · 2026 · Headache
Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real-world setting. Background Oral migraine preventives are previously mainly explored in…
Sonnhoff M, Oyur M, Becker JN et al. · 2026 · Radiation oncology (London, England)
BACKGROUND: Despite the favorable toxicity profiles of whole breast radiotherapy, there are subgroups that tend to experience high toxicity. This study examines anatomical and physiological characteristics that can predict the induction of…
Hunter-Cooper SD, Rahimi M, Millet P et al. · 2026 · European journal of nutrition
Introduction High sodium intake has been associated with greater pressor responses in Black compared with White adults. While the acute effects of sodium on BP have been studied in Black adults, to our knowledge, no studies have explored…
Kreko-Pierce T, Chen L, Qu G et al. · 2026 · Membranes
HIV-associated neurocognitive disorders (HAND) persist despite combination antiretroviral therapy (cART) and can be exacerbated by repeated cocaine (COC) exposure. Because COC, HAND, and cART independently disrupt medial prefrontal cortex…
Bracci EL, Barnett AG, Brown C et al. · 2023 · Preprint
Background: Non-beneficial treatment affects a considerable proportion of older people in hospital, and some will choose to decline invasive treatments when they are approaching the end of their life. The Intervention for Appropriate Care…
Krittaphol W, Martin LW, Walker GF et al. · 2025 · Pathogens (Basel, Switzerland)
Chronic infections of Pseudomonas aeruginosa are commonly treated with tobramycin. During infections, the bacteria can exist under conditions of oxygen deprivation that render them less susceptible to this antibiotic. The aims of this…
Newman MS, Smeaton J · 2025 · Menopause (New York, N.Y.)
Objectives 3,3'-diindolylmethane (DIM) is a supplement, investigational drug, and the primary in vivo product of indole-3-carbinol. DIM is sometimes recommended to postmenopausal women by functional or integrative medicine providers. Some…
Vega-Trejo R, Sanghvi K, Todorova B et al. · 2024 · Scientific reports
Mate availability and social information can influence mating behaviour in both males and females. Social information obtained from conspecifics can influence mate choice, particularly shown by studies on mate choice copying. However, the…
Hemmingsen MG, Zhang GF, Ma Y et al. · 2025 · JCI insight
Methylmalonic acidemia (MMA) is a severe metabolic disorder affecting multiple organs because of a distal block in branched-chain amino acid (BCAA) catabolism. Standard of care is limited to protein restriction and supportive care during…
Rolig AS, Ziglari T, McGee GH et al. · 2026 · Scientific reports
The tumor microenvironment (TME), which heavily influences immune checkpoint blockade (ICB) efficacy, is shaped by host-microbe interactions. Endogenous intratumoral bacteria have been implicated in efficacy of ICB, such as anti-PD-1…
Hauber MM, Nordahl O, Todisco V et al. · 2026 · PloS one
Many coregonine species have declined drastically across the Northern Hemisphere, including populations of Coregonus maraena (whitefish) in the Baltic Sea, and the mechanisms leading to these declines are not well investigated. An abrupt…
Marquis-Gravel G, Tong G, Dodd M et al. · 2025 · Journal of the Society for Cardiovascular Angiography & Interventions
Background Coronary artery bypass grafting (CABG) improves survival compared with optimal medical therapy (OMT) alone in patients with ischemic left ventricular systolic dysfunction (iLVSD), but percutaneous coronary intervention (PCI) did…
Shahid N, Kim CH, Jabilona KB et al. · 2026 · PloS one
Tyrosine kinase inhibitors (TKI) are often used in combination with other chemotherapeutic nucleoside/nucleobase analogues, such as gemcitabine and 6-mercaptopurine, in the treatment of various cancers. Past studies have shown that several…
Lubineau M, Watkins CP, Glasel H et al. · 2023 · Proceedings. Biological sciences
Does word flickering facilitate reading? Despite a lack of scientific evidence, flickering glasses and lamps for dyslexia are being marketed in various countries. We conducted four experiments to assess their efficacy. Two experiments…
Salerno JW, Xu S, Rainforth M et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Cardiovascular disease (CVD) is the leading cause of death globally. The World Health Organization has called for investigations into traditional systems of medicine for CVD prevention. Ayurveda includes a…
Stark R, Zigman JM, Andrews ZB · 2025 · Journal of neuroendocrinology
The olfactory bulb (OB) is an emerging neuroendocrine centre regulating appetite, metabolism, and behaviours such as those linked to anxiety, motivation and spatial navigation. These processes are likely mediated by one or more of the many…
Liu S, Hu S, Chen J et al. · 2025 · Psychological research
Previous research has shown that the addition of happy or angry expressions to other-race faces can assist infants in overcoming the perceptual narrowing of face race and reinstating their recognition of other-race faces. In the present…
Draper B, Wand APF · 2025 · Current opinion in psychiatry
Purpose of review Depression and physical illnesses have long been recognized as risk factors for suicidal behaviour in late life. Qualitative studies have previously identified frailty as being an issue in late life suicidal behaviour,…
Sieborg J, Maul JT, Wu JJ et al. · 2025 · Acta dermato-venereologica
Biosimilars are designed to be analogous to the biologic originators. However, comprehensive comparisons between biosimilars are limited and lacking for patients with psoriasis. This study's objective was to compare 1-year drug survival of…
Hossain SJ, Tofail F, Mehrin SF et al. · 2023 · Pediatrics
Background and objectives Previously, in 30 Bangladeshi villages, 2 groups of children with iron-deficiency anemia (IDA) and nonanemic (NA) iron sufficiency aged 6 to 24 months participated in 2 parallel cluster randomized controlled…
Bingöl G, Jesurasa S, Stroethoff M et al. · 2025 · Frontiers in cardiovascular medicine
Remote ischemic preconditioning (RIPC) has been shown in several experimental studies as an organ protective procedure against ischemic injury, but the implementation of RIPC into routine clinical practice has so far failed due to…
Mayer L, Lichtblau M, Furian M et al. · 2025 · Journal of the American Heart Association
Background Exposure to high altitude triggers hypoxic pulmonary vasoconstriction with a rise in pulmonary artery pressure (PAP). This may lead to symptomatic pulmonary hypertension with impaired right heart function and exercise capacity.…
López-de la Rosa A, Díez-Montero C, Martínez-Plaza E et al. · 2024 · Ophthalmology and therapy
Introduction Characterizing lens thickness (LT) in patients with cataracts is important for better understanding the lens aging process and for designing new intraocular lens power formulas. This study aimed to analyze the influence of…
Fitzgerald LS, Reynoso Spurrier CS, Lau NJ et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Mitochondria are key regulators of metabolism and ATP supply in skeletal muscle, while circadian rhythms influence many physiological processes. However, whether mitochondrial function is intrinsically regulated in a circadian manner in…
Fernández-Ruiz M, Sánchez Moreno B, Santiago Almeda J et al. · 2023 · Transplant infectious disease : an official journal of the Transplantation Society
Previous studies have suggested that exposure to statins confers a protective effect in bloodstream infection (BSI) due to the anti-inflammatory and immunomodulatory properties attributed to these lipid-lowering drugs. Scarce evidence is…
Vilk Ayalon N, Omer Vilk N, Sompolinsky Y et al. · 2026 · Reproductive health
BACKGROUND: Frozen embryo transfer (FET) is widely used due to its safety and effectiveness. However, it has been associated with an increased risk of large for gestational age (LGA) infants. Proposed mechanisms include effects of embryo…