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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19843 results in Negative / Null Result Report · page 292 of 662

Negative / Null Result ReportMedicine

Acute effect of aerobic exercise on inhibitory control and task-related heart rate variability in preadolescent children.

Berger M, Bruggisser F, Schwarz A et al. · 2025 · Physiology & behavior

Objectives To investigate whether a single session of aerobic exercise improves inhibitory control in preadolescent children and whether this effect is mediated by changes in parasympathetic activity. Design In this experimental study, an…

View details →DOI: 10.1016/j.physbeh.2025.114820
Negative / Null Result Report

Evaluating Working Memory as a Buffer for Visual Search

Su Z, Wyble B, Fu Y · 2024 · Preprint

This study explores the relationship between working memory and attention during visual search tasks, focusing on how time constraints affect the encoding of visual information into working memory. The research is based on the premise that…

View details →DOI: 10.31234/osf.io/d4hc5
Negative / Null Result ReportMedicine

Insufficient Evidence for Load as the Primary Cause of Nonspecific (Chronic) Low Back Pain. A Scoping Review.

de Bruin LJE, Hoegh M, Greve C et al. · 2024 · The Journal of orthopaedic and sports physical therapy

OBJECTIVE: To assess the causal role of the relationship between loading and the onset of nonspecific low back pain (NSLBP) and persistence of NSLBP (chronic low back pain [CLBP]). DESIGN : Scoping review. LITERATURE SEARCH : We searched…

View details →DOI: 10.2519/jospt.2024.11314
Negative / Null Result ReportMedicine

The Role of Mitochondrial DNA Copy Number in Venous Thromboembolism: Insights from a 2-Sample Mendelian Randomization Study.

Xiang C, Zheng M, Li Y et al. · 2025 · Annals of vascular surgery

Background Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial…

View details →DOI: 10.1016/j.avsg.2025.01.013
Negative / Null Result ReportOpen accessMedicine

Are the Previously Reported Risk Factors for Endometriosis Actually Associated With Pain and Infertility Rather Than Endometriosis Itself?

Matsuzaki S · 2026 · Reproductive medicine and biology

Background Endometriosis is often diagnosed late due to a lack of noninvasive diagnostic tools and the varied presentation of its symptoms. Identifying risk factors for endometriosis is crucial for reducing diagnosis delays, mitigating the…

View details →DOI: 10.1002/rmb2.70041
Negative / Null Result Report

Multiple mating predicts queen reproductive output in the polygynous Neotropical trap-jaw ant, Odontomachus chelifer (Formicidae: Ponerinae)

Florindo HS, Azevedo-Silva M, Pereira-Romeiro MP et al. · 2025 · Preprint

The factors that influence the organisms’ ability to reproduce are diverse. In ants, social structure may contribute to queens’ Reproductive Output (RO), alongside environmental conditions and genetic attributes. Polygynous species like…

View details →DOI: 10.1101/2025.05.05.652256
Negative / Null Result ReportOpen accessMedicine

C-reactive protein and prospective cardiometabolic risk: observational and Mendelian randomization study of ischemic stroke and all-cause death.

Rolver MG, Emanuelsson F, Nordestgaard BG et al. · 2025 · Cardiovascular diabetology

Background and objectives Elevated C-reactive protein (CRP) is a well-established marker of low-grade systemic inflammation often accompanying cardiometabolic diseases like type 2 diabetes. We sought to determine if plasma CRP…

View details →DOI: 10.1186/s12933-025-03028-5
Negative / Null Result ReportMedicine

Goal framing of health promotion messages in contact lens wear.

Wagner H, Lam D, Nguyen AL · 2025 · Contact lens & anterior eye : the journal of the British Contact Lens Association

Purpose Appropriate framing of health information influences the adoption of health behaviors. This study explored whether (1) gain- or loss-framed health promotion messages, emphasizing positive or negative consequences, respectively,…

View details →DOI: 10.1016/j.clae.2025.102387
Negative / Null Result ReportMedicine

Exposure to Acetaminophen (Paracetamol) during Pregnancy and Childhood Cancer: A Population-Based Cohort Study in Taiwan.

Sirirungreung A, Lee PC, Hu YH et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background The safety of using acetaminophen (paracetamol) during pregnancy has been questioned because of concerns about its potential negative impact on fetal development and the risk of adverse pediatric outcomes. We aimed to…

View details →DOI: 10.1158/1055-9965.epi-25-1034
Negative / Null Result ReportMedicine

Estimation of the economic impacts and operational limitations imposed on unmanned aerial systems by poor sky conditions

Prince Czarnecki JM, Shockley JM, Wasson L et al. · 2024 · Precision Agriculture

Cloudy skies reduce image quality obtained from unmanned aerial vehicles (UAV) due to variable lighting conditions imposed on the surface. This study provides a novel approach for identifying temporal windows of opportunity that show…

View details →DOI: 10.1007/s11119-023-10055-3
Negative / Null Result ReportOpen accessMedicine

Retraction: miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT axis.

· 2024 · Journal of cellular and molecular medicine

Xin Li, Hao Xu, Jianfeng Yi, Chunlu Dong, Hui Zhang, Zhengfeng Wang, Long Miao, Wence Zhou. miR-365 secreted from M2 Macrophage-derived extracellular vesicles promotes pancreatic ductal adenocarcinoma progression through the BTG2/FAK/AKT…

View details →DOI: 10.1111/jcmm.18188
Negative / Null Result ReportMedicine

The relationship between smoking and clinical outcome in ischemic stroke patients undergoing reperfusion therapy.

Kömürcü HF, Sever N, Gökdereli NS et al. · 2025 · Neurological research

Background It has been suggested that smokers have higher recanalization rate, lower risk of cerebral hemorrhage and better prognosis than non-smokers (smoking paradox) after reperfusion therapy in patients with acute ischemic stroke (IS).…

View details →DOI: 10.1080/01616412.2024.2448628
Negative / Null Result ReportMedicine

Behavior of Listeria monocytogenes in commercial queso fresco and queso cotija and investigation of salt concentration as a control factor

Andersen Z, Kilgore S, Waite-Cusic J et al. · 2025 · Journal of Dairy Science

Hispanic-style cheeses (HSC), particularly fresh soft varieties, have been associated with numerous outbreaks of Listeria monocytogenes, highlighting the need to identify product characteristics or interventions that could mitigate L.…

Negative / Null Result ReportOpen accessMedicine

Adolescent Exposure to Nicotine and Ethanol Attenuates Adult Nicotine Reward Sensitivity in Rats.

Toyoshima M, Toyofuku R, Shimoda S et al. · 2026 · Neuropsychopharmacology reports

Adolescence is a sensitive developmental stage in which exposure to addictive substances can produce long-lasting changes in the neural circuits that regulate reward. Nicotine and ethanol are frequently co-used among adolescents, and…

View details →DOI: 10.1002/npr2.70132
Negative / Null Result ReportOpen accessMedicine

An Occurrence of Mass Psychogenic Illness: LeRoy, New York.

McVige J, Masset L, Mechtler L et al. · 2026 · Journal of child neurology

Mass psychogenic illness (MPI), also known as mass sociogenic illness, is a functional neurologic symptom disorder affecting multiple people simultaneously. This study presents a pediatric MPI outbreak involving abrupt-onset tics in LeRoy,…

View details →DOI: 10.1177/08830738251369759
Negative / Null Result ReportMedicine

Presence and potential impact of anthropogenic nesting materials on a colonial breeding waterbird.

Ferreira HRS, Hadden AC, Champagnon J et al. · 2025 · The Science of the total environment

Despite the vital importance of wetlands globally, these habitats have increasingly received anthropogenic materials, such as plastics, which can impact the wildlife these habitats support. Despite commonly found in the nests of Eurasian…

View details →DOI: 10.1016/j.scitotenv.2025.178588
Negative / Null Result ReportOpen accessMedicine

Do ChatGPT and Gemini provide accurate answers to patient questions about glenohumeral arthritis?

Ohlsen SM, Pirkle SB, Yang J et al. · 2026 · JSES reviews, reports, and techniques

Background Machine learning, a subset of artificial intelligence, enables large language models (LLMs) like ChatGPT and Gemini to analyze data, learn from context, and generate responses without explicit programming. While machine learning…

View details →DOI: 10.1016/j.xrrt.2026.100715
Negative / Null Result ReportMedicine

Thrombectomy in Stroke Patients with Large Vessel Occlusion and Mild Symptoms: Insights from a Multicenter Observational Study.

Qiu K, Hang Y, Lv P et al. · 2025 · Translational stroke research

To evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) is more effective than BMM alone in treating mild stroke patients (National Institutes of Health Stroke Scale score pri ) group and the primary…

View details →DOI: 10.1007/s12975-025-01337-1
Negative / Null Result ReportOpen accessMedicine

Use of oXiris<sup>®</sup> vs standard AN69ST filters in sepsis-associated acute kidney injury requiring continuous renal replacement therapy: a retrospective matched cohort study.

Yepes Gómez D, Moreno-Bedoya S, Lohle-Rueda S et al. · 2026 · Frontiers in nephrology

Background Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and carries high short-term mortality despite timely antimicrobials and organ support. Adsorptive hemofilters such as the oXiris ® membrane have…

View details →DOI: 10.3389/fneph.2026.1810007
Negative / Null Result ReportMedicine

Diverging paths: Modeling the relation between adverse effects, attitudes, perceived adherence, and treatment effect in an internet-based cognitive-behavioral intervention for obsessive-compulsive disorder.

Baumeister A, Schuurmans L, Schultz J et al. · 2025 · Behaviour research and therapy

Background and aim The efficacy of internet-based interventions (IBI) for various psychiatric disorders is widely established, but little is known about the mechanisms or possible influencing factors. One of the most prominent problems in…

View details →DOI: 10.1016/j.brat.2024.104673