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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19843 results in Negative / Null Result Report · page 291 of 662

Negative / Null Result ReportOpen accessMedicine

Progestogen supplementation to prevent miscarriage: Evidence and controversies.

Saccone G, Berghella V, Gulersen M et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Progesterone plays a key role in the establishment and maintenance of pregnancy and its deficiency has been associated with early pregnancy loss. Progestogen supplementation has therefore been widely investigated as a preventive strategy…

View details →DOI: 10.1002/ijgo.70793
Negative / Null Result ReportMedicine

Semantic facilitation in blocked picture categorization: Some data and considerations regarding task selection.

Wöhner S, Luckow J, Brandt M et al. · 2024 · Journal of experimental psychology. Human perception and performance

Semantic context effects in picture naming and categorization tasks are central to the development and evaluation of current models of word production. When pictures are named in a semantically blocked context, response latencies are…

View details →DOI: 10.1037/xhp0001203
Negative / Null Result ReportOpen accessMedicine

Comparison of AAV9-driven motor neuron transduction following different CNS-directed delivery methods in mice.

Mortimer AJ, Sander CF, Parmar AR et al. · 2026 · Scientific reports

Gene therapies are promising for diseases previously considered incurable. Adeno-associated virus serotype 9 (AAV9) demonstrates remarkable tropism for motor neurons (MNs) and represents an exciting candidate to target genetic causes of…

View details →DOI: 10.1038/s41598-026-38039-z
Negative / Null Result ReportMedicine

Do uncontrolled processes contribute to evaluative learning? Insights from a new two-US process dissociation procedure and ambivalence measures.

Béna J, Lacassagne D, Corneille O · 2025 · Quarterly journal of experimental psychology (2006)

The contribution of uncontrolled processes to evaluative learning has been examined in evaluative conditioning procedures by comparing evaluations of conditioned stimuli between tasks or within tasks but between learning instruction…

View details →DOI: 10.1177/17470218241248138
Negative / Null Result ReportOpen accessMedicine

Same Sentences, Different Grammars, Different Brain Responses?: An MEG Study on Case and Agreement Encoding in Hindi and Nepali Split-Ergative Structures.

Chacón DA, Shrestha S, Dillon BW et al. · 2026 · Neurobiology of language (Cambridge, Mass.)

At first glance, the brain's language network appears to be universal, but languages clearly differ. Does the brain adapt to the specific details of individual grammatical systems? Here, we present a magnetoencephalography (MEG) study on…

View details →DOI: 10.1162/nol.a.247
Negative / Null Result ReportMedicine

Does sensitive skin lie in epidermal barrier impairment or abnormalities? Results from an observational study assessing biophysical parameters.

Borghi A, Guarneri F, Pacetti L et al. · 2024 · Italian journal of dermatology and venereology

Background The pathophysiology of sensitive skin is largely unknown and no univocal data on the role of the epidermal barrier impairment have been identified. The aim of this study was to assess whether subjects with or without sensitive…

View details →DOI: 10.23736/s2784-8671.24.07714-4
Negative / Null Result ReportOpen accessMedicine

An Exploratory Pilot Study to Investigate the Potential Relationship Between Porcine Reproductive and Respiratory Syndrome (PRRS) Virus Viremia Changes and Barn Manure Pit Management Procedures.

Melini CM, Kikuti M, Yue X et al. · 2026 · Pathogens (Basel, Switzerland)

Porcine reproductive and respiratory syndrome virus (PRRSV)-positive pigs can be exposed to high concentration of gases, such as ammonia and hydrogen sulfide when manure and urine stored in the pits beneath them is agitated and pumped.…

View details →DOI: 10.3390/pathogens15050453
Negative / Null Result ReportMedicine

The Effect of Contrast Rationing on the Development of Acute Kidney Injury During the Global Contrast Shortage.

Bellew SD, Kahler Z, Hamm J et al. · 2024 · The Journal of emergency medicine

Background In April of 2022, the COVID-19 pandemic resulted in a global shortage of intravenous contrast media (ICM), which led our health care system to implement rationing measures. Study objectives We set out to determine if the…

View details →DOI: 10.1016/j.jemermed.2024.04.009
Negative / Null Result ReportOpen accessMedicine

Parent emotion regulation difficulties statistically mediate the association between parental adverse childhood experiences and child emotion regulation.

Freeman SE, Staples AD, Loverich TM et al. · 2025 · Frontiers in global women's health

Introduction Emotion regulation (ER) abilities predict positive outcomes among children. While parenting behaviors that promote young children's ER development have been widely studied, less is known about how a parent's history of early…

View details →DOI: 10.3389/fgwh.2025.1587786
Negative / Null Result ReportOpen accessMedicine

Less Than Zero?

Hackländer RPM, Schlüter H, Rolke AK et al. · 2025 · Experimental psychology

Not all information encountered is equally important to remember. Some information may be valuable, while others may be irrelevant. Importantly, retrieving and acting upon some information may even have negative consequences. Research has…

View details →DOI: 10.1027/1618-3169/a000641
Negative / Null Result ReportMedicine

Internalizing symptoms, negative urgency, and coping motives: Potential pathways to alcohol consequences.

McDonald A, Corbin W · 2025 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

Objective Building upon prior research, the present study tested coping motives as a mediator of relations between both negative urgency and internalizing symptoms (depression, anxiety, and stress), and alcohol-related consequences using…

View details →DOI: 10.1037/adb0001038
Negative / Null Result ReportOpen access

No evidence that retinol is protective for skin cancer

Helder M, Pandeya N, Seviiri M et al. · 2024 · Preprint

ABSTRACT With over 1.5 million new cases annually, skin cancers are the most commonly diagnosed group of cancers worldwide. Among these, melanoma and keratinocyte cancers (KC), comprising squamous cell carcinoma (SCC) and basal cell…

View details →DOI: 10.1101/2024.08.27.24312670
Negative / Null Result ReportMedicine

The temporal order of emotional, cognitive, and behavioral gains in daily life during treatment of depression.

Snippe E, Elmer T, Ceulemans E et al. · 2024 · Journal of consulting and clinical psychology

Objective Despite the importance for understanding mechanisms of change, little is known about the order of change in daily life emotions, cognitions, and behaviors during treatment of depression. This study examined the within-person…

View details →DOI: 10.1037/ccp0000890
Negative / Null Result ReportOpen accessMedicine

Overconfidence, Time-on-Task, and Medical Errors: Is There a Relationship?

Al-Maghrabi M, Mamede S, Schmidt HG et al. · 2024 · Advances in medical education and practice

Background Literature suggest that physicians' high level of confidence has a negative impact on medical decisions, and this may lead to medical errors. Experimental research is lacking; however, this study investigated the effects of high…

View details →DOI: 10.2147/amep.s442689
Negative / Null Result ReportMedicine

Relationship between facility type and bulk tank milk bacteriology, udder health, udder hygiene, and milk production on Vermont organic dairy farms.

Jeffrey CE, Andrews T, Godden SM et al. · 2024 · Journal of dairy science

The primary objective of this cross-sectional observational study was to determine whether bulk tank milk quality, udder health, udder hygiene, and milk production outcomes were associated with facility type on organic dairies. A secondary…

View details →DOI: 10.3168/jds.2023-24576
Negative / Null Result ReportMedicine

Behavioral and Neural Correlates of Visual Working Memory Reveal Metacognitive Aspects of Mental Imagery.

Bates KE, Smith ML, Farran EK et al. · 2024 · Journal of cognitive neuroscience

Mental imagery (MI) is the ability to generate visual phenomena in the absence of sensory input. MI is often likened to visual working memory (VWM): the ability to maintain and manipulate visual representations. How MI is recruited during…

View details →DOI: 10.1162/jocn_a_02085
Negative / Null Result ReportOpen accessMedicine

Quick returns, sleep, sleepiness and stress - An intra-individual field study on objective sleep and diary data.

Öster K, Tucker P, Söderström M et al. · 2024 · Scandinavian journal of work, environment & health

Objectives Quick returns ( Methods Of 225 nurses and assistant nurses who wore actigraphy wristbands and kept a diary of work and sleep for seven days, a subsample of 90 individuals with one observation of both a quick return and a control…

View details →DOI: 10.5271/sjweh.4175
Negative / Null Result ReportMedicine

Serum heat shock protein concentrations are not associated with amyotrophic lateral sclerosis risk or survival in three European populations.

Rooney JPK, Geoghegan G, O'Reilly F et al. · 2024 · Amyotrophic lateral sclerosis & frontotemporal degeneration

Introduction : Serum heat shock protein (HSP) concentrations have been reported as potential biomarkers for amyotrophic lateral sclerosis (ALS). Here, we investigate the role of serum HSP70, HSP90, and DNAJC7 as biomarkers for ALS. Methods…

View details →DOI: 10.1080/21678421.2024.2358805
Negative / Null Result ReportMedicine

Social Determinants of Health and Health-Related Quality of Life Following Pediatric Septic Shock: Secondary Analysis of the Life After Pediatric Sepsis Evaluation Dataset, 2014-2017.

Lenz KB, McDade J, Petrozzi M et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives Social determinants of health (SDOH) are associated with disparities in disease severity and in-hospital outcomes among critically ill children. It is unknown whether SDOH are associated with later outcomes. We evaluated…

View details →DOI: 10.1097/pcc.0000000000003550
Negative / Null Result ReportOpen accessMedicine

Stable White Matter Structure in the First Three Years After Psychosis Onset.

Van Dyken PC, Yang K, Faria AV et al. · 2025 · Biological psychiatry global open science

Background White matter alterations observed using diffusion weighted imaging have become a hallmark of chronic schizophrenia, but it is unclear when these changes arise over the course of the disease. Nearly all studies reported to date…

View details →DOI: 10.1016/j.bpsgos.2025.100472
Negative / Null Result ReportMedicine

Cognitive behavioral program for the prevention of depression in at-risk adolescents: isolating the effects of dose.

Dickerson JF, Clarke G, Weersing VR et al. · 2025 · American journal of epidemiology

The current study estimated effects of intervention dose (attendance) of a cognitive behavioral prevention (CBP) program on depression-free days (DFDs) in adolescent offspring of parents with a history of depression. As part of secondary…

View details →DOI: 10.1093/aje/kwae131
Negative / Null Result ReportOpen accessMedicine

The Airway, Breathing, Circulation-Plan, Risk, Options (ABC-PRO) Handover Tool in the PICU: Retrospective Evaluation of Pre- Versus Post-Implementation and Occurrence Rate of Cardiac Arrests, 2020-2023.

De Gaudenzi M, Mozun R, Schlapbach LJ et al. · 2026 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives Healthcare improvement studies indicate a potential to reduce cardiac arrests in the PICU through anticipatory care and shared awareness. We developed a structured risk-assessment and anticipation tool (i.e., the Airway,…

View details →DOI: 10.1097/pcc.0000000000003884