Negative / Null Result ReportMedicine
Alvarez Mulett S, Molina Garcia S, Abu Saleh O et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Central nervous system (CNS) infections are significant causes of morbidity and mortality, especially when diagnosis is delayed. Traditional cerebrospinal fluid diagnostic methods for CNS infections have limited sensitivity.…
View details →DOI: 10.1093/cid/ciaf390 Negative / Null Result ReportOpen accessMedicine
Lükewille L, Wiegand S, Fazel A et al. · 2026 · Journal of cancer research and clinical oncology
Purpose Sentinel lymph node biopsy (SLNB) is a standard procedure for nodal staging in cutaneous melanoma. However, its diagnostic performance in the head and neck region remains limited due to complex lymphatic drainage patterns. This…
View details →DOI: 10.1007/s00432-026-06499-5 Negative / Null Result ReportMedicine
Zhang J, Su M, Zhang Y et al. · 2025 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Objective To explore the reasons for false negative results by Optical genome mapping (OGM) analysis of three cases and propose strategies for handling them. Methods Three patients presented at the Affiliated Hospital of Nantong University…
View details →DOI: 10.3760/cma.j.cn511374-20250725-00455 Negative / Null Result ReportMedicine
Pantazis JC, Palmer AC · 2026 · Molecular cancer therapeutics
The phase III study of romidepsin plus CHOP for peripheral T-cell lymphoma (PTCL) yielded negative results in the overall analysis and showed that outcomes were only improved in the T follicular helper (TFH) subgroup of PTCL, with no…
View details →DOI: 10.1158/1535-7163.mct-25-0941 Negative / Null Result ReportOpen accessMedicine
Kwatra D, Wakeford W, Ally M et al. · 2026 · BMC endocrine disorders
BACKGROUND: To evaluate the concordance of the NBCL CONNECT Point-of-Care (POC) Intraoperative Parathyroid Hormone (IOPTH) assay with a Central Laboratory standard, with a focus on percentage drops and the usefulness of POC testing in…
View details →DOI: 10.1186/s12902-025-02112-x Negative / Null Result ReportMedicine
Saucedo M, Chamorro MF, Passler T et al. · 2026 · Journal of the American Veterinary Medical Association
Objective This study aimed to compare the most accurate sample type, test, and timing for detecting bovine viral diarrhea virus (BVDV) in persistently infected (PI) calves at different time points following birth and colostrum intake.…
View details →DOI: 10.2460/javma.25.06.0397 Negative / Null Result ReportOpen accessMedicine
Badelita SN, Sandu HM, Coriu D et al. · 2026 · Frontiers in oncology
Bone marrow hemodilution could compromise next generation flow cytometry based measurable residual disease evaluation in multiple myeloma and may cause false negative results. This review summarizes definitions, markers, indices,…
View details →DOI: 10.3389/fonc.2026.1849714 Negative / Null Result ReportOpen accessMedicine
Behjatnia H, Couto P, Castillo Y et al. · 2026 · The American journal of case reports
BACKGROUND Fungal endocarditis constitutes up to 3% of diagnosed infective endocarditis cases, and Histoplasma spp. cause approximately 10% of fungal endocarditis cases. Histoplasma infection occurs through inhalation of spores typically…
View details →DOI: 10.12659/ajcr.950135 Negative / Null Result ReportOpen accessMedicine
Shi H, Li W, Guo L et al. · 2025 · Journal of thoracic disease
Background Both amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and next-generation sequencing (NGS) are able to identify sensitizing epidermal growth factor receptor ( EGFR ) mutations of non-small cell lung…
View details →DOI: 10.21037/jtd-24-1787 Negative / Null Result ReportMedicine
Ceran Serdar C · 2026 · The Turkish journal of pediatrics
Background Biotinidase deficiency is a core condition in newborn screening programs worldwide. While fluorometric enzyme activity assays from dried blood spots (DBS) are the standard first-tier test, their accuracy can be susceptible to…
View details →DOI: 10.24953/turkjpediatr.2026.6966 Negative / Null Result ReportOpen accessMedicine
Guerrero-Tánori DM, Martínez-Guerrero A, Müller MF et al. · 2026 · MethodsX
The Mozart effect has been the subject of lively but also controversial debate in literature during the last decades. Positive as well as negative results have been reported, using different musical stimuli as well as cognitive tasks. In…
View details →DOI: 10.1016/j.mex.2026.103964 Negative / Null Result Report
Orciari LA, Wicker V, Bonaparte S et al. · 2025 · Preprint
Point-of-care, immunochromatographic tests have not reliably detected rabies virus and have not utilized a consistent diagnostic protocol. International diagnostic standards established by the World Organization for Animal Health require…
View details →DOI: 10.1101/2025.10.25.25338785 Negative / Null Result ReportMedicine
Loomba R, Sanyal AJ, Nakajima A et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Pegbelfermin is a polyethlene glycol-conjugated analog of human fibroblast growth factor 21, a nonmitogenic hormone that regulates energy metabolism. This phase 2b study evaluated 48-week pegbelfermin treatment in…
View details →DOI: 10.1016/j.cgh.2023.04.011 Negative / Null Result Report
Bedia-Tanoh VA, Konaté-Touré A, Kouakou OMK et al. · 2025 · Preprint
Abstract Background Accurate malaria diagnosis and reporting are critical for effective case management and surveillance. In sub-Saharan Africa, rapid diagnostic tests (RDTs) are widely used to support clinical decision-making. However,…
View details →DOI: 10.21203/rs.3.rs-7334541/v1 Negative / Null Result ReportMedicine
Yang YJ, Lee MR, Chung CL et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Despite the availability of rapid tuberculosis (TB) nucleic acid amplification (NAA) testing, prevention of TB transmission within healthcare facilities remains a challenge due to ongoing difficulties in promptly isolating…
View details →DOI: 10.1016/j.ijid.2026.108538 Negative / Null Result ReportMedicine
Nielsen SM, Russell EM, Ellsworth RE et al. · 2025 · Journal of the National Comprehensive Cancer Network : JNCCN
Background The presence of variants of uncertain significance (VUS) should not influence clinical management; however, prior studies on breast cancer-related health care utilization in women with VUS versus negative germline genetic test…
View details →DOI: 10.6004/jnccn.2025.7011 Negative / Null Result ReportMedicine
Salman E · 2026 · Indian journal of medical microbiology
Background The primary reason for increased lab use is inappropriate or needless test requests. Our study examined the benefits of repeated antinuclear antibody (ANA) testing and the reasons for ANA test requests in accordance with…
View details →DOI: 10.1016/j.ijmmb.2025.101035 Negative / Null Result ReportMedicine
Watanabe K, Takahashi H, Narumi R et al. · 2025 · The journal of obstetrics and gynaecology research
Non-invasive prenatal testing (NIPT) is a screening method that analyzes cell-free DNA (cfDNA) in maternal plasma to detect major aneuploidies. However, NIPT can fail to identify subtle chromosomal aberrations. We report a case in which…
View details →DOI: 10.1111/jog.70168 Negative / Null Result ReportOpen accessMedicine
Sridapan T, Jaturapaktrarak C, Rujirawat T et al. · 2026 · Journal of fungi (Basel, Switzerland)
Pythiosis is an emerging infectious disease caused by the oomycete Pythium insidiosum , affecting humans and animals primarily in subtropical and tropical regions. The pathogen is commonly found in swampy environments, and exposure can…
View details →DOI: 10.3390/jof12050351 Negative / Null Result ReportOpen accessMedicine
Meng S, Zhao W, Zhang H et al. · 2026 · EJHaem
Objective To retrospectively analyze the early efficacy and safety of azacitidine plus lisaftoclax in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome with increased blasts (MDS-IB), providing a reliable clinical…
View details →DOI: 10.1002/jha2.70305 Negative / Null Result ReportMedicine
Castle PE, Befano B, Hyer M et al. · 2026 · Journal of the National Cancer Institute
Background We demonstrated that cervical cancer risk following any screening result is lower if there is a known prior negative screening history vs an unknown screening history. We extended these findings to look at how screening performs…
View details →DOI: 10.1093/jnci/djaf317 Negative / Null Result ReportMedicine
Çubuk F, Öksüz C, Öz M · 2026 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Objective A substantial proportion of urine cultures in patients with suspected urinary tract infections (UTIs) yield negative results. This study aimed to evaluate whether parameters from automated urinalysis could predict the likelihood…
View details →DOI: 10.1016/j.jiac.2026.102904 Negative / Null Result ReportOpen accessMedicine
Sato R, Takasaka N, Hosaka Y et al. · 2025 · BMC infectious diseases
Background The T-SPOT.TB assay is widely used for the adjunctive diagnosis of tuberculosis (TB). However, clinicians often encounter false-negative T-SPOT.TB results. The extent of TB spread may influence host immune functions, which can…
View details →DOI: 10.1186/s12879-025-10777-x Negative / Null Result ReportOpen accessMedicine
Sripa J, Suebsamran P, Pangjit K · 2026 · BMC infectious diseases
Background Opisthorchiasis remains an important public health problem in Southeast Asia and is strongly associated with cholangiocarcinoma. Although stool-based diagnosis is widely used, its sensitivity is limited in light infections,…
View details →DOI: 10.1186/s12879-026-13445-w Negative / Null Result ReportOpen accessMedicine
Unubol N, Ayaş M, Uyar NY et al. · 2025 · Microorganisms
In recent years, the World Health Organization has highlighted biofilm-derived multidrug-resistant bacteria as a critical threat to both global health and the environment. Although various testing methods are available, crystal violet and…
View details →DOI: 10.3390/microorganisms14010021 Negative / Null Result Report
AL-Saeedi A, Abdulamir AS, Aufi IM et al. · 2025 · Preprint
Abstract Background The widespread use of accurate real-time RT-PCR tests for community individuals is a critical approach to managing the disease and reducing COVID-19 transmission effectively. In addition, serological ELISA assays are…
View details →DOI: 10.21203/rs.3.rs-8233598/v1 Negative / Null Result ReportOpen accessMedicine
Mukherjee S, Fujiwara Y, Fountzilas C et al. · 2025 · Cancer medicine
Background Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel…
View details →DOI: 10.1002/cam4.70835 Negative / Null Result ReportMedicine
Fu Q, Chen Y, Huang D et al. · 2023 · Annals of surgical oncology
Background Folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) or modified FOLFIRINOX (mFFX) is the first-line standard of care for metastatic pancreatic adenocarcinoma; effective and safe treatment strategies are needed…
View details →DOI: 10.1245/s10434-023-13383-w Negative / Null Result ReportMedicine
Hiester A, Che Y, Lusch A et al. · 2023 · European urology
Background Primary retroperitoneal lymph node dissection (RPLND) for clinical stage (CS) IIA/B seminoma without adjuvant treatment is an experimental treatment to avoid radiotherapy- or chemotherapy-related toxicity from standard…
View details →DOI: 10.1016/j.eururo.2022.10.021 Negative / Null Result ReportMedicine
Schwartz A, Mikati S, Knipper F et al. · 2025 · Applied biosafety : journal of the American Biological Safety Association
Background The COVID-19 pandemic highlighted critical shortages in personal protective equipment (PPE), particularly respirators, which limited healthcare workers' safety worldwide. Decontamination and reuse of PPE, including powered-air…
View details →DOI: 10.1089/apb.2025.0006 