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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20230 results in Negative / Null Result Report · page 289 of 675

Negative / Null Result ReportMedicine

Immersive Haptic Simulation for Psychomotor Skill Acquisition in Preclinical Prosthetic Dentistry: A Randomized Study.

Bandiaky ON, Volteau C, Bihan A et al. · 2026 · The International journal of prosthodontics

Purpose The aim of this study was to evaluate the effect of using the VirTeaSy Dental simulator in conjunction with a virtual reality headset on student performance in conventional fixed prosthodontics simulations. Material and methods The…

View details →DOI: 10.11607/ijp.9731
Negative / Null Result ReportOpen accessMedicine

Does closed suction drainage reduce postoperative hematoma and muscle swelling after total hip arthroplasty? A retrospective comparative study using computed tomography.

Asano T, Uemura K, Higuchi R et al. · 2026 · Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs

Purpose Closed suction drainage has been used after total hip arthroplasty (THA) to prevent hematoma, muscle swelling, and complications, but its effectiveness remains controversial. This study evaluated the effects of drains on…

View details →DOI: 10.1007/s10047-026-01561-y
Negative / Null Result ReportMedicine

Constrained acetabular liner total hip arthroplasty versus conventional hemiarthroplasty for unstable comminuted femoral intertrochanteric fractures in elderly patients with neurological disorders.

Dong M, Liu Y, Wei C · 2026 · BMC surgery

Background To evaluate whether constrained acetabular liners (CAL) used in total hip arthroplasty (THA) reduce the risk of dislocation and related complications in patients with neuromuscular disorders and unstable comminuted femoral…

View details →DOI: 10.1186/s12893-026-03973-2
Negative / Null Result ReportMedicine

Clinical outcomes of conventional Vs. transepithelial photorefractive keratectomy: A prospective contralateral eye study.

Marchi MB, Al Harami A, Maher A et al. · 2026 · European journal of ophthalmology

PurposeTo compare the clinical outcomes of conventional photorefractive keratectomy (PRK) and transepithelial PRK (TransPRK) for the correction of myopic refractive errors.MethodsThis prospective, paired-eye comparative study included 48…

View details →DOI: 10.1177/11206721261461914
Negative / Null Result ReportMedicine

Comparison of Nasal Tip Projection and Rotational Stability between Structural Rhinoplasty with Strut Graft and Preservation Rhinoplasty with Pitanguy Ligament Graft.

Farhadi F, Ahmadpour F, Nezafati S et al. · 2026 · Aesthetic plastic surgery

Background and aim The nasal tip plays a central role in facial aesthetics, and achieving long-term tip stability is a key objective in rhinoplasty. This study compared postoperative tip stability between structural rhinoplasty using a…

View details →DOI: 10.1007/s00266-026-05847-7
Negative / Null Result ReportOpen accessMedicine

Impact of sport disciplines on gut microbiota in elite athletes: evidence from Taekwondo and diving athletes.

Chen X, Xie L, Li B · 2026 · Frontiers in microbiology

Objective Gut microbiota is closely associated with athletic performance, but differences between sport disciplines have rarely been reported. This study collected gut microbiota samples from athletes across different sport disciplines to…

View details →DOI: 10.3389/fmicb.2026.1770499
Negative / Null Result ReportOpen accessMedicine

A chlorine releasing solution as an alternative for dental biofilm control.

Telles PYV, Oliveira VC, Geng Vivanco R et al. · 2026 · Scientific reports

To evaluate the antibiofilm activity of a chlorine-releasing solution (CRS) and its in vitro effects on enamel color stability, surface roughness, and microhardness. A mixed biofilm composed of Staphylococcus aureus, Candida albicans, and…

View details →DOI: 10.1038/s41598-026-49642-5
Negative / Null Result ReportOpen accessMedicine

Comparison of Postoperative Analgesic Efficacy of Two Intrathecal Morphine Doses (75 μg vs 100 μg) for Cesarean Delivery: A Double-Blind Randomized Study.

Veraza JA, Martinez MA, Angulo P et al. · 2026 · Cureus

Background Intrathecal morphine remains a cornerstone of post-cesarean analgesia due to its prolonged spinal effect; however, its use is limited by dose-dependent adverse effects. Contemporary practice trends favor dose minimization, yet…

View details →DOI: 10.7759/cureus.107761
Negative / Null Result ReportOpen accessMedicine

Do the Pre-Existing Class III and Class V Composite Restorations Affect the Sealing Ability and Integrity of 3D-Printed Laminate Veneer Margins? An In Vitro Study.

Qaraghuli AM, Cagidiaco EF, Ferrari M · 2026 · Journal of functional biomaterials

Background: The application of veneer restorations over previously composite-restored anterior teeth presents significant clinical challenges, particularly in achieving optimal marginal sealing. Aim: This in vitro study aimed to evaluate…

View details →DOI: 10.3390/jfb17050249
Negative / Null Result ReportOpen accessMedicine

Current status of 5-aminosalicylic acid in Crohn's disease treatment: a nationwide survey and analysis of perspectives and practice patterns among inflammatory bowel disease physicians.

Li Y, Chen C, Wang C · 2026 · Frontiers in gastroenterology (Lausanne, Switzerland)

Objective To investigate the perspectives and clinical practice patterns of inflammatory bowel disease (IBD) physicians regarding the use of 5-aminosalicylic acid (5-ASA) in Crohn's disease (CD). Methods A 21-item questionnaire was…

View details →DOI: 10.3389/fgstr.2026.1783772
Negative / Null Result ReportMedicine

Acute effects of the FIFA 11 + kids warm-up program compared with a judo-specific warm-up on explosive and functional performance in youth judo athletes: a randomized crossover study.

Mor H, Şar H, Arslan T et al. · 2026 · BMC sports science, medicine & rehabilitation

Background The FIFA 11 + Kids (FIFA 11+) warm-up program is effective for injury prevention and to enhance sports performance, including vertical jump (VJ), sprint, balance, and agility. However, no previous study has examined the acute…

View details →DOI: 10.1186/s13102-026-01751-4
Negative / Null Result Report

Validation of a novel indirect Swept-source optical coherence tomography method for assessing internal fit and marginal adaptation: An in vitro study

Zeng C, Tabata T, Takahashi R et al. · 2026 · Preprint

Abstract Background Adaptation of indirect restorations is critical for clinical success. Although the conventional silicone replica method is destructive, direct in-situ Swept-source optical coherence tomography (SS-OCT) can be used to…

View details →DOI: 10.21203/rs.3.rs-9841824/v1
Negative / Null Result ReportOpen accessMedicine

Clinicopsychological stratification of recovery outcomes in cerebral aneurysm patients following cluster analysis.

Reder SR, Hardt J, Brockmann MA et al. · 2026 · PNAS nexus

The aim of this present study was to investigate the multifactorial determinants of recovery outcomes in cerebral aneurysm patients by identifying subgroups based on clinical and psychological factors. A cross-sectional approach was used (…

View details →DOI: 10.1093/pnasnexus/pgag157
Negative / Null Result ReportOpen accessMedicine

Delayed orocecal transit in pediatric gut-brain interaction disorders: A comparative study using the lactulose breath test.

Devanarayana NM, Rajindrajith S, de Silva DGH et al. · 2025 · World journal of gastrointestinal pathophysiology

Background Functional abdominal pain disorders (FAPDs) are common gut-brain interaction disorders with unclear pathophysiology. While impaired gastrointestinal motility is thought to play a key role, small intestinal dysmotility remains…

View details →DOI: 10.4291/wjgp.v16.i4.110421
Negative / Null Result Report

A population genetic study of Fusarium graminearum , the causal agent of Fusarium Head Blight, provides insights into patterns of inoculum dispersal in wheat fields at a regional scale

Nguyen TBH, Le Floch G, Henri-Sanvoisin A et al. · 2025 · Preprint

ABSTRACT Fusarium graminearum is the primary pathogen responsible for Fusarium Head Blight (FHB) in cereals, causing yield losses and mycotoxin contamination. The present study investigated the genetic diversity and population structure of…

View details →DOI: 10.1101/2025.07.11.664332
Negative / Null Result ReportMedicine

Immunotherapy Strategies After Immune Checkpoint Inhibitor Exposure in Renal Cell Carcinoma: A Review.

Giudice GC, Beckermann KE, Siqueira Do Amaral P et al. · 2025 · JAMA oncology

Importance Immune checkpoint inhibitors have transformed the treatment landscape for metastatic renal cell carcinoma; however, the failure of first-line therapeutic strategies remains a considerable challenge. Currently, clinicians face…

View details →DOI: 10.1001/jamaoncol.2025.0017
Negative / Null Result ReportOpen accessMedicine

Non-tobacco nicotine dependence is associated with increased complications following clavicle open reduction internal fixation.

Adio AA, Goyal RK, Skiena A et al. · 2026 · Archives of orthopaedic and trauma surgery

Background Tobacco dependence is well established to impair bone healing and increase postoperative complications. However, the independent effects of nicotine, separate from combustion-related factors, remain unclear. This study aimed to…

View details →DOI: 10.1007/s00402-026-06377-2
Negative / Null Result ReportOpen accessMedicine

Changes in the Mechanical Properties of Nickel-Titanium Orthodontic Archwires After Clinical Use with Conventional and Self-Ligating Brackets.

Ruiz G, Moyano J, Alcaraz I et al. · 2026 · Dentistry journal

Background/Objectives : Changes in the mechanical behavior of orthodontic archwires during clinical use are not fully understood, particularly when different bracket systems are employed. Self-ligating (SL) brackets have gained…

View details →DOI: 10.3390/dj14060351
Negative / Null Result ReportOpen accessMedicine

Effectiveness of Dry Needling Versus Percutaneous Electrolysis in Achilles Tendinopathy: A Randomized Clinical Trial.

Delgado Álvarez S, Méndez Sánchez R, Polo Ferrero L et al. · 2026 · Cureus

Introduction Achilles tendinopathy (AT) is characterized by pain, inflammation, and functional limitations. It is also the most common cause of pain located at the back of the calcaneus. The Achilles tendon is among the most vulnerable…

View details →DOI: 10.7759/cureus.104384
Negative / Null Result Report

Exploration of shift work among nursing professionals related to interconnected determinants of health in a hospital: a cross-sectional study

Rubiño-Díaz JÁ, Ferrández-Sempere S, Canellas F et al. · 2026 · Preprint

Abstract Aim To assess sleep quality and its relationship with interconnected health variables among nursing professionals working shifts. Methods A cross-sectional descriptive observational study. A total of 247 nursing professionals…

View details →DOI: 10.21203/rs.3.rs-9731930/v1
Negative / Null Result ReportOpen accessMedicine

Gut microbiota dysbiosis in intensive care unit patients with acute kidney injury: insights from 16S sequencing and mediation analysis.

Li J, Shi Y, Meng H et al. · 2026 · BMC nephrology

Background The gut-kidney axis is critical in acute kidney injury (AKI) pathophysiology, but its specific characteristics in intensive care unit (ICU) patients remain unclear. This study aimed to investigate compositional and functional…

View details →DOI: 10.1186/s12882-026-05134-2
Negative / Null Result ReportOpen accessMedicine

Effects of Defatted Black Soldier Fly (<i>Hermetia illucens</i>) Meal on the Performance, Digestibility and Blood Parameters of Weaned Piglets.

Parreiras M, Pinheiro V, Moreira O et al. · 2026 · Animals : an open access journal from MDPI

This study investigated the effects of different inclusion levels of defatted black soldier fly ( Hermetia illucens : BSF) larval meal on growth performance, haematological and biochemical blood parameters, and nutrient digestibility in…

View details →DOI: 10.3390/ani16111571
Negative / Null Result ReportMedicine

Relationships between morphological score changes during embryonic development and pregnancy outcomes.

Gan Q, Ma W, Liu L et al. · 2026 · Clinical and experimental reproductive medicine

Objective This study investigated whether changes in embryonic morphological scores can predict pregnancy outcomes to support optimal blastocyst selection. Methods This retrospective dual-center study analyzed 1,492 single blastocyst…

View details →DOI: 10.5653/cerm.2025.08179
Negative / Null Result ReportOpen accessMedicine

Effect of different feed particle size on digestive tract morphology, digesta viscosity, nutrient retention, and blood biochemical parameters in slow-growing broiler chickens.

Novotný J, Čumplík L, Horáková L et al. · 2026 · Veterinary and animal science

The study evaluated the effect of feed particle size on health and performance indicators in slow-growing broiler chickens. Performance traits, digestive tract morphology, digesta viscosity, nutrient retention, and blood biochemical…

View details →DOI: 10.1016/j.vas.2026.100715