A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19843 results in Negative / Null Result Report · page 288 of 662
Idani D, Mashhadi SM, Babaei H et al. · 2024 · Preprint
Purpose: To evaluate vascular changes in patients with diabetic macular ischemia (DMI) after systemic oxygen therapy using Optical coherence tomography angiography (OCTA). Methods: : This interventional before-after study included 26 eyes…
Cavalcante FP, Cardoso A, Antonini M et al. · 2025 · Translational breast cancer research : a journal focusing on translational research in breast cancer
Background Neoadjuvant chemotherapy (NAC) is widely accepted as standard treatment in breast cancer, particularly in cases of tumors with aggressive biology. NAC has increased the rates of breast-conserving surgery (BCS) and the conversion…
Díaz de Terán T, Bolado J, Palomo P et al. · 2025 · Sleep & breathing = Schlaf & Atmung
Objective To assess the effectiveness of an intervention programme combining Oropharyngeal Myofunctional Therapy (OMT) and cervical spine exercises in the general population with mild to moderate Obstructive Sleep Apnoea (OSA), analysing…
Shamsi F, Aligholi H, Karimi MT et al. · 2024 · Journal of motor behavior
The current study aimed to evaluate the effects of action observation on the walking ability and oscillatory brain activity of chronic stroke patients. Fourteen chronic stroke patients were allocated randomly to the action observation (AO)…
Tadesse M, Tesfaye BA, Taye B et al. · 2026 · Medicine
Hyperthyroidism accelerates bone turnover and increases the risk of secondary osteoporosis. However, evidence from sub-Saharan Africa remains scarce. This study assessed the prevalence and predictors of osteoporosis among hyperthyroid…
Makino M, Shishikura D, Kusumoto H et al. · 2026 · Cardiovascular diagnosis and therapy
Background The micro-axial intravascular flow pump (mAFP) may potentially improve the prognosis of cardiogenic shock (CS). Despite its advanced hemodynamic profile, efficacy remains undetermined. Safety and mid-term outcomes were compared…
Serwer T, Wahid M, Imtiaz F et al. · 2024 · JPMA. The Journal of the Pakistan Medical Association
Objective To identify the mutation in codon 201 of the deleted in colorectal cancer gene in colorectal cancer, and to correlate that mutation to the histopathological grading of colorectal cancer. Methods The cross-sectional study was…
Dureha R, Navit S, Khan SA et al. · 2024 · International journal of clinical pediatric dentistry
Aim The aim of this study was to evaluate the antimicrobial efficacy and minimum inhibitory concentration (MIC) of commercially available pediatric dentifrices containing different compositions against Streptococcus mutans and…
Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V et al. · 2024 · Free radical biology & medicine
Calcium (Ca 2+ )/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca 2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammatory, metabolic and…
O'Leary RM, Zavlun N, Kinney A et al. · 2025 · Frontiers in psychology
Pupil dilation has become a well-established physiological index of cognitive effort. Here we examined the often-cited finding of an inverted U-shaped function of pupil size across the continuum from highly degraded to clear speech. Unlike…
Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin
Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…
Bukhari SS, Saeed F, Tahir I et al. · 2023 · Preprint
Abstract Background: The standard of care for gliomas includes maximum safe resection of the tumor. This may lead to inadvertent damage to tissue directly or vasculature supplying normal brain tissue. This may result in perilesional brain…
Karra DA, Suchodolski JS, Newman SJ et al. · 2025 · Journal of veterinary internal medicine
Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/objectives To evaluate the efficacy of a single enema fecal microbiota transplantation…
Rivera D, Robinson T, King AC · 2024 · Perceptual and motor skills
In this investigation, we examined the influence of two approaches of motor skill learning (differential learning and repetition-based) for an explosive motor skill. Twenty-seven individuals completed four training sessions of a standing…
Song M, Launder NH, Phutane VH et al. · 2026 · Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
ObjectiveMajor depressive disorder (MDD) is a highly prevalent debilitating mental health disorder with a lifetime risk of 11-15% in Australia. The most effective treatment for severe depression is electroconvulsive therapy (ECT), but it…
Judith PJ, Maureen B, Mélanie P et al. · 2024 · Health science reports
Background In this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second-line treatment potentiated the objective response rate. Patients/methods A…
Thach B, Wang Y, Heng S et al. · 2024 · Placenta
Introduction The syncytiotrophoblast (STB) of the human placenta facilitates vital maternal-fetal communication and is maintained by fusion (syncytialization) of cytotrophoblasts. Serine protease HtrA4 (high temperature requirement factor…
Li M, Chen H · 2025 · BMC cardiovascular disorders
Background Eosinophilic myocarditis (EM) is a rare cardiac condition that is often difficult to diagnose. Although endocardial myocardial biopsy is considered the gold standard for diagnosis, sampling errors can lead to false-negative…
Valle AEPd, Hare M, Karley A et al. · 2026 · Preprint
Abstract Systems approaches are becoming widely recognised for their potential to address the complexity of food systems’ challenges and lead needed transformations. However, there is limited attention on how systems thinking is being…
Zahl-Olsen R, Gausel N, Håland ÅT et al. · 2026 · Journal of clinical psychology
Routine Outcome Monitoring systems have been developed to monitor how clients' lives change over the course of therapy. However, for such systems to be effective, they must possess sufficient construct validity and scale-reliability to…
Ito R, Okanoya K · 2026 · Preprint
Octave equivalence—the tendency to perceive tones separated by a 2:1 frequency ratio as perceptually similar—is a fundamental feature of human pitch perception and a key component of musical pitch organization. Evidence for octave…
Singh S, Jagannathan K, Childress AR et al. · 2026 · European eating disorders review : the journal of the Eating Disorders Association
Objective Weight suppression (WS), or the difference between one's highest past and current weights, may help maintain bulimia nervosa (BN) by altering reward response to food cues. This pilot study tested associations among WS, brain…
· 2006
The effects of maternal alcohol (ethanol) ingestion during lactation are complex and depend on the pattern of maternal drinking. With casual alcohol use (such as 1 glass of wine or beer) it is best to wait 2 to 2.5 hours per drink before…
Gámez Martínez S, Lovatón Romero G, Alcañiz Raya M et al. · 2026 · Cyberpsychology, behavior and social networking
The diagnosis of autism spectrum disorder is based on clinical judgment, as there are no clearly identified markers to determine the presence of this condition. Gaze patterns have been proposed as a potential biomarker for autism. This…
Knight KF, Milton F, Zeman A · 2026 · Neuropsychologia
Visual mental imagery and visual working memory are often thought to be closely related. After all, both have been argued to involve the temporary maintenance of visual representations in conscious awareness. We might expect, therefore,…
Randa L, Lee C, Cheng J et al. · 2026 · Journal of electrocardiology
Background The frequency of cardiac ectopy, including premature atrial contractions (PACs), premature ventricular contractions (PVCs), non-sustained supraventricular tachycardia (SVT), and non-sustained ventricular tachycardia (NSVT), is…
Koß C, Blanke JH, de la Cuesta-Ferrer L et al. · 2026 · Preprint
Signal detection theory posits that subjects in two-stimulus, two-choice discrimination tasks decide by comparing random samples of an evidence variable to a static decision criterion. While the core assumptions of the theory have received…
Cuspidi C, Facchetti R, Tadic M et al. · 2026 · Journal of hypertension
Background The long-term reproducibility of the nighttime blood pressure (BP) phenotypes, namely, dipping (D) and nondipping (ND) has never been described in population-based studies. We investigated this issue in the participants to the…
Lu S, Efendić E, Feldman G · 2025 · Journal of personality and social psychology
The appraisal-tendency framework proposed that specific emotions predispose individuals to appraise future events corresponding to the core appraisal themes of the emotions. In a registered report with a U.S. American online Amazon…
Kurian C, Kurian E, Orhurhu V et al. · 2026 · Regional anesthesia and pain medicine
Background While many medical specialties have established links between bibliometric indices, academic rank, leadership roles, and National Institutes of Health (NIH) funding, there exists a gap within the field of pain medicine. The…