A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19843 results in Negative / Null Result Report · page 286 of 662
Brolin KA, Bäckström D, Wallenius J et al. · 2024 · Preprint
Variants in GBA1 are important genetic risk factors in Parkinson’s disease (PD). GBA1 T369M has been linked to an ∼80% increased PD risk but the reports are conflicting and the relevance of GBA1 variants in different populations varies. A…
Nakamura T, Hatanaka KC, Kawamoto Y et al. · 2025 · Journal of cancer research and clinical oncology
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Despite the use of aggressive combination chemotherapy regimens, outcomes remain unsatisfactory. Schlafen family member 11 (SLFN11) has been reported to regulate the DNA…
Tsui ST, Zhou N, Tan KS et al. · 2025 · JTCVS open
Objectives The study objectives were to determine whether diagnostic laparoscopy improves staging accuracy in selected patients with distal esophageal adenocarcinoma and to identify clinicopathologic features associated with positive…
Tabara Y, Shoji-Asahina A, Ogawa A et al. · 2024 · International journal of obesity (2005)
Background Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy…
Tseng YT, Chen II, Wang CH · 2025 · Healthcare (Basel, Switzerland)
Background : The long-term effects of hormone replacement therapy (HRT) on inflammatory bowel disease (IBD) remain unclear, necessitating further investigations of the association between HRT and the development of ulcerative colitis and…
Schiff DM, Wheeler A, Lewis D et al. · 2026 · Journal of substance use and addiction treatment
Objective Identify sociodemographic and substance use characteristics associated with pregnancy intention and explore the relationship between pregnancy intent and postpartum contraception interest among pregnant individuals with opioid…
Reda B, Zanon G, Contardo L et al. · 2025 · Orthodontics & craniofacial research
Objective Orthodontic treatment is a common approach for correcting malocclusion but is often associated with discomfort. The aim of this study was to assess the longitudinal changes in oral behaviours, temporomandibular disorder…
Kholili U, Hidayat AA, Bintoro UY et al. · 2026 · Cancers
Introduction Mounting evidence indicates that the p53 Pro72Arg single-nucleotide polymorphisms (SNPs) may play a role in modulating hepatocarcinogenesis in the setting of chronic HBV infection. However, there is currently a lack of studies…
Petzke TM, Köteles F, Pohl A et al. · 2024 · Journal of psychosomatic research
Objective (Cardiac) interoception was long considered a key mechanism behind symptom perception in persistent somatic symptoms (PSS). In this study, we aimed to extend earlier findings to clarify this potential interoceptive mechanisms of…
Kohno C, Higuchi A, Miyagawa E et al. · 2026 · Modern rheumatology
Objectives Low-dose aspirin (LDA) is widely recommended to prevent hypertensive disorders of pregnancy (HDP). However, the evidence of its effectiveness in pregnancies with systemic lupus erythematosus (SLE) remains limited. This study…
· 2006
Lurasidone is more than 99% bound to plasma proteins, so it is unlikely that the drug would be excreted into milk in sufficient amounts to affect a breastfed infant. Data from one mother-infant pair appears to support the poor excretion…
Kishinevsky M, Ferrer-Suay M, Ives AR · 2026 · Biol Invasions.
The enemy release hypothesis—that the success of invading species is due to release from natural enemies that occur in their home range but not in the new range—can be an important explanation for successful invasions. Testing this…
Sebbag A, SAKDAVONG J · 2025 · Preprint
In the scientific literature, avatars are representations that can take various forms and fulfill multiple functions and roles for learners. The recent emergence of ultra-realistic avatars generated by artificial intelligence presents new…
Neal RA, Corbett J, Costello JT et al. · 2026 · European journal of sport science
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterised by chronic hyperglycaemia, whereas obesity is a major risk factor which increases morbidity and mortality. Treatments that alter white adipose tissue to express a…
Abbasi H, Ashtiani MN · 2026 · Journal of motor behavior
This study investigated the impact of real-time laser-guided visual cues on spatiotemporal gait parameters during initiation and termination in people with Parkinson's (PwP). Fifteen PwP walked a 5-m path under uncued and laser-cued…
DeGrado J, Devlin JW · 2025 · Critical care clinics
Antipsychotics are an attractive option for adjunctive sedation in critically ill adults given their sedating effects, short duration of action, lack of effect on respiratory drive, and multiple routes of administration but high-quality…
Singier A, Jarne Munoz A, Maumus-Robert S et al. · 2025 · JAMA network open
Importance Although pharmacovigilance signals and a strong pathophysiological rationale have suggested a potential risk of arterial dissections or aneurysms associated with angiogenesis inhibitors, this association deserves to be further…
Ellis K, Moss J, Dziwisz M et al. · 2025 · Oxford open neuroscience
It has been suggested that mentalizing abilities underlie the distinct profiles of autism characteristics observed between Cornelia de Lange (CdLS) and fragile X syndromes (FXS) and autistic people without a genetic syndrome. However,…
Turmanbayeva A, Sadykova K, Nuskabayeva G et al. · 2026 · Journal of clinical medicine
Background : Metabolic syndrome (MetS) is influenced by behavioral and genetic factors, yet evidence on eating behavior patterns and related genetic polymorphisms in Central Asian populations remains limited. Aim: The aim of this study was…
Santamaria-Guzman K, Holmes H, Kosek J et al. · 2026 · Archives of orthopaedic and trauma surgery
Introduction Visual processing speed and cognitive interference control are critical for athletic performance and Anterior Cruciate Ligament (ACL) injury risk. However, how these cognitive functions relate to biomechanical performance…
Matsumoto N · 2024 · Memory & cognition
Autobiographical memory specificity is known to contribute to better mental health, social problem-solving, and episodic future thinking. While numerous studies have addressed variables that affect autobiographical memory specificity,…
Masal TA, Kholinne E · 2026 · Cureus
Background Fractures are a major public health concern among the elderly and contribute substantially to morbidity and disability. Sedentary behavior has been proposed as a modifiable risk factor for fractures; however, evidence regarding…
Khalil E, Yüksel B · 2026 · Archives of medical sciences. Atherosclerotic diseases
Introduction Perioperative atrial fibrillation (POAF) remains the most common arrhythmic complication occurring in the setting of isolated coronary artery bypass grafting (CABG), and it is now being increasingly recognised as a marker of…
Beesiga B, Litunya J, Nakato JZ et al. · 2026 · AIDS and behavior
Alcohol-serving venues in East Africa are high-risk environments for HIV transmission but few studies in sub-Saharan Africa (SSA) have examined perceived HIV risk and sexual risk behaviors by alcohol use levels on a broader population of…
Shinde SS, Naik NS, Adhyapak SU et al. · 2025 · Journal of pharmacy & bioallied sciences
Background Emotional hyporexia, a form of intentional food avoidance triggered by emotional distress, presents a growing health concern among adolescent girls. Addressing this behavior through psychological intervention is essential for…
Wang Y, Xu P, Wang K et al. · 2024 · Neurological research
Objective The association between herpes zoster (HZ) and stroke has been the subject of much previous research. Nevertheless, the connection remains ambiguous. A two-sample Mendelian randomisation study was conducted to explore the…
Yohe LR, Miller LB, Kaliszewska ZA et al. · 2024 · Preprint
ABSTRACT Under an adaptive hypothesis, the reciprocal influence between mutualistic plants and frugivores is expected to result in dispersal syndromes comprising both frugivore and plant traits that structure fruit consumption. Tests of…
Kutumova E, Kovaleva A, Sharipov R et al. · 2024 · Preprint
The angiotensin converting enzyme (ACE) gene ( ACE ) insertion/deletion ( I/D ) polymorphism has attracted much attention in recent years, as it raises the hope of personalizing ACE inhibitor therapy to optimize its efficiency and reduce…
Randall B, Leković A, Nikolić S et al. · 2025 · Lipids in health and disease
The role of omega-3 fatty acids in the atherosclerotic process remains unclear. Early studies demonstrated a profound anti-atherogenic effect of cod liver oil in a pig model, and autopsy reports from Alaska Natives consuming omega-3 rich…
Sharpe AR, Richardson K, Stanton M et al. · 2023 · The Journal of emergency medicine
Background Cardiac arrest occurs in approximately 350,000 patients outside the hospital and approximately 30,000 patients in the emergency department (ED) annually in the United States. When return of spontaneous circulation (ROSC) is…