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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19843 results in Negative / Null Result Report · page 281 of 662

Negative / Null Result Report

ADHD is not a risk factor for service-related PTSD in Israeli military conscripts: Evidence from a population-based cohort study of 1.4 million recruits

Porat DB, Abuhasira S, Ekka-Zohar A · 2026 · Preprint

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been hypothesized to increase vulnerability to post-traumatic stress disorder (PTSD) due to emotional dysregulation, impulsivity, and executive function deficits. Most…

View details →DOI: 10.21203/rs.3.rs-9741341/v1
Negative / Null Result ReportMedicine

Understanding Repression Under Secretion Stress in <i>Trichoderma reesei</i> During Cellulase Expression.

Jadhav R, Demirbas Uzel G, Charest J et al. · 2026 · Microorganisms

The filamentous fungus Trichoderma reesei is one of the most important workhorses for industrial enzyme production, but the cellular mechanisms that balance protein folding stress with secretion, such as the unfolded protein response (UPR)…

View details →DOI: 10.3390/microorganisms14061371
Negative / Null Result ReportMedicine

Donning gloves before patient contact, with or without prior hand hygiene.

Bayhan GI, Aydın Altuntaş C, Cevahir N · 2026 · Journal of infection in developing countries

Objective Hand hygiene (HH) is a fundamental infection prevention measure in healthcare settings, playing a crucial role in reducing healthcare-associated infections (HAIs). Despite its importance, HH compliance remains suboptimal…

View details →DOI: 10.3855/jidc.22190
Negative / Null Result ReportOpen accessMedicine

Changes in THC Positivity Rates in Adolescents Corresponding to Legalization of Recreational Marijuana in Illinois.

Gassé E, Brill A · 2026 · The western journal of emergency medicine

Introduction As public access to tetrahydrocannabinol (THC) products expands under state legalization, there is concern for increased use in adolescents under 18 years of age and its subsequent effects. Adverse effects of THC use have been…

View details →DOI: 10.5811/westjem.62946
Negative / Null Result ReportMedicine

Differential Expression of Dopamine-Related Genes Across Developmental and Parental Stages in the Burying Beetles, Nicrophorus orbicollis.

Panaitof SC, Kermagi MM · 2026 · Archives of insect biochemistry and physiology

Dopamine has diverse roles in the regulation of reproduction and social behaviors in insects. In the burying beetle, Nicrophorus orbicollis, a species with extended care, our previous work has shown that brain dopamine levels increase…

View details →DOI: 10.1002/arch.70177
Negative / Null Result ReportMedicine

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus.

Majoe M, Stolarek N, Vizueta J et al. · 2026 · Journal of evolutionary biology

Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers…

View details →DOI: 10.1093/jeb/voag043
Negative / Null Result ReportOpen accessMedicine

Effects of an orexin receptor 2-selective agonist on salivary secretion in rats.

Ichishima J, Nakakariya M, Kimura H · 2026 · Scientific reports

Narcolepsy type 1 (NT1) is caused by a significant loss of orexin-producing neurons. In clinical trials, multiple orexin receptor 2 (OX2R)-selective agonists (e.g., danavorexton, TAK-994, and oveporexton) improved wakefulness and decreased…

View details →DOI: 10.1038/s41598-026-44080-9
Negative / Null Result Report

Community-level Monitoring of Antimicrobial Resistance following Mass Administration of Azithromycin to Reduce Child Mortality in Côte d’Ivoire: Results from Two Rounds of Surveillance

Dulli L, Gbonon V, Touré F et al. · 2026 · Preprint

Background Mass Drug Administration (MDA) of azithromycin for the elimination of trachoma and, more recently, for the reduction of child mortality, are public health strategies shown, with mixed results, to contribute to the development of…

View details →DOI: 10.12688/gatesopenres.16385.1
Negative / Null Result ReportMedicine

Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study.

Normand-Gravier T, Solsona R, Bertrand-Gaday C et al. · 2026 · Experimental physiology

Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both…

View details →DOI: 10.1113/ep093111
Negative / Null Result ReportMedicine

Non-tuberculous mycobacteria in primary ciliary dyskinesia: a national multicenter cohort study.

Bar-On O, Less Elazari S, Ben-Zvi H et al. · 2026 · Respiration; international review of thoracic diseases

Introduction The prevalence and clinical significance of non-tuberculous mycobacteria (NTM) in individuals with primary ciliary dyskinesia (PCD) remain unclear, with most data extrapolated from cystic fibrosis. This first national…

View details →DOI: 10.1159/000552722
Negative / Null Result ReportMedicine

Effects of providing access to a cycling exergaming platform on cardiorespiratory fitness and cardiometabolic health in adolescents: a randomised, controlled trial.

Berg J, Wang AI, Madssen E et al. · 2026 · Scientific reports

Insufficient physical activity (PA) among adolescents has deleterious consequences for their health. Exergaming, which combines exercise with gaming, is enjoyable, but the long-term effects of exergaming on adolescent health remain poorly…

View details →DOI: 10.1038/s41598-026-48327-3
Negative / Null Result ReportMedicine

The Association Between Sitting Delivery During the Second Stage of Labor and Pelvic Floor Function in Primiparas: A Prospective Cohort Study.

Gong J, Xie B, Wei Y et al. · 2026 · Healthcare (Basel, Switzerland)

Background/objectives Pregnancy and childbirth are independent risk factors for pelvic floor injury. The choice of delivery position, as an interventionable factor during labor, has received much attention. This study aimed to assess the…

View details →DOI: 10.3390/healthcare14121681
Negative / Null Result ReportMedicine

Nationwide questionnaire survey on collaboration for the management of chronic kidney disease from the perspective of referrals in Japan.

Hatta T, Kobayashi K, Tatematsu S et al. · 2026 · Clinical and experimental nephrology

Background Preventing end-stage renal failure progression of patients with chronic kidney disease (CKD) requires collaboration between nephrologists and general practitioners. Following the 2013 and 2019 surveys in Japan, a nationwide…

View details →DOI: 10.1007/s10157-026-02878-x
Negative / Null Result ReportMedicine

Effects of reduced metabolizable protein diets supplemented with rumen-protected His under adequate Met and Lys supply on production, nutrient digestibility, N utilization, and manure ammonia emissions in lactating cows.

Park K, Kim J, Hu H et al. · 2026 · Journal of dairy science

Balancing for limiting AA may prevent reduced production when deficient MP is provided. The objective of the study was to determine the effects of rumen-protected (RP) His supplementation at different levels of MP when Lys and Met supplies…

View details →DOI: 10.3168/jds.2025-27548
Negative / Null Result ReportMedicine

Are gaps in the time of submissions and approvals of new drugs between Health Canada and the Food and Drug Administration related to therapeutic value? A cross-sectional study.

Lexchin J · 2026 · Health policy (Amsterdam, Netherlands)

Background Health Canada is proposing to use decisions by foreign regulators in approving new drugs to speed up their marketing. Objectives To investigate the length of gaps in submissions to and approvals by Health Canada compared to the…

View details →DOI: 10.1016/j.healthpol.2026.105631
Negative / Null Result ReportMedicine

Do potentially traumatic events experienced by people in one's social circle affect one's own mental health and emotional support? Findings from a prospective population-based study.

van der Velden PG, Contino C, Kempe S et al. · 2026 · Acta psychologica

Background Adults may have individuals in their social circle who were recently exposed to potentially traumatic events (PTEs). The present study aims to examine if these adults are at increased risk for mental health problems and reduced…

View details →DOI: 10.1016/j.actpsy.2026.107136