Negative / Null Result ReportOpen accessMedicine
Grząsiak-Kraj O, Majos A, Durczyński A et al. · 2026 · Przeglad gastroenterologiczny
Introduction Impaired glucose metabolism and diabetes frequently accompany pancreatic cancer. In patients with unresectable disease, palliative gastrojejunostomy is commonly performed to relieve gastrointestinal obstruction; however, its…
View details →DOI: 10.5114/pg.2026.160484 Negative / Null Result ReportOpen accessMedicine
Nowak R, Olejnik A, Zawiślak E et al. · 2026 · Head & face medicine
Background Maxillary constriction in adults often requires surgically assisted maxillary expansion. While skeletal and dental changes are well described, soft-tissue effects remain less clear. This study evaluated soft-tissue changes using…
View details →DOI: 10.1186/s13005-026-00616-y Negative / Null Result ReportOpen accessMedicine
Mahajan A, Upadhyay M, Reddy RN et al. · 2026 · Journal of education and health promotion
Background Systemic sclerosis is an autoimmune disorder characterized by progressive fibrosis which affects skin and internal organs. There is also involvement of oral cavity seen as microstomia which affects oral hygiene and subsequently,…
View details →DOI: 10.4103/jehp.jehp_1395_25 Negative / Null Result ReportOpen accessMedicine
Hegde NN, Attavar S, Banerjee A et al. · 2026 · Journal of conservative dentistry and endodontics
Background Apical extrusion of debris during root canal preparation is inevitable and may contribute to postoperative pain and periapical inflammation. The extent of extrusion varies with instrument design and motion. ProTaper Next (PTN),…
View details →DOI: 10.4103/jcde.jcde_514_25 Negative / Null Result ReportOpen accessMedicine
Fousekis E, Arhakis A, Arapostathis K et al. · 2026 · Biomimetics (Basel, Switzerland)
The aim of the study was to evaluate the immediate and aged shear bond strength (SBS) of a dual-cured and a light-cured universal adhesive to primary and permanent dentin. Twenty caries-free primary molars and twenty permanent third molars…
View details →DOI: 10.3390/biomimetics11050358 Negative / Null Result ReportOpen accessMedicine
Makrantonakis A, Mantzoros I, Ioannidis O et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Intraperitoneal onlay mesh (IPOM) reduces ventral/incisional hernia recurrence but raises concern for adhesions and infection, particularly when the operative field is not strictly clean. We aimed to determine…
View details →DOI: 10.3390/medicina62050803 Negative / Null Result ReportOpen accessMedicine
Seetharama DB, Prasad K, Prakash VR et al. · 2026 · Cureus
Introduction Acute coronary syndrome (ACS) is a major manifestation of coronary heart disease and is associated with significant morbidity and mortality. Inflammatory and thrombotic mechanisms play an important role in its pathogenesis.…
View details →DOI: 10.7759/cureus.105558 Negative / Null Result ReportMedicine
Eminsoy Avcı AT, Yavuz B, Karakaya B et al. · 2026 · BMC oral health
Background This randomized clinical trial aimed to compare postoperative pain (PP) and analgesic consumption following single-visit root canal treatment using two calcium silicate-based sealers (BioMTA + and Well-Root PT) and one epoxy…
View details →DOI: 10.1186/s12903-026-08525-x Negative / Null Result ReportOpen accessMedicine
Al-Eitan LN, Alasmar MK, Alorjani MS et al. · 2026 · Frontiers in medicine
Background Vitamin D exerts a protective role in carcinogenesis by regulating signaling pathways implicated in tumor growth and progression. Variants in CYP2R1, CYP24A1, CYP27B1, and DBP have been reported to influence circulating 25(OH)D…
View details →DOI: 10.3389/fmed.2026.1816935 Negative / Null Result ReportMedicine
Leung EYH, Ng PHJ, Tan JHE et al. · 2026 · Singapore medical journal
Introduction High-energy open fractures are complex orthoplastic problems. Limb salvage surgical goals include achieving bony stabilisation and adequate soft tissue coverage, while minimising bone and soft tissue complications. Soft tissue…
View details →DOI: 10.4103/singaporemedj.smj-2025-034 Negative / Null Result ReportOpen accessMedicine
Adeeb S, Kriger A, Żmudzki J et al. · 2026 · Materials (Basel, Switzerland)
Interactions between the chemical compounds contained in mouthwashes and the components of dental composites may significantly influence their functional properties. The study investigated the effect of mouthwashes on the mechanical…
View details →DOI: 10.3390/ma19071304 Negative / Null Result ReportOpen accessMedicine
Zawar I, Zhu S, Quigg M et al. · 2026 · Brain communications
Epilepsy is a common comorbidity of Alzheimer's disease (AD) and related dementias (ADRD). Both epilepsy and ADRD affect the mesial temporal structures in volume and morphology. Nonetheless, mesial temporal shape and volume asymmetry…
View details →DOI: 10.1093/braincomms/fcag179 Negative / Null Result ReportOpen accessMedicine
Xu L, Wang X, Meng X et al. · 2026 · Oral health & preventive dentistry
Purpose To explore the relationship between dental caries and non-alcoholic fatty liver disease (NAFLD) and its advanced stage of liver fibrosis, and to confirm causality by employing a bidirectional two-sample Mendelian Randomization (MR)…
View details →DOI: 10.3290/j.ohpd.c_2714 Negative / Null Result ReportMedicine
Popovici I, Carvajal MJ, Higgins T et al. · 2026 · The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG
Objectives While gender disparities in the US workforce have received substantial attention, income inequalities among subspecialty pharmacists remain understudied. This study aimed to develop a professional profile of pediatric…
View details →DOI: 10.5863/jppt-25-00095 Negative / Null Result ReportOpen accessMedicine
Stępień S, Morawiec ML, Smycz-Kubańska M et al. · 2026 · Frontiers in oncology
Ovarian cancer (OC) is a major clinical problem in gynaecological oncology, characterised by difficulties in early diagnosis, which contributes to the high mortality rate from OC. Therefore, the search for new biological markers continues,…
View details →DOI: 10.3389/fonc.2026.1757624 Negative / Null Result ReportOpen accessMedicine
Espinoza-Ríos J, Ruiz-Cortez R, Santiago B et al. · 2026 · BMC gastroenterology
Background Upper gastrointestinal bleeding (UGIB) remains one of the most common emergencies in gastroenterology, with mortality rates reaching 14% in some settings. Despite advances in management, mortality has remained relatively…
View details →DOI: 10.1186/s12876-026-04963-7 Negative / Null Result ReportOpen accessMedicine
Shinde N, Warad VG, Potkar S et al. · 2026 · Cureus
Introduction Type 2 diabetes mellitus (T2DM) is a growing global health concern. Emerging evidence suggests that vitamin D and calcium play an important role in glucose metabolism and insulin function. The present study aimed to compare…
View details →DOI: 10.7759/cureus.108040 Negative / Null Result ReportOpen accessMedicine
Spasić M, Todorović K, Živković N et al. · 2026 · Journal of functional biomaterials
Impacted mandibular third molars present a common challenge in oral surgery, often associated with postoperative complications such as delayed healing and periodontal defects; therefore, optimizing adjunctive therapies is clinically…
View details →DOI: 10.3390/jfb17060307 Negative / Null Result ReportOpen accessMedicine
Gül T, Seçme M · 2026 · Biomedicines
Background/Objectives : Neuroblastoma is the most frequent solid tumor outside the brain in children and is associated with unfavorable outcomes in high-risk patients. Tannic acid, a naturally occurring polyphenolic compound, has been…
View details →DOI: 10.3390/biomedicines14051117 Negative / Null Result ReportOpen accessMedicine
Thakur A, Singh BP, Parihar YS · 2026 · Cureus
Background Frozen shoulder (adhesive capsulitis) is a common cause of shoulder pain and disability in middle-aged adults, characterized by progressive pain and restriction of both active and passive range of motion. Despite multiple…
View details →DOI: 10.7759/cureus.105746 Negative / Null Result ReportMedicine
Chong JT, Yi H, Wang AE et al. · 2026 · Cardiovascular engineering and technology
Purpose The intracranial aneurysm (IA) model reconstruction is critical for pathophysiology diagnosis and computational simulations. This study aimed to quantify the impact of segmentation thresholds and software platforms on the…
View details →DOI: 10.1007/s13239-026-00841-1 Negative / Null Result ReportOpen accessMedicine
Wen Z, Ye Y, Chen H et al. · 2026 · Indian journal of orthopaedics
Objective To compare and verify the effectiveness of tendon-to-bone suture technique for the repair of external rotator injuries after hip arthroplasty. Methods This was a prospective, randomized, controlled study including 178 patients…
View details →DOI: 10.1007/s43465-026-01748-8 Negative / Null Result ReportOpen accessMedicine
Kondo K, Morita I, Sakuma S et al. · 2026 · PloS one
Objectives This study aimed to longitudinally examine nationwide changes in smoking behavior among the Japanese population in response to the COVID-19 pandemic. Design and setting A secondary analysis was conducted using cigarette sales…
View details →DOI: 10.1371/journal.pone.0350820 Negative / Null Result ReportMedicine
Borghgraef D, Sienaert P, Lambrichts S · 2026 · Canadian journal of psychiatry. Revue canadienne de psychiatrie
BackgroundPreventing relapse following a successful acute treatment of major depressive disorder (MDD) remains a clinical challenge. The presence of residual depressive symptoms seems to be a reliable predictor of relapse. However, few…
View details →DOI: 10.1177/07067437261448747 Negative / Null Result ReportOpen accessMedicine
Metin Yamac D, Erguven N, Ozenc E · 2026 · Anesthesiology research and practice
Aim The aim of this study is to compare the effect of intranasal and oral midazolam administered for premedication to children of preschool age on hemodynamic parameters, sedation, and separation from parents. Method A prospective,…
View details →DOI: 10.1155/anrp/4837750 Negative / Null Result ReportMedicine
Reina Abellán J, Bonato F, Ángel García D · 2026 · Military medicine
Background Elite acrobatic military parachutists are exposed to extreme repetitive axial loads and high gravitational forces, and low back pain (LBP) is common; however, the relationship between LBP and trunk neuromuscular function in this…
View details →DOI: 10.1093/milmed/usag301 Negative / Null Result ReportMedicine
Tasgaonkar A, Rathi N, Tasgaonkar M et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
Purpose Paediatric dental anxiety remains a significant challenge in clinical practice, often impacting co-operation and treatment outcomes. This randomised controlled trial compares the anxiety-reducing effects of AI-based self-modelling…
View details →DOI: 10.1007/s40368-026-01241-8 Negative / Null Result ReportOpen accessMedicine
Wong AJ, Donnell CC · 2026 · European journal of pediatrics
This study aims to synthesise and interpret evidence relating to fluoride-free toothpaste alternatives for caries prevention, examining how these products have been studied, the outcomes used to evaluate them, and how this evidence may…
View details →DOI: 10.1007/s00431-026-07176-y Negative / Null Result Report
Osei F · 2026 · Preprint
Abstract Drug repurposing and indication expansion remain important in pharmaceutical development, but the evidence supporting candidate drug--disease hypotheses is often fragmented across clinical trial registries, biomedical literature,…
View details →DOI: 10.21203/rs.3.rs-10046462/v1 Negative / Null Result ReportOpen accessMedicine
Zhao FY, Yue LP, Ho YS et al. · 2026 · Nature and science of sleep
Background and aims Insomnia during pregnancy is potentially associated with adverse outcomes, including gestational diabetes mellitus, pre-eclampsia, cesarean delivery, preterm birth, and depression. This study aimed to synthesize…
View details →DOI: 10.2147/nss.s607896 