Negative / Null Result ReportMedicine
Ledesma V, Vanbaelen T, Gestels Z et al. · 2024 · FEMS microbiology letters
The ResistAZM randomized controlled trial found that the receipt of ceftriaxone/azithromycin, compared to ceftriaxone was not associated with an increase in the proportion of oral commensal Neisseria spp. and streptococci with azithromycin…
View details →DOI: 10.1093/femsle/fnae104 Negative / Null Result ReportMedicine
Petr V, Tichanek F, Liu SL et al. · 2025 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Targeting peritransplant inflammation via tumor necrosis factor alpha blockade failed to improve kidney transplantation outcomes in the CTOT-19 trial that tested infliximab (IFX) induction. As natural antibodies (nAbs) to cardiolipin and…
View details →DOI: 10.1016/j.ajt.2025.06.003 Negative / Null Result ReportMedicine
Lähteenmäki EI, Lehti S, Jauhiainen M et al. · 2025 · American journal of physiology. Endocrinology and metabolism
Although high-density lipoprotein (HDL) has cardiometabolic protecting properties, interventions to raise HDL cholesterol concentration have failed to improve cardiometabolic health. Hence, HDL composition and functionality might be key…
View details →DOI: 10.1152/ajpendo.00130.2025 Negative / Null Result ReportOpen accessMedicine
El Jalkh J, Obeid PM, Guermazi D et al. · 2025 · Dermatopathology (Basel, Switzerland)
A 64-year-old patient presented for management of symptomatic skin-colored papules symmetrically distributed over the lateral neck over the past two years, which failed to improve on multiple topical corticosteroids, antifungal creams, and…
View details →DOI: 10.3390/dermatopathology12020015 Negative / Null Result ReportMedicine
Mohammed SA, Gorica E, Albiero M et al. · 2025 · Diabetes
Revascularization strategies failed to improve outcome in patients with diabetes with peripheral artery disease (PAD). Histone modifications are key modulators of gene expression and could play a role in angiogenic response. This study…
View details →DOI: 10.2337/db24-0997 Negative / Null Result ReportMedicine
Zhang H, Yang Y, Sun S · 2024 · Acta psychologica
In response to the public's puzzle about why maternity leave has unexpectedly failed to improve fertility problem in the Chinese context of a widespread extension of maternity leave, our study concentrates on a prevailing stigmatization…
View details →DOI: 10.1016/j.actpsy.2024.104413 Negative / Null Result ReportOpen accessMedicine
Gorka J, Putowski Z, Wludarczyk A et al. · 2025 · Anaesthesiology intensive therapy
Background The PREVENT-MINS trial investigated whether perioperative heart rate reduction with ivabradine could prevent myocardial injury after noncardiac surgery (MINS). Although ivabradine modestly reduced heart rate, it did not reduce…
View details →DOI: 10.5114/ait/216162 Negative / Null Result ReportMedicine
Liu Y, Ren Y, Yang Y et al. · 2025 · Acta cardiologica
Background In 2012, the randomised trial IABP SHOCK II demonstrated that IABP did not reduce 30-day mortality in patients with acute myocardial infarction complicating cardiogenic shock (CS). However, SCAI proposed a new standardised…
View details →DOI: 10.1080/00015385.2025.2569023 Negative / Null Result ReportMedicine
Perkins JA, Price RS, Vizcarra JA · 2026 · Neurology
We describe a 70-year-old man with no significant medical history who developed progressive left leg numbness, gait dysfunction, and recurrent falls. Within a year, he reported difficulty with both initiating steps and perceiving his left…
View details →DOI: 10.1212/wnl.0000000000218062 Negative / Null Result ReportMedicine
Yamaguchi T, Akai S, Uozumi N et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
A 53-year-old male patient presented with dyspnea and was admitted with the diagnosis of bacterial pneumonia.His respiratory condition did not improve despite the resolution of fever with antibiotic therapy, and he was eventually diagnosed…
Negative / Null Result ReportMedicine
Diprose W, Fahed R, Volders D et al. · 2026 · Journal of neurointerventional surgery
Background Randomized trials showed that endovascular thrombectomy (EVT) did not improve outcomes in medium vessel occlusion (MeVO) stroke compared with usual care. We investigated whether patients randomized to EVT who achieved…
View details →DOI: 10.1136/jnis-2025-024733 Negative / Null Result ReportMedicine
Olatunji BO, Cusack CE, Levinson CA · 2026 · Journal of anxiety disorders
Although disgust proneness has been implicated in the development of obsessive-compulsive disorder (OCD), studies to date have failed to identify the core symptom of disgust proneness that may be most strongly associated with OCD and its…
View details →DOI: 10.1016/j.janxdis.2026.103204 Negative / Null Result ReportMedicine
Balziano S, Margalit I, Kollender R et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Fever often delays urgent hip fracture surgery due to infection concerns. This study found that operating early, despite fever, did not increase complications or death compared to waiting. Thus, early surgery appears to be a feasible…
View details →DOI: 10.1007/s00198-026-07904-y Negative / Null Result ReportMedicine
Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…
View details →DOI: 10.1007/s00198-026-08113-3 Negative / Null Result Report
Treeratanapun N, Lerttiendamrong B, Vacharathit V et al. · 2026 · Preprint
Abstract Background The implementation of sentinel lymph node biopsy (SLNB) with permanent section (PS) analysis alone in patients who satisfied the ACOSOG Z0011 criteria did not alter the standard of care offered by the additional frozen…
View details →DOI: 10.21203/rs.3.rs-9454590/v1 Negative / Null Result ReportOpen accessMedicine
Lee N, Yang Y, Tian D et al. · 2026 · Journal of ginseng research
We determined whether Korean Red Ginseng (KRG) extract and ginsenosides (Rb1, Rg1, or Rg3) have estrogen receptor-mediated or androgen receptor-mediated activities using OECD TG455/458 assays with S9 metabolic activation. They did not…
View details →DOI: 10.1016/j.jgr.2026.100989 Negative / Null Result ReportMedicine
Adams MS, Mensink RP, Plat J et al. · 2026 · European journal of clinical nutrition
Background Previous almond intervention studies involving relatively healthy populations did not demonstrate improvements in cognitive performance. However, a long-term study with participants at risk of cognitive decline, such as those…
View details →DOI: 10.1038/s41430-026-01705-6 Negative / Null Result ReportMedicine
Kant N, Garssen SH, Vernooij CA et al. · 2024 · Studies in health technology and informatics
Adding continuous monitoring to usual care at an acute admission ward did not have an effect on the proportion of patients safely discharged. Implementation challenges of continuous monitoring may have contributed to the lack of effect…
View details →DOI: 10.3233/shti240764 Negative / Null Result ReportMedicine
Sanders JF, de Boer SE, Jonker J et al. · 2026 · Journal of the American Society of Nephrology : JASN
Key points Low-dose tacrolimus, everolimus, and prednisolone did not result in a higher rate of successful transplantation in older kidney transplant recipients. Low-dose tacrolimus, everolimus, and prednisolone did not result in better…
View details →DOI: 10.1681/asn.0000000924 Negative / Null Result ReportMedicine
Hüther A, Sherman CL, Sumaroka A et al. · 2026 · Ophthalmic genetics
Purpose To describe the phenotype of a patient with bi-allelic pathogenic variants in NR2E3 that did not result in an overt enhanced S-cone syndrome (ESCS) phenotype. Methods The patient underwent a comprehensive ophthalmic exam, imaging…
View details →DOI: 10.1080/13816810.2026.2635611 Negative / Null Result ReportMedicine
Wu C, Zhu X, Dai Q et al. · 2026 · Chest
Case presentation A 74-year-old woman sought treatment with a 4-day history of high fever and rapidly progressive dyspnea. A 2-day course of ceftriaxone and betamethasone administered in an outpatient setting did not result in any clinical…
View details →DOI: 10.1016/j.chest.2025.07.4069 Negative / Null Result ReportMedicine
Stewart D, Greenberg M, Heppell S et al. · 2025 · Emergency medicine Australasia : EMA
Objective To determine the proportion of patients who are admitted to hospital following a 'did not wait' (DNW) encounter that are related to the initial episode of care, and to assess the frequency of clinical deterioration in this…
View details →DOI: 10.1111/1742-6723.70134 Negative / Null Result Report
Furne Gouveia G · 2026 · Preprint
The Michelson–Morley experiment yielded a null result, indicating equal light travel times in the longitudinal and transverse arms of an interferometer, traditionally interpreted as evidence against a light-propagating medium. This paper…
View details →DOI: 10.20944/preprints202601.0623.v2 Negative / Null Result Report
Furne Gouveia G · 2026 · Preprint
The Michelson–Morley experiment yielded a null result, indicating equal light travel times in the longitudinal and transverse arms of an interferometer, traditionally interpreted as evidence against a light-propagating medium. This paper…
View details →DOI: 10.20944/preprints202601.0623.v1 Negative / Null Result Report
Schwab S, Giuachin K, Held L · 2020 · Preprint
Publication bias is a persisting problem in meta-analyses for evidence based medicine. As a consequence small studies with large treatment effects are more likely to be reported than studies with a null result which causes asymmetry. Here,…
View details →DOI: 10.31222/osf.io/t6cjx Negative / Null Result ReportMedicine
Dora J, Kuczynski AM, McCabe CJ et al. · 2026 · Journal of psychopathology and clinical science
Etiological models of alcohol and cannabis use disorders hypothesize that people are more likely to use substances when experiencing heightened negative affect, yet recent Ecological Momentary Assessment (EMA) studies found no evidence for…
View details →DOI: 10.1037/abn0001097 Negative / Null Result ReportOpen access
Lin W, Clarke AM, Pilz KS et al. · 2023 · Preprint
What does age in ageing? Results in reinforcement learning (RL) are mixed. Some studies found deteriorated performance in older participants compared to younger controls whereas other studies did not. Daniel et al. (2020) suggested that…
View details →DOI: 10.1101/2023.05.25.542104 Negative / Null Result ReportMedicine
Finkelstein A, Cantor JC, Gubb J et al. · 2024 · Health affairs (Project Hope)
When a randomized evaluation finds null results, it is important to understand why. We investigated two very different explanations for the finding from a randomized evaluation that the Camden Coalition's influential care management…
View details →DOI: 10.1377/hlthaff.2023.01151 Negative / Null Result ReportMedicine
Eulenburg C, Celik Y, Redline S et al. · 2023 · Annals of the American Thoracic Society
Rationale: Recent randomized controlled trials did not show cardiovascular benefits of continuous positive airway pressure (CPAP) in adults with coronary artery disease (CAD) and obstructive sleep apnea (OSA) in intention-to-treat…
View details →DOI: 10.1513/annalsats.202208-676oc Negative / Null Result ReportMedicine
Ryser MD, Holloway ST, Morsomme R et al. · 2025 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Background The UK Collaborative Trial of Ovarian Cancer Screening did not detect a reduction in ovarian cancer mortality with either multimodal screening (MMS) or transvaginal ultrasound screening (USS) compared with no screening. The…
View details →DOI: 10.1158/1055-9965.epi-25-0498 