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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20230 results in Negative / Null Result Report · page 275 of 675

Negative / Null Result ReportOpen accessMedicine

Effect of low-dose atropine on young premyopic and low-myopic children: atropine treatment of myopia (ATOM3) - a randomised control trial.

Chia A, Burkill S, Ling Y et al. · 2026 · The British journal of ophthalmology

Aim To evaluate the effectiveness of atropine 0.01% in young premyopic and low-myopic children. Methods Children (5-9 years old) with premyopia (spherical equivalent refraction, SER+1.00 to -0.49D, n 156) or low myopia (SER -0.50 to…

View details →DOI: 10.1136/bjo-2025-328221
Negative / Null Result ReportOpen accessMedicine

WNT16 Overexpression is Insufficient to Counteract Inflammation-induced Bone Loss in Female Mice.

Nilsson KH, Henning P, Lagerquist MK et al. · 2026 · Calcified tissue international

Osteoporosis is characterized by an imbalance in bone remodeling, resulting in bone loss and increased fracture risk. Inflammatory diseases, such as rheumatoid arthritis, are strongly associated with secondary osteoporosis due to…

View details →DOI: 10.1007/s00223-026-01481-2
Negative / Null Result ReportMedicine

Progression of multiple vertebral fractures after denosumab discontinuation under treatment with romosozumab. A case-report.

Krikelis M, Gazi S, Trovas G et al. · 2024 · Joint bone spine

Introduction Denosumab (Dmab) is widely used for the treatment of post-menopausal osteoporosis. Its discontinuation is sometimes accompanied by multiple vertebral fractures. Romosozumab (Rmab) has not been tested for its ability to prevent…

View details →DOI: 10.1016/j.jbspin.2024.105754
Negative / Null Result ReportMedicine

Dietary milk polar lipids modulate gut barrier integrity and lipid metabolism in C57BL/6J mice during systemic inflammation induced by Escherichia coli lipopolysaccharide.

Zhou AL, Ward RE · 2024 · Journal of dairy science

The focus of this work is the role milk polar lipids play in affecting gut permeability, systemic inflammation, and lipid metabolism during acute and chronic inflammation induced by a single subcutaneous injection of lipopolysaccharide.…

View details →DOI: 10.3168/jds.2024-24759
Negative / Null Result ReportOpen accessMedicine

Pulmonary Aspergillosis in an Infant with Multiple Hepatic Hemangiomas.

Karp Z, Czarny J, Adamczewska-Wawrzynowicz K et al. · 2026 · Children (Basel, Switzerland)

Background : Infantile hepatic hemangiomas (IHH) are common benign vascular tumors in infancy with diverse presentations. Methods : We report a 7-week-old infant presenting with hepatosplenomegaly, multiple skin and hepatic hemangiomas,…

View details →DOI: 10.3390/children13040556
Negative / Null Result ReportOpen accessMedicine

Case Report: ROSAH syndrome presents diagnostic and therapeutic challenges.

Shunyakova J, Reynolds M, Taylor A et al. · 2025 · Frontiers in ophthalmology

Background Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache (ROSAH) syndrome is an autosomal dominant disorder caused by a heterozygous missense mutation in alpha kinase 1 (ALPK1). This series reports the…

View details →DOI: 10.3389/fopht.2025.1535805
Negative / Null Result ReportMedicine

Presumed post-traumatic subdural hygroma in a 2.5-year-old spayed female Chihuahua.

Frouin M, Cavalerie R, Piazza S et al. · 2024 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

A 2.5-year-old spayed female Chihuahua dog was presented with chronic cervical pain and exhibited a "prayer-like position" following a history of a 4-meter fall. CT and MRI revealed a moderate right-sided enlargement of the subdural space…

View details →DOI: 10.1111/vru.13362
Negative / Null Result ReportOpen accessMedicine

Clinical outcomes and association with disease progression and survival of subclinical bacteriuria in cats with chronic kidney disease: a multicenter retrospective study.

Le Corre E, Jousserand N, Maurey C et al. · 2026 · Journal of veterinary internal medicine

Background Subclinical bacteriuria (SBU) is frequently encountered in cats with chronic kidney disease (CKD), but it remains unclear if it is associated with survival and disease progression. Hypothesis/objectives To determine the…

View details →DOI: 10.1093/jvimsj/aalag064
Negative / Null Result ReportOpen accessMedicine

<i>Astragalus membranaceus</i> Modulates Inflammatory Markers Without Enhancing Muscle Function Following Intensified Resistance Training.

Villanova S, Gatti M, Colosio M et al. · 2026 · Nutrients

Background: Astragali radix is a traditional herb known for its antioxidant, anti-inflammatory, and immunomodulatory properties and has gained attention for its potential to support post-exercise recovery. However, the effects of long-term…

View details →DOI: 10.3390/nu18101598
Negative / Null Result ReportOpen accessMedicine

Convalescent plasma therapy for COVID-19 prophylaxis in adults early post-hematopoietic stem cell transplantation: one-year outcomes from a randomized controlled trial.

Cao Y, Li Q, Guo W et al. · 2025 · Frontiers in immunology

To evaluate the efficacy of COVID-19 convalescent plasma (CCP) in preventing SARS-CoV-2 infection in hematopoietic stem cell transplantation (HSCT) recipients during the early post-transplant period, a single-center, randomized controlled…

View details →DOI: 10.3389/fimmu.2025.1626775
Negative / Null Result ReportOpen accessMedicine

Mild hyperbaric oxygen does not attenuate mitochondrial decrease induced by detraining in mice.

Takemura A, Egawa T, Uemichi K et al. · 2025 · Biochemistry and biophysics reports

Mild hyperbaric oxygen (MHO) attenuates the muscle atrophy caused by muscle disuse. Training cessation results in the partial or complete loss of training-induced adaptations, including mitochondrial enzyme activities. The present study…

View details →DOI: 10.1016/j.bbrep.2025.102341
Negative / Null Result ReportOpen accessMedicine

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol.

van de Wetering R, Alder AF, Biggerstaff A et al. · 2025 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

The development of safer mu opioid receptor (MOR) agonists with reduced side effects is a key focus of pain research. Some studies have suggested that MOR agonists with reduced β-arrestin 2 (βArr2) signaling (i.e. G-protein biased…

View details →DOI: 10.1038/s41386-025-02214-z
Negative / Null Result ReportOpen accessMedicine

Rate of growth of Merkel cell carcinoma: a unique photographic evidence.

Bearzi E, Sola S, Defferrari C et al. · 2026 · Dermatology reports

Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin tumor, mainly linked to Merkel cell polyomavirus (MCPyV) and less often to ultraviolet exposure. Additional risk factors include advanced age and immunosuppression.…

View details →DOI: 10.4081/dr.2025.10457
Negative / Null Result ReportOpen accessMedicine

Protective effects of antidepressants against ulcerogenic agents: insights from nonclinical studies.

Stringari C, Stringari H, de Queiroz E Silva TF et al. · 2026 · Inflammopharmacology

INTRODUCTION: There is a marked overlap among the neuronal pathogenetic pathways involved in ulcer genesis and depression, and antidepressants can also exert a protective effect against gastric ulcers. OBJECTIVE: To summarize and…

View details →DOI: 10.1007/s10787-026-02240-3
Negative / Null Result ReportOpen accessMedicine

Fluorescent Light Energy in Feline Surgical and Traumatic Wounds: A Prospective Single-Arm Pilot Study of Healing Progression and Bacterial Findings.

Nocera FP, Fantini O, Abate G et al. · 2026 · Veterinary medicine and science

Background Traumatic and surgical wounds are common in cats, but their management is often challenging due to anatomical factors, delayed presentation, behavioural issues and frequent bacterial colonization. Objectives This prospective,…

View details →DOI: 10.1002/vms3.70929
Negative / Null Result ReportOpen accessMedicine

Reduced Frequency of Prolonged Sporadic Hemiplegic Migraine Attacks Following Fremanezumab Treatment-A Case Report.

Hotz JF, Kaindl L, Krebs S et al. · 2026 · European journal of neurology

Introduction Hemiplegic migraine (HM) is a rare subtype of migraine with aura, characterized by transient, unilateral motor weakness. Due to its rarity, treatment strategies are lacking. Monoclonal antibodies targeting the calcitonin…

View details →DOI: 10.1111/ene.70514
Negative / Null Result ReportOpen accessMedicine

A Pilot, Randomised, Placebo-Controlled, Double-Blind Trial of a Single Oral Dose of Ivermectin for Post-Exposure Prophylaxis of SARS-CoV-2.

Wagstaff KM, Stein MS, Herschtal A et al. · 2025 · Pharmaceutics

Background: The efficacy of a single oral dose of Ivermectin as prophylaxis for SARS-CoV-2 is uncertain. This trial sought to evaluate the effectiveness of a single oral low dose of Ivermectin to prevent SARS-CoV-2 infection or reduce…

View details →DOI: 10.3390/pharmaceutics17091205
Negative / Null Result ReportMedicine

The effect of fluoride varnish application on colour change due to paediatric drug usage in polyacid-modified composite resin: an in vitro study.

Çevik N, Hazar Bodrumlu E · 2024 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

Objective Colour stability is important in the long-term aesthetic success of restorative materials and is affected by both internal and external factors. Internal discolourations are due to the properties of the restorative materials.…

View details →DOI: 10.1007/s40368-024-00894-7
Negative / Null Result ReportMedicine

Can a Sacrococcygeal Epidural of 0.25% Bupivacaine Prevent the Activation of the Sympathetic Nervous System during Feline Ovariectomy?

Martins J, Eliseu A, Campos S et al. · 2024 · Animals : an open access journal from MDPI

The ovariectomy (OVE) procedure can trigger somatosensory and visceral peritoneal nociception. Sacrococcygeal epidural (ScE) anesthesia may complement or replace systemic analgesia used for feline OVE, reducing opioid consumption and their…

View details →DOI: 10.3390/ani14121732
Negative / Null Result ReportMedicine

Redox potential in animal andrology: An experimental study on boar semen.

Pintus E, Scaringi M, Engelen J et al. · 2026 · Theriogenology

Impaired seminal redox balance is a main factor that contributes to male fertility disorders and reduced sperm survival during storage. Although several methods are available to measure antioxidant and reactive oxygen species (ROS) levels,…

View details →DOI: 10.1016/j.theriogenology.2026.118051
Negative / Null Result ReportOpen accessMedicine

Dual Mechanisms of the Diazepine-Benzimidazole Derivative, DAB-19, in Modulating Glutamatergic Neurotransmission.

Nikolaev MV, Fedorova IM, Chistyakova OV et al. · 2025 · International journal of molecular sciences

The search for novel compounds with anticonvulsant properties remains a key focus in neuropharmacology. Recently, the diazepine-benzimidazole derivative, DAB-19, has emerged as a promising candidate due to its demonstrated anxiolytic and…

View details →DOI: 10.3390/ijms26115299