Negative / Null Result ReportOpen accessMedicine
Chen H, Huang X, Wang C et al. · 2025 · The Journal of infectious diseases
Assessing the time-varying effectiveness of coronavirus disease 2019 (COVID-19) vaccines is critical to guiding vaccine strategies and public health policies. We developed a Bayesian framework to estimate the waning vaccine effectiveness…
View details →DOI: 10.1093/infdis/jiaf207 Negative / Null Result ReportMedicine
Horizono J, Mizumoto K, Suico MA et al. · 2025 · Biological & pharmaceutical bulletin
Cyclodextrins (CDs) are cyclic oligosaccharides that encapsulate hydrophobic molecules such as cholesterol. Hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic heptasaccharide, has gained attention as a protective agent for chronic kidney…
View details →DOI: 10.1248/bpb.b25-00417 Negative / Null Result ReportMedicine
Hojo FR, Martins TC, Vieira-Junior WF et al. · 2025 · Operative dentistry
This study evaluated the influence of six resin composite coating agents on color stability and surface roughness after toothbrushing abrasion. Discs (Ø6 mm x 2 mm) of nanofilled resin composite (Filtek Z350XT) were prepared for…
View details →DOI: 10.2341/24-069-l Negative / Null Result Report
Chen A, Chou TY, Chen Y et al. · 2024 · Preprint
Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is a major disease affecting banana production around the globe. To study the movement of Foc in planta and investigate potential physical mechanisms of deterrence, the roots…
View details →DOI: 10.20944/preprints202410.2171.v1 Negative / Null Result Report
Giles C, Lee J · 2024 · Preprint
Abstract Nearly 90% of cancer deaths are due to metastasis. Conventional cancer therapeutics including chemotherapy, surgery, and radiotherapy, are effective in treating primary tumors, but may aggravate disseminated tumor cells (DTCs)…
View details →DOI: 10.21203/rs.3.rs-4719290/v1 Negative / Null Result ReportMedicine
Beningaza AM, Di Benedetto IMD, Babino L et al. · 2025 · Acta tropica
Chagas disease, vectored by kissing bugs, poses a public health problem across the Americas. The best way for reducing disease transmission is through vector control, which is currently based on the use of insecticides. However,…
View details →DOI: 10.1016/j.actatropica.2024.107520 Negative / Null Result ReportMedicine
Asadikorayem M, Weber P, Zhang S et al. · 2025 · Biomaterials advances
Osteoarthritis (OA) is one of the most common degenerative joint diseases, with no effective therapeutic options available. In this study, we aimed to develop an interpenetrating, in-situ-forming hydrogel based on biocompatible and…
View details →DOI: 10.1016/j.bioadv.2024.214151 Negative / Null Result ReportMedicine
Baudat M, Joosten EAJ, Simons SHP · 2025 · Pediatric research
Background While the incidence of neonatal intensive care unit (NICU) admission steadily increases, neonatology lacks evidence of a safe, effective, and preventive analgesic for treating procedural pain. Given its role in nociception and…
View details →DOI: 10.1038/s41390-024-03680-9 Negative / Null Result ReportOpen accessMedicine
Moksi L, Sissala N, Ojala R et al. · 2026 · Journal of orthopaedic surgery and research
Background Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger…
View details →DOI: 10.1186/s13018-025-06647-6 Negative / Null Result ReportMedicine
Shimada T, Iwahashi T, Suzuki K et al. · 2025 · Journal of pharmacological sciences
Chronic nerve compression disorders, such as carpal tunnel syndrome, are common and can significantly impair daily activities due to motor and sensory dysfunctions. Currently, no systemic pharmacotherapy exists for preventing or treating…
View details →DOI: 10.1016/j.jphs.2024.12.006 Negative / Null Result ReportMedicine
Guo Z, Hu Y, Zhou J et al. · 2025 · Biochemical and biophysical research communications
Iron overload leads to apoptosis and increased expression of receptor activator of nuclear factor kappa-Β ligand (RANKL) in osteocytes, which in turn accelerates osteoclastogenesis. Since osteocytes are the main RANKL producers, we…
View details →DOI: 10.1016/j.bbrc.2024.151152 Negative / Null Result ReportMedicine
Rumanova VS, Foppen E, Okuliarova M et al. · 2025 · Physiology & behavior
Exposure to artificial light at night (ALAN) disrupts natural darkness and desynchronizes daily rhythms in physiological processes and behavior. Previously, in rats, we have shown that dim ALAN disturbed the central circadian control and…
View details →DOI: 10.1016/j.physbeh.2024.114780 Negative / Null Result ReportOpen accessMedicine
Lima da Silva AP, de Oliveira TP, Nogueira RD et al. · 2025 · Journal of clinical and experimental dentistry
Background The objective was to evaluate the surface hardness of white spot lesions (WSL) treated with different caries prevention methods. Material and methods The Knoop microhardness (µKH) of 50 bovine dental enamel fragments was…
View details →DOI: 10.4317/jced.62588 Negative / Null Result ReportMedicine
Correia de Lima Junior N, Fernandes-Batista T, Ferreira-Serra L et al. · 2025 · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
The consumption of Western diet, characterized by high sugar and saturated fat content, often leads to weight gain and promotes oxidative stress. Intermittent fasting has emerged as a potential strategy to combat obesity, but its effects…
View details →DOI: 10.1055/a-2634-0201 Negative / Null Result Report
Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2024 · Preprint
Abstract Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
View details →DOI: 10.21203/rs.3.rs-4712325/v1 Negative / Null Result ReportMedicine
Rajsiglova L, Babic M, Krausova K et al. · 2024 · Journal of immunotoxicology
Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles…
View details →DOI: 10.1080/1547691x.2024.2416988 Negative / Null Result ReportOpen accessMedicine
de Araújo IM, Le PT, de Carvalho Picoli C et al. · 2026 · JBMR plus
Caloric restriction (CR) alters energy metabolism and increases systemic glucocorticoid production, contributing to bone loss and bone marrow adipose tissue (BMAT) expansion. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)…
View details →DOI: 10.1093/jbmrpl/ziag075 Negative / Null Result ReportMedicine
Damica FZ, Lucas DR, Toledo EB et al. · 2025 · Biochimica et biophysica acta. General subjects
Antimicrobial peptides (AMPs) are promising drugs, though their fungal combat mechanisms remain partly unclear. We designed three AMPs (dAMPs) based on the γ-core of the Vu-Def 1 seed defensin from Vigna unguiculata L. Walp. named RR,…
View details →DOI: 10.1016/j.bbagen.2025.130795 Negative / Null Result ReportMedicine
Magnuson JR, Bruce CD, Dalton BH et al. · 2024 · Journal of neurophysiology
The increasing descending drive needed to sustain submaximal isometric torque makes it difficult to isolate fatigue-related changes to neural excitability because evoked electromyography (EMG) responses are influenced by the relative…
View details →DOI: 10.1152/jn.00309.2024 Negative / Null Result ReportMedicine
Shaidullov I, Bouchareb D, Sorokina D et al. · 2025 · Naunyn-Schmiedeberg's archives of pharmacology
Irritable bowel syndrome (IBS) is a multifactorial disorder, with altered intestinal motility, visceral hypersensitivity, and dysfunction of the gut-brain axis. The aim of our study was to analyze the role of nitric oxide (NO) in the…
View details →DOI: 10.1007/s00210-024-03403-1 Negative / Null Result ReportMedicine
Villa M, Martínez-Vega M, Silva L et al. · 2024 · Pediatric research
Background Neonatal rats can manifest post-stroke mood disorders (PSMD) following middle cerebral artery occlusion (MCAO). We investigated whether cannabidiol (CBD) neuroprotection, previously demonstrated in neonatal rats after MCAO,…
View details →DOI: 10.1038/s41390-024-03077-8 Negative / Null Result ReportOpen access
Hoyle C, Pino RD, Lai SM et al. · 2025 · Preprint
Interleukin (IL)-1α is a pro-inflammatory member of the IL-1 cytokine superfamily and is important for inflammatory responses to infection and injury. Unlike pro-IL-1β, pro-IL-1α is mainly localised to the nucleus upon expression. This is…
View details →DOI: 10.1101/2025.09.30.679460 Negative / Null Result ReportOpen accessMedicine
Gam S, Hermann AP, Juhl CB et al. · 2026 · Obesity (Silver Spring, Md.)
Objective This study aimed to investigate whether a single infusion of 5 mg zoledronic acid, given before bariatric surgery to prevent bone loss, could also hinder the loss of muscle mass, strength, and physical function. Methods In this…
View details →DOI: 10.1002/oby.70062 Negative / Null Result ReportOpen accessMedicine
Dubourg V, Akhtar N, Kopf M et al. · 2026 · iScience
Vascular smooth muscle cells (VSMCs) are at the center of vascular diseases but studies on VSMCs from human females are rare and the medical need for female-specific vascular research is urgent. VSMCs are simultaneously subjected to…
View details →DOI: 10.1016/j.isci.2026.115886 Negative / Null Result ReportMedicine
Lyons J, Chatha HN, Boutros C et al. · 2025 · Surgical endoscopy
Background Fundoplication at the time of paraesophageal hernia (PEH) repair is thought to help prevent the development or persistence of postoperative gastroesophageal reflux (GERD) and might also prevent hernia recurrence. However, the…
View details →DOI: 10.1007/s00464-024-11317-5 Negative / Null Result ReportMedicine
Weerts EM, Jenkins BW, Kuang RY et al. · 2024 · Pharmacology, biochemistry, and behavior
Cannabigerol (CBG) is a phytocannabinoid found in cannabis that is promoted for medical use and other health benefits, but current empirical data on the behavioral effects of CBG are lacking. The purpose of this study was to evaluate the…
View details →DOI: 10.1016/j.pbb.2024.173883 Negative / Null Result ReportOpen accessMedicine
Maier KS, Schiener T, Frigg A · 2025 · Journal of orthopaedic surgery and research
Background Short femoral stems were introduced for total hip arthroplasty (THA) to preserve bone stock, increase proximal load transfer, and enable minimal invasive approaches. However, after implanting the short curved Fitmore hip stem,…
View details →DOI: 10.1186/s13018-025-06064-9 Negative / Null Result ReportOpen accessMedicine
Comboni LM, Glover ES, Napolitano SC et al. · 2026 · Foods (Basel, Switzerland)
We assessed whether consuming UV light-exposed mushrooms (UVMs) would offset the seasonal decline in circulating total 25-hydroxyvitamin D (25OHD), an index of vitamin D status. During late fall and winter, 41 adults (19 M/22 F, age 43 ±…
View details →DOI: 10.3390/foods15091572 Negative / Null Result ReportMedicine
Tuffs C, Dupovac M, Richter K et al. · 2025 · The American journal of pathology
Liver fibrosis is characterized by excessive deposition of extracellular matrix due to chronic inflammation of the liver. Hepatic stellate cells (HSCs) become activated and produce increased amounts of extracellular matrix. Loss of…
View details →DOI: 10.1016/j.ajpath.2024.10.018 Negative / Null Result ReportOpen accessMedicine
Quan J, Kriebel M, Anunu R et al. · 2026 · Scientific reports
The Median Raphe (MR) provides a major, mainly serotonergic, input to the hippocampus, particularly influencing the dentate gyrus (DG), but its specific role remains unclear. Here, focusing on the dorsal DG, we investigated its…
View details →DOI: 10.1038/s41598-026-38004-w 