A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19840 results in Negative / Null Result Report · page 274 of 662
Hsu G, Petticord DF, Slimon KF et al. · 2025 · Oikos
Prey capture by carnivorous plants is influenced by plant traits, environmental factors and interactions with animals. However, little is known about how interactions with heterospecific plant neighbors affect prey capture. Here, we…
Azzopardi S, Garcin B, Mesrati F et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology
Background and objective In patients with functional neurological disorder (FND), transcranial magnetic stimulation (TMS) can be used for either diagnostic or therapeutic purpose. This study aimed to determine patients' expectations and…
Rodriguez AK, Taylor TL, Fawver B et al. · 2026 · Psychology of sport and exercise
Individuals experiencing anxiety exhibit attentional biases towards unpleasant stimuli. Exercise is an anxiolytic intervention, evidenced by changes in attentional bias following physical activity. Many individuals experience 'anxiety…
Amaravadi RK · 2022 · Autophagy
Macroautophagy/autophagy is a resistance mechanism to targeted therapy in BRAF mutant cancers. Preclinical evidence and clinical trial data demonstrate that hydroxychloroquine (HCQ) is an effective autophagy inhibitor at clinically…
Okuizumi R, Maruyama S, Okamoto M et al. · 2026 · Journal of clinical biochemistry and nutrition
Coenzyme Q10 is a lipid-soluble antioxidant essential for the mitochondrial electron transport chain. Its concentration in the body decreases with age. The biosynthesis of coenzyme Q10 involves enzymes coq1 (PDSS1, PDSS2) through coq9,…
Martin BI, Mirza SK, Ko H et al. · 2026 · The spine journal : official journal of the North American Spine Society
Background context Medicare's Transforming Episode Accountability Model (TEAM) holds hospitals accountable for 30-day postoperative complications across 18 categories of spinal fusion bundles, yet baseline differences in complication rates…
Anijs RJS, Nguyen YN, Yanovska M et al. · 2025 · Thrombosis research
Background Colorectal cancer (CRC) patients are at increased risk of developing venous thromboembolism (VTE), leading to high morbidity and mortality. The exact mechanism remains unknown, which complicates risk prediction and treatment.…
Yang S, Qin M, Wei J et al. · 2026 · Industrial Crops & Products.
Nicotinic acid (NIA) is known to function in heavy metal detoxification; however, the regulation and physiological significance of its endogenous secretion in metal tolerance remain unclear. In this study, NIA was identified as a…
Jung J, Lutz KL, Dreager-Tougas KC et al. · 2025 · Journal of neurophysiology
Proctolin, an arthropod neuropeptide, is present in synaptic terminals innervating body wall muscles of Drosophila larvae. It acts as a cotransmitter with the excitatory neurotransmitter, l-glutamate (Glu). Previous work showed that…
Vondrasek JD, Brown JE, Grosicki GJ et al. · 2026 · Journal of strength and conditioning research
Abstract Vondrasek, JD, Brown, JE, Grosicki, GJ, and Flatt, AA. Effects of short-duration cycling after resistance exercise on aortic stiffness and next-day recovery in strength-trained men. J Strength Cond Res 40(5): 536-544, 2026-We…
Bessonova Y, Clark I, Sumida R et al. · 2025 · Preprint
Neuromodulators play a key role in determining how an organism processes and responds to sensory cues. Often, different neuromodulators act on the same set of neural circuits to produce diverging behavioral outcomes. In this study, we…
Scherer JS, Wu W, Wetmore JB et al. · 2026 · Kidney360
Background Legalization of cannabis across several US states may increase its use by individuals on hemodialysis, particularly among those with chronic pain. Contemporary data on frequency or factors associated with cannabis use by this…
Men X, Taylor ZL, Marshe VS et al. · 2026 · Canadian journal of psychiatry. Revue canadienne de psychiatrie
BackgroundVenlafaxine is commonly prescribed for older adults with depression, yet the relationship between venlafaxine-related exposure and treatment outcomes remains unclear. We aimed to assess the association of exposure to venlafaxine,…
Littmann J, Steiner N, Cabrejo-Jones K et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background A Moberg osteotomy is a dorsal closing wedge osteotomy of the base of the first proximal phalanx that is thought to augment the effect of cheilectomy by increasing dorsiflexion and ultimately improve patient outcomes in Hallux…
Terentieva EI, Komleva PD, Antonova SM et al. · 2026 · International journal of molecular sciences
Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like…
Ghazali M, Sele V, Sahuquillo A et al. · 2026 · Journal of hazardous materials
The increasing interest in seaweed as a potential feed and food source has prompted concerns regarding the presence of potentially toxic arsenic (As) species. Seaweed is known to contain the organic As species arsenosugars, but the…
Daniloski D, Ibáñez RA, McCarthy NA et al. · 2026 · Journal of dairy science
Bovine β-casein (β-CN) is a major milk protein that exists as multiple genetic variants, distinguished by differences in their amino acid sequences. Among these, the A1 and A2 variants are the most extensively studied. They differ at…
Noorman L, Bekebrede AF, de Vries S et al. · 2026 · Animal : an international journal of animal bioscience
In vitro and in situ experiments, primarily conducted using human cells, have demonstrated that metabolites produced during protein fermentation can negatively affect intestinal health. However, in vivo research on their impact on…
Nass N, Sprung S, Ignatov A et al. · 2026 · Cancer treatment and research communications
In cancer, aerobic glycolysis predominantly used to provide energy. This high glycolytic flow results in the formation of reactive aldehydes such as glyoxal and methylglyoxal forming advanced glycation end products (AGEs) by reacting with…
Willey CN, Bufi R, Takemon Y et al. · 2026 · American journal of physiology. Renal physiology
Increased concentrations of neuroblastoma suppressor of tumorigenicity 1 (NBL1) in the blood have been associated with disease progression in diabetic kidney disease (DKD) and IgA nephropathy. However, it is unclear whether NBL1 is a…
Claus L, Zhang X, Ocasio L et al. · 2026 · Clinical radiology
Aim Computed tomography angiography (CTA) is essential for preprocedural assessment in transcatheter aortic valve replacement (TAVR), particularly as TAVR becomes the preferred treatment for high-risk patients with severe aortic stenosis.…
Söröd M, Gyllencreutz E · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Introduction Cardiotocography (CTG) is used for fetal surveillance to prevent asphyxia related neonatal outcomes during pregnancy and delivery. In Sweden, all delivery wards have transitioned from CTG registered and printed on paper inside…
Dai R, Wells CD · 2025 · Preprint
Climate change is driving the poleward expansion of many species, including the Atlantic blue crab ( Callinectes sapidus ), whose northern range now extends into the Gulf of Maine. As a recently arrived predator, the blue crab may pose a…
Böhm M, Stegemann A, Wolnicka-Głubisz A et al. · 2026 · Aging and disease
Alpha-melanocyte-stimulating hormone (α-MSH) is a key endocrine mediator of photoprotection in the ultraviolet (UV)B-induced skin response. Its effects are mediated by the melanocortin-1 (MC1R) receptor and include increased eumelanin…
Cabaret J, Guerrero Molina C, Martínez-Ortiz-de Montellano C et al. · 2026 · Pathogens (Basel, Switzerland)
Faecal egg counts (FECs) are used to assess the intensity of gastrointestinal nematode (GIN) infections in herbivores. FEC distribution is aggregated, meaning that approximately 20% of animals harbour 80% of infections. In times of…
Santos de Oliveira N, Barbieri M, Moraes PA et al. · 2026 · Women & health
A prospective longitudinal study was conducted among 70 users of the etonogestrel contraceptive implant. World Health Organization Quality of Life (WHOQOL-BREF), Female Sexual Function Index (FSFI), and Birth Control Satisfaction…
Yaqub M, Bonde N, Maity T et al. · 2026 · Preprint
Acinetobacter baumannii is a major cause of multidrug-resistant nosocomial infections, particularly ventilator-associated pneumonia, for which therapeutic options are increasingly limited. Colistin, a polymyxin antibiotic, is a drug of…
Nie Y, Staley A, Hinz TK et al. · 2026 · Clinical lung cancer
Background Although ALK-positive non-small cell lung cancer (NSCLC) derives limited benefit from immune checkpoint inhibitors, PD-L1 expression is frequently elevated at diagnosis. The clinical relevance of PD-L1 expression for the…
Bonilla AM, Garrido G, Consolini AE et al. · 2025 · Preprint
Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties re-main unexplored. The behavioral effects, underlying mechanisms,…
Marcotte-Chénard A, Sandilands RE, Teixeira AA et al. · 2026 · American journal of physiology. Cell physiology
Beta-hydroxybutyrate (BHB) exerts anti-inflammatory effects in cell and animal models, but translational work in humans remains limited. We investigated how exogenous ketone monoester (KME) ingestion in vivo and BHB treatment of human…