A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20230 results in Negative / Null Result Report · page 272 of 675
Ricalde A, Chen JW, Lim LJ et al. · 2025 · Pediatric dentistry
Purpose: To investigate the color difference between groups and changes over time of resin-modified glass ionomer (RMGI) restorations placed immediately after silver diammine fluoride (SDF) treatment. Methods: Thirty-six specimens were…
Berger L, Mulder E, Zange J et al. · 2025 · Medicine and science in sports and exercise
Purpose During spaceflight, countermeasures are crucial to counteract cardiorespiratory and musculoskeletal deconditioning, similar to effects seen after prolonged immobilization. Within a bed rest study simulating the effects of…
Breen DM, Saavedra-Peña RM, Joaquim S et al. · 2026 · Diabetes, obesity & metabolism
Aims To evaluate the therapeutic potential of leptin treatment for weight loss maintenance preclinically, through a systematic evaluation of leptin efficacy (a) following a period of weight loss stability (as in published clinical…
Jefferies S, Gilkison C, Duff P et al. · 2025 · Public health
Objectives Aotearoa New Zealand employed one of the most stringent public health pandemic responses internationally. We investigated whether ethnic health equity was achieved in the response and outcomes, from COVID-19 elimination in June…
Park SJ, Park JS, Kang DH et al. · 2025 · Neurosurgery
Background and objectives Cement augmentation and hook fixation are popular prophylactic techniques against proximal junctional kyphosis (PJK) development. However, the efficacy of cement and hook has been inconsistent and conflicting.…
Plastina L, Gähwiler K, Gaertner VD et al. · 2025 · BMC pediatrics
Background To evaluate changes in end-expiratory lung impedance (EELI), a surrogate for end-expiratory lung volume (EELV), during a minimal-handling extubation protocol in very preterm infants in prone position. The protocol aimed to…
Grotemeyer A, Alexander S, Frieß L et al. · 2026 · NPJ Parkinson's disease
Neuroinflammation is deeply intertwined with dopaminergic (DA) neurodegeneration in Parkinson's disease (PD). We tested whether delphinidin, an anthocyanidin with reported inflammasome/NF-κB modulatory activity, alters neuroinflammation…
Paulsson M, Ekholm C, Rolfson O et al. · 2024 · Geriatric orthopaedic surgery & rehabilitation
Introduction Surgical treatment of distal femoral fractures (DFFs) in osteoporotic bone is challenging despite improvements in hardware and surgical techniques. The occurrence and degree of secondary displacement during healing after…
Ponsford R, Meiksin R, Sturgess J et al. · 2026 · Journal of epidemiology and community health
Background Relationships and sex education (RSE) impacts some sexual behaviours but could be strengthened by incorporating whole-school approaches (eg, building engagement, providing contraception). These can prevent pregnancies and…
Cao J, Guo M, Wang J et al. · 2025 · Fish physiology and biochemistry
Plant-based essential oils have been considered to be used as fish anesthetics and as suitable alternatives to synthetic anesthetics. In this study, we evaluated the effect of Cinnamomum camphora var. linaloofera Fujita essential oil…
Cifelli A, Butt Z, Cifelli E et al. · 2026 · Case reports in neurological medicine
We present the case of a lady in her early 20s who developed over a few weeks progressive appendicular and limb ataxia and dysarthria. She was found to have a high titer of voltage-gated calcium channel antibodies (VGCCAs) and was started…
Moran MC, Tammone Santos A, Dominguez P et al. · 2025 · Veterinary immunology and immunopathology
Brucella ovis (B. ovis) is the etiological agent of ram-contagious epididymitis, the leading cause of reproductive disorders in flocks worldwide. Although the attenuated B. melitensis Rev.1 strain gives heterologous protection against this…
Seco-Cervera M, Gisbert-Ferrándiz L, Macias-Ceja DC et al. · 2025 · PloS one
Epigenetics has emerged as a modulator of inflammation-related diseases and changes in miRNA expression have been associated with regional location, inflamed mucosa and disease activity in Crohn´s disease (CD). We analyse here the…
Casadevall A · 2025 · The Journal of clinical investigation
Invasive fungal infections carry high morbidity and mortality, but there are no fungal vaccines. In this issue of the JCI, Okaa et al. report that endonuclease 2 (Eng2), an antigen shared by the Blastomyces, Histoplasma, and Coccidioides…
Cao L, Hu J, Mao X et al. · 2026 · Frontiers in oncology
Background Malignant phyllodes tumors (MPTs) of the breast are rare fibroepithelial neoplasms characterized by aggressive clinical behavior and limited evidence guiding systemic therapy in the metastatic setting. Immune checkpoint…
Castro LA, Chen DE, O'Scannlain A et al. · 2026 · Journal of the mechanical behavior of biomedical materials
Elastic fibers are critical for proper mechanical function of large arteries such as the aorta. Fragmentation, degradation, or reduced amounts of elastic fibers are associated with aortic diseases such as stiffening-induced hypertension…
Fage C, Loison S, Zwygart AC et al. · 2025 · Antiviral research
Influenza viruses pose a significant threat due to annual epidemics and pandemic potential. Resistance to current antivirals underscores the need for new drugs and strategies to prevent its emergence. We previously developed two novel…
Jacob A, Mahmoud A, Eldweik L et al. · 2025 · BMJ neurology open
Background Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing autoimmune disease of the central nervous system (CNS). Management during pregnancy is challenging due to limited safety data for disease-modifying therapies.…
Tekin-Taş Z, Özger HS, Sultanova F et al. · 2025 · Infectious diseases & clinical microbiology
Objective Real-time multiplex polymerase chain reaction (PCR) test increases the detection of viral respiratory tract infections. This study aimed to evaluate the effect of real-time multiplex PCR on antibiotic use in viral respiratory…
Cajado AG, Lopes MH, Rangel GFP et al. · 2025 · European journal of pharmacology
Irinotecan-based anticancer therapy induces intestinal mucositis, increasing the risk of sepsis and patient death. The phosphoinositide 3-kinases (PI3K) are involved in cancer and inflammatory diseases, but their role in intestinal…
Etemadi R, Mansouri A, Salehidoost R et al. · 2025 · International journal of endocrinology
Objective Hungry bone syndrome (HBS), marked by severe and persistent hypocalcemia, frequently occurs after parathyroidectomy for primary hyperparathyroidism (PHPT). Despite its prevalence, there is limited research on this complication.…
Mütze U, Stengel J, Gleich F et al. · 2025 · Pediatrics
Objective Although newborn screening (NBS) programs were expanded with the implementation of tandem mass spectrometry in the late 1990s, the impact on long-term clinical and cognitive outcomes of adolescents and young adults with inherited…
Watanabe S, Furuya N, Nakamura A et al. · 2024 · European journal of cancer (Oxford, England : 1990)
Introduction Treatment options for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) after EGFR-tyrosine kinase inhibitor (TKI) treatment failure are limited. An exploratory analysis of 26…
Boess FG, Scelsi MA, Grimmer T et al. · 2024 · The journal of prevention of Alzheimer's disease
Background Monoclonal antibodies that target amyloid-beta and remove amyloid plaques can slow cognitive and functional decline in early Alzheimer's disease. Gantenerumab is a subcutaneously administered fully-human anti-amyloid-beta…
Del Rivero J, Donahue RN, Marte JL et al. · 2026 · The oncologist
Background Medullary thyroid cancer (MTC) accounts for approximately 4% of thyroid carcinomas. Patients with unresectable, metastatic disease are candidates for approved agent-targeted therapies such as vandetanib, cabozantinib, or…
Hanna GJ, Scarfo N, Shin KY et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Glycogen synthase kinase 3β (GSK-3β) is a known therapeutic target in cancer. Aberrant nuclear GSK-3β (nGSK-3β) expression has been shown in some salivary gland cancers. Elraglusib is a small-molecule GSK-3β inhibitor with…
Finch L, Andres S, Iasonos A et al. · 2025 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Objective We sought to determine the safety and efficacy of the oral progesterone antagonist onapristone in combination with anastrozole in patients with recurrent progesterone receptor-positive adult-type granulosa cell tumor of the…
Kim EH, Carr WW, Assa'ad AH et al. · 2025 · The journal of allergy and clinical immunology. Global
Background Oral immunotherapy is an established approach to desensitize the immune system in the context of allergic disease; however, the only currently approved product is for peanut allergy. ADP101 is a novel, pharmaceutical-grade,…
Ozer BH, Cohen AL, Colman H et al. · 2026 · Neuro-oncology advances
Background Glioblastoma (GBM) has limited effective salvage therapy options. The combination of the Type 1B topoisomerase/HIF1α inhibitor topotecan and the tyrosine kinase inhibitor pazopanib has shown promise in solid tumors and may be…
Roberts G, Just J, Nolte H et al. · 2025 · Allergy
Background In children, house dust mite (HDM) sensitisation is a contributing factor for developing allergic asthma. HDM allergen immunotherapy has demonstrated efficacy and safety in adults with allergic asthma; however, evidence for its…