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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20230 results in Negative / Null Result Report · page 271 of 675

Negative / Null Result ReportOpen accessMedicine

Risk factors and a prediction model for false-negative diagnosis in repeat EUS-FNA/B of pancreatic solid lesions following initially nondiagnostic or inconclusive findings.

Ma JY, Jiang W, Cheng B et al. · 2026 · Endoscopic ultrasound

Background and objectives Repeated EUS-guided fine-needle aspiration/biopsy (rEUS-FNA/B) is recommended in solid pancreatic lesions (SPLs) with inconclusive initial results. However, even rEUS-FNA/B cannot completely eliminate false…

View details →DOI: 10.1097/eus.0000000000000171
Negative / Null Result ReportMedicine

Clinical utility of non-induced sputum galactomannan testing for suspected invasive pulmonary aspergillosis: a real-world retrospective cohort study.

Tsai CT, Liang SY, Lai CH et al. · 2026 · Infection

Purpose Non-induced sputum galactomannan (GM) testing is increasingly used in routine evaluation of suspected invasive pulmonary aspergillosis (IPA), yet its real-world performance and the clinical implications of negative results remain…

View details →DOI: 10.1007/s15010-026-02784-0
Negative / Null Result ReportMedicine

When pooling fails: low-intensity <i>Angiostrongylus cantonensis</i> infections in <i>Theba pisana</i> result in false-negativity.

Anettová L, Jaume-Ramis S, Paredes-Esquivel C et al. · 2026 · Journal of helminthology

Pooling of gastropod samples is frequently used in surveys of the neurotropic nematode Angiostrongylus cantonensis to reduce cost and processing time. Here we highlight a potential limitation of this technique using the snail Theba pisana…

View details →DOI: 10.1017/s0022149x26101588
Negative / Null Result Report

Pre-ejaculate – an overlooked body fluid with high amounts of DNA

Lienesch M, Sibbing U, Schürenkamp M et al. · 2026 · Preprint

Abstract Pre-ejaculate is a clear, sperm-free liquid secreted by the male bulbourethral glands. Pre-ejaculate is currently not a subject of routine forensic testing and consequently, often overlooked. The aim of this study was to…

View details →DOI: 10.21203/rs.3.rs-9823035/v1
Negative / Null Result Report

In-house designed Multiplex Real-Time PCR Assay Developed for Epstein - Barr virus and Cytomegalovirus DNA detection in Pooled Blood Samples from Iraqi blood donors

Majid GS, Abdulamir AS, Aufi IM · 2026 · Preprint

Background: The problem of transmissible human herpesvirus infections through blood donation has not been completely resolved by serological testing due to issues such as delayed in seroconversion or false-negative results. This study…

View details →DOI: 10.12688/f1000research.173833.2
Negative / Null Result ReportMedicine

DNA metabarcoding for food authentication: identification of freshwater, marine, and terrestrial gastropods in commercial food products.

Andronache J, Cichna-Markl M, Dobrovolny S et al. · 2026 · NPJ science of food

Food fraud through species substitution has been reported for edible gastropods, particularly in processed products where morphological identification is not feasible. DNA-based methods have been used to identify gastropod species in food…

View details →DOI: 10.1038/s41538-026-00961-x
Negative / Null Result ReportOpen accessMedicine

Reality check: testing the <i>in silico</i> predictions of false negative results due to mutations in SARS-CoV-2 PCR assays using templates with mismatches <i>in vitro</i>.

Otwell T, Knight B, Coryell M et al. · 2025 · Frontiers in cellular and infection microbiology

Molecular diagnostic assays are critical tools to test, diagnose and treat infectious and other diseases. For example, PCR test results have been extremely valuable during the COVID-19 pandemic, not only to provide appropriate health care…

View details →DOI: 10.3389/fcimb.2025.1524025
Negative / Null Result ReportMedicine

Diagnostic performance of somatostatin receptor positron emission tomography in preoperative evaluation of pancreatic neuroendocrine tumor lymph node metastases.

Gudmundsdottir H, Hernandez-Delima FJ, McDowell BC et al. · 2026 · Surgery

Background Regional lymph node involvement impacts prognosis for patients with pancreatic neuroendocrine tumors and may influence management decisions for small tumors. Conventional cross-sectional imaging modalities have low sensitivity…

View details →DOI: 10.1016/j.surg.2026.110136
Negative / Null Result ReportOpen accessMedicine

Endogenous Biomarkers Analysis and False-Negative Results for SARSCov2 Using two Commercial RT-PCR Diagnostic Kits.

Khoshakhlagh M, Dehghani T, Alizadeh A et al. · 2026 · Iranian journal of pathology

Background & objective Real-time PCR is widely used to detect SARS-CoV-2, the virus responsible for COVID-19, but false-negative results can occur even with internal controls. This study aimed to investigate the impact of using alternative…

View details →DOI: 10.30699/ijp.2025.2053609.3417
Negative / Null Result ReportOpen accessMedicine

Verification of the Phadebas® forensic press test for the screening of human saliva.

Cañete FT, Williams L, Parry R et al. · 2026 · Forensic science international. Synergy

The Phadebas® Forensic Press Test (PFPT) is widely employed in forensic laboratories for presumptive saliva screening by observation of α-amylase activity. This enzyme hydrolyses starch embedded in the test paper, resulting in a blue…

View details →DOI: 10.1016/j.fsisyn.2026.100691
Negative / Null Result ReportMedicine

Clinical Features, Treatment, and Outcomes of Nivolumab-induced Autoimmune Hemolytic Anemia.

Liu M, Kong L, Sun W et al. · 2026 · Journal of immunotherapy (Hagerstown, Md. : 1997)

To investigate the clinical profile of nivolumab-induced autoimmune hemolytic anemia (AIHA) and to reveal the diagnostic and therapeutic patterns of this disease. Articles on nivolumab-induced AIHA published before October 31, 2025 were…

View details →DOI: 10.1097/cji.0000000000000612
Negative / Null Result ReportMedicine

When the test lies: Fatal cryptococcosis and the prozone effect in advanced HIV infection.

Costa M, Rodrigues P, Araújo B et al. · 2026 · Diagnostic microbiology and infectious disease

Cryptococcal meningitis is a life-threatening opportunistic infection in advanced HIV disease. Cryptococcal antigen (CrAg) detection by lateral flow assay (LFA) is the diagnostic cornerstone, offering high sensitivity and specificity.…

View details →DOI: 10.1016/j.diagmicrobio.2026.117512
Negative / Null Result ReportOpen accessMedicine

False-negative results of combined endobronchial and endoscopic ultrasound in mediastinal staging of lung cancer.

Gambuś K, Moszczyński K, Popovchenko S et al. · 2026 · Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

Introduction Accurate assessment of mediastinal lymph node involvement is crucial for treatment planning in lung cancer. Combined endobronchial and endoscopic ultrasound (CUS) offers high sensitivity and negative predictive value (NPV),…

View details →DOI: 10.5114/kitp.2026.160677
Negative / Null Result ReportMedicine

Prenatal Genetic Testing for Beckwith-Wiedemann Syndrome: Considerations, Challenges and Observations (A Real-World Study).

Connolly M, McClelland L, Tannorella P et al. · 2026 · Prenatal diagnosis

Objective Prenatal genetic testing for imprinting disorders is rarely requested with the exception of Beckwith-Wiedemann syndrome (BWS) which is associated with specific ultrasound findings (e.g., placental mesenchymal dysplasia,…

View details →DOI: 10.1002/pd.70206
Negative / Null Result ReportMedicine

Ovarian carcinosarcoma (malignant mixed Müllerian tumor, MMMT) in a premenopausal woman: a diagnostic challenge-a case report.

Ailun G, Li Y, Zhang D et al. · 2026 · Journal of medical case reports

Ovarian carcinosarcoma, also known as malignant mixed Müllerian tumor (MMMT), is a rare and highly aggressive gynecologic malignancy characterized by the presence of both epithelial and mesenchymal components. It predominantly affects…

View details →DOI: 10.1186/s13256-026-06253-y
Negative / Null Result ReportMedicine

Influence of Ongoing Antibiotic Therapy on the Detection of Pathogenic Microorganisms Using Metagenomic Next-Generation Sequencing and Blood Culture in ICU Patients.

Schroeder TH, Eliwi Alsaffan M, Stäudle H et al. · 2026 · Journal of clinical medicine

Background: Blood cultures often yield negative results in critically ill patients, particularly after antimicrobial therapy has started. Plasma metagenomic next-generation sequencing enables culture-independent pathogen detection, but its…

View details →DOI: 10.3390/jcm15124434
Negative / Null Result ReportMedicine

Butyrate in ulcerative colitis and pouchitis: friend or foe?

Rhodes JM · 2026 · The British journal of nutrition

It is widely known that the short chain fatty acid (SFA) butyrate, generated mainly through fermentation of dietary fibre by anaerobic bacteria, has beneficial effects on health. Less widely known is that butyrate, at the concentration…

View details →DOI: 10.1017/s0007114526107247
Negative / Null Result ReportOpen accessMedicine

False-negative CMV PCR results due to viral sequence variation: a diagnostic pitfall with the potential for serious consequences.

Wang H, Ardura MI, Oyeniran SJ et al. · 2026 · ASM case reports

Background Cytomegalovirus (CMV) continues to be a significant cause of morbidity and mortality in immunocompromised patients. Nucleic acid amplification tests (NAATs) are the preferred method for both diagnosing CMV infection and…

View details →DOI: 10.1128/asmcr.00159-25
Negative / Null Result ReportOpen accessMedicine

Impact of Blood Herpes Simplex Virus Polymerase Chain Reaction Testing in Neonatal Management of Herpes Simplex Virus Infection: An Institutional Experience.

Alvarez AM, Vega M, Valencia-Shelton F et al. · 2026 · Cureus

Background The evaluation of neonatal herpes simplex virus (HSV) includes HSV culture and/or polymerase chain reaction (PCR) of different surfaces, cerebrospinal fluid (CSF), and blood. However, the impact of blood HSV PCR for the…

View details →DOI: 10.7759/cureus.102996
Negative / Null Result Report

Anterior middle cingulate cortex gamma-aminobutyric acid level is elevated in children with both familial and prenatal alcohol exposure-associated attention deficit hyperactivity disorder

Alger JR, Gupta I, Farkouh L et al. · 2026 · Preprint

Background Prior neuroimaging suggests brain differences between children with attention deficit hyperactivity disorder due to prenatal alcohol exposure (ADHD+PAE) and non-exposed children with ADHD due to other, e.g., familial, causes…

View details →DOI: 10.64898/2026.05.25.26354065
Negative / Null Result ReportMedicine

[Tuberculous mastitis: A rare manifestation of extrapulmonary tuberculosis].

Dellbrügge F, Schaumann N, Kruppa M et al. · 2026 · Pneumologie (Stuttgart, Germany)

Abstract We present the case of a 39-year-old Indian female patient diagnosed with tuberculous mastitis and lymph node tuberculosis. The patient had a history of tuberculosis infection treatment as a newborn. She initially presented with…

View details →DOI: 10.1055/a-2845-3440
Negative / Null Result ReportMedicine

A Case Report of HIV Transmission Within a Household Involving a Married Man Who Has Sex with Men in China.

Li X, Huang Y, Hao J et al. · 2026 · Current HIV research

Background Married Men who have Sex with Men (MSM) constitute a bridge population for HIV diffusion into low-risk groups, with spousal non-disclosure rates exceeding 60% in China. It will increase the risk of secondary transmission within…

View details →DOI: 10.2174/011570162x444930260409114355
Negative / Null Result ReportMedicine

Evaluation of a Point-of-Care Multiplex PCR Analyser for Detection of <i>Babesia gibsoni</i> in the Canine Population of Hong Kong.

Tsang SM, Merino Gutierrez V, Yu J et al. · 2026 · Veterinary sciences

Canine babesiosis caused by Babesia gibsoni is prevalent in Hong Kong. While molecular diagnosis via PCR is highly sensitive, it typically requires reference laboratory access, delaying clinical decisions. This study evaluated the…

View details →DOI: 10.3390/vetsci13060548
Negative / Null Result ReportMedicine

The Usefulness of Antinuclear Antibody Multiplex Immunoassay for Screening of Rheumatological Diseases: A Real-World Population-Based Study.

Hijaze E, Razi T, Arbel R et al. · 2026 · Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

Objective To evaluate the diagnostic performance of BioPlex 2200 multiplex immunoassay (BI) for detecting antinuclear antibodies (ANA), compared with the gold standard, the indirect immunofluorescence assay (IIF), as a screening…

View details →DOI: 10.1097/rhu.0000000000002372
Negative / Null Result ReportMedicine

Early computed tomography may miss main pancreatic duct injury in distal pancreatic trauma: a prospective surgically verified diagnostic accuracy study.

Tri PM, Hung NT, Liet DH et al. · 2026 · Emergency radiology

Purpose To assess the diagnostic performance of computed tomography (CT) for predicting main pancreatic duct injury in surgically explored patients with distal pancreatic trauma. Methods We conducted a prospective single-center diagnostic…

View details →DOI: 10.1007/s10140-026-02504-z
Negative / Null Result ReportMedicine

[Evaluation of the screening performance of ultrasound for fatty liver using transient elastography in the elderly population of Shanghai communities].

Wei XT, Zhu LY, Wu YL et al. · 2026 · Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

Objective: To evaluate the screening performance and related factors of ultrasound for hepatic steatosis in community-based elderly populations using controlled attenuation parameter (CAP) measured by transient elastography as the…

View details →DOI: 10.3760/cma.j.cn112338-20250626-00436