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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 271 of 662

Negative / Null Result ReportMedicine

Prospective Monitoring of Serum Values of CBC, Total IgE, Thyroid Findings, D-Dimer, Vitamin D, and Inflammatory Molecules CRP, ESR, and IL-6 and Clinical Features of Chronic Spontaneous Urticaria Patients During Antihistamine Treatment.

Kuna M, Štefanović M, Barac E et al. · 2026 · International journal of molecular sciences

Having appropriate and meaningful diagnostic procedures is crucial in the approach to patients with chronic spontaneous urticaria (CSU), so we wanted to investigate relationships between CSU patients' common serum factors and clinical CSU…

View details →DOI: 10.3390/ijms27052503
Negative / Null Result ReportOpen accessMedicine

Analysis of PR-1, PR-2, PR-10, chitinases and chitinase-like proteins genes expression in pea roots under the action of salicylic acid and methyl jasmonate.

Egorova AM · 2026 · Vavilovskii zhurnal genetiki i selektsii

Stress phytohormones - salicylic and jasmonic acids - participate in the plant defense response. The increase in the content of these compounds during plant infection by pathogens leads to the activation of signaling pathways, ultimately…

View details →DOI: 10.18699/vjgb-26-24
Negative / Null Result ReportMedicine

Advances in Marfan Syndrome Care: The Limits of Type B Dissection.

Tchitchinadze M, Milleron O, Eliahou L et al. · 2026 · The Annals of thoracic surgery

Background To evaluate the progress of care for patients with Marfan syndrome with FBN1 pathogenic variant carriers over the past 30 years. Methods Patients who visited the center were entered into a prospective registry. Aortic events…

View details →DOI: 10.1016/j.athoracsur.2026.01.045
Negative / Null Result ReportMedicine

Return to Driving After Anterior Total Hip Arthroplasty.

Masturov YA, Hogan WB, Regal S et al. · 2026 · Orthopedics

Background Traditional guidance after posterior-approach total hip arthroplasty (THA) recommends return to driving at 6-8 weeks. Muscle-sparing direct anterior THA (A-THA) may enable earlier recovery. Our objective was to assess brake…

View details →DOI: 10.3928/01477447-20260113-01
Negative / Null Result ReportMedicine

Structure of sulfur chains encapsulated in single-walled carbon nanotubes.

Saiful Islam M, Fujimori T, Miyanaga T et al. · 2025 · Journal of physics. Condensed matter : an Institute of Physics journal

The encapsulation of sulfur (S) within single-walled carbon nanotubes (S@SWCNTs) provides a unique opportunity to stabilize and study the structure and bonding of one-dimensional sulfur chains, which do not exist in a free state. In this…

View details →DOI: 10.1088/1361-648x/ae2f88
Negative / Null Result ReportMedicine

Evaluation of skeletal muscle indicators following allogeneic hematopoietic stem cell transplantation: verification of skeletal muscle mass adjustment.

Hamada R, Tamaki A, Murao M et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Purpose Bioelectrical impedance analysis (BIA) has emerged as a simple, noninvasive method for evaluating skeletal muscle. However, BIA is sensitive to fluctuations in body water and can overestimate skeletal muscle mass, which may obscure…

View details →DOI: 10.1007/s00520-026-10516-1
Negative / Null Result Report

Challenging the Culture of Stress: Evaluating a Brief, Theory-Driven Mental Health Help-Seeking Intervention for Undergraduate Engineering Students

Parrott J, Joseph H, Vahidi E et al. · 2025 · Preprint

Abstract Engineering undergraduate students report high levels of mental health distress yet exhibit comparatively low rates of engagement with professional mental health services compared to students in other academic majors. These low…

View details →DOI: 10.21203/rs.3.rs-8205457/v1
Negative / Null Result ReportMedicine

Remote monitoring contribution to the continuation of CPAP treatment in the long term: which gain and for whom? A cohort analysis.

Bayle JY, Onen F, Onen SH · 2025 · Sleep & breathing = Schlaf & Atmung

PURPOSE: The impact of remote monitoring (RM) on the likelihood of continuing CPAP therapy in apneic patients remains unknown in the long term and was addressed by a comparative cohort analysis. METHODS: The probability of continuing CPAP…

View details →DOI: 10.1007/s11325-025-03558-y
Negative / Null Result ReportMedicine

Adding free leucine to a balanced essential amino acid mixture suppresses intracellular transamination of isoleucine and valine in healthy older adults.

Knezek SB, Engelen MPKJ, Coyle KS et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)

Background Adding leucine (LEU) to protein meals enhances protein anabolism, but excess LEU reduces valine (VAL) and isoleucine (ILE) plasma concentrations. We examined in older adults whether additional LEU added to an essential amino…

View details →DOI: 10.1016/j.clnu.2026.106659
Negative / Null Result ReportMedicine

Differential astrocyte activation by Taenia solium antigens: Specific induction of IL-10 and IL-1β by Excretory/Secretory (ES) products.

Gonzales K, Condori J, Fernández G et al. · 2026 · Immunobiology

Background Neurocysticercosis (NCC) is a parasitic infection of the central nervous system (CNS) caused by the larval form of Taenia solium. This disease provokes an inflammatory response that intensifies when the parasite dies. This study…

View details →DOI: 10.1016/j.imbio.2026.153162
Negative / Null Result ReportMedicine

Zinc deficiency is associated with erythropoietin-stimulating agents hyporesponsive anemia in peritoneal dialysis patients: a cross-sectional study.

Kuwahara F, Harada K, Nagata M et al. · 2026 · Clinical and experimental nephrology

Background Zinc deficiency is widely recognized as a cause of anemia, but no studies have clarified the impact of zinc deficiency on achieving target hemoglobin levels in patients undergoing peritoneal dialysis (PD) and receiving high-dose…

View details →DOI: 10.1007/s10157-026-02816-x
Negative / Null Result ReportMedicine

Risk factors for asseptic loosening after revision total knee replacement (rTKR): a component-specific analysis of femoral and tibial reconstruction.

Souto CS, Pereira F, Carvalho A et al. · 2026 · The Knee

Background Revision total knee arthroplasty (rTKA) remains a technically demanding procedure, with re-revision representing a major clinical challenge. The role of reconstruction strategies, particularly the use of augments and metaphyseal…

View details →DOI: 10.1016/j.knee.2026.104528
Negative / Null Result ReportMedicine

Similar Outcomes in Proximal Humerus Fractures Treated With Conventus Intramedullary Cage Device and Open Reduction Internal Fixation.

Kurkowski SC, Taleghani ER, McMillan P et al. · 2026 · Journal of orthopaedic trauma

Objectives To compare clinical outcomes between open reduction and internal fixation (ORIF) with or without Conventus intramedullary cage (CC) for proximal humerus fractures. Methods Design Retrospective cohort study. Setting Level 1…

View details →DOI: 10.1097/bot.0000000000003161
Negative / Null Result ReportMedicine

A comparative experimental study on the impact of radiotherapy dose rate and melatonin pretreatment in tongue and esophageal tissues.

Hacımustafaoğlu F, Aras S, Çaykara Peran B et al. · 2026 · International journal of radiation biology

Aim This study aimed to investigate the differential biological responses in tongue and esophageal tissues induced by flattening filter (FF) and flattening filter-free (FFF) beams at varying dose rates, and to assess the radioprotective…

View details →DOI: 10.1080/09553002.2026.2669157
Negative / Null Result ReportMedicine

Contralateral vs. ipsilateral hemilaminectomy for spinal meningiomas: impact on resection completeness, stability, and recurrence.

Yavuz AY, Can F, Avci İ et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Aim Spinal meningiomas (SMs) account for approximately 25-40% of intradural extramedullary spinal tumors [1]. The classical symptomatology typically begins with pain, followed by motor and/or sensory deficits, gait disturbances, and…

View details →DOI: 10.1007/s00586-026-10035-x
Negative / Null Result ReportMedicine

Early non-contrast CT morphology at emergency admission in acute pancreatitis: real-world associations with clinical course.

Molasy B, Zawolik-Kosek W, Gronowska A et al. · 2026 · Emergency radiology

Purpose To evaluate the clinical associations of admission non-contrast CT morphology in acute pancreatitis within a real-world emergency workflow. Materials and methods This retrospective observational cohort study included 264…

View details →DOI: 10.1007/s10140-026-02475-1
Negative / Null Result ReportMedicine

Is torsion of the undescended testis intrinsically associated with worse salvage? A matched cohort analysis.

Ahmad I, Khondker A, Rickard M et al. · 2026 · Journal of pediatric surgery

Background Testicular torsion in undescended testes (UDT) has poor salvage rates, but it remains unclear if the cryptorchid state itself confers an intrinsic disadvantage. We aimed to compare testicular salvage between UDT and descended…

View details →DOI: 10.1016/j.jpedsurg.2026.163210
Negative / Null Result ReportMedicine

Data-Driven Discovery of Plant-Based Dietary Subtypes and Their Association with Cancer, Cardiovascular diseases, and Type 2 diabetes in Postmenopausal Women: Insights from the Women's Health Initiative.

Moosavi D, Nejati N, Arcan C et al. · 2026 · Journal of the Academy of Nutrition and Dietetics

Background Plant-based diets have been associated with lower risks of chronic diseases; however, not all plant-based diets confer equal health benefits. Data-driven methods provide an opportunity to empirically identify distinct…

View details →DOI: 10.1016/j.jand.2026.156406
Negative / Null Result ReportMedicine

Early outcomes of facilitated transfemoral versus alternative access for transcatheter aortic valve replacement in patients with peripheral arterial disease.

Mustafa A, Wang D, Dutton C et al. · 2026 · The Journal of invasive cardiology

Objectives Transfemoral (TF) access for transcatheter aortic valve replacement (TAVR) may be challenging in patients with peripheral arterial disease (PAD). Alternative access through intra- and extrathoracic approaches can be performed.…

View details →DOI: 10.25270/jic/25.00171
Negative / Null Result ReportMedicine

Clinical Impact of Using Real-Time Image-Processing Algorithms (Comb Removal and Image Sharpening) in Dacryoendoscopic Surgery.

Tasaki K, Hoshi S, Hiraoka T et al. · 2026 · Journal of clinical medicine

Background/Objectives: Lacrimal passage intubation is commonly used to treat lacrimal duct obstruction. However, conventional dacryoendoscopes, which are limited by their low resolution and comb-structure artifacts, pose challenges for…

View details →DOI: 10.3390/jcm15051951
Negative / Null Result ReportOpen accessMedicine

Predictors of <i>Candida auris</i> Infection in Previously Colonized Patients: A Retrospective Cohort Study from a Large Tertiary Reference Center.

Ergün N, Karabulut SS, Türken M et al. · 2026 · Journal of fungi (Basel, Switzerland)

Candida auris is a multidrug-resistant fungal pathogen associated with high mortality in healthcare settings. Although colonization is recognized as the harbinger of invasive infection, predicting which patients will develop bloodstream…

View details →DOI: 10.3390/jof12060449
Negative / Null Result ReportOpen accessMedicine

Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis: A Retrospective Cohort Study.

Abid H, Khan Y, Khan N et al. · 2026 · Journal of clinical medicine

Background: Angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) were historically considered contraindicated in severe aortic stenosis (AS) due to theoretical haemodynamic risks. Contemporary evidence…

View details →DOI: 10.3390/jcm15082904
Negative / Null Result Report

High Variability in Resistance to Deformation Under Valgus Load of Knee Braces used for the Treatment of Medial Collateral Ligament Tears: A Comparative Biomechanical Analysis

Pechlivanidou E, Stacheter M, Wahl P et al. · 2026 · Preprint

Abstract Introduction To quantify valgus deformation and per-load mechanical stiffness of commercially available knee braces indicated for medial collateral ligament (MCL) injuries, and to evaluate whether mechanical performance is…

View details →DOI: 10.21203/rs.3.rs-9849551/v1
Negative / Null Result ReportMedicine

Development of Chimeric Antigen Receptor-Modified NK Cells for the Immunotherapy of Adult T-Cell Leukemia/Lymphoma.

Uchida Y, Tateo S, Wakao M et al. · 2026 · European journal of haematology

Adult T-cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase…

View details →DOI: 10.1111/ejh.70199