A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19743 results in Negative / Null Result Report · page 27 of 659
Stefan Roehling, Monika Astasov‐Frauenhoffer, Irmgard Hauser‐Gerspach et al. · 2016 · Journal of Periodontology
Background: It has been hypothesized that zirconia might have a reduced bacterial adhesion compared with titanium; however, results from experimental studies are rather controversial. The aim of the present study is to compare biofilm…
Taraka Davies‐Barnard, Pierre Friedlingstein · 2020 · Global Biogeochemical Cycles
Abstract Biological nitrogen fixation is a key contributor to sustaining the terrestrial carbon cycle, providing nitrogen input that plants require. However, the amount and global distribution of this fixation is highly disputed. Using a…
Titus O. Awokuse, Ruizhi Xie · 2014 · Canadian Journal of Agricultural Economics/Revue canadienne d agroeconomie
This paper revisits the debate on the role of agriculture in promoting economic growth in a selection of nine developing countries. We investigated the causal linkages between agriculture and gross domestic product growth with the aid of…
Candida P. Shirima, Martin Kimanya, Michael N. Routledge et al. · 2014 · Environmental Health Perspectives
BACKGROUND: Aflatoxin and fumonisin are toxic food contaminants. Knowledge about effects of their exposure and coexposure on child growth is inadequate. OBJECTIVE: We investigated the association between child growth and aflatoxin and fumonisin exposure in Tanzania. METHODS: A total of 166 children were recruited at 6-14 months of age and studied at recruitment, and at the 6th and 12th month following recruitment. Blood and urine samples were collected and analyzed for plasma aflatoxin-albumin adducts (AF-alb) using ELISA, and urinary fumonisin B1 (UFB1) using liquid chromatography-mass spectr
Monica J. Grant, Cynthia B. Lloyd, Barbara Mensch · 2013 · Comparative Education Review
The provision of toilets and menstrual supplies has emerged as a promising programmatic strategy to support adolescent girls' school attendance and performance in less developed countries. We use the first round of the Malawi Schooling and…
Céline Teplitsky, Virginie Millien · 2013 · Evolutionary Applications
Climate change is expected to induce many ecological and evolutionary changes. Among these is the hypothesis that climate warming will cause a reduction in body size. This hypothesis stems from Bergmann's rule, a trend whereby species exhibit a smaller body size in warmer climates, and larger body size under colder conditions in endotherms. The mechanisms behind this rule are still debated, and it is not clear whether Bergmann's rule can be extended to predict the effects of climate change through time. We reviewed the primary literature for evidence (i) of a decrease in body size in response
Rana Kıdak, Şifa Doğan · 2017 · Ultrasonics Sonochemistry
(625 times higher than ultrasound). In the processes where ozone was used, humic acid did not show any significant effect because the rate constant was so high that ozone has easily overcome the scavenging effects of natural water…
Kieu Trinh, Simone Wahl, Johannes Raffler et al. · 2018 · Metabolomics
BACKGROUND: Untargeted mass spectrometry (MS)-based metabolomics data often contain missing values that reduce statistical power and can introduce bias in biomedical studies. However, a systematic assessment of the various sources of missing values and strategies to handle these data has received little attention. Missing data can occur systematically, e.g. from run day-dependent effects due to limits of detection (LOD); or it can be random as, for instance, a consequence of sample preparation. METHODS: We investigated patterns of missing data in an MS-based metabolomics experiment of serum sa
Qian Huang, Robert M. Davison, Jibao Gu · 2010 · Information Systems Journal
Knowledge sharing is recognised as one of the most critical components of knowledge management. Successful and efficient knowledge sharing could directly facilitate knowledge creation and so help a firm to maintain its competitive…
Dorothee Schär, Christoph A. Ramseier, Sigrun Eick et al. · 2012 · Clinical Oral Implants Research
OBJECTIVE: To compare the adjunctive clinical effects in the non-surgical treatment of peri-implantitis with either local drug delivery (LDD) or photodynamic therapy (PDT). MATERIAL AND METHODS: Forty subjects with initial…
Jack Kuipers, Katharina Jahn, Benjamin J. Raphael et al. · 2017 · Genome Research
Intra-tumor heterogeneity poses substantial challenges for cancer treatment. A tumor's composition can be deduced by reconstructing its mutational history. Central to current approaches is the infinite sites assumption that every genomic…
Panagiotis Ganotakis, James H. Love · 2010 · Oxford Economic Papers
We examine the relationship between R&D, product innovation, and exporting for a sample of new technology based firms (NTBFs) in the UK. Allowance is made for selection bias and for endogeneity between innovation and exporting. Product…
Mahvash Shahidi, Ali Mojtahed, Amirhossein Modabbernia et al. · 2010 · International Journal of Geriatric Psychiatry
BACKGROUND: Laughter Yoga founded by M. Kataria is a combination of unconditioned laughter and yogic breathing. Its effect on mental and physical aspects of healthy individuals was shown to be beneficial. OBJECTIVE: The objective of this…
Daniel E. Bonder, Ken D. McCarthy · 2014 · Journal of Neuroscience
Local blood flow is modulated in response to changing patterns of neuronal activity (Roy and Sherrington, 1890), a process termed neurovascular coupling. It has been proposed that the central cellular pathway driving this process is…
Brian J. Bushee, Mary Ellen Carter, Joseph Gerakos · 2013 · Journal of Management Accounting Research
ABSTRACT We examine institutional investors' preferences for corporate governance mechanisms. We find little evidence of an association between total institutional ownership and governance mechanisms. However, using revealed preferences,…
David I. Levine, Michael W. Toffel, Matthew S. Johnson · 2012 · Science
Controversy surrounds occupational health and safety regulators, with some observers claiming that workplace regulations damage firms' competitiveness and destroy jobs and others arguing that they make workplaces safer at little cost to…
Jacob Ricker‐Gilbert, Charles Jumbe, Jordan Chamberlin · 2014 · Food Policy
This article uses nationally representative household-level panel data from Malawi to estimate how rural population density impacts agricultural intensification and household well-being. We find that areas of higher population density are…
Surendrakumar Bagde, Dennis Epple, Lowell J. Taylor · 2016 · American Economic Review
Public policy in modern India features affirmative action programs intended to reduce inequality that stems from a centuries-old caste structure and history of disparate treatment by gender. We study the effects of one such affirmative…
Fiona Smaill, Mangalakumari Jeyanathan, Marek Smieja et al. · 2013 · Science Translational Medicine
There is an urgent need to develop new tuberculosis (TB) vaccines to safely and effectively boost Bacille Calmette-Guérin (BCG)-triggered T cell immunity in humans. AdHu5Ag85A is a recombinant human type 5 adenovirus (AdHu5)-based TB…
Elizabeth A. Landis, Angela Oliverio, Erin A. McKenney et al. · 2021 · eLife
Humans have relied on sourdough starter microbial communities to make leavened bread for thousands of years, but only a small fraction of global sourdough biodiversity has been characterized. Working with a community-scientist network of bread bakers, we determined the microbial diversity of 500 sourdough starters from four continents. In sharp contrast with widespread assumptions, we found little evidence for biogeographic patterns in starter communities. Strong co-occurrence patterns observed in situ and recreated in vitro demonstrate that microbial interactions shape sourdough community str
Otto Erlwein, Steve Kaye, Myra O. McClure et al. · 2010 · PLoS ONE
BACKGROUND: In October 2009 it was reported that 68 of 101 patients with chronic fatigue syndrome (CFS) in the US were infected with a novel gamma retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), a virus previously linked to prostate cancer. This finding, if confirmed, would have a profound effect on the understanding and treatment of an incapacitating disease affecting millions worldwide. We have investigated CFS sufferers in the UK to determine if they are carriers of XMRV. METHODOLOGY: Patients in our CFS cohort had undergone medical screening to exclude detectable organi
Sarah Fiddyment, Bruce Holsinger, Chiara Ruzzier et al. · 2015 · Proceedings of the National Academy of Sciences
Tissue-thin parchment made it possible to produce the first pocket Bibles: Thousands were made in the 13th century. The source of this parchment, often called "uterine vellum," has been a long-standing controversy in codicology. Use of the…
C. Abel, N. J. Ayres, Ban, Giles et al. · 2017 · Repository for Publications and Research Data (ETH Zurich)
We report on a search for ultralow-mass axionlike dark matter by analyzing the ratio of the spin-precession frequencies of stored ultracold neutrons and 199Hg atoms for an axion-induced oscillating electric dipole moment of the neutron and an axion-wind spin-precession effect. No signal consistent with dark matter is observed for the axion mass range 10â24â¤maâ¤10â17 eV. Our null result sets the first laboratory constraints on the coupling of axion dark matter to gluons, which improve on astrophysical limits by up to 3 orders of magnitude, and also improves on previous laboratory constra
Susanna C. Larsson, Paul Carter, Siddhartha Kar et al. · 2020 · PLoS Medicine
BACKGROUND: Smoking is a well-established cause of lung cancer and there is strong evidence that smoking also increases the risk of several other cancers. Alcohol consumption has been inconsistently associated with cancer risk in observational studies. This mendelian randomisation (MR) study sought to investigate associations in support of a causal relationship between smoking and alcohol consumption and 19 site-specific cancers. METHODS AND FINDINGS: We used summary-level data for genetic variants associated with smoking initiation (ever smoked regularly) and alcohol consumption, and the corr
Loukas Balafoutas, Nikos Nikiforakis, Bettina Rockenbach · 2014 · Proceedings of the National Academy of Sciences
Many interactions in modern human societies are among strangers. Explaining cooperation in such interactions is challenging. The two most prominent explanations critically depend on individuals' willingness to punish defectors: In models…
Pedram Gerami, Richard A. Scolyer, Xiaowei Xu et al. · 2013 · The American Journal of Surgical Pathology
Risk assessment for atypical Spitz tumors remains an enigma for physicians. Many prognosticators including sentinel lymph node biopsy fail to show the same prognostic significance in these tumors as seen in conventional melanoma. We…
Swarkar Sharma, Xiaochong Gao, Douglas Londoño et al. · 2011 · Human Molecular Genetics
Adolescent idiopathic scoliosis (AIS) is an unexplained and common spinal deformity seen in otherwise healthy children. Its pathophysiology is poorly understood despite intensive investigation. Although genetic underpinnings are clear,…
Aaron J. Lorenz, Timothy J. Gustafson, J. G. Coors et al. · 2010 · Crop Science
ABSTRACT The use of maize ( Zea mays L.) stover as a feedstock for cellulosic biofuels production will create demand for maize hybrids with greater stover yield. It is expected that grain yield will remain the most critical trait and…
Gang Wang, Christo Wilson, Xiaohan Zhao et al. · 2012
Popular Internet services in recent years have shown that remarkable things can be achieved by harnessing the power of the masses using crowd-sourcing systems. However, crowd-sourcing systems can also pose a real challenge to existing…
Terry Judd, Gregor Kennedy, Simon J. Cropper · 2010 · Australasian Journal of Educational Technology
<span>Wikis are widely promoted as collaborative writing tools and are gaining in popularity in educational settings. However, while wikis include features that are designed to facilitate collaboration, it does not necessarily follow…