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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 265 of 662

Negative / Null Result ReportMedicine

Proteomic insight into the beneficial effect of mannoproteins on Oenococcus oeni in wine malolactic fermentation.

Toraño P, Balmaseda A, Bordons A et al. · 2025 · Food microbiology

Oenococcus oeni is the main species of lactic acid bacteria (LAB) responsible for malolactic fermentation (MLF) in winemaking. MLF development can present difficulties because of the harsh, stressful conditions of wine. Yeast mannoproteins…

View details →DOI: 10.1016/j.fm.2025.104754
Negative / Null Result ReportMedicine

The effect of prenatal stressor exposure on child cognitive functioning: the importance of timing of stress and domain of cognition.

Roberts E, Francesconi M, Flouri E · 2025 · Stress (Amsterdam, Netherlands)

Prenatal stress has been associated with poor cognitive outcomes in offspring, but the evidence about the role of exact timing of exposure is mixed and that about causal mechanisms is limited. Using the Avon Longitudinal Study of Parents…

View details →DOI: 10.1080/10253890.2025.2553135
Negative / Null Result ReportOpen accessMedicine

Nocturnal Cardiac Arrhythmias in Sleep Apnoea After Acute Myocardial Infarction and the Effect of Adaptive Servo-Ventilation: An Ancillary Study of the TEAM-ASV I Trial.

Pec J, Nigl M, Fox H et al. · 2026 · Journal of cardiovascular development and disease

(1) Background: Early treatment of sleep-disordered breathing (SDB) with adaptive servo-ventilation (ASV) after acute myocardial infarction (AMI) has been shown to improve myocardial salvage. This analysis evaluates nocturnal…

View details →DOI: 10.3390/jcdd13040157
Negative / Null Result ReportMedicine

Exploring the Long-Lasting Effect of Mindfulness-Based Intervention in Very Preterm Adolescents on Executive and Socio-Emotional Competencies.

Siffredi V, Liverani MC, Fernandez NB et al. · 2025 · Child: care, health and development

Background Very preterm (VPT) adolescents show executive and socio-emotional difficulties that persist into adulthood. Beneficial effect of mindfulness-based intervention (MBI) has been found in VPT young adolescents immediately after the…

View details →DOI: 10.1111/cch.70051
Negative / Null Result ReportMedicine

Impact of Tourniquet Type on Outcomes in ORIF of Pediatric Distal Radius Fractures.

Conteduca J, Longo D, Casto A et al. · 2025 · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

Purpose   The objective of this study was to assess the benefits of utilizing a silicone ring tourniquet in relation to traditional pneumatic cuff tourniquets and scenarios without any tourniquet intervention. The tested hypothesis…

View details →DOI: 10.17392/1922-22-02
Negative / Null Result ReportMedicine

Failed, Inconclusive or Interrupted Trials in Multiple Sclerosis: 2020-2024 Update.

Ricigliano VA, Szejko N, Camera V et al. · 2026 · Multiple sclerosis and related disorders

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neuronal loss, with significant public health impact. Despite important therapeutic advances, major unmet needs remain, mainly in…

View details →DOI: 10.1016/j.msard.2026.107140
Negative / Null Result ReportMedicine

[Two Cases of Node-Positive Breast Cancer in Which the Oncotype DX Test Was Performed but Yielded Inconclusive Results].

Terakawa H, Kawata C, Kurokawa Y et al. · 2025 · Gan to kagaku ryoho. Cancer & chemotherapy

Oncotype DX is performed to predict prognosis and the added benefit of chemotherapy in hormone receptor-positive, HER2-negative breast cancer, with the goal of individualizing chemotherapy decisions. Here, we report 2 cases of early- stage…

Negative / Null Result ReportMedicine

Anthelmintic resistance of gastrointestinal nematodes in cattle herds in mid-mountain central France.

Dravigney L, Chartier C, Grelaud P et al. · 2026 · Journal of helminthology

Anthelmintic resistance (AR) in gastrointestinal nematodes is insufficiently studied in cattle in many European regions, including France, where only three studies have been conducted in the north-west. This study evaluated the efficacy of…

View details →DOI: 10.1017/s0022149x26101746
Negative / Null Result ReportMedicine

Dietary patterns are associated with premenstrual symptoms: a cross-sectional study among women from Central Europe.

Granda D, Szmidt MK, Jarmuzek-Orska P et al. · 2026 · Scientific reports

To date, only a few studies have examined the relationship between dietary patterns and premenstrual syndrome (PMS), and these have been limited to Asian populations with inconclusive results, while studies in European populations are…

View details →DOI: 10.1038/s41598-026-58236-0
Negative / Null Result ReportMedicine

Chemical and visual compatibility of dexmedetomidine injection with parenteral medications used in neonatal intensive care settings.

De Silva DTN, Hamilton AJ, Strunk T et al. · 2026 · European journal of hospital pharmacy : science and practice

Objective To investigate the chemical and visual compatibility of dexmedetomidine injection with 44 secondary intravenous (IV) drugs and six 2-in-1 parenteral nutrition (PN) solutions used in neonatal intensive care unit settings. Methods…

View details →DOI: 10.1136/ejhpharm-2026-004995
Negative / Null Result ReportMedicine

The evaluation of Copy Number Variants in an unselected population of patients with Inherited Cardiac Conditions: The INTERACTION Study.

Giulia C, Simona M, Monia M et al. · 2026 · Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Background and aims The current diagnostic approach to inherited cardiac conditions (ICCs) is primarily focused on the analysis of single-nucleotide variants (SNVs) and small insertions/deletions (InDels). However, as recommended for other…

View details →DOI: 10.1093/europace/euag150
Negative / Null Result ReportMedicine

Effects of continuous vs. intermittent transcutaneous electrical stimulation of the auriculotemporal nerve on nociceptive processing: a pilot randomized controlled double-blind crossover trial in asymptomatic volunteers.

Barone M, Guli L, Centurión J et al. · 2026 · Cranio : the journal of craniomandibular practice

Objective To compare the effects of two transcutaneous electrical stimulation (TES) patterns applied to the auricular branches of the auriculotemporal nerve on nociceptive processing. Methods Twelve asymptomatic volunteers received…

View details →DOI: 10.1080/08869634.2026.2645872
Negative / Null Result Report

Real-time resolution of VP ellipsis ambiguity and processing depth

Fujita H, Yoshida M · 2026 · Preprint

In the VP ellipsis sentence “Bill liked himself, and John did too”, the second conjunct “John did too” can be interpreted in two ways: either as “John liked Bill too” (strict interpretation) or “John liked himself too” (sloppy…

View details →DOI: 10.31234/osf.io/qx85z_v1
Negative / Null Result ReportMedicine

Comparative analysis of PTH Washout and 99mTc-MIBI SPECT/CT in presurgical localization for patients with primary hyperparathyroidism.

Cieślewicz M, Szczepanek-Parulska E, Witowska A et al. · 2026 · Journal of endocrinological investigation

Purpose Our study aimed to evaluate the performance and concordance of parathyroid hormone wash-out (PTHw) and 99m Tc-MIBI+SPECT/CT (MIBI) in preoperative localization for patients with primary hyperparathyroidism (PHPT), and assess…

View details →DOI: 10.1007/s40618-026-02873-9
Negative / Null Result ReportMedicine

'White autopsies': an overview of cases with inconclusive results of post-mortem examinations in the Department of Forensic Medicine of the Jagiellonian University Medical College in Kraków, Poland.

Zwierzewicz Z, Szpakowska A, Bistroń D et al. · 2025 · Archiwum medycyny sadowej i kryminologii

The aim of the study The aim of the study was to accurately determine the incidence of white autopsies and to identify possible conditions responsible for such autopsies by means of analyzing confirmed causes of death in the same age…

View details →DOI: 10.4467/16891716amsik.25.008.22186
Negative / Null Result ReportMedicine

COMPARING THE ABILITY OF GENETIC TESTING TO PROVIDE A DEFINITIVE DIAGNOSIS IN PATIENTS WITH PERIPHERAL AND MACULAR INHERITED RETINAL DISEASE.

Dones AM, Bou Ghanem G, Kessler C et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose We performed a retrospective cross-sectional study to determine whether there is a significant difference in the percentage of patients with diagnosed inherited macular or peripheral disease who receive more definitive genetic…

View details →DOI: 10.1097/iae.0000000000004732
Negative / Null Result ReportMedicine

Robotic arm-assisted <sup>18</sup>F-FDG PET/CT-guided biopsy in febrile patients with biopsy accessible FDG-avid lesions: a single-centre experience.

Aggarwal P, Singh H, Kumar R et al. · 2026 · European journal of nuclear medicine and molecular imaging

Purpose Fever of unknown origin (FUO) is a prolonged fever with unknown etiology after an extensive outpatient or inpatient workup. 18 F-Flurodeoxyglucose (FDG) positron emission tomography (PET) with computed tomography (CT) has shown a…

View details →DOI: 10.1007/s00259-026-07928-w
Negative / Null Result ReportMedicine

Enteral When Compared With IV Magnesium Replacement in the Critically Ill: A Noninferiority Randomized Clinical Trial.

Nguyen CD, Panganiban HP, Karahalios A et al. · 2026 · Critical care medicine

Objectives Enteral magnesium replacement may be as effective as IV replacement while being a cheaper and more environmentally sustainable intervention. The primary objective was to evaluate whether enteral magnesium is noninferior to IV…

View details →DOI: 10.1097/ccm.0000000000007174
Negative / Null Result ReportMedicine

Development and validation of a nomogram model for predicting negative/indeterminate HIV-1 antibody confirmation: a strategy to streamline the diagnostic pathway.

Liao G, Zhang S, Wei Y et al. · 2026 · BMC medical informatics and decision making

Background The standard HIV diagnostic algorithm comprises sequential serological screening, confirmatory antibody testing, and nucleic acid confirmation when necessary. This multi-step process often causes diagnostic delays, particularly…

View details →DOI: 10.1186/s12911-026-03546-6
Negative / Null Result ReportMedicine

Effect of re-biopsy and re-vitrification on clinical outcomes in preimplantation genetic testing for aneuploidy.

Wu H, Wang H, Liang Y et al. · 2025 · Journal of assisted reproduction and genetics

Purpose To investigate whether re-biopsy and re-vitrification affect embryo developmental potential and clinical outcomes. Methods Embryos that underwent preimplantation genetic testing for aneuploidy (PGT-A) and single embryo transfer…

View details →DOI: 10.1007/s10815-025-03675-3
Negative / Null Result ReportMedicine

Changes in Attitudes After Suicide Prevention Media Campaigns in Three Norwegian Regions.

Mohn C, Haga E, Nilsson HSW et al. · 2026 · Archives of suicide research : official journal of the International Academy for Suicide Research

Background In a recent Norwegian regional suicide prevention media campaign, we found small and inconclusive results regarding changes in attitudes to suicide and help-seeking. In this exploratory study we add the data from two other…

View details →DOI: 10.1080/13811118.2026.2624605
Negative / Null Result Report

Identification of a Pathogenic BRCA2 Variant by Multigene Panel Testing in a Blood Group Chimera/Mosaic Case Unclassifiable by Conventional BRCA1/2 Testing

GONDA K, Ozaki A, Ito S et al. · 2026 · Preprint

Abstract In the setting of blood group chimerism/mosaicism, conventional BRCA1/2 genetic testing may yield inconclusive results. Multigene panel testing (MGPT) may overcome this limitation. We report a case in which BRCA2 pathogenic…

View details →DOI: 10.21203/rs.3.rs-8494624/v1
Negative / Null Result ReportMedicine

Biomagnetism of oral tissues and external magnetic field interactions with cell membranes, oral microflora, and orthodontic magnetic therapies: A review.

Itabaiana Sobrinho S, Meira-Belo LC, Mohallem NDS · 2026 · Progress in biophysics and molecular biology

Various rare earth magnets have been successfully applied in clinical orthodontics; however, their interactions with the oral environment remain only partially understood. Various controversies remain regarding magnetic fields (MFs) in…

View details →DOI: 10.1016/j.pbiomolbio.2026.01.003
Negative / Null Result ReportMedicine

Effects of Glucagon-Like Peptide-1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review.

Vieira FT, Deng Z, Muller MJ et al. · 2026 · Obesity reviews : an official journal of the International Association for the Study of Obesity

Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat-free mass and fat mass losses) and mass-independent adaptations in EE (e.g., hormones). Glucagon-like peptide-1 receptor…

View details →DOI: 10.1111/obr.70116