e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 264 of 662

Negative / Null Result ReportOpen accessMedicine

Safety and clinical outcomes of micro-axial intravascular flow pump compared to intra-aortic balloon pump in cardiogenic shock.

Makino M, Shishikura D, Kusumoto H et al. · 2026 · Cardiovascular diagnosis and therapy

Background The micro-axial intravascular flow pump (mAFP) may potentially improve the prognosis of cardiogenic shock (CS). Despite its advanced hemodynamic profile, efficacy remains undetermined. Safety and mid-term outcomes were compared…

View details →DOI: 10.21037/cdt-2025-302
Negative / Null Result ReportMedicine

Identification of specific codon 201 mutation of the DCC Gene in the colonoscopic specimen of colorectal cancer.

Serwer T, Wahid M, Imtiaz F et al. · 2024 · JPMA. The Journal of the Pakistan Medical Association

Objective To identify the mutation in codon 201 of the deleted in colorectal cancer gene in colorectal cancer, and to correlate that mutation to the histopathological grading of colorectal cancer. Methods The cross-sectional study was…

View details →DOI: 10.47391/jpma.9158
Negative / Null Result ReportOpen accessMedicine

Comparative Evaluation of Antimicrobial Activity and Minimum Inhibitory Concentration of Commercially Available Pediatric Dentifrices: An In Vitro Study.

Dureha R, Navit S, Khan SA et al. · 2024 · International journal of clinical pediatric dentistry

Aim The aim of this study was to evaluate the antimicrobial efficacy and minimum inhibitory concentration (MIC) of commercially available pediatric dentifrices containing different compositions against Streptococcus mutans and…

View details →DOI: 10.5005/jp-journals-10005-2939
Negative / Null Result ReportMedicine

CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: Isoform specificity.

Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V et al. · 2024 · Free radical biology & medicine

Calcium (Ca 2+ )/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca 2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammatory, metabolic and…

View details →DOI: 10.1016/j.freeradbiomed.2024.08.030
Negative / Null Result ReportOpen accessMedicine

The "inverted-U" of cognitive effort across speech rates holds for simple but not complex sentence structures.

O'Leary RM, Zavlun N, Kinney A et al. · 2025 · Frontiers in psychology

Pupil dilation has become a well-established physiological index of cognitive effort. Here we examined the often-cited finding of an inverted U-shaped function of pupil size across the continuum from highly degraded to clear speech. Unlike…

View details →DOI: 10.3389/fpsyg.2025.1685938
Negative / Null Result ReportMedicine

Bactericidal Efficacy of So-Called Sanitizers in Japan.

Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin

Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…

View details →DOI: 10.1248/bpb.b24-00439
Negative / Null Result Report

Predicting clinical outcomes of post-operative focal neurological deficits after glioma resection based on MRI characteristics: A retrospective chart review

Bukhari SS, Saeed F, Tahir I et al. · 2023 · Preprint

Abstract Background: The standard of care for gliomas includes maximum safe resection of the tumor. This may lead to inadvertent damage to tissue directly or vasculature supplying normal brain tissue. This may result in perilesional brain…

View details →DOI: 10.21203/rs.3.rs-2616875/v1
Negative / Null Result ReportOpen accessMedicine

Single Enema Fecal Microbiota Transplantation in Cats With Chronic Enteropathy.

Karra DA, Suchodolski JS, Newman SJ et al. · 2025 · Journal of veterinary internal medicine

Background Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis. Hypothesis/objectives To evaluate the efficacy of a single enema fecal microbiota transplantation…

View details →DOI: 10.1111/jvim.70054
Negative / Null Result ReportMedicine

The Effects of Differential Learning on the Standing Broad Jump.

Rivera D, Robinson T, King AC · 2024 · Perceptual and motor skills

In this investigation, we examined the influence of two approaches of motor skill learning (differential learning and repetition-based) for an explosive motor skill. Twenty-seven individuals completed four training sessions of a standing…

View details →DOI: 10.1177/00315125231218465
Negative / Null Result ReportOpen accessMedicine

Preventing relapse in patients with major depressive disorder after an effective acute course of electroconvulsive therapy.

Song M, Launder NH, Phutane VH et al. · 2026 · Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

ObjectiveMajor depressive disorder (MDD) is a highly prevalent debilitating mental health disorder with a lifetime risk of 11-15% in Australia. The most effective treatment for severe depression is electroconvulsive therapy (ECT), but it…

View details →DOI: 10.1177/10398562251389557
Negative / Null Result ReportOpen accessMedicine

Curcumin's effect in advanced and metastatic breast cancer patients treated with first or second-line docetaxel: A randomized trial.

Judith PJ, Maureen B, Mélanie P et al. · 2024 · Health science reports

Background In this study, we investigated whether the association of curcumin and docetaxel among advanced and metastatic breast cancer patients in first or second-line treatment potentiated the objective response rate. Patients/methods A…

View details →DOI: 10.1002/hsr2.70052
Negative / Null Result ReportOpen accessMedicine

Eosinophilic myocarditis in dilated cardiomyopathy: a case report.

Li M, Chen H · 2025 · BMC cardiovascular disorders

Background Eosinophilic myocarditis (EM) is a rare cardiac condition that is often difficult to diagnose. Although endocardial myocardial biopsy is considered the gold standard for diagnosis, sampling errors can lead to false-negative…

View details →DOI: 10.1186/s12872-025-04826-1
Negative / Null Result ReportMedicine

"Back to the Future": Testing the "Individual Problems and Strengths" Scale With a Stepwise Confirmatory Factor Analysis Approach.

Zahl-Olsen R, Gausel N, Håland ÅT et al. · 2026 · Journal of clinical psychology

Routine Outcome Monitoring systems have been developed to monitor how clients' lives change over the course of therapy. However, for such systems to be effective, they must possess sufficient construct validity and scale-reliability to…

View details →DOI: 10.1002/jclp.70164
Negative / Null Result Report

No Robust Evidence for Octave Equivalence in Bengalese Finches

Ito R, Okanoya K · 2026 · Preprint

Octave equivalence—the tendency to perceive tones separated by a 2:1 frequency ratio as perceptually similar—is a fundamental feature of human pitch perception and a key component of musical pitch organization. Evidence for octave…

View details →DOI: 10.31234/osf.io/pfw9x_v1
Negative / Null Result ReportMedicine

Lung ultrasound score and prediction of patient outcomes in hypoxaemic intubated and mechanically ventilated critically ill: A cohort study.

Ntoumenopoulos G, Hansell L, Neindre AL et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background The extent of pulmonary aeration present on admission to the intensive care unit (ICU) as determined by the lung ultrasound score (LUSS) may be useful to predict weaning from mechanical ventilation. The aim of this study was to…

View details →DOI: 10.1016/j.aucc.2025.101495
Negative / Null Result ReportMedicine

Longitudinal relations between parental burden, adolescent externalizing symptoms, and mental health service use in the year following adolescent psychiatric hospitalization.

Harris KM, Curby TW, Goldston DB et al. · 2026 · Psychological services

Rates of adolescent psychiatric hospitalization have increased significantly over the last decade. Despite heightened risk for life-threatening behavior and readmission in the year following hospitalization, mental health service use has…

View details →DOI: 10.1037/ser0001050
Negative / Null Result ReportMedicine

Outcome of Severe Adenoviral Respiratory Infection Supported With Extracorporeal Membrane Oxygenation: A Multicenter PICU Study From Colombia (2018-2022).

Acevedo L, Fernández-Sarmiento J, Mulett H et al. · 2026 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To compare survival, clinical characteristics, complications, and duration of extracorporeal membrane oxygenation (ECMO) support in pediatric patients with severe adenoviral respiratory infections vs. those with other viral…

View details →DOI: 10.1097/pcc.0000000000003936
Negative / Null Result ReportMedicine

Mismatch Response to Native and Nonnative Vowels in Czech and Russian: Where's the Phoneme Effect?

Dvořáková M, Chládková K · 2025 · Journal of speech, language, and hearing research : JSLHR

Purpose The mismatch negativity (MMN), a neural index of speech sound discrimination, is reportedly stronger for phonemically relevant speech sound differences than for phonemically irrelevant differences, even if the former are…

View details →DOI: 10.1044/2024_jslhr-23-00788
Negative / Null Result ReportOpen accessMedicine

What Is the Impact of Second Language Exposure and Intellectual Disability Status on Executive Function and Functional Communication Outcomes in Children and Adolescents With and Without Autism Spectrum Disorder (ASD)?

Hutchison SM, DiazPinzon N, Oberlander TF et al. · 2025 · Autism research : official journal of the International Society for Autism Research

Over the past 10 years, research has suggested no negative effect on second language exposure in children with autism spectrum disorder (ASD), yet, parents and professionals may be concerned that using a second language with a child with…

View details →DOI: 10.1002/aur.70070
Negative / Null Result ReportOpen accessMedicine

Immune Globulin

· 2006

Immune globulin G (IgG) is a normal component of breastmilk. Data from 2 mothers indicate that IgG concentrations in milk are normal or higher and IgM levels in milk are normal or lower during intravenous immunoglobulin (IVIG) therapy. The…

Negative / Null Result ReportMedicine

Caregiver emotional support and youth mental health after sexual abuse.

Sitton MJ, McDonald R, Rosenfield D et al. · 2026 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

Emotional support from a caregiver is theorized to benefit adolescents after sexual abuse, yet the empirical evidence for this is inconsistent. The present study examines the cross-sectional relation between caregiver emotional support and…

View details →DOI: 10.1037/fam0001371
Negative / Null Result ReportMedicine

Mobile App Use in Clinical Care for Cleft Patients in the UK and Republic of Ireland.

de Berker HT, Rivers CM · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo establish whether mobile applications (apps) are used as part of routine care for patients with cleft lip and palate in the UK and Republic of Ireland and to determine what role apps could play in the delivery of care.DesignA…

View details →DOI: 10.1177/10556656251338951
Negative / Null Result ReportMedicine

Tumor-induced rickets/osteomalacia (TIO): diagnostic pitfalls and therapeutic options.

Ito N, Fukumoto S · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

A 10-year-old girl developed bilateral gonalgia and waddling gait. Biochemical and imaging studies showed hypophosphatemia with impaired proximal tubular phosphate reabsorption and high intact fibroblast growth factor 23 (FGF23) level,…

View details →DOI: 10.1093/jbmr/zjaf047
Negative / Null Result ReportOpen accessMedicine

Randomized controlled trial of intravenous dexamethasone to prevent relapse in the treatment of migraine in a pediatric emergency department.

Tourigny-Ruel G, Bailey B, Jean-Charles S et al. · 2026 · Headache

Objective This study aimed to evaluate whether a single dose of intravenous dexamethasone, when added to standard abortive therapy, reduces relapse of migraine after emergency department (ED) discharge in children and adolescents.…

View details →DOI: 10.1111/head.70087