A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20230 results in Negative / Null Result Report · page 264 of 675
Schimmele T, Castaneda NM, Mazzari G et al. · 2026 · Neuroimmunomodulation
Early life adversity (ELA) is a potent risk factor for negative mental health outcomes, in part through its enduring effects on neuroimmune function. The hippocampus is particularly sensitive to stress across the lifespan, and…
Charoenphannathon JS, Royce SG, Higham Y et al. · 2026 · British journal of pharmacology
Background and purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell-derived extracellular vesicles…
Maddahi N, Zamani B, Nadjarzadeh A et al. · 2026 · Urology journal
Purpose This study investigated the impact of synbiotics on blood and urinary concentrations of factors related to kidney stone formation in overweight or obese patients with hyperoxaluria. Materials and methods A randomized double-blind…
Mishukov AA, Ignatova AA, Ogneva AL et al. · 2026 · Cytometry. Part A : the journal of the International Society for Analytical Cytology
Increasing evidence suggests connection between mitochondrial dysfunction and platelet-related disorders, necessitating developing of a high throughput method for assessing the functioning of mitochondria in platelets. Here we develop an…
Alaoui-Ismaili Z, Grand J, Frydland M et al. · 2026 · Resuscitation plus
Background Early risk assessment is crucial in comatose survivors of out-of-hospital cardiac arrest (OHCA) for timely resource allocation and initiation of interventions. Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory…
Fida TT, Sherman T, Hall M et al. · 2026 · Biofouling
Acid-producing bacteria (APB) play significant role in pipeline corrosion by producing corrosive metabolites. Current APB mitigation strategies are often unsuccessful, costly, or not environmentally friendly. In this study, nitrate was…
Abt K, Amato CM, Kitakule A et al. · 2026 · Preprint
Periods of elevated ambient temperature challenge the body’s ability to maintain internal homeostasis, and heat stress poses particular risks during pregnancy. Epidemiological studies associate gestational heat exposure with higher rates…
Randunu RS, Huber LA, Van Vliet BN et al. · 2026 · The Journal of nutrition
Background Developmental programming is a key determinant of adult hypertension. Total parenteral nutrition (TPN) can exert nutritional stress during development and cause irreversible programming of metabolism via epigenetic…
Abe I, Kubo K, Fujita Y et al. · 2026 · Drug discoveries & therapeutics
The metabolic and endocrinological effects in patients with adult growth hormone deficiency (AGHD) who switched from daily growth hormone (GH) replacement therapy to weekly GH replacement therapy with somapacitan were evaluated and…
Bittarello F, Girardello MdM, Santos ALR et al. · 2026 · Preprint
Objective: To evaluate the removal of simulated deposits in molar furcations using Dual Gracey™ curettes and sonic instruments. Material and method: Sixteen molars (80 tooth surfaces) were divided into maxillary (n=8) and mandibular (n=8)…
Weldon K, O'Meara C, Lonergan P et al. · 2026 · Animal reproduction science
Extremolytes are compatible solutes that protect macromolecules and cell structures under extreme stress. The objectives of this study were to assess the biocompatibility of the extremolyte ectoine with bull sperm during cryopreservation,…
Ruiz R, Ramirez J, Velay-Lizancos M · 2026 · Preprint
Abstract Corrosion of steel reinforcement in concrete is one of the main issues plaguing aging infrastructure worldwide. While concrete’s carbonation is usually associated with an increased risk of corrosion, this study proposes a…
Dialoke NG, Murata K, Zhang Y et al. · 2026 · The journal of poultry science
From an animal welfare perspective, thirst avoidance is an important criterion for the poultry industry. Neuropeptide Y (NPY) and α-melanocyte-stimulating hormone (α-MSH) play critical roles in regulating food intake, which is closely…
Cruz Flores M, Fort J, Barbraud C et al. · 2026 · Preprint
Environmental modifications due to climate change impact the phenology, distribution and demography of marine organisms. Such effects are striking in the Arctic, which is warming up to four times faster than other regions of the planet.…
Li F, Du C, Yu Q et al. · 2026 · Diabetes, obesity & metabolism
Aim Evaluate ecnoglutide (XW003) effects on rosuvastatin and digoxin pharmacokinetics (PKs) in healthy adults. Methods This was an open-label, single-sequence crossover Phase 1 study. Eligible participants received rosuvastatin (10 mg,…
Matsuda S, Nakano K · 2026 · The Journal of eukaryotic microbiology
In Tetrahymena, autophagy appears to be involved in the integrity of the mitochondria which supply energy for active ciliary movement on the cell surface, the maintenance of various structures such as cilia, and cell shape changes…
Fan Y, Gao G, Jiang X et al. · 2026 · Preprint
The objective of this study was to evaluate the effects of partially replacing wheat bran with poplar wood composite fiber (PWCF) on growth performance, immune status, apparent total tract digestibility (ATTD), and gut microbial…
Lin M, Tapuc A, Matyjek M et al. · 2026 · Comprehensive psychiatry
Autistic traits are associated with atypical social behaviors, particularly in approach-avoidance tendencies. However, the differential impact of these traits on responses to social versus non-social stimuli, and the variation of these…
Geng F, Guo R, Shao Y · 2026 · Journal of psychiatric research
Background The jumping-to-conclusions (JTC) bias, which involves making hasty decisions based on limited evidence, has been extensively studied in schizophrenia spectrum disorders but remains under-explored in affective disorders,…
Yang Y, Fu H, Chang M et al. · 2026 · Preprint
Abstract Background Up to now, few drugs are available for treatment of feline infectious peritonitis (FIP) which causes death of young cats less than 2 years old, and is a fatal infectious disease caused by feline infectious peritonitis…
Khan H, Ghafoor T, Khattak TA et al. · 2026 · Transplantation and cellular therapy
Infantile Osteopetrosis is a rare inherited bone disorder characterized by a reduced or complete lack of osteoclast function, leading to defective bone resorption and increased bone density. The defective osteoclast differentiation or…
Incerti Parenti S, Evangelisti E, Maglioni A et al. · 2026 · Cranio : the journal of craniomandibular practice
Objective To investigate whether fixed orthodontic treatment affects sleep and awake bruxism activities, temporomandibular disorder (TMD) prevalence, and pressure pain thresholds (PPTs) of masticatory muscles in healthy adults. Methods In…
Jacob G, Lourenço PR, Diniz FMM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective This study evaluated the effect of calcium hydroxide-based intracanal medication protocols on the sealer-dentin interface, considering bond strength, adhesive interface adaptation, failure pattern, and dentin gelatinolytic…
Jian PT, Lin YW · 2026 · Contact dermatitis
Background Hairdressers often reuse disposable gloves, yet the effect of repeated washing on protection against oxidative hair-dye sensitizers is unclear. Objectives To determine how reuse and wash type influence the permeation of…
Soares EADS, Crisp AH, Fernandes PT et al. · 2026 · Scandinavian journal of psychology
Premenstrual syndrome (PMS) is a set of symptoms related to hormonal changes occurring during the premenstrual period. Effective coping strategies for managing PMS have not been clearly established, and it remains unclear whether these…
Mies F, Olchowik-Grabarek E, Crutzen R et al. · 2026 · Biochemical and biophysical research communications
In this report we demonstrate that iodogallic acid (IGA) and iodoferulic acid (IFA) do not acutely affect transepithelial cation transport, however, prolonged basolateral application of IFA induced a delayed decrease in open-circuit…
Bodilsen TS, Andreasen TH, Olsen MH et al. · 2026 · Acta neurochirurgica
Background Invasive multimodal neuromonitoring (MMNM) is standard of care in many neuro-intensive care units for patients with severe acute brain injury. MMNM is used for monitoring of early signs of secondary brain injury. Still, the…
Lindhard K, Hansen HP, Gliese K et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN
Introduction In patients on hemodialysis, the risk of arteriovenous fistula (AVF) failure is unacceptably high. Up to 67% of AVFs need an intervention within one year after placement. There are no effective treatments to prolong AVF…
Goto K, Ishizuka S, Nakamura-Takahashi A et al. · 2026 · Journal of oral biosciences
Objectives Hypophosphatasia (HPP) is a congenital disease caused by mutations in the tissue non-specific alkaline phosphatase gene. HPP is characterized by impaired hard tissue mineralization and premature tooth loss. Mild-type HPP…
Van Daele A, Labarque V, Dereymaeker A et al. · 2026 · Neuropediatrics
Background Neonatal stroke is a rare but potentially severe condition that may lead to long-term neurological impairment. Several factors may influence both its occurrence and outcomes. Methods In this retrospective, single-center cohort…