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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 260 of 662

Negative / Null Result ReportMedicine

Examining the Factor Structure and Subgroup Invariance of the Deliberate Denial of Disordered Eating Behaviors Scale.

Howard L, Hawn S, Pitchford KD et al. · 2026 · Behavioral sciences (Basel, Switzerland)

The denial, concealment, or omission of disordered eating behaviors has received limited attention in the eating disorder literature, partly due to the lack of reliable and valid measures. This study re-examined the factor structure of the…

View details →DOI: 10.3390/bs16060898
Negative / Null Result ReportMedicine

Association of Prophylactic Corticosteroids with Post-Extubation Outcomes in Pediatric Cardiac Critical Care: A Retrospective Propensity-Weighted Cohort Study.

Saengsin K, Jirattikanwong N, Wongyikul P et al. · 2026 · Journal of clinical medicine

Background/Objectives : Post-extubation stridor (PES) is common in pediatric critical care and may contribute to extubation failure, particularly in children with heart disease. Prophylactic corticosteroids are frequently used before…

View details →DOI: 10.3390/jcm15124762
Negative / Null Result ReportMedicine

Does a non-dipping heart rate profile predict adverse maternal-fetal outcomes? evidence from 24-h ambulatory monitoring in the second half of high-risk pregnancies.

Espeche W, Minetto J, Cerri G et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension

Hypertensive disorders of pregnancy are a leading cause of maternal-fetal morbidity and mortality, with preeclampsia representing a major contributor to adverse outcomes. Ambulatory blood pressure monitoring (ABPM) has improved risk…

View details →DOI: 10.1038/s41440-026-02687-5
Negative / Null Result ReportMedicine

Clinical Evaluation of a Real-Time Wearable System for Monitoring In-Hospital Ambulatory Patients With COVID-19: Retrospective Data Study.

Vollam S, Roman C, Santos M et al. · 2026 · JMIR medical informatics

Background Many studies have evaluated the use of wearable monitoring systems to improve patient safety in hospital. Although some have demonstrated effects on intensive care admissions, there remains little evidence of impact on patient…

View details →DOI: 10.2196/81304
Negative / Null Result Report

Physical activity during anthracycline chemotherapy: exploratory secondary analysis of a randomized trial of functional capacity, free-living activity, and ejection fraction

Appiah KN, Sharma N, Adu N et al. · 2026 · Preprint

Abstract Background: Anthracycline-based chemotherapy produces progressive functional decline and cardiotoxicity in adults with cancer. Physical activity interventions may attenuate these effects, yet evidence across multiple domains…

View details →DOI: 10.21203/rs.3.rs-9439431/v1
Negative / Null Result Report

Colocalization Reprioritizes the Major Depressive Disorder Druggable Genome: Demotion of the Top TWAS Signal (DRD2) and Nomination of SLC12A5/FURIN/DCC by Direction-Aware, Confirmation-Gated Analysis of 635 GWAS Loci

Kang B · 2026 · Preprint

Abstract Background: Major depressive disorder (MDD) is highly polygenic, yet translating genome-wide association study (GWAS) findings into therapeutics remains challenging. Using PGC MDD2025, we integrated gene-level mapping, brain TWAS,…

View details →DOI: 10.21203/rs.3.rs-9880173/v1
Negative / Null Result ReportMedicine

Relationships Between Estradiol Levels and Vaginal Lactobacillus Abundance Across the Menstrual Cycles in Women.

Koczur K, Blukacz M, Galbarczyk A et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Microbiota of the urogenital tract is crucial for women's reproductive and sexual health and is largely dominated by Lactobacillus strains. A reduction of these bacteria within the vaginal microbial community has been linked to…

View details →DOI: 10.1002/ajhb.70291
Negative / Null Result Report

Within-person prospective associations between youth psychopathology and white matter development and the moderating role of parental mental health

Karl V, Beck D, Dall'Aglio L et al. · 2026 · Preprint

Background: Adolescence is a developmental period involving ongoing white matter (WM) maturation and rising risk for psychopathology. This risk is particularly elevated among youth whose parents have mental health problems. Methods:…

View details →DOI: 10.31234/osf.io/ksy2n_v1
Negative / Null Result ReportMedicine

Investigational Approaches in Treatment of Nonadvanced Mastocytosis.

Pongdee T · 2026 · Current allergy and asthma reports

PURPOSE OF REVIEW: Recent strategies to treat nonadvanced SM have focused on targeted therapies to inhibit mast cell activation and/or proliferation. Several investigational approaches are being explored to treat nonadvanced SM in this…

View details →DOI: 10.1007/s11882-026-01263-8
Negative / Null Result ReportMedicine

Voxel-wise case-control analysis of dose, linear energy transfer and symptomatic brainstem necrosis in pediatric brain tumors treated with proton therapy.

Handeland AH, Indelicato DJ, Engeseth GM et al. · 2026 · International journal of radiation oncology, biology, physics

Introduction Brainstem necrosis is a rare but serious toxicity following radiotherapy for pediatric brain tumors. In proton therapy (PT), concerns have emerged around elevated linear energy transfer (LET) and the relative biological…

View details →DOI: 10.1016/j.ijrobp.2026.05.054
Negative / Null Result ReportMedicine

Functional stupidity in Danish intersectoral pathways: An institutional ethnographic text analysis of documentary practices.

Kamionka SL, Sodemann M, Bilenberg N et al. · 2026 · Health (London, England : 1997)

Written information exchange is widely used to share information and coordinate care across services. Yet, its coordinating effects remain unclear. The aim of the study was to explore the textually mediated practices through which…

View details →DOI: 10.1177/13634593261419400
Negative / Null Result ReportMedicine

Fragmentation as a population rate-changer: A field experiment.

Nichols JD, Hines JE, Hinz RL et al. · 2026 · Ecology

Experimental and observational studies of effects of fragmentation on biodiversity and population dynamics have produced mixed results, with some reviews concluding strong evidence of negative effects and others concluding small positive…

View details →DOI: 10.1002/ecy.70327
Negative / Null Result Report

From Silos to Flows by Redesigning Regional Care for System-Wide Coordination: A Qualitative Study of Organizational Capabilities and Governance in Sweden

Carlsson KS, Brommels M, Ohrling M · 2026 · Preprint

Abstract Background Decentralised and market-inspired health system reforms have increased organisational plurality and local autonomy but often intensify fragmentation and complicate system-wide coordination. This study explored how…

View details →DOI: 10.21203/rs.3.rs-8703981/v1
Negative / Null Result ReportMedicine

Association Between Plasma Pentosidine and Skeletal Muscle-Related Indices in Older Adults Without Diabetes.

Shida T, Hatanaka S, Ohta T et al. · 2026 · Geriatrics & gerontology international

Aim This study examined the association between plasma pentosidine concentrations-an advanced glycation end-product marker-and skeletal muscle morphometric indices, physical function, and sarcopenia among community-dwelling older adults…

View details →DOI: 10.1111/ggi.70515
Negative / Null Result ReportMedicine

Prevention or relief? Voters' support for disaster policies.

Kim HH, Cragun J, DeScioli P · 2026 · Disasters

Researchers have argued that preventing disasters is more efficient than providing relief. Yet, previous scholarship has found that voters in the United States reward politicians more for relief than for prevention policies. It is unclear,…

View details →DOI: 10.1111/disa.70016
Negative / Null Result ReportMedicine

Educational Interventions to Improve Student Pharmacists' Empathy and Attitudes Toward Older Adults or Aging: A Scoping Review.

Gray SL, Liberman M, Onukwufor E et al. · 2026 · American journal of pharmaceutical education

Objectives Ageism remains a pervasive barrier to delivering high-quality health care to older adults. The objective of this scoping review is to describe studies on educational interventions aimed at improving the empathy and attitudes of…

View details →DOI: 10.1016/j.ajpe.2026.101960
Negative / Null Result ReportMedicine

Exploring Dimensions of Posttraumatic Stress in Young Children.

Mulligan DJ, Grasso DJ, Greene CA et al. · 2026 · Research on child and adolescent psychopathology

The latent structure of posttraumatic stress symptoms (PTSS) in early childhood remains poorly understood. This study aimed to assess PTSS in young children, identify underlying latent constructs, and evaluate their construct validity.…

View details →DOI: 10.1007/s10802-025-01396-w
Negative / Null Result ReportOpen accessMedicine

Validation of the Leuven Postprandial Distress Scale According to the Rome IV Criteria for Functional Dyspepsia.

Van de Bruaene C, Carbone F, Van den Houte K et al. · 2026 · Journal of neurogastroenterology and motility

Background/aims : The Leuven Postprandial Distress Scale (LPDS) is a validated patient reported outcome (PRO) measure for functional dyspepsia (FD)/postprandial distress syndrome (PDS) patients according to Rome III criteria. However,…

View details →DOI: 10.5056/jnm25108
Negative / Null Result ReportMedicine

The role of allopurinol in metabolic dysfunction-associated steatotic liver disease: A randomized clinical trial.

Khani E, Khoshbaten M, Jafarabadi MA et al. · 2026 · Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

Background and study aims Despite being the leading cause of liver-related mortality, the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) remains challenging. This study aimed to assess the effects of…

View details →DOI: 10.1016/j.ajg.2025.11.004
Negative / Null Result ReportMedicine

BDNF Val66Met polymorphism is linked to elevated levels of serotonin-transporter in the medial prefrontal cortex but not to altered eating behavior.

McLeod A, Rullmann M, Hinderberger P et al. · 2026 · Neuroscience

A single nucleotide polymorphism in the brain derived neurotrophic factor (BDNF)-encoding gene leads to diminished BDNF signaling resulting from Val66Met and has been linked to obesity. Previous imaging studies regarding the impact of BDNF…

View details →DOI: 10.1016/j.neuroscience.2026.03.008
Negative / Null Result ReportMedicine

Presence and correlation of potentially toxic elements in honey, pollen, and soil samples in Kosovo.

Kastrati G, Sopaj F, Bytyqi V et al. · 2025 · Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

The study involved the determination of the concentrations of 11 potentially toxic elements (PTEs) in soil, honey, and pollen samples collected in the territory of Kosovo, followed by a statistical analysis. Inductively coupled…

View details →DOI: 10.1080/10934529.2025.2594372
Negative / Null Result Report

Personality disorder traits and impression formation: Individuals higher in detachment and antagonistic traits are perceived as less likable and trustworthy

Niedtfeld I, Störkel L, Didushok V et al. · 2025 · Preprint

The first impression a person makes can substantially influence whether and how they areapproached and treated by others. Prior research on this process suggests that individualsexhibiting higher levels of maladaptive personality traits…

View details →DOI: 10.31234/osf.io/k9sdg_v1