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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 260 of 675

Negative / Null Result ReportMedicine

Differences in Immunological Impact of Chemically and Biologically Synthesized Silver Nanoparticles.

Demeckova V, Demcakova V, Sedlakova-Kadukova J · 2025 · IEEE transactions on nanobioscience

Silver nanoparticles (AgNPs) are widely used for their antimicrobial properties but pose risks like environmental contamination and potential harm to human health. Nanoparticles' small size facilitates translocation within the body, often…

View details →DOI: 10.1109/tnb.2025.3564822
Negative / Null Result ReportMedicine

Improving sleep on the inpatient general, non-stroke neurology service: A quasi-experimental interventional trial.

Shaik NF, Denison L, Venezia GMA et al. · 2026 · Journal of hospital medicine

Background Hospitalized patients often experience poor sleep, which is associated with worse health outcomes, increased rates of delirium, and readmissions. Objective To improve overnight sleep for clinically stable general neurology…

View details →DOI: 10.1002/jhm.70223
Negative / Null Result ReportMedicine

Developing more effective phosphorus-loaded iron modified biochar fertilisers for improvement of peanut yield and regulation of soil phosphorus fractions

Zhang J, Wu Q, Chi D et al. · 2025 · Soil & tillage research

Phosphorus-loaded iron-modified biochar (Fe-BP) can be used as farmlands' slow-release phosphorus (P) fertilizer. This study aimed to explore the effects of Fe-BP on soil P composition, phosphatase activity, peanut P accumulation, and P…

Negative / Null Result ReportMedicine

The influence of the Hunga Tonga-Hunga Ha'apai water vapor on ozone content in the Antarctic and Arctic stratospheric polar vortex in the winter 2023 and 2023–2024

Lukyanov AN, Vargin PN, Yushkov VA · 2025 · Atmospheric research

The eruption of the underwater volcano Hunga Tonga – Hunga Ha'apai (20.54° S, 178.3° W) on January 15, 2022, resulted in the first significant increase in the stratospheric water vapor content in the entire satellite observation era. This…

Negative / Null Result ReportMedicine

Motivation-informed digital reminders were no more effective than standard reminders for trial task completion in a randomized Study Within A Trial (SWAT).

Ackermann DM, Medcalf E, Bracken K et al. · 2026 · Journal of clinical epidemiology

Objectives Digital reminders are widely used in clinical trials, but their design is rarely evidence-based. We evaluated the effectiveness of two types of digital reminders for trial task completion. Study design and setting This…

View details →DOI: 10.1016/j.jclinepi.2026.112263
Negative / Null Result Report

Incidence of Postoperative Pulmonary Complications in Patients with Prior COVID-19 Infection: A Lebanese Prospective Cohort Study

Hadi CE, Dailaty AA, Sobh AH et al. · 2025 · Preprint

Abstract Background Postoperative pulmonary complications (PPCs) remain a major determinant of morbidity after noncardiac surgery. Whether prior SARS-CoV-2 infection independently heightens PPC risk in the contemporary, highly vaccinated,…

View details →DOI: 10.21203/rs.3.rs-8100907/v1
Negative / Null Result ReportMedicine

Breastfeeding-injury link: are concerns warranted?

Jones PAT, Brockwell E, Hassan A et al. · 2025 · British journal of sports medicine

Objective Recreational and elite athletes report avoiding breastfeeding when returning to physical activity following childbirth due to a perceived increased risk of injury; yet, there are no empirical data to support this relationship. We…

View details →DOI: 10.1136/bjsports-2024-109310
Negative / Null Result ReportMedicine

Cytomegalovirus DNAemia in the lower respiratory tract in nontransplant patients with hematologic malignancies.

Sadowska-Klasa A, Bełdzińska-Gądek K, Klein-Awerjanow K et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Cytomegalovirus (CMV) pneumonia is a serious complication in immunocompromised patients, but its role in non-transplant populations remains unclear. Methods We analyzed CMV DNA in bronchoalveolar lavage (BAL) samples from 100…

View details →DOI: 10.1016/j.ijid.2025.108231
Negative / Null Result ReportMedicine

Fine-Scale Variation in Optimal Clutch Size in a Blue Tit Population.

Garrido-Bautista J, Ortega Z, Pérez-Jiménez A et al. · 2025 · Ecological and evolutionary physiology

AbstractClutch size variation may be adaptive in bird populations if parents lay a clutch size that maximizes offspring recruitment. Brood size manipulation experiments allow for testing the optimization of clutch size by studying the…

View details →DOI: 10.1086/738587
Negative / Null Result ReportMedicine

Sodium substitutes synergizing with dietary fiber: Effect on the textural, sensory, digestive, and storage properties of emulsified sausages.

Nie C, Zhong H, Shi H et al. · 2026 · Food chemistry

This study evaluated the effects of sodium substitutes (KCl, MgCl 2 , and CaCl 2 ) and soybean dietary fiber (SDF) on the textural, sensory, digestive, and storage properties of emulsion sausages. Replacing 25 % of NaCl with KCl or MgCl 2…

View details →DOI: 10.1016/j.foodchem.2025.147414
Negative / Null Result ReportMedicine

Pictures are not always worth a thousand words: Non-probative pictures did not increase the effectiveness of misinformation corrections.

Whitehead PS, Davis CP, Park JS et al. · 2025 · Journal of applied research in memory and cognition

Much research has focused on the language used for debunking false beliefs: communications should lead with facts, label misinformation as false, and reinforce true information. Pictures are used in debunking messages, but it remains…

View details →DOI: 10.1037/mac0000214
Negative / Null Result ReportMedicine

Evaluating Text Messaging Approaches to Promote Enrollment in Smoking Cessation Treatment Among Latino Adults: A Pragmatic Randomized Clinical Trial.

Cartujano-Barrera F, Catley D, Chávez-Iñiguez A et al. · 2026 · Chest

Background Little is known about the use of text messages to promote enrollment in smoking cessation treatment. Research question What is the impact of the number of outreach messages and monetary incentives on enrollment in smoking…

View details →DOI: 10.1016/j.chest.2025.11.054
Negative / Null Result ReportMedicine

Genome-Wide Identification, Characterization, and Nutrigenomics of ELOVL Genes in Laying Hens and Their Responses to Various Levels of Dietary Curcumin.

Dumlu B, Bölükbaşi ŞC, Bayir A · 2026 · Lipids

We investigated molecular characteristics and tissue distribution of elongation of very long chain fatty acids (ELOVL) genes in the chicken (Gallus gallus) genome. The research specifically examines the expression levels of these genes in…

View details →DOI: 10.1002/lipd.70013
Negative / Null Result ReportMedicine

Indocyanine green in intestinal endometriosis surgery: a multicenter evaluation of anastomotic safety.

Barretto R, Sonnenfeld MM, da Silva RCM et al. · 2026 · Journal of robotic surgery

Objective To evaluate whether the use of intraoperative indocyanine green (ICG) fluorescence impacts anastomotic safety and surgical outcomes in patients undergoing bowel endometriosis resection. Methods Retrospective, multicenter…

View details →DOI: 10.1007/s11701-025-03136-0
Negative / Null Result ReportMedicine

Clinical efficacy and safety of long-term treatment, discontinuation, and extended dosing intervals of denosumab treatment for solid cancer bone metastasis: A retrospective study.

Mihara A, Iwanaga R, Muramatsu K et al. · 2025 · Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

Background Metastatic bone tumors in solid cancer often induce excessive local bone resorption leading to skeletal related events (SRE) which may impact patients' quality of life and survival of the primary cancer. Denosumab, a bone…

View details →DOI: 10.1016/j.jos.2025.04.012
Negative / Null Result ReportMedicine

Development and testing of implementation strategies to increase the use of midline catheters in a paediatric intensive care unit.

Weber MD, Frankenberger W, Ullman AJ et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Paediatric critically ill patients are at risk of harm from central venous catheter overuse. We applied an implementation science approach to promote appropriate use of midline catheters. The aim of this study was to evaluate…

View details →DOI: 10.1016/j.aucc.2025.101514
Negative / Null Result ReportOpen accessMedicine

First report of bilateral Bronchial Rheoplasty for treating chronic bronchitis performed in a single procedure.

Jensen K, Secher EL, Libermann RH et al. · 2025 · European clinical respiratory journal

Introduction The RheOx system delivers brief, high-voltage electrical pulses to the airway lining, promoting the regeneration of healthy tissue and reducing mucus production in COPD patients with chronic bronchitis. The procedure, called…

View details →DOI: 10.1080/20018525.2025.2591506
Negative / Null Result ReportOpen accessMedicine

Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study.

Tsujio G, Yashiro M, Miki Y et al. · 2026 · PloS one

Background Our group revealed that the combination of intra-operative stamp cytology and peritoneal lavage cytology (CY) improved the identification of individuals with high risk of peritoneal metastasis. In this exploratory Phase II…

View details →DOI: 10.1371/journal.pone.0347742
Negative / Null Result ReportMedicine

The Impact of Preoperative Positive Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial.

Lee D, Lee H, Lee C et al. · 2026 · Anesthesia and analgesia

Background Drug-induced dreams during intravenous sedation vary by pharmacological agent and influence patient experiences, yet the role of preoperative positive suggestions in modulating these dreams is unclear. This study aimed to…

View details →DOI: 10.1213/ane.0000000000007818
Negative / Null Result ReportMedicine

A Phase 1, Open-Label, Single Ascending Dose Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of ES-481 After Oral Administration in Healthy Volunteers.

Niecestro R, Foster EC, Millist L et al. · 2026 · European journal of drug metabolism and pharmacokinetics

Background and objectives ES-481 is a potent and selective antagonist of the transmembrane alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptor regulatory protein (TARP)-y8-dependent AMPA receptor being developed for…

View details →DOI: 10.1007/s13318-025-00979-8
Negative / Null Result ReportMedicine

Manipulating attention during eating effects food intake and medial prefrontal cortex fNIRS response in women with cognitive restraint.

Albajri E, Ayaz H, Shewokis PA et al. · 2026 · Appetite

Objective To investigate how shifting the attention away from food being eaten (by women who are cognitively restrained) toward another food-related stimulus affects food intake and relative increases in neural activity from baseline (as…

View details →DOI: 10.1016/j.appet.2025.108416
Negative / Null Result ReportMedicine

Human chorionic gonadotropin inhibits locomotion but not food intake independently of the area postrema and the nucleus tractus solitarius in female mice.

Anan M, Kagawa K, Okamatsu-Ogura Y et al. · 2026 · Physiology & behavior

The nausea and vomiting of pregnancy (NVP) affect many pregnant women's quality of life, and the underlying mechanisms are still unclear. Human chorionic gonadotropin (hCG) is suspected to be a factor in exacerbating NVP due to its…

View details →DOI: 10.1016/j.physbeh.2025.115151