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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19840 results in Negative / Null Result Report · page 256 of 662

Negative / Null Result ReportMedicine

Smartphone-based approach-avoidance bias modification training for anorexia nervosa - A randomized clinical trial.

Blomberg M, Schaper R, Bonabi A et al. · 2025 · Behaviour research and therapy

Background Effective treatments for anorexia nervosa (AN) are available, yet many patients do not respond to treatment or experience relapse. Cognitive bias modification aims to ameliorate cognitive biases that are assumed to contribute to…

View details →DOI: 10.1016/j.brat.2025.104900
Negative / Null Result ReportMedicine

The telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): A randomized open-label phase 2 study.

Lorigan P, Medina TM, Nyakas M et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Purpose Immune checkpoint inhibitor (ICI) combinations have improved outcomes in patients with advanced melanoma; however, long term survival remains poor. The addition of therapeutic cancer vaccines to ICI combinations represents a…

View details →DOI: 10.1016/j.ejca.2025.116162
Negative / Null Result ReportOpen accessMedicine

Improving Diagnostic Quality of Anogenital Photodocumentation in Emergency Department Evaluations for Acute Child Sexual Assault.

Miller ZE, Digirolamo SJ, Molnar J et al. · 2026 · Pediatric quality & safety

Introduction Emergency department evaluations for acute child sexual assault include anogenital photodocumentation as a standard of care, which has implications for accurate clinical care and forensic significance. If photodocumentation…

View details →DOI: 10.1097/pq9.0000000000000876
Negative / Null Result ReportMedicine

Alignment and early clinical outcomes following total knee arthroplasty using a handheld navigation system compared to conventional instruments.

Nishida C, Shimoda B, Weldon RH et al. · 2025 · Archives of orthopaedic and trauma surgery

Introduction Proper lower extremity alignment is important for success and longevity of total knee arthroplasty (TKA). Conventional instrumentation has demonstrated higher rates of mechanical axis (MA) malalignment compared to robotic or…

View details →DOI: 10.1007/s00402-025-05998-3
Negative / Null Result ReportOpen accessMedicine

The murine Irs1 knockout model, generated by the spontaneous Irs1<sup>S57X</sup> mutation in homozygosity, exhibits high embryonic lethality, limiting studies of adult hematopoiesis.

Fenerich BA, Fernandes JC, Silva CLA et al. · 2026 · Hematology, transfusion and cell therapy

Introduction Insulin Receptor Substrate 1 (IRS1) is differentially expressed in hematological neoplasms suggesting a role in hematopoiesis and neoplastic transformation. Irs1 knockout mice represent a tool to investigate IRS1 function.…

View details →DOI: 10.1016/j.htct.2026.106465
Negative / Null Result ReportMedicine

Common Divalent Cations Elicit Sublethal Effects of Negatively Charged Nanoplastics on <i>Shewanella oneidensis</i> by Compromising Membrane Protein Functionality.

Zhang S, Jia B, Huang W et al. · 2025 · ACS nano

The toxicity of negatively charged nanoplastics (NNP) to bacteria is generally subtler than that of positively charged counterparts, owing to limited NNP-cell interaction. This study hypothesized that common environmental cations (Na + ,…

View details →DOI: 10.1021/acsnano.5c04610
Negative / Null Result ReportMedicine

Combination of Exercise and Group Occupational Therapy for Behavioural and Psychological Symptoms of Dementia: A Pilot Randomised Controlled Trial.

Yoshiura K, Murata M, Hamasuna M et al. · 2025 · Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

Background The behavioural and psychological symptoms of dementia (BPSD) increase the burden for the caregiver, often leading to difficulties in maintaining home care and triggering psychiatric hospitalisation. Effective management of BPSD…

View details →DOI: 10.1111/psyg.70085
Negative / Null Result ReportMedicine

Oxidation of Platina(II)corrole to Platina(IV)corrole.

Kato S, Miwa K, Takano H et al. · 2025 · Inorganic chemistry

Recently, the aromaticity and antiaromaticity of organometallacycles have received much attention to understand the cyclic electronic delocalization through d orbitals on the metal center. Here, we prepared a Pd(II) platina(II)corrole…

View details →DOI: 10.1021/acs.inorgchem.5c00942
Negative / Null Result ReportMedicine

Retrospective analysis of early functional and radiological outcomes between robotic, navigated and conventional total knee arthroplasty: A single Surgeon's series.

Leong JWK, Lee BH, Haniball J et al. · 2025 · Journal of clinical orthopaedics and trauma

Background Achieving a neutral mechanical axis alignment (MAA) in Total Knee Arthroplasty (TKA) is associated with increased implant longevity and patient satisfaction, and robot-assisted (robotic) TKA is touted to improve implant…

View details →DOI: 10.1016/j.jcot.2025.103145
Negative / Null Result Report

A Comprehensive Null Search for Prompt Radio Bursts Associated with 218 Gravitational Wave Events: The Strongest Constraints on Pre-Merger Fast Radio Burst Emission

Prajapati S · 2026 · Preprint

Abstract Binary neutron star mergers are known to produce gravitational waves and panchromatic electromagnetic afterglow emission hours to days after coalescence. However, a fundamental question remains unanswered: do these mergers…

View details →DOI: 10.21203/rs.3.rs-9595477/v1
Negative / Null Result ReportMedicine

Experimental and clinical evidence on radiofrequency electromagnetic field effects on the blood-brain barrier: a scoping review.

Simsek ET, Sumser K, Mansourinezhad P et al. · 2026 · Physics in medicine and biology

Objective. This scoping review evaluates evidence on whether radiofrequency electromagnetic field (RF-EMF) exposure influences blood-brain barrier (BBB) permeability. Given inconsistent findings across decades of research and expanding…

View details →DOI: 10.1088/1361-6560/ae6e17
Negative / Null Result ReportMedicine

Can ovarian cancer screening work? A secondary analysis of the UK collaborative trial of ovarian cancer screening.

Lange JM, Ahmad I, Dengos IJ et al. · 2026 · British journal of cancer

Background The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS; 2001-2020) showed no reduction in disease mortality in its primary intervention arm using multimodal screening (MMS) with longitudinal Cancer Antigen 125 (CA125)…

View details →DOI: 10.1038/s41416-026-03490-2
Negative / Null Result ReportMedicine

Spectroscopic analysis of the N<sub>2</sub> B<sup>3</sup>Π<sub>g</sub>-A<sup>3</sup>Σ+u in radiation-induced air ionization.

Murzyn CM, Jans ER, Marshall GJ · 2026 · Physical chemistry chemical physics : PCCP

This article presents experimental results from probing atmospheric air irradiated by a Polonium-210 alpha particle source using both optical emission spectroscopy and continuous wave cavity ring down absorption spectroscopy to study the…

View details →DOI: 10.1039/d5cp03971a
Negative / Null Result Report

Assessing Brain-Behaviour Coupling in Non-invasive Brain Stimulation Using Reliable Change Indices: Evidence from pre-Supplementary Motor Area – right Inferior Frontal Gyrus transcranial Alternating Current Stimulation

Fujiyama H, Wansbrough K, Lebihan B et al. · 2026 · Preprint

Non-invasive brain stimulation (NiBS) studies frequently report exploratory correlations between individual-level changes in neurophysiological and behavioural measures. However, these analyses are typically underpowered and rely on…

View details →DOI: 10.64898/2026.03.24.714072
Negative / Null Result ReportOpen accessMedicine

Does Provider Identity at Triage Improve Machine Learning Prediction of Hospital Admission? A Comparative Analysis of Ten Supervised Classifiers with SHAP Explainability.

Brown AE, Marostica CW, Martini WA · 2026 · Journal of personalized medicine

Background/Objectives: Machine learning (ML) models can predict hospital admission from emergency department (ED) triage data with areas under the receiver operating characteristic curve (AUC) exceeding 0.85. Whether incorporating the…

View details →DOI: 10.3390/jpm16040204
Negative / Null Result ReportOpen accessMedicine

The Question of Violent Video Games and Aggression: Testing Statistical and Methodological Issues of Null Effects Using Data From an Open-Access Case Study.

Miles-Novelo A, Anderson CA · 2025 · Aggressive behavior

While numerous meta-analyses, reviews, and task forces from various scientific bodies have linked violent media use to aggression, some studies report null effects and claim that such a relationship is non-existent. Several scholars have…

View details →DOI: 10.1002/ab.70042
Negative / Null Result ReportOpen accessMedicine

FreeSurfer-Based MRI Volumetry Reveals Thalamic and Hippocampal Atrophy as Significant Correlates of Disability in Multiple Sclerosis.

Juković M, Stošić S, Kostić D et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease that progressively leads to brain atrophy and the accumulation of disability over time. In this study, we used FreeSurfer to…

View details →DOI: 10.3390/medicina62050886
Negative / Null Result ReportOpen accessMedicine

Optimizing and Benchmarking Machine Learning and Traditional Synaptic Event Detection Pipelines in Neurophysiology Experiments.

Sevigny JP, Schrank S, Donka RM et al. · 2026 · eNeuro

Synaptic physiology experiments are fundamental to neuroscience research. Consequently, accurate detection of synaptic currents is crucial for conducting high-quality experiments. Traditionally, detecting inhibitory and excitatory…

View details →DOI: 10.1523/eneuro.0410-25.2026
Negative / Null Result ReportOpen accessMedicine

Economic incentives contribute little to reducing agricultural damage from invasive non-native species: evidence from raccoon management in Hokkaido, Japan.

Mameno K, Suzuki T, Yamaguchi S et al. · 2026 · Pest management science

Background An economic incentive scheme is utilized to enhance citizens' support for managing invasive non-native species. However, the effectiveness of the incentive scheme in the outcomes of the management remains unclear. This study…

View details →DOI: 10.1002/ps.70397
Negative / Null Result ReportOpen accessMedicine

The effect of performance-based financing interventions on health worker motivation and job satisfaction: experimental evidence from six national pilots.

Lamba S, Friedman J, Kandpal E · 2025 · Health policy and planning

A long-standing concern suggests that performance-based financing (PBF) may undermine the intrinsic motivation of health workers by heightening extrinsic motivation concerns via the novel introduction of financial incentives. However, the…

View details →DOI: 10.1093/heapol/czaf035