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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19830 results in Negative / Null Result Report · page 252 of 661

Negative / Null Result ReportMedicine

A study on the role of palliative care in the physical and psychological well-being of people with life-limiting illnesses in Kashmir, India.

Wani SQ, Matia M, Jayaprakasan AK et al. · 2026 · BMC palliative care

Background Living with life-limiting illnesses (LLIs) is psychologically distressing, even more so in areas with a complicated terrain and which are conflict-prone, where insecurity, displacement, and limited healthcare access adds to the…

View details →DOI: 10.1186/s12904-026-02142-9
Negative / Null Result ReportOpen accessMedicine

Mental health strain due to COVID-19: Psychological distress and somatic symptoms among health care workers and the general population in Kashmir, India.

Manzoor M, Banday MS, Para BA et al. · 2026 · Virus research

Background/objectives The COVID-19 pandemic precipitated a global rise in psychological morbidities, markedly increasing depression, anxiety, and stress. This study provides early region-specific evidence from Kashmir on the post-pandemic…

View details →DOI: 10.1016/j.virusres.2026.199753
Negative / Null Result ReportOpen accessMedicine

Ferroptosis inhibits biological behaviors of glioma cells by downregulating Galectin-9 transcriptional level via extracellular Acetyl-HMGB1.

Xu Y, Tan G, Zhu R · 2026 · Scientific reports

Ferroptosis, the most common programmed cell death process, and immune checkpoints play increasingly prominent roles in glioma. However, the effects of ferroptosis on immune checkpoints on glioma remain unclear. The intracellular ROS…

View details →DOI: 10.1038/s41598-026-45969-1
Negative / Null Result ReportOpen accessMedicine

Comparison of perioperative chemotherapy and neoadjuvant chemoradiotherapy (CRT) in locally advanced resectable distal esophageal/esophagogastric junction (EGJ) adenocarcinomas.

Şahin Çelik B, Ağdaş G, Genç V · 2026 · BMC cancer

Objective To compare the real-world outcomes of perioperative chemotherapy (ChT) and neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced resectable distal esophageal and esophagogastric junction (EGJ) adenocarcinomas,…

View details →DOI: 10.1186/s12885-026-16110-2
Negative / Null Result ReportOpen accessMedicine

Linguistic complexity of EFL writing with different levels of English proficiency: A stratified study of an application-oriented university.

Zhang J · 2026 · PloS one

English writing competence is a significant manifestation of students' second language proficiency. However, comprehensive synchronic empirical research remains scarce regarding how students at application-oriented universities perform in…

View details →DOI: 10.1371/journal.pone.0349399
Negative / Null Result ReportOpen accessMedicine

Anti-inflammatory and antioxidative stress effects of <i>Sclerocarya birrea</i> (Anacardiaceae) trunk bark aqueous extract on acetic acid-induced ulcerative colitis in rats.

Dongmo F, Kom B, Akiki À Tsang G et al. · 2026 · Annals of medicine and surgery (2012)

Background Sclerocarya birrea is used in traditional medicine for the treatment of many diseases, including gastritis, diarrhea, dysentery, and hemorrhoids. The objective of this study was to evaluate the efficacy of Sclerocarya birrea…

View details →DOI: 10.1097/ms9.0000000000005042
Negative / Null Result ReportMedicine

The effect of podcasts delivered to female university students on HPV knowledge, awareness, and anxiety levels: A randomized controlled trial.

Çi̇men HN, Uğur S, Çıralı A et al. · 2026 · Nurse education in practice

Aim The aim of this study was to evaluate the effect of podcast-based educational content delivered to students on their knowledge, awareness and anxiety levels regarding Human Papillomavirus (HPV). Method This randomized controlled…

View details →DOI: 10.1016/j.nepr.2026.104902
Negative / Null Result ReportMedicine

[Study on stability of elastic fixation with TightRope button-loop titanium plate in the reconstruction of the lower tibiofibular joint].

Wang S, Ma J, Ma S et al. · 2026 · Zhongguo gu shang = China journal of orthopaedics and traumatology

Objective To compare clinical efficacy of TightRope button-loop titanium plate elastic fixation and hollow tension screw fixation in treating ankle fractures with accompanying tibiofibular syndesmosis injury. Methods A retrospective…

View details →DOI: 10.12200/j.issn.1003-0034.20250097
Negative / Null Result ReportOpen accessMedicine

The effect of mindfulness-based intervention on mother's body image and maternal fetal attachment.

Rezaiyan A, Sohrabi Z, Ramezani N et al. · 2026 · Journal of education and health promotion

Background Pregnancy is associated with a wide range of physiologic and psychologic changes that could affect a mother's body image and maternal-fetal attachment. One of the presented interventions regarding body image and maternal fetal…

View details →DOI: 10.4103/jehp.jehp_2111_24
Negative / Null Result ReportOpen accessMedicine

A Botanical Mixture of Boswellia serrata, Commiphora myrrha, Propolis and Scutellaria baicalensis Reduces Expression of Inflammatory Chemokines in Canine Keratinocytes In Vitro.

Ha D, Jung K, Choi H et al. · 2026 · Veterinary medicine and science

Background Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases. Objectives This study aimed to investigate the anti-inflammatory effects of a mixture of Boswellia serrata, Commiphora myrrha,…

View details →DOI: 10.1002/vms3.70963
Negative / Null Result ReportOpen accessMedicine

'To improve is to change'-but is it safe? A single surgeon's transition from lateral to vertical hemispherotomy.

Salim O, Chari A, Tahir MZ · 2026 · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Purpose Hemispherotomy is an established treatment for children with drug-resistant epilepsy. Recent reports have suggested a superiority of outcomes with the vertical approach compared to the traditional lateral approach. This study…

View details →DOI: 10.1007/s00381-026-07353-2
Negative / Null Result ReportOpen accessMedicine

Assessment and Correlation of the Vitamin D Level With Growth Status as Measured by the Cervical Vertebral Maturation Index and Insulin-Like Growth Factor 1 Level in 10-14-Year-Old Patients.

Jaiswal M, Hazare A, Karia H et al. · 2026 · Cureus

Introduction Growth assessment is a fundamental process in orthodontics as accurate determination of skeletal maturity guides the timing of treatment intervention. Biochemical and radiographic indicators can be used to evaluate growth…

View details →DOI: 10.7759/cureus.109014
Negative / Null Result ReportMedicine

Sirolimus-based treatment regimens for antinuclear antibody (ANA)-positive immune thrombocytopenia: a retrospective single-center cohort study.

Tan A, Liu J, Chen X et al. · 2026 · Hematology (Amsterdam, Netherlands)

Objectives To evaluate the efficacy and safety of sirolimus-based treatment regimens in patients with antinuclear antibody (ANA)-positive immune thrombocytopenia (ITP). Methods This retrospective single-center study enrolled patients with…

View details →DOI: 10.1080/16078454.2026.2678626
Negative / Null Result ReportOpen accessMedicine

The Effects of Heated Tobacco Products on Oral Health and Quality of Life: An Observational Cross-Sectional Study.

Glavina A, Gravić A, Demo J et al. · 2026 · Healthcare (Basel, Switzerland)

Background/objectives Over the past decade, the popularity of smokeless tobacco products, particularly heated tobacco products (HTPs), has increased among adolescents and young adults. This study aimed to determine the effects of HTPs and…

View details →DOI: 10.3390/healthcare14101297
Negative / Null Result ReportMedicine

A new clinical examination finding in obstructive sleep apnea; diagonal auricular fold (Frank sign).

Dogan R, Kulaksiz Y, Yeni̇gun A et al. · 2026 · Sleep & breathing = Schlaf & Atmung

Objective Diagonal ear lobule fold (DELF)(Frank sign); It is a diagonal fold in the earlobe at an angle of about 45°, running diagonally from the tragus to the edge of the auricle at varying depths. In our study, the relationship between…

View details →DOI: 10.1007/s11325-026-03700-4
Negative / Null Result ReportOpen accessMedicine

Melody vs. message: Effects of traditional song and concise social media communications on iodine knowledge, attitudes, behaviors, and biomarkers in pregnant women-A randomized controlled trial.

Ruengsiriphakakul S, Bumrerraj S, Thaenkham T · 2026 · Journal of education and health promotion

Background Iodine deficiency remains a global public health problem. Urinary iodine concentration (UIC) in pregnant women is a key indicator of iodine status in the population. Knowledge (K), attitude (A), and practice (P) levels of…

View details →DOI: 10.4103/jehp.jehp_815_25
Negative / Null Result ReportOpen accessMedicine

Novel Taiwan-I-type infectious bronchitis virus: First evidence of testicular atrophy and efficacious protection with strain-matched oil-emulsified inactivated vaccine.

Zhang T, Xie Y, Yang C et al. · 2026 · Virulence

The Taiwan-I-type infectious bronchitis virus (IBV) has become one of the most dominant and threatening genotypes circulating in China poultry farms. In this study, we characterized the Taiwan-I-type IBV strain GX-NN200723 and evaluated…

View details →DOI: 10.1080/21505594.2026.2664950
Negative / Null Result ReportOpen accessMedicine

A comparative evaluation of apical sealing ability of NeoPutty, Biodentine, and Bio-c repair using a radioactive isotope method - An <i>in vitro</i> study.

Rathore S, Bhushan J, Uppal AS et al. · 2026 · Journal of conservative dentistry and endodontics

Background Treatment of teeth with immature apices is difficult to manage by conventional endodontics. Apical barrier formation using bioceramic materials offers a biologically favorable solution, providing a hermetic seal that supports…

View details →DOI: 10.4103/jcde.jcde_97_26
Negative / Null Result ReportMedicine

Comparison of Dexamethasone versus Ondansetron for Postoperative Nausea and Vomiting in Laparoscopic Cholecystectomy.

Loomba P, Nayak M, Podder S et al. · 2026 · Annals of African medicine

Background Postoperative nausea and vomiting (PONV) are a prevalent complication after laparoscopic surgeries, with an incidence reaching up to 63% without antiemetic prophylaxis. Objectives To evaluate the efficacy of dexamethasone and…

View details →DOI: 10.4103/aam.aam_60_26
Negative / Null Result ReportMedicine

The Effect of Virtual Simulation of Parenteral Medication Administration on Nursing Students' Knowledge and Skills: A Randomized Controlled Experimental Study.

Biyik Bayram S, Gülnar E, Çalişkan N et al. · 2026 · Computers, informatics, nursing : CIN

This study investigated the effect of virtual simulation of parenteral medication administrations on nursing students' knowledge and skills. This randomized controlled experimental study adopted a pretest-posttest research design. The…

View details →DOI: 10.1097/cin.0000000000001581
Negative / Null Result ReportOpen accessMedicine

Evaluation of Time-Dependent Chemical Alterations in Sodium Hypochlorite Solution Kept on the Unit Tray During an Average Root Canal Treatment Period.

Bastug Guven E, Genc Sen O · 2026 · Medical science monitor : international medical journal of experimental and clinical research

BACKGROUND Sodium hypochlorite (NaOCl) is the most commonly used irrigant in root canal treatment because of its antimicrobial activity and tissue-dissolving capacity. Since these properties are related to its physicochemical…

View details →DOI: 10.12659/msm.952416
Negative / Null Result ReportOpen accessMedicine

Safety and Efficacy of Stereotactic Body Radiation Therapy in Very Elderly Patients (≥80 Years) with Solitary Hepatocellular Carcinoma.

Tamura Y, Tojima H, Takizawa D et al. · 2026 · Cancers

Background The number of elderly patients with hepatocellular carcinoma (HCC) has been increasing worldwide. This study aimed to evaluate the clinical outcomes of stereotactic body radiation therapy (SBRT) for patients aged ≥80 years with…

View details →DOI: 10.3390/cancers18111809
Negative / Null Result ReportOpen accessMedicine

Impact of hyperbaric oxygen as initial treatment on idiopathic sudden sensorineural hearing loss prognosis: a propensity scores matching analysis.

Xie S, Hong W, Huang L et al. · 2026 · Brazilian journal of otorhinolaryngology

Objective This study aimed to evaluate the effect of Hyperbaric Oxygen Therapy (HBOT) combined with steroids as initial treatment on the prognosis of patients with Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL) by using propensity…

View details →DOI: 10.1016/j.bjorl.2026.101775
Negative / Null Result ReportOpen accessMedicine

Research on the intervention of Mandala drawing therapy for social interaction disorders in children with autism.

Zhang L, Luo L, Xia Q et al. · 2026 · Frontiers in psychiatry

Social communication disorder is a core impairment in children with Autism Spectrum Disorder (ASD) and is essential for establishing connections with the external world. This study aimed to explore the effects of Mandala drawing therapy on…

View details →DOI: 10.3389/fpsyt.2026.1757575
Negative / Null Result ReportOpen accessMedicine

Effects of Norbixin on Growth Performance, Immunomodulation, Antioxidant Systems, and Metabolic Alterations in the Oriental River Prawn (Macrobrachium nipponense): An Integrative Analysis.

Ettefaghdoost M, Haghighi H, Haghdoost A · 2026 · Veterinary medicine and science

Background Natural carotenoids have gained considerable attention in aquaculture due to their potential to enhance growth performance, physiological status, and product quality in crustaceans. However, limited information is available…

View details →DOI: 10.1002/vms3.71014
Negative / Null Result ReportMedicine

The Effect of Education Through Interactive Videos on Noninvasive Blood Pressure Measurement Knowledge and Skill Level of Nursing Students.

Can Ş, Eren H · 2026 · Computers, informatics, nursing : CIN

Measuring noninvasive blood pressure (NIBP) is a fundamental skill that nursing students are trained to master, and they are expected to possess comprehensive knowledge and proficiency in this procedure to ensure accurate measurements. The…

View details →DOI: 10.1097/cin.0000000000001582
Negative / Null Result ReportOpen accessMedicine

Identical versus compatible blood typing: investigating best practices in lung transplantation.

Bugacov H, Cusmai C, Li K et al. · 2026 · Transplant international : official journal of the European Society for Organ Transplantation

This study investigated acute rejection in ABO-compatible versus ABO-identical lung transplants from 2005-2023, with a secondary objective of comparing 5-year survival. Lung transplantation improves quality of life and survival; however,…

View details →DOI: 10.3389/ti.2026.15722
Negative / Null Result ReportMedicine

The effect of midwife-led education based on Pender's health promotion model (MidLed-PHPM) on the perinatal mental health of immigrant women.

Cevik A, Alan S · 2026 · Women and birth : journal of the Australian College of Midwives

Background Perinatal mental health issues are a global problem that constitutes a significant part of the burden on maternal and infant health. This situation could pose a risk, especially for immigrant women, who are a vulnerable group.…

View details →DOI: 10.1016/j.wombi.2026.102213