A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19830 results in Negative / Null Result Report · page 251 of 661
Weldon K, O'Meara C, Lonergan P et al. · 2026 · Animal reproduction science
Extremolytes are compatible solutes that protect macromolecules and cell structures under extreme stress. The objectives of this study were to assess the biocompatibility of the extremolyte ectoine with bull sperm during cryopreservation,…
Ruiz R, Ramirez J, Velay-Lizancos M · 2026 · Preprint
Abstract Corrosion of steel reinforcement in concrete is one of the main issues plaguing aging infrastructure worldwide. While concrete’s carbonation is usually associated with an increased risk of corrosion, this study proposes a…
Dialoke NG, Murata K, Zhang Y et al. · 2026 · The journal of poultry science
From an animal welfare perspective, thirst avoidance is an important criterion for the poultry industry. Neuropeptide Y (NPY) and α-melanocyte-stimulating hormone (α-MSH) play critical roles in regulating food intake, which is closely…
Cruz Flores M, Fort J, Barbraud C et al. · 2026 · Preprint
Environmental modifications due to climate change impact the phenology, distribution and demography of marine organisms. Such effects are striking in the Arctic, which is warming up to four times faster than other regions of the planet.…
Li F, Du C, Yu Q et al. · 2026 · Diabetes, obesity & metabolism
Aim Evaluate ecnoglutide (XW003) effects on rosuvastatin and digoxin pharmacokinetics (PKs) in healthy adults. Methods This was an open-label, single-sequence crossover Phase 1 study. Eligible participants received rosuvastatin (10 mg,…
Matsuda S, Nakano K · 2026 · The Journal of eukaryotic microbiology
In Tetrahymena, autophagy appears to be involved in the integrity of the mitochondria which supply energy for active ciliary movement on the cell surface, the maintenance of various structures such as cilia, and cell shape changes…
Fan Y, Gao G, Jiang X et al. · 2026 · Preprint
The objective of this study was to evaluate the effects of partially replacing wheat bran with poplar wood composite fiber (PWCF) on growth performance, immune status, apparent total tract digestibility (ATTD), and gut microbial…
Lin M, Tapuc A, Matyjek M et al. · 2026 · Comprehensive psychiatry
Autistic traits are associated with atypical social behaviors, particularly in approach-avoidance tendencies. However, the differential impact of these traits on responses to social versus non-social stimuli, and the variation of these…
Geng F, Guo R, Shao Y · 2026 · Journal of psychiatric research
Background The jumping-to-conclusions (JTC) bias, which involves making hasty decisions based on limited evidence, has been extensively studied in schizophrenia spectrum disorders but remains under-explored in affective disorders,…
Yang Y, Fu H, Chang M et al. · 2026 · Preprint
Abstract Background Up to now, few drugs are available for treatment of feline infectious peritonitis (FIP) which causes death of young cats less than 2 years old, and is a fatal infectious disease caused by feline infectious peritonitis…
Khan H, Ghafoor T, Khattak TA et al. · 2026 · Transplantation and cellular therapy
Infantile Osteopetrosis is a rare inherited bone disorder characterized by a reduced or complete lack of osteoclast function, leading to defective bone resorption and increased bone density. The defective osteoclast differentiation or…
Incerti Parenti S, Evangelisti E, Maglioni A et al. · 2026 · Cranio : the journal of craniomandibular practice
Objective To investigate whether fixed orthodontic treatment affects sleep and awake bruxism activities, temporomandibular disorder (TMD) prevalence, and pressure pain thresholds (PPTs) of masticatory muscles in healthy adults. Methods In…
Jacob G, Lourenço PR, Diniz FMM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective This study evaluated the effect of calcium hydroxide-based intracanal medication protocols on the sealer-dentin interface, considering bond strength, adhesive interface adaptation, failure pattern, and dentin gelatinolytic…
Jian PT, Lin YW · 2026 · Contact dermatitis
Background Hairdressers often reuse disposable gloves, yet the effect of repeated washing on protection against oxidative hair-dye sensitizers is unclear. Objectives To determine how reuse and wash type influence the permeation of…
Soares EADS, Crisp AH, Fernandes PT et al. · 2026 · Scandinavian journal of psychology
Premenstrual syndrome (PMS) is a set of symptoms related to hormonal changes occurring during the premenstrual period. Effective coping strategies for managing PMS have not been clearly established, and it remains unclear whether these…
Mies F, Olchowik-Grabarek E, Crutzen R et al. · 2026 · Biochemical and biophysical research communications
In this report we demonstrate that iodogallic acid (IGA) and iodoferulic acid (IFA) do not acutely affect transepithelial cation transport, however, prolonged basolateral application of IFA induced a delayed decrease in open-circuit…
Bodilsen TS, Andreasen TH, Olsen MH et al. · 2026 · Acta neurochirurgica
Background Invasive multimodal neuromonitoring (MMNM) is standard of care in many neuro-intensive care units for patients with severe acute brain injury. MMNM is used for monitoring of early signs of secondary brain injury. Still, the…
Lindhard K, Hansen HP, Gliese K et al. · 2026 · Clinical journal of the American Society of Nephrology : CJASN
Introduction In patients on hemodialysis, the risk of arteriovenous fistula (AVF) failure is unacceptably high. Up to 67% of AVFs need an intervention within one year after placement. There are no effective treatments to prolong AVF…
Goto K, Ishizuka S, Nakamura-Takahashi A et al. · 2026 · Journal of oral biosciences
Objectives Hypophosphatasia (HPP) is a congenital disease caused by mutations in the tissue non-specific alkaline phosphatase gene. HPP is characterized by impaired hard tissue mineralization and premature tooth loss. Mild-type HPP…
Van Daele A, Labarque V, Dereymaeker A et al. · 2026 · Neuropediatrics
Background Neonatal stroke is a rare but potentially severe condition that may lead to long-term neurological impairment. Several factors may influence both its occurrence and outcomes. Methods In this retrospective, single-center cohort…
Zeni NG, Perricone V, Tognoli C et al. · 2026 · Poultry science
The poultry sector faces increasing sustainability challenges related to feed-food competition, volatility in the cereal markets and the environmental impact of poultry production. In this context, the use of products from the bakery and…
Flämig L, Felix Zhu W, Hoffmann K et al. · 2026 · Organic & biomolecular chemistry
Agonists of the κ-opioid receptor are useful drugs for the treatment of severe pain, itching skin diseases and inflammatory and immunological diseases. Herein, novel κ agonists with the κ-pharmacophoric ethylenediamine system embedded in a…
Chiang YW, Chang JY, Yeh KL et al. · 2026 · Investigative ophthalmology & visual science
Purpose To investigate whether exposure to artificial lighting with different correlated color temperatures (CCTs) affects ocular structure and myopia-related molecular signaling pathways before axial elongation in a murine model. Methods…
Yamakawa R, Sakaue Y, Okada S et al. · 2026 · Gait & posture
Background Hip osteoarthritis (HOA) often leads to compensatory movements such as trunk lateral bending during gait due to pain and restricted range of motion. Because multiple joints coordinate to control the center of mass (CoM) during…
van der Velde M, de Boer J, Arslan B et al. · 2026 · Preprint
Background. Multiplication is a key skill in primary education, but traditional teaching methods vary in effectiveness and may not suit individual needs. Adaptive learning systems personalise practice and promote the use of effective study…
Swainson A, Cerminara NL, Apps R et al. · 2026 · Psychology and aging
Studies over the past 3 decades have shown decreased motor adaptation with age. The most widely supported theory for this change proposes that older adults fail to successfully implement cognitive strategies to facilitate performance.…
Yu H, Wang T, Chen X et al. · 2026 · Preprint
Abstract Motherwort (MW) is known for its renoprotective effects, but it has also been reported to potentially cause kidney damage. This study aimed to explore the distinct mechanisms underlying the protective and detrimental effects of MW…
Ma Y, Lai A, Deng X et al. · 2026 · Food chemistry
β-glucan could regulate starch retrogradation and digestion; however, its combined role with starch fine molecular structures remains unknown. Therefore, nine starches were selected, and their retrogradation and digestion properties were…
Sharma P, Sivaramakrishnan P, Dahal S et al. · 2026 · Respiratory medicine
In malignant pleural effusion (MPE), malignant cells may settle in a gravity-dependent gradient due to the weight of cells. We aimed to compare diagnostic yield of cytology between aspirates from lower, upper and 5th intercostal spaces in…
Nijssen KMR, Adam TC, Mensink RP et al. · 2026 · Metabolism: clinical and experimental
Introduction Nutritional ketosis may prevent age-related cognitive decline, but underlying mechanisms remain unclear. This study investigated acute ketone monoester (KME) supplementation on brain insulin responsiveness and cognitive…