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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20227 results in Negative / Null Result Report · page 249 of 675

Negative / Null Result ReportMedicine

Exploring factors influencing the ecological host range of Trissolcus japonicus: foraging strategy and nontarget host use.

Paul RL, Porter DC, Mutschler-Aldine S et al. · 2026 · Environmental entomology

Evaluation of potential classical biological control agents typically begins with laboratory testing for their fundamental host range. These experiments are intended to evaluate the propensity for nontarget attack but often do so in highly…

View details →DOI: 10.1093/ee/nvaf125
Negative / Null Result ReportMedicine

DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue.

Häring M, Zhang Y, Zhang N et al. · 2026 · Biophysical journal

Cell junction remodeling is central to epithelial morphogenesis and tissue rheology and depends on the interplay between adhesion molecules and the actomyosin cortex. E-cadherin constitutes the molecular basis for epithelial cell adhesion,…

View details →DOI: 10.1016/j.bpj.2026.01.026
Negative / Null Result ReportMedicine

The 3,4-methylenedioxymethamphetamine (MDMA) reduces prosocial behavior in the social preference test in male and female rats.

Palacios-Lagunas DA, Hernández-Mondragón JC, Fuxe K et al. · 2026 · Pharmacology, biochemistry, and behavior

The promotion of prosocial behavior is a remarkable MDMA property. Such an effect is rather uncommon among other psychoactive substances and has been proposed to be of relevance for the potential therapeutic utility of MDMA. We aim to…

View details →DOI: 10.1016/j.pbb.2025.174135
Negative / Null Result ReportMedicine

Cognitive and subjective effects of psilocybin microdosing: Results from two double-blind placebo-controlled longitudinal trials.

Prochazkova L, Marschall J, Lippelt DP et al. · 2026 · Neuropharmacology

Objective Microdosing psychedelics has been widely reported to enhance focus and problem-solving, sparking interest in its potential to treat attentional disorders such as ADHD. However, existing studies largely rely on anecdotal evidence…

View details →DOI: 10.1016/j.neuropharm.2025.110722
Negative / Null Result ReportMedicine

Why the present is not the key to past or future: moving beyond restricted relict habitat conditions to improve outcomes in mountain woodland restoration

Watts SH, Barsoum N, Park KJ et al. · 2025 · Restoration Ecology

INTRODUCTION: Mountain woodland restoration can enhance upland biodiversity and contribute to nature‐based solutions mitigating climate change impacts. However, high‐altitude planting of trees and shrubs requires considerable commitment of…

Negative / Null Result ReportMedicine

γM23K mutation enhances ADP inhibition of mitochondrial F-ATPase yet has a minor effect on yeast growth rate.

Zubareva VM, Galkina KV, Lapashina AS et al. · 2026 · Archives of biochemistry and biophysics

ADP inhibition of ATP hydrolysis is a conserved regulatory mechanism found in virtually all F-type ATP synthases. It occurs when ADP binds tightly to a catalytic site in the absence of phosphate, locking the enzyme in an inactive…

View details →DOI: 10.1016/j.abb.2025.110674
Negative / Null Result ReportMedicine

Limited microbial community responses of marine macroalgae to artificial light at night and moderate warming conditions.

Caley A, Marzinelli EM, Mayer-Pinto M · 2025 · Marine environmental research

Multiple stressors such as Artificial Light at Night (ALAN) and warming are increasingly common in marine systems and can interact in complex ways. Microbial communities play critical roles in the functioning of coastal habitat-forming…

View details →DOI: 10.1016/j.marenvres.2025.107536
Negative / Null Result ReportMedicine

Exploring the influence of job characteristics on the adoption of driver advisory systems for energy-efficient driving: Insights from a longitudinal field study in rail operations.

Schnücker GN, Salge J, Onnasch L · 2025 · Applied ergonomics

This study investigates the impact of Driver Advisory Systems (DAS) for eco-efficient driving on train drivers' job characteristics and job satisfaction, and their effects on acceptance and compliance with the system. Driving and…

View details →DOI: 10.1016/j.apergo.2025.104597
Negative / Null Result ReportMedicine

Response Inhibition in Autistic Children Predicts Positive Psychotic Symptoms in Young Adulthood-Results from an 8-Year Follow-up Study.

Ziermans T, Kok B, van Rijn S · 2025 · Journal of autism and developmental disorders

Purpose Attenuated positive symptoms constitute the most validated vulnerability marker for psychosis in non-autistic young adults. Early deviations in executive functioning and social cognition are believed to contribute to the onset of…

View details →DOI: 10.1007/s10803-025-07015-3
Negative / Null Result ReportMedicine

The Role of Supportive Adults: Are These Relationships Able to Mitigate the Effects of Adverse Childhood Experiences on Adolescent Adjustment?

Wilde ZC, Smith SD, Murphy MB et al. · 2026 · Journal of child & adolescent trauma

Adverse childhood experiences (ACEs) place adolescents at higher risk of developing physical and mental health problems later in life. Further, vulnerable adolescents-those from resource-limited households, communities, or schools; exposed…

View details →DOI: 10.1007/s40653-025-00770-6
Negative / Null Result ReportOpen accessMedicine

Drug-Induced Anaphylaxis in Children: A Comparative Analysis of Inpatient versus Outpatient Settings.

Koken G, Ertoy Karagol HI, Terece SP et al. · 2026 · International archives of allergy and immunology

Introduction Studies specifically focusing on drug-induced anaphylaxis (DIA) in children are few. There is no study comparing inpatient (IP) and outpatient (OP) settings in DIA, either in children or in adults. We aimed to compare the…

View details →DOI: 10.1159/000550779
Negative / Null Result ReportMedicine

The influence of algae habitat refuge complexity on juvenile fish growth, condition, and survival under the presence or absence of predators.

Hinz H, Del Mar Gil M, Anglada P et al. · 2026 · Marine environmental research

Macrophyte habitats are key for juvenile fish survival in coastal littoral zones, yet they are increasingly degraded by human activities. While macrophytes offer both shelter and food, their protective function may be context-dependent,…

View details →DOI: 10.1016/j.marenvres.2026.107844