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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19830 results in Negative / Null Result Report · page 248 of 661

Negative / Null Result ReportOpen accessPhysics

$α^4$ Ry corrections to singlet states of helium

Krzysztof Pachucki · 2006 · arXiv

Corrections of order $α^4$Ry are calculated for the singlet states $1^1S_0$ and $2^1S_0$ of the helium atom. The result for $1^1S_0$ state is in slight disagreement with that of Korobov and Yelkhovsky in [Phys. Rev. Lett. {\bf 87}, 193003 (2001)]. The results obtained lead to a significant improvement of transition frequencies between low lying levels of the helium atom. In particular theoretical predictions for the $2^1S_0 - 1^1S_0$ transition are found to be in disagreement with experimental values.

Negative / Null Result ReportOpen accessMathematics

Phase limitations of multipliers at harmonics

William Paul Heath, Joaquin Carrasco, Jingfan Zhang · 2021 · arXiv

We present a phase condition under which there is no suitable multiplier for a given continuous-time plant. The condition can be derived from either the duality approach or from the frequency interval approach. The condition has a simple graphical interpretation, can be tested in a numerically efficient manner and may be applied systematically. Numerical examples show significant improvement over existing results in the literature. The condition is used to demonstrate a third order system with delay that is a counterexample to the Kalman Conjecture.

Negative / Null Result ReportOpen accessComputer Science

Positive pion absorption on 3He using modern trinucleon wave functions

S. Schneider, J. Haidenbauer, C. Hanhart et al. · 2002 · arXiv

We study pion absorption on 3He employing trinucleon wave functions calculated from modern realistic NN interactions (Paris, CD Bonn). Even though the use of the new wave functions leads to a significant improvement over older calculations with regard to both cross section and polarization data, there are hints that polarization data with quasifree kinematics cannot be described by just two-nucleon absorption mechanisms.

Negative / Null Result ReportOpen accessPhysics

Admire vs. Safire: Objective comparison of CT reconstruction algorithms and their noise properties

Ingvild Dalehaug, Kirsten Nygaard Bolstad, Daniel Aadnevik et al. · 2017 · arXiv

Purpose: Siemens has developed several iterative reconstruction (IR) algorithms on their CT scanners. SAFIRE is available on most of their CT scanners. The latest algorithm, ADMIRE, is available on their newest high-end CT scanners. The aim of our study was to compare the noise reduction properties of the two IR algorithms using objective methods. Methods and Materials: The homogeneous module of the Catphan phantom was scanned on a Siemens AS+ and a Siemens Flash CT scanner using an axial abdomen protocol with fixed tube current at two dose levels. The images were reconstructed with an abdomen

Negative / Null Result ReportOpen accessMathematics

Opening the Black Box: Towards inherently interpretable energy data imputation models using building physics insight

Antonio Liguori, Matias Quintana, Chun Fu et al. · 2023 · arXiv

Missing data are frequently observed by practitioners and researchers in the building energy modeling community. In this regard, advanced data-driven solutions, such as Deep Learning methods, are typically required to reflect the non-linear behavior of these anomalies. As an ongoing research question related to Deep Learning, a model's applicability to limited data settings can be explored by introducing prior knowledge in the network. This same strategy can also lead to more interpretable predictions, hence facilitating the field application of the approach. For that purpose, the aim of this

Negative / Null Result ReportMedicine

Impact of blinatumomab and inotuzumab exposure on apheresis composition for CAR T in patients with B-cell acute lymphoblastic leukemia.

Cantilena A, Han KL, Cai Y et al. · 2026 · Cytotherapy

Children with B-cell acute lymphoblastic leukemia (B-ALL) are increasingly treated with immunotherapeutic agents such as blinatumomab and inotuzumab. Thus, those who present in relapse for chimeric antigen receptor (CAR) T-cell therapy are…

View details →DOI: 10.1016/j.jcyt.2026.102788
Negative / Null Result ReportOpen accessComputer Science

Hydrodynamic behaviour of Lattice Boltzmann and Lattice BGK models

O. Behrend, R. Harris, P. Warren · 1993 · arXiv

We present a numerical analysis of the validity of classical and generalized hydrodynamics for Lattice Boltzmann Equation (LBE) and Lattice BGK methods in two and three dimensions, as a function of the collision parameters of these models. Our analysis is based on the wave-number dependence of the evolution operator. Good ranges of validity are found for BGK models as long as the relaxation time is chosen smaller than or equal to unity. The additional freedom in the choice of collision parameters for LBE models does not seem to give significant improvement.

Negative / Null Result Report

Can Machine Learning Predict Vessels Encapsulating Tumor Clusters Patterns and Histological Differentiation in Solitary Small (<5 cm) Hepatocellular Carcinoma?

Toshida K, Sugitani Y, Itoh S et al. · 2025 · Preprint

Abstract Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. While systemic therapies have improved outcomes, predicting tumor histopathology remains difficult. Machine learning (ML) offers a…

View details →DOI: 10.21203/rs.3.rs-7704748/v1
Negative / Null Result Report

Evaluation of the effect of photodynamic therapy using Rose Bengal Pigment in the Presence of Sodium Nitrite and carbon quantum dots Synthesized from Acyclovir Precursor on Growth inactivating of Herpes Simplex Virus

Farmany A, Razavi P, Parsania M et al. · 2025 · Preprint

Abstract Purpose To evaluate whether Rose Bengal (RB) with sodium nitrite (NaNO₂) and acyclovir derived carbon quantum dots (CQDs) can photodynamically inactivate herpes simplex virus type 1 (HSV 1) in vitro. Methods Acyclovir-derived CQDs…

View details →DOI: 10.21203/rs.3.rs-7694736/v1
Negative / Null Result ReportMedicine

Standard- versus high-dose tigecycline in pneumonia due to carbapenem-resistant Acinetobacter baumannii: A propensity score-matched retrospective study.

Özgen-Top Ö, Aysert-Yildiz P, Tekin-Taş Z et al. · 2026 · Infectious diseases now

Objectives This study aimed to compare the effectiveness and safety of standard-dose and high-dose tigecycline in pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB). Methods This retrospective, propensity score-matched…

View details →DOI: 10.1016/j.idnow.2025.105242
Negative / Null Result ReportMedicine

Whole-lesion histogram analysis of multi-model diffusion-weighted imaging for characterization and molecular classification of breast lesions.

Yuan Y, Huang M, Peng J et al. · 2026 · La Radiologia medica

Purpose To evaluate the value of whole-lesion histogram analysis derived from mono-exponential, bi-exponential, and stretched-exponential DWI models in differentiating benign from malignant breast lesions and exploring molecular subtypes.…

View details →DOI: 10.1007/s11547-025-02156-y
Negative / Null Result ReportMedicine

Neuroinflammation does not exacerbate post-traumatic stress-disorder (PTSD)-like brain measures or behaviour after a traumatic event in male rats.

Xavier S, Al-Saabary H, Foran D et al. · 2026 · Neuroscience

Post-traumatic stress disorder (PTSD) is strongly linked to neuroinflammation, with immune activation in brain regions such as the amygdala and hippocampus potentially contributing to its long-term persistence. Yet, whether…

View details →DOI: 10.1016/j.neuroscience.2025.12.014
Negative / Null Result Report

Agreements between 24-2 and 24-2C Test Grids for Chloroquine/Hydroxychloroquine Retinopathy Patients and High-Risk Patients

Ratanawongphaibul K, Wongwachira C, Suwajanakorn D et al. · 2025 · Preprint

Abstract Purpose To compare the SITA Standard 24-2 and SITA Faster 24-2C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk. Methods A prospective, cross-sectional study of 75 participants who…

View details →DOI: 10.21203/rs.3.rs-6769459/v1
Negative / Null Result ReportMedicine

Evaluation of pharmacy unit inspection utilizing a mobile application with smart glasses.

Abdel-Kerem A, Wei W, Calzado A et al. · 2025 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose This study aimed to evaluate the impact of integrating smart glasses with a pharmacy compliance mobile application on the efficiency of completing medication unit inspections. The goal was to compare traditional inspection methods…

View details →DOI: 10.1093/ajhp/zxaf083
Negative / Null Result ReportMedicine

Provisional Treatment of Volumetric Muscle Loss With Insulin-like Growth Factor 1 Releasing Muscle Void Fillers.

Clark AR, Adams AT, McKinley TO et al. · 2026 · The Journal of surgical research

Introduction Volumetric muscle loss (VML) resulting from severe extremity injuries in combat remains a significant clinical challenge, particularly in austere environments. Current research emphasizes the development and evaluation of…

View details →DOI: 10.1016/j.jss.2025.11.043
Negative / Null Result ReportMedicine

Antigenic Imprinting and Immune Response Dynamics: Neutralization Against Emerging SARS-CoV-2 Omicron Variants Following Breakthrough Infections.

Li J, Wang X, Li J et al. · 2025 · Journal of medical virology

The recently mutated Omicron variant of SARS-CoV-2 exhibits extremely high infectivity and strong evolution and immune escape capabilities. Given the unique epidemic prevention policies of China, we collected 16 sets of sera from…

View details →DOI: 10.1002/jmv.70681
Negative / Null Result ReportMedicine

Assessing the Impact of Visualizations of Quantitative and Qualitative Risk Information on the Comprehension of Hypothetical Risk-Based Breast Cancer Screening Results.

van Strien-Knippenberg IS, Timmermans DRM, Weber M et al. · 2025 · Health communication

This study aimed to assess whether, in the context of communicating risk-based breast cancer screening results, visualizations of risk information consisting of an icon array depicting quantified breast cancer risk and simplified drawings…

View details →DOI: 10.1080/10410236.2025.2582779
Negative / Null Result Report

Vibratory stimulation and not action observation or mirror therapy reduces paralyzed hand spasticity in chronic stroke survivors

Nakano H, Nakagawa K, Ikuno T et al. · 2024 · Preprint

Objective Post-stroke spasticity prevalence increases with time from stroke onset, and negatively impacts the patient’s quality of life. Vibratory stimulation (VS) to the spastic muscles can reduce spasticity, whereas action observation…

View details →DOI: 10.1101/2024.12.03.24318436
Negative / Null Result ReportMedicine

Unveiling the linkage between low-carbon energy and energy sources diversification.

Kuziboev B, Pícha K, Nazif Çatık A et al. · 2025 · Journal of environmental management

This research is the first to investigate the effect of low-carbon energy risk on the diversification of energy sources. To this end, a sample of 64 countries from 2000 to 2018 is analysed. For empirical estimations, we employ the Method…

View details →DOI: 10.1016/j.jenvman.2025.127544
Negative / Null Result Report

Effects of Two Different Intraoperative Fluid Rates on Tissue Oxygenation and Haemodynamic Stability in Anaesthetised Horses

Moura RA, Bisiau A, Freeman D et al. · 2025 · Preprint

Background: Perioperative fluid therapy can influence oxygen delivery and tissue oxygenation, but its effects in horses are poorly understood. Objectives: To compare two intraoperative fluid administration strategies on peripheral tissue…

View details →DOI: 10.22541/au.176131103.35539940/v1
Negative / Null Result Report

Multimodal Approach to Intraventricular Hemorrhage Using Echocardiography, Near-Infrared Spectroscopy, and Electrical Cardiometry in Preterm Infants

Hibner A, Tong MK, Liu L et al. · 2025 · Preprint

Abstract OBJECTIVE: To investigate single versus combination hemodynamic parameters on intraventricular hemorrhage (IVH) or mortality in preterm infants. STUDY DESIGN: Data from 482 infants under 32 weeks gestational age were analyzed,…

View details →DOI: 10.21203/rs.3.rs-7376716/v1
Negative / Null Result Report

Optimizing Biomass and Phycobilin Production in Arthrospira platensis Through Carbon Source Variation and Developing a Cost-Effective Purification Method

Far ZS, Nematollahi MA, Hosseini SV et al. · 2025 · Preprint

Abstract Arthrospira platensis, commonly known as Spirulina , is an industrially cultivated cyanobacterium due to its high content of phycobiliproteins, mainly phycoerythrin, phycocyanin, and allophycocyanin. In this work, a low-cost…

View details →DOI: 10.21203/rs.3.rs-7284160/v1
Negative / Null Result ReportMedicine

Mental Fatigue Impairs Motor Performance but Not Motor Learning in Fatigued or Non-Fatigued Conditions.

Godoi Filho JRM, Abreu TFO, Vieira QR et al. · 2026 · Journal of motor behavior

We investigated the influence of mental fatigue on motor performance and learning. Additionally, we examined whether practicing under mental fatigue induces resilience in future performance under similar fatigue conditions. Ninety-two…

View details →DOI: 10.1080/00222895.2025.2585181
Negative / Null Result ReportMedicine

Effect of copper and iron on the oxidation of vegetable oil during aging

Randhawa S, Mukherjee T · 2025 · Journal of Food Composition and Analysis.

The research paper investigates how elemental copper and iron, affect the aging process of canola, coconut, groundnut, rice bran, soybean, and sunflower oils. Samples analysed biannually over two years indicate that the addition of copper,…

Negative / Null Result ReportMedicine

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.

Borges CC, Alves da Silva W, de Sá Filho AS et al. · 2026 · International journal of sport nutrition and exercise metabolism

This study aimed to evaluate the effects of short-term oral L-arginine (ARG) supplementation on vascular parameters, nitric oxide (NO) concentration, and muscular performance during upper limb resistance exercise in healthy young men. A…

View details →DOI: 10.1123/ijsnem.2025-0125
Negative / Null Result Report

Metabolic interoceptive rewards shape affect, but not action

Fleming HA, Whines A, Whelehan P et al. · 2025 · Preprint

Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…

View details →DOI: 10.31234/osf.io/px3ub_v1
Negative / Null Result ReportMedicine

Electrocardiographic LVH criteria: Poor diagnostic accuracy even with optimized cutoffs. Insights from MESA study.

de Alencar JN, Felicioni SP · 2025 · Journal of electrocardiology

Background Electrocardiographic (ECG) "left ventricular hypertrophy (LVH) criteria" are widely used as surrogates for increased LV mass but show limited sensitivity. We evaluated their diagnostic performance against cardiac magnetic…

View details →DOI: 10.1016/j.jelectrocard.2025.154138
Negative / Null Result ReportOpen accessMedicine

Biomechanical evaluation of patch augmentation in a rotator cuff repair model using a porcine flexor digitorum profundus tendon: influence of knot tying and time-zero stability.

Rhee SM, Cho CH, Kim M et al. · 2025 · Clinics in shoulder and elbow

Background This study evaluates the biomechanical effects of acellular dermal matrix (ADM) patch augmentation in a rotator cuff repair model and determines the effect of medial knot tying on time-zero stability. Methods A biomechanical…

View details →DOI: 10.5397/cise.2025.00164