A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20227 results in Negative / Null Result Report · page 248 of 675
Ma F, Hu J, Bai M et al. · 2024 · Clinical laboratory
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection typically relies on reverse transcription-polymerase chain reaction (RT-PCR) technology. However, there is a certain rate of missed detection of SARS-CoV-2…
Lauffer P, van Weelden W, van Haelst MM et al. · 2025 · Journal of community genetics
Polygenic risk scores (PRS) have emerged as a potential tool for predicting complex genetic traits and disorders, which may complement traditional rare variant testing. As genome-wide association studies (GWAS) expand, PRS predictive…
Cassileth LB, Killeen K, York A et al. · 2026 · Aesthetic surgery journal. Open forum
Background Mastectomy skin flap necrosis (MSFN) is a critical postoperation complication in postmastectomy breast reconstruction. High replacement tissue expander fill volume and large mastectomy specimen size are commonly assumed to…
Akella JS, Onken BD, Sedore CA et al. · 2026 · microPublication biology
The Caenorhabditis Intervention Testing Program aims to identify lifespan-extending interventions that are effective across diverse genetic backgrounds. Previous studies identified a role for anticonvulsants in lifespan extension in the…
Jones GT, Bennett AN, Sengupta R et al. · 2025 · Arthritis care & research
Objective Imaging evidence of active sacroiliitis is important for diagnosis, classification, and monitoring of axial spondyloarthritis (axSpA). However, there is no consistent guidance on whether patients should temporarily stop…
Karlsen KL, Clausen CL, Kahiyah RAS et al. · 2026 · Open forum infectious diseases
Background Adults hospitalized with respiratory syncytial virus (RSV) face mortality risks comparable to or higher than those with influenza A or B. However, studies on the impact of bacterial co-infections on mortality are inconsistent.…
Kocaaslan H, Ceylan C, Sümer F et al. · 2026 · BMC surgery
PURPOSE: In non-metastatic advanced gastric cancer, gastrectomy with D2 lymph node dissection is the main curative treatment. The clinical benefit of omentectomy in gastric cancer surgery is still controversial. We planned to investigate…
Domche A, Nomo A, Yemele RD et al. · 2026 · BMC ophthalmology
BACKGROUND: Loiasis is a parasitic disease caused by the filarial nematode Loa loa. CASE PRESENTATION: This report describes loiasis in a 6-year-old child presented to a public hospital in Yaoundé, Cameroon, with an immobile worm located…
Trka J, Fronkova E · 2025 · British journal of haematology
Can peripheral blood be used to detect residual disease in acute lymphoblastic leukaemia (ALL) when we increase the sensitivity of the method used? Bendig et al. found that a larger amount of material and the use of next-generation…
Lykkegaard J, Olsen JK, Wehberg S et al. · 2024 · Scandinavian journal of primary health care
Objective Patients previously examined for cancer with a negative result may present in general practice with ongoing or new symptoms or signs suggestive of cancer. This paper explores the potential existence of a relatively safe period…
Bellott TR, Luz FB, Fausto da Silva AK et al. · 2024 · Anais brasileiros de dermatologia
Background Merkel cell polyomavirus (MCPyV), a human polyomavirus that is unequivocally linked to merkel cell carcinoma (MCC), has been found in association with keratinocytes carcinomas (KC), especially basal cell carcinoma (BCC) and…
Lund A, Nielsen CK, Jensen RB et al. · 2026 · International journal of pediatric otorhinolaryngology
Background Newborn hearing screening programmes aim to identify hearing loss early; however, infants with recognised risk factors may have different screening outcomes, including false-negative results. This study evaluates screening…
Tao Y, Zheng A, Li X et al. · 2026 · Surgical oncology
Objective To construct and validate a nomogram for predicting false-negative results of axillary lymph node (ALN) fine needle aspiration (FNA) in breast cancer (BC). Methods Using the surgical pathological results of axillary lymph nodes…
Shukla A, Paturu T, Shivan S et al. · 2026 · Southern medical journal
Objective The objective of our study was to determine the extent of publication bias of clinical trials pertaining to the treatment of coronary artery disease. Specifically, studies are more likely to be published if the results are…
Uchida S, Mizuguchi Y, Sato S et al. · 2026 · Journal of human genetics
Non-invasive prenatal testing (NIPT) is widely used for fetal aneuploidy screening; however, most evaluations of test accuracy rely on pregnancy outcomes rather than cytogenetic confirmation after birth, and evidence regarding the…
Sobhi A, Hegazy RM, Zolfakar DS et al. · 2026 · Preprint
Abstract Purpose Ovarian lesions are common diseases nowadays that should be diagnosed accurately. The Ovarian-Adnexal Reporting and Data System (O-RADS) classification helps to a great extent in categorizing the type of ovarian lesions,…
Mayorga AP, Peña CO, Muñoz DB et al. · 2026 · Preprint
Abstract Background The rapid urease test (RUT) is widely used for Helicobacter pylori (H. pylori) diagnosis, but its diagnostic performance in advanced gastric atrophy remains poorly characterized. Aims To evaluate RUT accuracy against…
Abi Kheir DJ, Moriles K, Carr AL et al. · 2026 · The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians
Background: The (1,3)-β-D-glucan (BDG) test can be used as a stewardship approach to decrease antifungal overutilization, development of resistance, and excess costs. Objective: This study assessed the impact that a BDG algorithm has on…
Auer A, Settypalli TBK, Rozstalnyy A et al. · 2026 · BMC veterinary research
Background Rapid diagnosis is critical for the early detection and control of transboundary animal diseases such as African Swine Fever (ASF) and Avian Influenza (AI), particularly because it enables timely containment measures at the farm…
Zougmore WAMJ, Kaboré NF, Bado P et al. · 2026 · Preprint
Abstract Background : Human Papillomavirus (HPV) testing is recommended as a high-performance screening method within the World Health Organization (WHO) global strategy for cervical cancer elimination. However, the programmatic…
Saliba M, Haddad E · 2026 · International journal of surgery case reports
Introduction The most common type of vulvar cancer is squamous cell carcinoma. The management of early-stage vulvar squamous cell carcinoma includes radical local excision of the primary tumor. Evaluation of sentinel nodes for metastases…
Lindsley IC, Juman MM, Seifert SN et al. · 2026 · PLoS neglected tropical diseases
Large host-virus association databases are increasingly used to explore broad questions in disease ecology, particularly around host range, pathogen diversity, and the potential for spillover. While these databases have been instrumental…
Wright L, Hamze J, Nagrani TR et al. · 2026 · Preprint
Abstract Background Coronary artery disease (CAD) places a disproportionate burden on rural Appalachian communities. Scioto County, Ohio has among the highest rates of CAD-related hospitalizations in the state, approaching double the…
Ibrahim M, Mostafa D, Manie EA et al. · 2026 · British poultry science
1. This study used unvaccinated sentinels plus Avian Influenza Virus (AIV) specific ELISA for differentiating infected from vaccinated animals (DIVA). Birds assessed were from 10 broiler flocks (F1-F10), three layer (F11-F13) and two…
Tavoly M, Jørgensen CT, Sandblad KG et al. · 2026 · Research and practice in thrombosis and haemostasis
Background It has been suggested that D-dimer testing should be avoided in patients with prolonged symptoms, as results may yield false negatives. However, the evidence supporting this recommendation is limited. Objectives This study…
Serrari M, Bianchi L, Tré-Hardy M et al. · 2026 · Microorganisms
Antenatal screening for Group B Streptococcus (GBS) does not always reflect intrapartum colonisation status, and rapid molecular point-of-care tests (POCT) have been developed to enable real-time detection during labour. This prospective…
McCulloch H, Lohr PA · 2026 · Obstetrics and gynecology
Objective To assess the accuracy of using the last menstrual period (LMP) date for determining gestational age, compared with ultrasonography, among patients aged younger than 16 years at British Pregnancy Advisory Service (BPAS), a large…
Özen A, Depoorter L, Huysentruyt K et al. · 2026 · Preprint
Background: /Objectives: Although cow’s milk allergy is the most common food allergy in infants, its diagnosis remains challenging. Conventional allergy tests, including skin prick testing and serum-specific IgE, can support the diagnosis…
Yi J, Bi K, Shen M et al. · 2026 · Academic radiology
Objectives This study aimed to develop a post-procedural predictive model for assessing the risk of false-negative results in ultrasound-guided percutaneous transthoracic needle lung biopsy (US-PTLB). Material and methods Two prospective…
Ma JY, Jiang W, Cheng B et al. · 2026 · Endoscopic ultrasound
Background and objectives Repeated EUS-guided fine-needle aspiration/biopsy (rEUS-FNA/B) is recommended in solid pancreatic lesions (SPLs) with inconclusive initial results. However, even rEUS-FNA/B cannot completely eliminate false…