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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19830 results in Negative / Null Result Report · page 245 of 661

Negative / Null Result ReportMedicine

The temporal order of emotional, cognitive, and behavioral gains in daily life during treatment of depression.

Snippe E, Elmer T, Ceulemans E et al. · 2024 · Journal of consulting and clinical psychology

Objective Despite the importance for understanding mechanisms of change, little is known about the order of change in daily life emotions, cognitions, and behaviors during treatment of depression. This study examined the within-person…

View details →DOI: 10.1037/ccp0000890
Negative / Null Result ReportOpen accessMedicine

Association between maternal serum levels of Alpha-Fetoprotein and eruption timing of the first central deciduous tooth: a cross-sectional study.

Faghihian E, Ghobadi S, Rezaei R et al. · 2025 · The Saudi dental journal

The current study investigated the relationship between the first central deciduous tooth eruption time and serum levels of maternal alpha-fetoprotein and related multiple of the median (MoM). The cross-sectional study was performed on a…

View details →DOI: 10.1007/s44445-025-00089-w
Negative / Null Result ReportOpen accessMedicine

Revisiting the relationship between impulsivity, apathy, and action control: Bayesian inference from a stop-signal task study.

Michel E, Garnier-Allain A, Kaliuzhna M et al. · 2026 · PloS one

Apathy and impulsivity are multidimensional constructs that shape goal-directed behavior. Although the motivational dopaminergic spectrum hypothesis frames them as opposing ends of a single continuum, questionnaire-based studies…

View details →DOI: 10.1371/journal.pone.0352351
Negative / Null Result ReportOpen accessMedicine

Exploring the effects of faecal microbiota transplantation on cognitive function: A review of clinical trials.

Alaeddin S, Chatterjee A, Roberts TL et al. · 2025 · Brain, behavior, & immunity - health

Faecal Microbiota Transplantation (FMT) is a widely used microbiota-modulation technique to treat recurrent Clostridioides difficile infections (rCDI). Rodent studies and clinical trials on probiotic interventions indicate that alterations…

View details →DOI: 10.1016/j.bbih.2025.101049
Negative / Null Result ReportOpen accessMedicine

Consensus Report by the Italian Academy of Osseointegration on the Importance of Peri-Implant Soft Tissues.

Bressan E, Zucchelli G, Tommasato G et al. · 2024 · Medicina (Kaunas, Lithuania)

Background and Objectives : The influence of the quantity and quality of peri-implant soft tissue on implant health and long-term maintenance is controversial. This consensus aimed to assess the importance of peri-implant soft tissue by…

View details →DOI: 10.3390/medicina60091393
Negative / Null Result ReportMedicine

Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke ? Discordance between randomised controlled trials and observational studies.

Scheen AJ · 2023 · Diabetes & metabolism

Stroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular complication has been less carefully investigated than the risk of cardiovascular mortality, heart failure and renal disease. Some data suggested…

View details →DOI: 10.1016/j.diabet.2023.101474
Negative / Null Result ReportMedicine

Effects of HIV and Adverse Childhood Experiences on Neurocognition.

Inman EM, Inman EM, Ramsammy CW et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)

Background Both HIV and adverse childhood experiences (ACEs) can affect neurocognitive performance. Among youth with perinatal HIV (PHIV), living with a chronic viral infection and experiencing ACEs simultaneously may result in an…

View details →DOI: 10.1097/qai.0000000000003858
Negative / Null Result ReportOpen accessMedicine

Use of alteplase continuous rate infusion, pentoxifylline, and cyproheptadine in association or not, in acute feline aortic thromboembolism: a study of nine cats.

Ray CC, Wolf J, Guillaumin J · 2025 · Frontiers in veterinary science

Introduction Locomotion improvement without serious complications is the main goal of treatment for feline aortic thromboembolism (FATE). We aimed to describe the survival and functional recovery of cardiogenic FATE treated with tissue…

View details →DOI: 10.3389/fvets.2025.1512649
Negative / Null Result ReportOpen accessMedicine

The effect of intraoperative low-dose ketamine versus dexmedetomidine infusion on postoperative bowel recovery in patients undergoing gastrointestinal malignancy surgeries: Placebo-controlled, randomized trial.

Kumar SK, Misra S, Behera BK et al. · 2025 · Journal of anaesthesiology, clinical pharmacology

Background and aims No studies have compared the effects of ketamine and dexmedetomidine on bowel recovery. We evaluated the effects of intraoperative low-dose ketamine or dexmedetomidine infusion on postoperative bowel recovery in…

View details →DOI: 10.4103/joacp.joacp_322_23
Negative / Null Result ReportMedicine

Extent of Lymphadenectomy for Surgical Management of Right-Sided Colon Cancer: The Randomized Phase III RELARC Trial.

Lu J, Xing J, Zang L et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer, although there is still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The…

View details →DOI: 10.1200/jco.24.00393
Negative / Null Result ReportOpen accessMedicine

The relationship between glaucoma and an electronic frailty index with the cumulative incidence of healthcare encounters for falls and fractures in older adults.

Duy WD, Pajewski NM, Williamson JD et al. · 2025 · The Journal of frailty & aging

Objective To compare the association of glaucoma and glaucoma suspect diagnoses with frailty, quantified via an electronic frailty index (eFI), and to evaluate whether a glaucoma diagnosis moderates the association between frailty and the…

View details →DOI: 10.1016/j.tjfa.2025.100051
Negative / Null Result ReportMedicine

Racial and ethnic disparities in the usage and outcomes of ischemic stroke treatment in the United States.

Metcalf D, Zhang D · 2023 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Objectives This study explores racial and ethnic differences in 1) receiving tissue plasminogen activator (tPA) and endovascular thrombectomy (EVT) as treatment for ischemic stroke and 2) outcomes and quality of care after use of tPA or…

View details →DOI: 10.1016/j.jstrokecerebrovasdis.2023.107393
Negative / Null Result ReportOpen accessMedicine

Pregnancy Outcomes Among Young, Middle-Aged, and Older Adolescents in Gadarif, Eastern Sudan: A Case-Control Study.

Munder O, Adam GK, Nasralla K et al. · 2025 · SAGE open nursing

Introduction Adolescent pregnancy is considered a global public health problem that affects both developed and developing countries. While the obstetric and perinatal outcomes of adolescent pregnancies have been extensively studied, there…

View details →DOI: 10.1177/23779608251364596
Negative / Null Result ReportOpen accessMedicine

Evaluating the impact of statin therapy on chronic obstructive pulmonary disease outcomes: A retrospective cohort study from a tertiary care hospital in India.

Chari HS, Padukone AM, Magazine R et al. · 2026 · The Journal of international medical research

ObjectiveChronic obstructive pulmonary disease is a common condition marked by significant disability and frequent exacerbations. Statins, owing to their anti-inflammatory and immunomodulatory effects, may offer therapeutic benefits in…

View details →DOI: 10.1177/03000605261417046
Negative / Null Result ReportOpen accessMedicine

Impact of pulsed stimulation on objective and subjective visual acuity measurements in nystagmus.

Quanz EV, Al-Nosairy KO, Stolle FH et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose Quanz et al. (Sci Rep 14:16797, 2024) reported that participants with nystagmus had higher objective visual evoked potential visual acuity estimates (VA VEP ) by 0.12 logMAR relative compared to standard psychophysical VA (VA…

View details →DOI: 10.1007/s10633-025-10060-z
Negative / Null Result ReportOpen accessMedicine

Comparison of effectiveness of common targeting heuristics in repetitive transcranial magnetic stimulation treatment of depression.

Sakreida K, Trapp NT, Kreuzer S et al. · 2025 · BMJ mental health

Background Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an effective non-pharmacological, non-invasive intervention for depression. However, the optimal strategy for localising…

View details →DOI: 10.1136/bmjment-2025-301598
Negative / Null Result ReportOpen accessMedicine

Clinical Impact of Flow-Adjusted Transprosthetic Pressure Gradient After Aortic Valve Replacement.

Ohmori T, Hiraoka A, Totsugawa T et al. · 2025 · Annals of thoracic surgery short reports

Background It is still controversial whether prosthesis-patient mismatch (PPM) adversely affects long-term outcomes after aortic valve replacement (AVR). The aim of this study was to examine whether flow-adjusted pressure gradient is a…

View details →DOI: 10.1016/j.atssr.2024.07.008
Negative / Null Result ReportOpen accessMedicine

Corneal biomechanics are not exclusively compromised in high myopia.

Yii F, Strang N, Bernabeu MO et al. · 2024 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Introduction Research assuming linearity has concluded that corneal biomechanics are compromised in high myopia. We investigated whether this assumption was appropriate and re-examined these associations across different levels of myopia.…

View details →DOI: 10.1111/opo.13313
Negative / Null Result ReportMedicine

The distribution of the Lansing Effect across animal species.

Ivimey-Cook ER, Shorr S, Moorad JA · 2023 · Evolution; international journal of organic evolution

Maternal senescence is the reduction in individual performance associated with increased maternal age at conception. When manifested on adult lifespan, this phenomenon is known as the "Lansing Effect." Single-species studies report both…

View details →DOI: 10.1093/evolut/qpac045
Negative / Null Result ReportOpen accessMedicine

An Exploratory Analysis of Essential Tremor and Associated Phenotypes.

Gharibian D, Medeiros M, Dion PA et al. · 2026 · Tremor and other hyperkinetic movements (New York, N.Y.)

Essential Tremor (ET) is a highly heterogeneous movement disorder with a strong genetic basis. However, the etiology of ET is unclear, largely due to its clinical heterogeneity and frequently observed comorbidities. We conducted a…

View details →DOI: 10.5334/tohm.1168
Negative / Null Result ReportMedicine

New Morbidities During Critical Illness and Associated Risk of ICU Readmission: Virtual Pediatric Systems Cohort, 2017-2020.

Heneghan JA, Akande MY, Ramgopal S et al. · 2024 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To describe change in Functional Status Scale (FSS) associated with critical illness and assess associated development of new morbidities with PICU readmission. Design Retrospective, cross-sectional cohort study using the…

View details →DOI: 10.1097/pcc.0000000000003542