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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21277 results · page 239 of 710

Negative / Null Result ReportOpen accessMedicine

Psychological Impact of AI-Simplified Brain MRI Reports: A Randomized Trial of Patient Understanding, Anxiety, and Health Literacy.

Alarifi M, Luo J, Jabour A et al. · 2026 · Journal of clinical medicine

Background/Objectives : Immediate patient access to radiology reports has increased the need for communication that patients can understand, yet it remains unclear whether simplifying report language improves comprehension without…

View details →DOI: 10.3390/jcm15114158
Negative / Null Result ReportMedicine

Argipressin for prevention of blood loss in hepatic resection: a randomised, placebo-controlled, double-blind trial.

Wisén E, Pivodic A, Skagervik A et al. · 2026 · British journal of anaesthesia

Background Blood loss and blood transfusion are associated with negative short-term and long-term outcomes in hepatic resection. Vasopressin decreases portal blood flow and could reduce bleeding during liver surgery. We compared the…

View details →DOI: 10.1016/j.bja.2025.09.021
Negative / Null Result ReportMedicine

In adults with TBI and anemia, liberal vs. restrictive RBC transfusion did not reduce unfavorable neurologic outcomes by 10% at 6 mo.

Malik A, Martin GS · 2024 · Annals of internal medicine

Source citation Turgeon AF, Fergusson DA, Clayton L, et al; HEMOTION Trial Investigators on behalf of the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group, and the Canadian Traumatic Brain…

View details →DOI: 10.7326/annals-24-02456-jc
Negative / Null Result ReportMedicine

Association of Stepping Up to High-Dose Inhaled Corticosteroids and Risk of Future Asthma Exacerbations: Data From the United States.

Tran TN, Kerkhof M, Le TT et al. · 2026 · The journal of allergy and clinical immunology. In practice

Background Real-world data on the benefit of high-dose inhaled corticosteroid (ICS) after exacerbation are limited. Objective To investigate whether stepping up to high-dose ICS after severe exacerbation reduces future asthma exacerbation…

View details →DOI: 10.1016/j.jaip.2025.10.005
Negative / Null Result ReportOpen accessMedicine

Reducing Noise Induced by Cardiac Pulsatility in Brain Maps of R<sub>2</sub>* and Magnetic Susceptibility Using Tailored k-space Sampling.

Raynaud Q, Dardano T, Oliveira R et al. · 2026 · NMR in biomedicine

Maps of the transverse relaxation rate R 2 * and magnetic susceptibility (χ) are computed from gradient-echo data and are sensitive to signal instabilities induced by cardiac pulsation. Here, we introduce two k-space sampling strategies…

View details →DOI: 10.1002/nbm.70305
Negative / Null Result ReportMedicine

Common channel length and implications to the weight loss.

Santoro S, Mota FC, de Aquino CGG et al. · 2025 · Updates in surgery

To present and analyze the results of sleeve gastrectomy with transit bipartition (SG + TB) with three different lengths of common channel (CC) and its implications for the weight loss and signals of residual malabsorption. A total of 790…

View details →DOI: 10.1007/s13304-025-02343-6
Negative / Null Result ReportMedicine

Effect of albumin infusion in patients with predicted severe acute pancreatitis: A randomized controlled trial.

Shu W, Wan J, Xu H et al. · 2025 · Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Background Although previous studies have shown the potential advantages of albumin administration in critically ill patients, it has not been tested in patients with severe acute pancreatitis. Methods In this single-center trial, we…

View details →DOI: 10.1016/j.pan.2025.08.012
Negative / Null Result ReportMedicine

The Effect of Intraoperative Methadone During Spine Fusion Surgery on Postoperative Opioid Requirements: A Randomized Clinical Trial.

Uhrbrand CG, Carlé N, Valancius K et al. · 2025 · Spine

Study design A randomized blinded trial with three groups. Objective To evaluate whether a single intraoperative methadone dose reduces postoperative opioid requirements and pain intensity in patients undergoing lumbar fusion surgery.…

View details →DOI: 10.1097/brs.0000000000005477
Negative / Null Result ReportMedicine

Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial.

Cariou B, Thys A, Oliveira AR et al. · 2025 · Diabetes, obesity & metabolism

Aims Postprandial hyperlipidaemia (PPL), characterized by elevated triglyceride (TG) concentrations after a meal, is common in type 2 diabetes (T2D) and is often recognized as an independent cardiovascular risk factor. Here, we aimed to…

View details →DOI: 10.1111/dom.16305
Negative / Null Result ReportMedicine

Impact of an electronic clinical decision support algorithm (eCDSA) on antibiotic prescribing in primary care in Cambodia: A cluster randomised controlled trial.

Wynberg E, Mishra A, Liverani M et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Objectives Poorly targeted antibiotic use in primary care is a driver of antimicrobial resistance. Electronic clinical decision support algorithms (eCDSAs) integrating point-of-care tests may improve prescribing. We evaluated the impact of…

View details →DOI: 10.1016/j.ijid.2026.108382
Negative / Null Result ReportMedicine

Proactive versus standard support of labor in the latent phase - A randomized, controlled clinical trial.

Larsen M, Underdal M, Salvesen Ø et al. · 2025 · Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives

Objective Long latent phase of labor with subsequent prolonged total labor duration increases the risk of obstetric interventions and complications. We explored whether Proactive Support of Labor (PSL) compared to Standard Support of Labor…

View details →DOI: 10.1016/j.srhc.2025.101144
Negative / Null Result ReportMedicine

Minimal Impact of Prophylactic Antibiotics in Pediatric Inguinal Hernia Surgery: Evidence From Real-World Data.

Fujii T, Kitadani Y, Tanaka A et al. · 2025 · Journal of pediatric surgery

Background The effectiveness of prophylactic antibiotics in pediatric inguinal hernia repair remains unclear. As the procedure is considered clean, the necessity of prophylactic antibiotics is debated. Methods We conducted a retrospective…

View details →DOI: 10.1016/j.jpedsurg.2025.162607
Negative / Null Result ReportOpen accessMedicine

Impact of electrocardiogram monitoring on the frequency of tracheal intubation at birth.

de Souza Freire T, Kawakami MD, de Almeida MF et al. · 2026 · Jornal de pediatria

Objective To determine whether the use of an electrocardiogram monitor in newborns receiving positive pressure ventilation (PPV) at birth affects the frequency of tracheal intubation in the delivery room. Methods Retrospective cohort of…

View details →DOI: 10.1016/j.jped.2026.101504
Negative / Null Result ReportOpen accessMedicine

Impact of Pre-Elite Anterior Cruciate Ligament (ACL) Reconstruction on Draft Outcomes and Reinjury Risk in Elite Australian Football Players: A Retrospective Cohort Study.

Veale JP, Shawdon A, D'Alessandro P et al. · 2025 · Sports (Basel, Switzerland)

A history of anterior cruciate ligament reconstruction (ACLR) during the Australian Football (AF) talent pathway may impact draft prospects and increase the risk of a second injury during a professional career. This study investigated…

View details →DOI: 10.3390/sports13090308
Negative / Null Result ReportOpen accessMedicine

Magnesium supplementation did not reduce serum calciprotein crystallization and arterial stiffness in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.

Meer R, Xu JY, Newsom SP et al. · 2026 · The American journal of clinical nutrition

Background Medial arterial calcification (MAC) and increased arterial stiffness contribute to cardiovascular disease risk in type 2 diabetes mellitus (T2DM). Experimental studies suggest that magnesium supplementation may halt arterial…

View details →DOI: 10.1016/j.ajcnut.2026.101299
Negative / Null Result ReportOpen accessMedicine

Effectiveness of a virtual hospital model of care for patients with low back pain presenting to emergency departments (Back@Home).

Sigera C, Oliveira CB, Melman A et al. · 2026 · NPJ digital medicine

This study evaluated the effectiveness of a virtual hospital model of care (Back@Home) for low back pain (LBP). We conducted an observational study across four hospitals in the Sydney Local Health District, Australia. We included patients…

View details →DOI: 10.1038/s41746-026-02425-8
Negative / Null Result ReportMedicine

Does Reiki Therapy ReducePreoperative Anxiety and Postoperative Pain in Third Molar Surgery? A Randomized Controlled Trial.

Ozden Yuce M, Simsek B, Dadas OF et al. · 2026 · Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Background Preoperative anxiety in patients undergoing third molar extraction can influence pain perception. Limited evidence suggests Reiki therapy may help manage anxiety and pain, but its effectiveness in dentistry is unclear. Purpose…

View details →DOI: 10.1016/j.joms.2025.09.003
Negative / Null Result ReportOpen accessMedicine

Biological vs Synthetic Mesh in Laparoendoscopic Inguinal Hernia Repair: The BIOLAP Randomized Clinical Trial.

Seefeldt CS, Knievel J, Deeb M et al. · 2025 · JAMA surgery

Importance Chronic postoperative pain and recurrence are relevant complications after inguinal hernia repair. Biological meshes have been proposed as a resorbable alternative to synthetic implants that may reduce postoperative pain.…

View details →DOI: 10.1001/jamasurg.2025.4071
Negative / Null Result ReportMedicine

Impact of a Urogynecology Telehealth Consultation on Genital Self-Image and Sexual Function After Obstetric Anal Sphincter Injury.

Bonasia K, Luong S, Stairs J et al. · 2026 · International urogynecology journal

Introduction and hypothesis Obstetric anal sphincter injuries (OASIs) are associated with increased risk of postpartum complications, including short- and long-term dyspareunia and sexual dysfunction. The primary aim of this analysis is to…

View details →DOI: 10.1007/s00192-025-06234-7
Negative / Null Result ReportMedicine

Analysis of the use of prophylactic ureteral stents in preventing iatrogenic ureteral injury during radical hysterectomy for cervical Cancer.

Wang Y, Jia Z, Jiao J et al. · 2025 · Gynecologic oncology

Objective To assess the use of prophylactic ureteral stent for preventing ureteral injury in patients with cervical cancer undergoing radical hysterectomy. Methods This retrospective study included 304 patients with cervical cancer who…

View details →DOI: 10.1016/j.ygyno.2025.07.022
Negative / Null Result ReportOpen accessMedicine

Effect of Extended Dual Antiplatelet Therapy on the Prognosis of Patients With ST Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Cohort Study.

Li YC, Wang JY, Lei MJ et al. · 2026 · Health science reports

Background and aims To inquire the effect of extending the duration of dual antiplatelet therapy (DAPT) to 18-24 months on the prognosis of patients with ST segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary…

View details →DOI: 10.1002/hsr2.71887
Negative / Null Result ReportOpen accessMedicine

Safety evaluation of a ketamine-dodecyl maltoside combination using angiogenesis and embryonic development models.

Idoudi S, Hassan AF, Kheraldine H et al. · 2026 · Scientific reports

Ketamine (KET) exhibits potential anticancer activity, with enhanced cytotoxicity against melanoma cells when combined with the permeation enhancer dodecyl maltoside (DDM). To support clinical translation, this study evaluated the…

View details →DOI: 10.1038/s41598-026-46828-9
Negative / Null Result ReportMedicine

Enhancing Removable Partial Denture Hygiene: Investigating Mucolytic Agents and Biocides for Disrupting Biofilms and Improving Antimicrobial Efficacy.

Moraes LGDS, Oliveira VC, Macedo AP et al. · 2025 · The International journal of prosthodontics

Purpose To evaluate the antibiofilm action of 2.5 mg/mL peracetic acid (PA), 0.5 mg/mL cetylpyridinium chloride (CPC), and 160 mg/mL N-acetylcysteine (NAC) against multispecies biofilm of Streptococcus mutans, Staphylococcus aureus,…

View details →DOI: 10.11607/ijp.9133
Negative / Null Result Report

Contribution of Bedside Ultrasound (POCUS) on acute heart failure management in hospitalized geriatric patients: a prospective study

saboul H, Lesage V, Beernaert L et al. · 2025 · Preprint

Abstract Methods: A prospective randomized trial was conducted from October 26, 2022, to September 15, 2023, involving 101 patients randomized into two groups: the interventional group received POCUS (pulmonary and inferior vena cava…

View details →DOI: 10.21203/rs.3.rs-6371377/v1
Negative / Null Result Report

Clinical Evaluation of PolyDeep, a Computer Aided Detection system: A Multicenter Randomized Tandem Colonoscopy Trial

Davila-Piñón P, Díez Martín AI, Nogueira-Rodríguez A et al. · 2025 · Preprint

Background: /Objectives: Computer-aided detection (CADe) systems are increasingly used in endoscopy to enhance lesion recognition. PolyDeep is a CADe/x tool previously assessed in an observational study. The aim of our study is to…

View details →DOI: 10.20944/preprints202509.1104.v1
Negative / Null Result ReportOpen accessMedicine

Effect of virtual reality distraction on anxiety, pain and discomfort during unsedated gastroscopy: Randomized controlled trial.

Bouman Z, De Vries F, De Ruiter M et al. · 2026 · Endoscopy international open

Background and study aims Esophagogastroduodenoscopy is a widely used medical examination. Despite the short duration of this procedure, many patients experience anxiety, pain, and discomfort. The aim of this study was to examine effects…

View details →DOI: 10.1055/a-2794-0424