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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21707 results · page 239 of 724

Negative / Null Result ReportOpen access

Fate of the veterinary medicine ivermectin in soil

Galtier, Pierre, Dubroca, Jacqueline, Mougin, Christian et al. · 2003

International audienceWe investigated the fate of the drug ivermectin in the soil. We found that ivermectin was transformed solely by photos, leading to the formation of two ivermectin isomers. We indeed failed to detect any…

View details →DOI: 10.1007/s10311-003-0032-9
Negative / Null Result ReportOpen access

On the Singularity at Light Velocity (replacement)

Nishida, Akira, ニシダ, アキラ, 西田, 晃

The Michelson-Morley experiment failed to detect evidence for the wind of luminiferous aether. However, the fact that light propagates without affecting aether wind on the rotating earth means that the medium is also rotating with us. For…

Negative / Null Result ReportOpen access

Distribution of the dysregulated plasma LncRNAs in the liver.

Junpei Wang (776880), Jian Tu (490588), Jichun Yang (458427) et al. · 2015

“Not detected” means microarrays failed to detect the significant signals of LncRNAs in mouse livers. Detailed information of dysregulated plasma LncRNAs was summarized in S2 and S3 Tables. The detailed information of liver LncRNAs had…

View details →DOI: 10.1371/journal.pone.0133462.t001
Negative / Null Result ReportOpen access

On the Singularity at Light Velocity

Nishida, Akira, ニシダ, アキラ, 西田, 晃

The Michelson-Morley experiment failed to detect evidence for the wind of luminiferous aether. However, the fact that light propagates without affecting aether wind on the rotating earth means that the medium is also rotating with us. For…

Negative / Null Result ReportOpen access

Multisegmental spondylitis due to Tropheryma whipplei : case report

Bär, Diego, Julian Cooper, Alan Tyndall et al. · 2009

We report a patient who presented with inflammatory back pain due to multisegmental spondylitis. Following a vertebral biopsy which failed to detect an infectious organism, the patient was treated with etanercept, a tumor necrosis factor…

View details →DOI: 10.1186/1750-1172-4-13
Negative / Null Result ReportOpen access

Fluorescence cystoscopy in patients with non-muscle invasive bladder cancer

I. G. Rusakov, R. V. Ulianov, E. V. Filonenko et al. · 2015

The main challenge of treating non-muscle invasive bladder cancer is multifocal tumors. Current methods of diagnosis are failed to detect all superficial flat tumor lesions in bladder mucosa. The use of fluorescence imaging with…

View details →DOI: 10.24931/2413-9432-2015-4-3-29-35
Short NoteOpen access

Additional file 2: of HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia

Luisa Seguella (2806498), Stefano Gigli (2806501), Luca Steardo (214519) et al. · 2018

PEA failed to improve diarrhea course in PPARα−/− mice. HIV-1 Tat (130 ng/Kg)-induced diarrhea in PPARα−/− mice, increasing (a) daily defecation frequency, (b) average daily number of wet spots, and (c) fluid accumulation within 7 days…

View details →DOI: 10.6084/m9.figshare.6025403.v1
Negative / Null Result Report

Scopolamine fails to demonstrate efficacy in depression treatment

· 2022 · The Brown University Psychopharmacology Update

The antimuscarinic agent scopolamine did not demonstrate antidepressant effects in a randomized trial that used an active placebo comparator and involved 40 patients with major depressive disorder. Researchers stopped the trial for…

View details →DOI: 10.1002/pu.30949
Negative / Null Result ReportOpen access

Renal fibrosis and inflammation.

Julianna Rugor (548251), Lukasz Przybyl (548252), Ralf Dechend (252651) et al. · 2014

Masson trichrome staining of kidney sections (A) showed increased matrix deposition in vehicle-treated dTGR. Relaxin did not reduce matrix formation in the kidney (representative images). The upper panel shows a higher magnification. (B)…

View details →DOI: 10.1371/journal.pone.0093743.g005
Negative / Null Result ReportOpen access

Box and whisker plot of HBV viral loads of the 71 HBV DNA +ve participants separated into the six serological groups (A to F), interpreted according to Hollinger (2008) with modifications [35].

Anna Kramvis (304621), Neil A. Martinson (198606), Trevor G. Bell (304619) et al. · 2013

“n” indicates the number of participants in each group. ALT and CD4 cell counts for each group are indicated in the table below the plot as “Median (Interquartile Range)”. Viral loads and CD4 cell counts did not differ significantly…

View details →DOI: 10.1371/journal.pone.0045750.g002
Negative / Null Result ReportOpen access

THE EFFECTS OF BOATING UPON LEAD CONCENTRATIONS IN FISH

Oates, David, David Oates · 1976

The concentration of lead in fish muscle tissue from lakes where boating is heavy and where it is prohibited was measured. The lead levels ranged from less than 0.05 to 1.35 ppm but did not differ significantly between those in the…

View details →DOI: 10.2307/3627294
Negative / Null Result ReportOpen access

Data_Sheet_1_Supplemental oxygen did not significantly affect two-year mortality in patients at-risk for cardiovascular complications undergoing moderate- to high-risk abdominal surgery–A follow-up analysis of a prospective randomized clinical trial.docx

Thomas Christian (2546665), Barbara Kabon (652817), David Emler (14540201) et al. · 2023

BackgroundIn relatively healthy middle-aged patients, recent studies have shown that supplemental oxygen did not significantly increase one-year mortality after noncardiac surgery. If supplemental oxygen influences long-term mortality,…

View details →DOI: 10.3389/fanes.2023.1108921.s001
Abandoned HypothesisOpen access

On the Singularity at Light Velocity

Nishida, Akira, 西田, 晃 · 2013

The Michelson-Morley experiment failed to detect evidence for the wind of luminiferous aether. However, the fact that light propagates without affecting aether wind on the rotating earth means that the medium is also rotating with us. For…

Negative / Null Result Report

Study: Medical cannabis did not reduce opioid pain prescriptions

Alison Knopf · 2023 · Alcoholism & Drug Abuse Weekly

State laws that allow medical cannabis to be prescribed and dispensed did not result in the reduced treatment of chronic noncancer pain, researchers have found. In the study, “Effects of U.S. State Medical Cannabis Laws on Treatment of…

View details →DOI: 10.1002/adaw.33870
Failed Experiment Report

Failed knee replacement: incorrect indication?

George Ampat, Emma Tixerant · 2019 · BMJ Case Reports

A 52-year-old woman sustained a direct soft tissue injury to the right knee following a fall onto the right knee. X-rays did not identify any bony injury. Physiotherapy decreased pain but instability persisted. MRI scans identified early…

View details →DOI: 10.1136/bcr-2019-230829