e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19830 results in Negative / Null Result Report · page 236 of 661

Negative / Null Result ReportMedicine

Comparative assessment of behavioural alterations induced by common laboratory solvents in zebrafish (Danio rerio) larvae.

Vujović T, Begić Biškup K, Bojanić K et al. · 2026 · Scientific reports

Organic solvents are routinely used to dissolve poorly water-soluble chemicals in zebrafish-based assays. However, their intrinsic biological activity may confound behavioural endpoints and compromise data interpretation. This study…

View details →DOI: 10.1038/s41598-026-59476-w
Negative / Null Result ReportMedicine

Multiple-Birth Family Knowledge in Maternity and Child Health Clinics: Filling Knowledge Gaps to Improve Multiple-Birth Family Nursing.

Heinonen K, Kaprio J, Trias T et al. · 2026 · Twin research and human genetics : the official journal of the International Society for Twin Studies

The purpose of this cross-sectional study was to investigate knowledge about multiple-birth families among midwives and public health nurses working in maternity and child health clinics in Finland. The data were collected with a Finnish…

View details →DOI: 10.1017/thg.2026.10055
Negative / Null Result ReportMedicine

Neurocognitive Function, Cerebral Blood Flow, and Hippocampal Volume After Catheter Ablation of Atrial Fibrillation.

Yamamoto T, Takahashi Y, Takagi S et al. · 2026 · JACC. Clinical electrophysiology

Background The effect of atrial fibrillation (AF) catheter ablation on neurocognitive function is debated. Objectives This study sought to investigate changes in cognitive function and brain imaging after AF ablation. Methods Patients…

View details →DOI: 10.1016/j.jacep.2025.12.037
Negative / Null Result ReportMedicine

Sociodemographic Factors Associated With Postpartum Readiness: A Survey Study.

McHugh EG, Marudo C, Safvati N et al. · 2026 · The Journal of perinatal education

The postpartum period is pivotal for both maternal and infant well-being, yet factors influencing postpartum readiness remain underexplored. This study investigates these factors with an emphasis on the impact of perinatal educators on…

View details →DOI: 10.1891/jpe-2024-0031
Negative / Null Result ReportMedicine

Absence of osteoclastogenic response to pooled polyclonal anti-citrullinated peptide/protein antibodies from patients with rheumatoid arthritis in vitro.

Chen X, An Z, Li C et al. · 2026 · Clinical and experimental medicine

Anti-citrullinated peptide/protein antibodies (ACPAs) are specific serological markers for rheumatoid arthritis (RA), but their direct role in promoting osteoclastogenesis remains controversial. This study aims to determine whether…

View details →DOI: 10.1007/s10238-026-02208-1
Negative / Null Result ReportMedicine

Effects of Different Monomeric Bile Acids in the Diet on the Growth and Lipid Metabolism of Juvenile Pacific White Shrimp.

Song Z, Liu Y, Liu H et al. · 2026 · Animals : an open access journal from MDPI

Bile acids are important for lipid digestion and metabolic regulation, but the roles of individual bile acids in crustaceans remain unclear. This study evaluated the effects of six dietary monomeric bile acids on growth and lipid…

View details →DOI: 10.3390/ani16121925
Negative / Null Result ReportMedicine

A Retrospective Study of Outcome Predictive Models for Anterior Circulation Stroke Post Endovascular Thrombectomy: Are CT-Derived Morphomics Useful?

Manole C, Shet S, O Apos Brien A et al. · 2026 · Cerebrovascular diseases extra

Introduction In acute ischaemic stroke secondary to a large vessel occlusion, endovascular thrombectomy (EVT) is the standard of care. However, prediction of functional outcomes following EVT remains challenging. We sought to determine…

View details →DOI: 10.1159/000550274
Negative / Null Result ReportMedicine

CT-confirmed union rates following ankle and hindfoot arthrodesis with and without biological augmentation: A retrospective series.

Matheron G, Pearse R, Dellis S et al. · 2026 · Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

Background Nonunion remains a major complication after ankle and hindfoot arthrodesis. Biologic augmentation is frequently used to mitigate this risk, but incremental benefit remains unproven. This study evaluated CT-verified union rates…

View details →DOI: 10.1016/j.fas.2026.06.003
Negative / Null Result Report

Evaluating eDNA Detection from Live and Dead Control Sources

Blankenship SM, Dean C, Karpenko K et al. · 2026 · Preprint

Environmental DNA (eDNA) methods offer a powerful tool for monitoring aquatic species, yet field applications remain challenged by uncertainty in DNA transport, mixing, and detection, particularly in flowing or tidally influenced systems.…

View details →DOI: 10.64898/2026.04.27.721176
Negative / Null Result ReportOpen accessMedicine

Effect of Phantom Containing Implants Angulation on the Amount of Metal Artifacts Around the Implants in CBCT Images.

Valizadeh S, Moshfeghi M, Bahrani Z et al. · 2026 · International journal of dentistry

Objective Artifacts from dental implants impact the clarity of cone-beam computed tomography (CBCT) scans, posing challenges to radiographic detection in adjacent areas. The aim of this in vitro study is to examine the effect of angling a…

View details →DOI: 10.1155/ijod/8828788
Negative / Null Result ReportMedicine

Monocyte-Containing Inflammatory Indices Show Stronger Association with 30-Day Mortality than the Systemic Immune-Inflammation Index in Elderly Sepsis: A Single-Center Retrospective Observational Cohort Study.

Irimie AI, Dinescu SN, Novac MB et al. · 2026 · Journal of clinical medicine

Background . Hematological inflammatory indices from the complete blood count have been proposed as inexpensive prognostic markers in sepsis. The systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) are the…

View details →DOI: 10.3390/jcm15124799
Negative / Null Result ReportMedicine

Postoperative duloxetine administration did not significantly modify overall pain trajectories following high tibial osteotomy: An open-label randomized controlled trial.

Sengoku M, Ogawa H, Nakamura Y et al. · 2026 · Journal of orthopaedic surgery (Hong Kong)

BackgroundDuloxetine is a potent analgesic that reduces pain associated with knee osteoarthritis. This study aimed to evaluate the analgesic effects of regular postoperative duloxetine after high tibial osteotomy (HTO) and its influence on…

View details →DOI: 10.1177/10225536261437327
Negative / Null Result ReportMedicine

Impact of resistant starch from high amylose wheat compared to inulin on human gut microbiota and host immune responses using an artificial colon associated to human leukocytes.

Couturier I, Denis S, Rossary A et al. · 2026 · Food chemistry

Cooked High Amylose Wheat (HAW) products are dietary sources of resistant starch (RS). While its effects on gut microbiota are known, links to immune responses remain unclear. This study evaluated the antioxidant and anti-inflammatory…

View details →DOI: 10.1016/j.foodchem.2026.149919
Negative / Null Result ReportMedicine

The efficacy of tranexamic acid in prevention and treatment of post-inflammatory hyperpigmentation: a pilot study.

Masood M, Lane B, Maghfour J et al. · 2026 · Clinical and experimental dermatology

Post-inflammatory hyperpigmentation (PIH) is a common complication following trauma or cutaneous inflammation, particularly affecting individuals with skin of colour. Tranexamic acid (TXA) is a lysine analogue with antifibrinolytic…

View details →DOI: 10.1093/ced/llag082
Negative / Null Result ReportMedicine

The impacts of public hospital compensation reform on the health workforce compensation and its structure: quasi-experimental evidence in China.

Zhao Y, Peng Z, Cao D et al. · 2026 · BMC health services research

Background The Chinese government piloted the public hospital's compensation system reform in 2017. It is important for policymakers to understand how this reform has affected the health workforce's compensation and its structure. We…

View details →DOI: 10.1186/s12913-026-14850-2
Negative / Null Result ReportMedicine

Beta cell function and insulin sensitivity during elexacaftor/tezacaftor/ivacaftor therapy in people with cystic fibrosis.

Zazzeron L, Grancini V, Trombetta M et al. · 2026 · Frontiers in endocrinology

Background Cystic fibrosis-related diabetes (CFRD) is the most common extra-pulmonary complication in adults with cystic fibrosis (CF) and is primarily driven by progressive beta-cell dysfunction. The impact of CFTR modulators,…

View details →DOI: 10.3389/fendo.2026.1774728
Negative / Null Result ReportMedicine

The renin angiotensin system in cognitive flexibility: Effects of single-dose losartan on task-switching in healthy volunteers.

Prasad D, Feltham G, De Giorgi R et al. · 2026 · Journal of psychopharmacology (Oxford, England)

Introduction Cognitive flexibility, defined as the ability to shift mental strategies when environmental demands change, may influence psychological well-being and psychiatric treatment outcomes. Research increasingly implicates the renin…

View details →DOI: 10.1177/02698811261456198
Negative / Null Result ReportMedicine

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb-Drug Interaction Investigation.

Gajula SNR, Kallam JS, Kanukolanu A et al. · 2026 · Biopharmaceutics & drug disposition

Echinacea is a widely used herbal supplement and is frequently co-administered with antiviral drugs, raising concerns regarding potential herb-drug interactions. This study evaluated the effect of repeated Echinacea administration on the…

View details →DOI: 10.1002/bdd.70034
Negative / Null Result ReportMedicine

Multitasking Across Physical and Virtual Displays: The Effect of Spatial Discontinuity and Task Load.

Zhang P, Iskandarani ME, Riggs S · 2026 · IEEE transactions on visualization and computer graphics

Optical see-through head-mounted displays (OST-HMDs) allow users to interact with both physical and virtual displays overlaid in the real world within augmented reality (AR) environments. When arranging these displays in space, spatial…

View details →DOI: 10.1109/tvcg.2026.3679118
Negative / Null Result Report

Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized mice

Liu W, Tang Y, Ding W et al. · 2026 · Preprint

Purpose: Estrogen deficiency drives bone loss through a complex interplay of endocrine, oxidative, inflammatory, and bone-remodeling disturbances. Ergothioneine (EGT) is a diet-derived thiol/thione antioxidant, yet its effects on the…

View details →DOI: 10.64898/2026.06.23.734114
Negative / Null Result ReportMedicine

Short-term intraocular pressure changes following intravitreal aflibercept 8 mg versus 2 mg in diabetic macular edema: a prospective observational study.

Hoshiyama K, Hirano T, Sekiya E et al. · 2026 · Scientific reports

This prospective observational study evaluated short-term intraocular pressure (IOP) changes and safety following intravitreal injection of aflibercept 8 mg versus 2 mg in diabetic macular edema (DME). We included 40 eyes from 36 patients…

View details →DOI: 10.1038/s41598-026-55363-6
Negative / Null Result ReportMedicine

The impact of the vaginal birth after cesarean as a new delivery mode on quality of life, sexual function, sleep quality and urinary incontinence during the postpartum period and comparison with the results of vaginal birth and cesarean delivery.

Bektaş B, Ulusoy CO, Uslu H et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective In the present study, we aimed to evaluate the impact of vaginal birth after cesarean (VBAC) on quality of life, sexual function, sleep quality, and urinary incontinence and compare the results with those of vaginal birth (VB)…

View details →DOI: 10.1002/ijgo.71150
Negative / Null Result ReportMedicine

Postural threat influences reactive stepping characteristics at the single-step threshold, but not when a step is necessary.

Avalos MA, Shah S, Rosenblatt NJ · 2026 · Experimental brain research

Following a loss of balance, proper reactive responses are needed to avoid a fall. Efforts have focused on how physiological factors affect these responses, but few have addressed psychological states. One psychological factor of…

View details →DOI: 10.1007/s00221-026-07328-4